Navigation Links
Androgen receptor may explain male dominance in liver cancer
Date:5/19/2010

od, namely that men with HBV are much more likely to develop cancer than women with the same infection," said Aram Hezel, M.D., a gastrointestinal oncologist at the James P. Wilmot Cancer Center at University of Rochester Medical Center. "This is great use of the tools of genetics and mouse modeling to explain a clinical finding and most importantly turn our attention to potentially more promising treatment approaches for patients with hepatocellular carcinoma."

"This study also raises the possibility of prevention among men with HBV infection through inhibition of the androgen receptor," Hezel added. "The potential impact on clinical care is great."

For decades Chang has focused on the particular role of the AR in human health. In 1988 he successfully cloned AR, which led to breakthroughs in several AR-related diseases such as prostate and bladder cancer, and Kennedy's neuron disease, a rare and progressive motor disorder similar to Lou Gehrig's disease, and that affects only men.

The AR is central to the action of testosterone and has a profound effect on many organs. In previous experiments, Chang has shown that mice without AR have dramatically lower rates of bladder cancer, a cancer that strikes men three times more often than women.

Male dominance in liver cancer suggested that the AR would be a key factor, as well. (About 74 percent of liver cancer cases occur in men.) Chang's objective was to locate a new pathway for treatment that would not require depletion of androgen levels in the entire body, which amounts to castration and causes severe side effects for patients.

His study took the first step toward demonstrating this could be done, at least for early stage liver cancer. Researchers showed that an experimental drug, ASC-J9, attacked and degraded the faulty AR, and suppressed liver tumors in mice.

Chang developed ASC-J9 earlier this decade and first reported on its clinical potential in March 2007
'/>"/>

Contact: Leslie Orr
Leslie_Orr@urmc.rochester.edu
585-275-5774
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Intermittent androgen deprivation at least as effective as continuous androgen deprivation
2. Brain dopamine receptor density correlates with social status
3. Pharmacokinetic/Pharmacodynamic Data Support Further Development of Tobiras Next-Generation CCR5 Receptor Antagonist
4. New Guidelines Issued on Hormone Receptor Testing for Breast Cancer
5. Cell study finds receptor can fight tamoxifen-resistant breast cancer cells
6. Estrogen receptor status of HER2+ breast cancer correlates with response to anti-HER therapies
7. Scientist Who Helps Explain Pain Wins Grawemeyer Award
8. Study explains why light worsens migraine headaches
9. Three Anticoagulant Studies May Change Current Medical Practice Including New Data Revealing That Preventative Use of Aspirin and Heparin is Not Effective in Reducing Recurrent, Unexplained Miscarriages
10. Fish Oil Explained Thanks To Unveiling of New Website “fishoil.com”
11. Personal Injury Attorney David Perecman Explains the Possible Legal Consequences of Fatal 911 Operator Error in New York
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/27/2015)... Las Vegas, NV (PRWEB) , ... July 27, 2015 , ... ... for their personalized approach to fertility treatment, has added a veteran physician to their ... Geoffrey Sher , making them one of the most experienced, most successful Reproductive Endocrinology ...
(Date:7/27/2015)... ... July 27, 2015 , ... The Advocator Group, ... has welcomed Jon Cogswell as the vice president of client services. Mr. Cogswell ... played a significant role in the growth and transformation of several businesses, including ...
(Date:7/27/2015)... ... July 27, 2015 , ... Continuing ... with offices serving the greater San Antonio area, is launching a joint charity ... , The Big Brother Big Sister Organization of South Texas is committed to ...
(Date:7/27/2015)... ... July 27, 2015 , ... Rountree Brady Insurance ... is launching a new charity drive to support Next Generation, a volunteer group ... in Savannah, Georgia. , Next Generation workers are dedicated to improving the lives ...
(Date:7/27/2015)... ... 27, 2015 , ... Noto Insurance Advisors, a locally owned ... charity venture with the Christine’s Hope for Kids Foundation, a non-profit based in ... Kids Foundation has already provided for tens of thousands of at risk youths. ...
Breaking Medicine News(10 mins):Health News:Dr. Mark Severino Joins Dr. Geoffrey Sher at Sher Fertility Las Vegas- Sher Fertility is National Network of Fertility Clinics Known for Exceptional Patient Care 2Health News:Dr. Mark Severino Joins Dr. Geoffrey Sher at Sher Fertility Las Vegas- Sher Fertility is National Network of Fertility Clinics Known for Exceptional Patient Care 3Health News:The Advocator Group, LLC Announces Jonathan Cogswell as Vice President of Client Services 2Health News:The Advocator Group, LLC Announces Jonathan Cogswell as Vice President of Client Services 3Health News:Shacklett Insurance Team Joins Local Chapter of Big Brother Big Sister Organization to Initiate Joint Charity Effort to Benefit Children in San Antonio 2Health News:Shacklett Insurance Team Joins Local Chapter of Big Brother Big Sister Organization to Initiate Joint Charity Effort to Benefit Children in San Antonio 3Health News:Rountree Brady Announces Charity Effort to Support Children’s Services at the Memorial University Medical Center Hospital 2Health News:Rountree Brady Announces Charity Effort to Support Children’s Services at the Memorial University Medical Center Hospital 3Health News:Noto Insurance Advisors and the Christine’s Hope for Kids Foundation are Launching a Charity Drive to Provide Underprivileged New Jersey Children with School Supplies 2
... March 11 Eli Manning, NFL Most,Valuable Player ... Champions New,York Giants, will address a National Press ... new national challenge to encourage Americans to be,more ... on the President,s Council on,Physical Fitness and Sports, ...
... Robbins & Myers, Inc.,(NYSE: RBN ) announced ... 2008 financial results for the period ended February 29, ... live webcast of the conference,call will be held at ... Peter,C. Wallace, President and Chief Executive Officer, and Christopher ...
... Kimmel Cancer Center have teased out two distinct sets ... that there are two completely different kinds of the ... neck tumors caused by the human papillomavirus (HPV), a ... certain sexual behaviors and marijuana use, rather than tobacco ...
... ZMH; SWX: ZMH), a leader in the orthopaedics industry, announced,today ... -- March 18, 2008 -- Cowen,s 28th Annual Health ... Eastern Time -- March 19, 2008 -- Eleventh Annual ... Beach, Florida, 8:30 a.m. Eastern Time, Live webcasts of ...
... to Strengthen,Human Services, which is committed to ensuring ... providers, today unveiled its,campaign website, http://www.strengthenhumanservices.org ... that human services providers bring to,all corners of ... Senate 65, a bill that would,establish a fair ...
... better survival rates, but one expert urges caution ... semi-specialized or specialized hospitals improved survival time for ovarian ... study, the researchers examined data on 8,621 ovarian cancer ... Of those women, 40 percent were treated in general ...
Cached Medicine News:Health News:Researchers ID behavioral risk factors for head and neck cancers 2Health News:Researchers ID behavioral risk factors for head and neck cancers 3Health News:New Human Services Website Details Economic Importance of Providers, Warns of Looming Crisis if System is Not Fixed Immediately 2Health News:Specialized Care for Ovarian Cancer Improves Outcomes 2
(Date:7/27/2015)... , July 27, 2015  Array ... financial results for the fourth quarter and ... a conference call to discuss those results ... Chief Executive Officer will lead the call. ... Eastern TimeToll-Free:(844) 464-3927Toll:(765) 507-2598Pass Code: 68380312 Webcast, ...
(Date:7/27/2015)... 2015  Linear accelerators used to treat patients ... only adequate space for the equipment itself, but ... to the size and complexity of the technology, ... addition of a new vault constitutes a formidable ... of patient treatment: with potential negative long-term effects ...
(Date:7/27/2015)... , July 27, 2015 Dynatronics Corporation (NASDAQ: ... its Solaris therapeutic modality products. This approval allows the company to ... other countries around the world. "Receiving the CE Mark ... efforts," stated Kelvyn H. Cullimore Jr. , president and CEO ... distribution network into China , Japan ...
Breaking Medicine Technology:Accelerating the Design Process for Cancer Treatment Centers 2Accelerating the Design Process for Cancer Treatment Centers 3Dynatronics Awarded CE Mark Approval for Its Solaris Products 2
... March 22, 2011 Instrumentation Laboratory (IL) today announced ... ($644.9 million US). This represents 11.5% growth v. previous ... the Company,s two major business segments, Critical Care and ... (11.9% in local currencies) and 9.7% (8.9% in local ...
... Valeant Pharmaceuticals International, Inc. (NYSE: VRX ) ... currently Valeant,s Chief Executive Officer (CEO), as Chairman of the ... the Valeant Board as an independent Board Director and Lead ... and has agreed to extend his contract through to February ...
Cached Medicine Technology:Instrumentation Laboratory Achieves Record Sales in 2010 2Instrumentation Laboratory Achieves Record Sales in 2010 3
... The SYNCHRON CX5-S workstation ... electrolyte testing, targeted to the ... than 200 samples per day. ... the CX5-S is easy to ...
... the high-volume lab, the SYNCHRON LX4201 simplifies ... up to 2,880 tests per hour. By ... SYNCHRON LX4201 with broad menu, speed and ... come to expect from Beckman Coulter-innovative, reliable ...
... It takes powerful technology to ... safety, and still lower costs. ... LX20 PRO, offering features that ... any other chemistry analyzer, including ...
... the power of the LX2000 Series ... resources without compromising testing quality.Plus, when ... LX20 PRO, you get advanced features ... other chemistry analyzer, including closed tube ...
Medicine Products: