Navigation Links
Allegheny Health Network, Johns Hopkins Research Points Potential Way to Effective Immunotherapy Use for Esophageal Cancer Patients
Date:9/5/2017

Immunotherapy drugs such as nivolumab (Opdivo) have given new hope to lung cancer and melanoma patients, some of whom are seeing remarkable response rates with the new therapies. However, progress has been slow for other cancers, including one of the deadliest, esophageal cancer.

Now, in research just published in Annals of Surgery, cancer specialists at Allegheny Health Network’s Esophageal and Lung Institute and the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins have looked at how the immune microenvironment changes during standard chemotherapy and radiation treatment in tissue samples from 31 esophageal cancer patients and a rat model of the disease to shed light on how immunotherapy drugs like nivolumab may help patients with esophageal cancer.

“As physicians who care for patients with esophageal cancer, we are continually working to find new ways to prevent and treat this aggressive cancer,” said Blair Jobe, MD, Chair of the Esophageal and Lung Institute at Allegheny Health Network and one of the principal investigators in the study. “We believe our findings could have significant implications for the treatment of esophageal cancer patients.”

Blair Jobe, MD and Ali Zaidi, MD, Director of Research at AHN’s Esophageal and Lung Institute led the research along with Ronan Kelly, MD, MBA, associate professor at the Johns Hopkins Kimmel Cancer Center. Other AHN researchers included E. Day Werts, PhD., radiation biologist, Division of Radiation Oncology, and Jan Silverman, MD, Chair of Pathology at AHN.

Among tissue samples of esophageal cancer patients treated with combined chemotherapy and radiation, the scientists report statistically significant increases of between nearly 20 and 30 percent of the expression of proteins such as PD-L1 and CTLA-4, which are involved in regulating tumor responses to immune system cells. They also found an increase in the number of T-cells, the soldiers of the immune system, within tumor tissue samples after the patients were treated with chemo and radiation, compared with before their treatment.

In a study of 22 rats which are bred to develop acid reflux disease and subsequent esophageal cancers, the scientists treated 10 of the rats with nine weeks of a lower dose of radiation and 12 rats with a higher dose. Among the esophageal tumors removed from the rats, the scientists found up to twice the levels of PD-L1 expression the within the tumors treated with higher doses of radiation than those that received lower doses. However, because of the small sample size of rats, the changes in protein expression levels was not considered statistically significant. What the scientists did find, though, was that the expression levels were highest immediately after radiation treatment and leveled off as time went on.

“If we continue to find that radiation causes immunologic changes in tumors, we can test whether drugs that target the immune system are able to drive more cancer-killing T-cells into the tumor,” says Kelly. The investigators hope that the human body’s dormant immune defenses can be tricked into recognizing and killing esophageal cancer cells when combined with chemo-radiation.

"Esophageal cancer is a deadly disease that even when detected early is fatal in the majority of patients. Chances of spreading throughout the body are extremely high even in patients where it is diagnosed early and resected. Therefore, newer ways are required to treat this deadly disease in real-time." says Ali Zaidi MD, Director Research at Esophageal and Lung Institute.

The scientists at AHN and Johns Hopkins are conducting a clinical trial to test the safety and effectiveness of adding immunotherapy to standard chemotherapy and radiation in patients with esophageal cancer.

“This research is a great example of how the AHN-Johns Hopkins collaboration is benefiting patients in Pittsburgh and nationwide, combining the expertise of these two great institutions in order to advance clinical cancer care,” said David Parda, MD, Chairman, AHN Cancer Institute. “We expect many more vital collaborations as our partnership continues to grow over the coming years.”

About Allegheny Health Network
Allegheny Health Network is a western Pennsylvania-based integrated healthcare system that serves patients from across a five state region that includes Pennsylvania, Ohio, West Virginia, Maryland and New York. The Network’s Cancer Institute offers a complete spectrum of oncology care, including access to state-of-the-art technologies and new therapies being explored in clinical cancer trials. The Network’s radiation oncology program is the largest in the country and accredited American College of Radiology. AHN also has a formal affiliation with the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, one of the nation’s 41 comprehensive cancer centers designated by the National Cancer Institute, for research, medical education and clinical services.

To schedule an appointment with an AHN oncologist, please call 412.DOCTORS or visit http://www.ahn.org/find-a-doctor.

Read the full story at http://www.prweb.com/releases/2017/09/prweb14654580.htm.


'/>"/>
Source: PRWeb
Copyright©2017 Vocus, Inc.
All rights reserved


Related medicine news :

1. Allegheny Health Network Partners with Region’s EMS Providers to Advance Treatment of Heart Attack Patients
2. Allegheny General Hospital Streamlines Testing for Liver Transplant Patients with Advanced Cardiac MRI
3. Allegheny Health Network Psychologist among Panelists at Senate Staff Briefing In Support of Legislation to Help Patients with Mental Health, Addiction Disorders
4. Four Allegheny Health Network Hospitals Named High Performers by U.S. News
5. Leading West Suburban OBGYN Practice, Premier Women’s Health, Joins Allegheny Health Network
6. Allegheny Health Network Team Develops Biomarker for Early Detection of Esophageal Cancer
7. Fertility Specialist Bryan R. Hecht, MD, Named Medical Director of Allegheny Health Network’s Jones Institute for Reproductive Medicine
8. Allegheny Health Network ALS Program Named Certified Treatment Center of Excellence
9. Allegheny Health Network’s Susan Manzi, MD, MPH, Named Corporate Chair of Pittsburgh JDRF Walk to Cure Diabetes
10. Allegheny Health Network and Come Ready Nutrition Announce Regional Partnership
11. Former Pittsburgh Pirates Pitcher and Baseball Analyst Kent Tekulve Undergoes Successful Heart Transplant at Allegheny General Hospital
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/8/2019)... ... October 08, 2019 , ... What unique insights can three former ... aging and wellness in the nation? That question will be answered at ICAA 2019: ... Summit and Expo. The event will take place October 10-12, 2019, at the Gaylord ...
(Date:10/8/2019)... ... October 08, 2019 , ... Cognosante has been awarded a ... Affairs Community Care Referrals and Authorizations program. The new task order will allow ... Manager (HSRM), an enterprise-wide system used by community care staff to generate referrals ...
(Date:10/8/2019)... ... 08, 2019 , ... Over the past three decades, Buffalo Wings & Rings ... restaurant category by providing a higher-quality product and experience than the competition. Now, the ... a "RAISE A MUG FOR THE CAUSE" campaign in support of Breast Cancer Awareness ...
(Date:10/8/2019)... Ark. (PRWEB) , ... October 08, 2019 , ... ... has selected CardioWise, Inc. a Digital Health Awards 1st Round (Top ... UCSF Digital Health Awards was to select companies that promote faster, better, more ...
(Date:10/8/2019)... ... October 08, 2019 , ... Fewer than 50 ... year, are reproducible. Rigor in bioanalytical method validation is emerging in the form ... than half of the time) and senior scientists add the management of an ...
Breaking Medicine News(10 mins):
(Date:10/10/2019)... ... , ... This World Sight Day, we honor the importance of global awareness ... announce their recent interview with Brand Manager Lynn Hicks and Accessibility Leader Sam Latif ... identify and choose effective hair care products. , Herbal Essences strives ...
(Date:10/9/2019)... ... ... Drs. Steven White, Brad Haines and Colton Fischer of White and Haines Advanced ... NC. If left untreated, sleep apnea can cause mental health concerns and systemic health ... who suffer from snoring at night and excessive fatigue during the day can finally ...
(Date:10/8/2019)... ... October 08, 2019 , ... Help.org, a trusted online resource for individuals who ... Boston, Massachusetts for 2019. The informational guide recognizes the top 17 rehab facilities based ... recent studies , drug overdose is the leading cause of death among people under ...
Breaking Medicine Technology: