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Aging cells lose their grip on DNA rogues
Date:1/30/2013

the organism or is it something that happens so late that by that point the organism has already accumulated so much age-associated damage?" he asked. "Then maybe this extra insult of transposition is not going to make a lot of difference."

The question matters, Sedivy says, because drugs might be able to suppress transposons in aging cells. Virtually all of the transposons of concern in mammals are so-called "retrotransposons" because they use RNA and an enzyme to copy themselves. Certain HIV drugs work by these enzymes called "reverse transcriptases." Remarkably, Sedivy said, the reverse transcriptase of the major human retrotransposons called "L1" has been shown by researchers to be inhibited by some HIV drugs widely used in the clinic.

"The prospects of coming up with an existing drug therapy is something we really need to think about seriously," he said. "We're definitely going to test that and in the future, if needed, we also should be able to design new drugs that are highly specific for L1."

Ultimate success would provide a way to restore order in the cells and forestall at least some of the molecular ravages of age.


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Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

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