Navigation Links
Aging cells lose their grip on DNA rogues
Date:1/30/2013

ntial genes are located and closed "heterochromatin" formations around areas with active transposable elements and few desirable genes.

The distinction appeared to become worn in aging, or senescent, cells. In the observations, the chromatin that once was open tended to become more closed and the chromatin that was once closed, tended to become more open.

Working with computational biologist and Nicola Neretti, assistant professor of biology, Sedivy and De Cecco conducted a genome-wide analysis of these differences. The team extracted and then sequenced DNA from young and senescent human fibroblast cells using a technique called FAIRE. Essentially FAIRE uses chemicals such as formaldehyde to separate out DNA that is loosely packed in euchromatin from DNA that is more tightly wound up in heterochromatin.

Then the scientists compared the DNA that was coming from open or closed chromatin formations in the young and senescent cells.

"Given that our genomes contain well over a million copies of transposable elements and that they are very similar to one another, tracking all this mayhem is no easy matter," Neretti said. "Computationally speaking, it's a nightmare."

But Sedivy said results were well worth the effort. In their study not only did they find that the chromatin lockdown was breaking down, but also that the newly freed transposons were taking full advantage.

"I was really surprised to see that first of all these transposable elements start to get expressed and that they actually start moving around [to other regions in the genome]," Sedivy said. "That's really an amazing thing."

How bad and how to stop it?

What's not clear from the study is the relevance of the damage that the cells suffer from the transposable element jailbreak and resulting genetic crime spree. That depends on the timing, which Sedivy's team measured only in approximate terms.

"Is the transposition really bad for
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
2. Social ties have mixed impact on encouraging healthy behaviors in low-income areas
3. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
4. MR enterography is as good or better than standard imaging exams for pediatric Crohns patients
5. Use of dedicated pediatric imaging departments for pediatric CT reduces radiation dose
6. Joslin scientists identify important mechanism that affects the aging process
7. Low-dose whole-body CT finds disease missed on standard imaging for patients with multiple myeloma
8. Staging and risk stratification of thyroid cancer improved with SPECT/CT
9. Study examines necessity of additional imaging in PET/CT oncologic reports
10. Self-Managing COPD Might Pose Risks, Study Suggests
11. CNIO scientists successfully test the first gene therapy against aging-associated decline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aging cells lose their grip on DNA rogues
(Date:4/22/2014)... of all lung cancers are small cell lung ... resistance to chemotherapy. However, researchers at Virginia Commonwealth ... into the mechanisms leading to this resistance that ... work primarily by mediating B-cell lymphoma 2 (Bcl-2) ... death. Depending on their function, this family of ...
(Date:4/22/2014)... The International Communication Association will hold its ... The theme of the 2014 conference will explore ... and digital society. , Featuring over 2,300 academic ... Communication scholars representing over 40 countries, the ICA ... in the world. This year,s conference features sessions ...
(Date:4/22/2014)... release is available in German . ... important intracellular signaling molecules, but their mode of action ... of cellular function and behavior, while at high concentrations ... and DNA. To analyze how redox signaling unfolds in ... microscopy technique has been developed jointly by the teams ...
(Date:4/22/2014)... (SALT LAKE CITY)A computational tool developed at the University ... with unknown gene mutations in three separate cases, U ... new study in The American Journal of Human ... Re-ranking tool), identifies undiagnosed illnesses and unknown gene mutations ... proteins that code for genes are made, in individual ...
(Date:4/22/2014)... demonstrated the first size-based form of chromatography that ... living cells. This unique physical approach to probing ... whether a cell lives or dies, remains normal ... conventional microscopy. , "We,ve developed membrane-embedded nanodot array ... probe and manipulate membrane assemblies, including signaling clusters, ...
Breaking Medicine News(10 mins):Health News:Scientists pinpoint protein that could improve small cell lung cancer therapies 2Health News:International Communication Association to hold Annual Conference in Seattle, Washington 2Health News:Neuroimaging: Live from inside the cell 2Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 2Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 3Health News:First size-based chromatography technique for the study of livi 2Health News:First size-based chromatography technique for the study of livi 3
... benefit from a shunt used for less common brain ... -- Some people with Alzheimer,s disease may be helped ... less common neurological condition, new research suggests. , The ... cerebrospinal fluid builds up in the ventricles, or cavities, ...
... Jefferson University have found that colonoscopy preparation drugs administered ... to those given the night before and the morning ... side effects such as abdominal pain, sleep loss and ... compared results between 116 colonoscopy patients given a split ...
... ... near some of the best hospitals and clinics in the world. , ... Monsey, NY (PRWEB) May 4, 2010 -- The new All Time ... , ,"We were physically bound by how many people we were able to hire. We literally ...
... An enchanted estate ... laidback escape, in total peace. , , ... May 1, 2010 -- What is Euterpini? , , ,Eight typical local villas, the so-called dammusi, that ... the western side of the island of Pantelleria , and named after local plants and flowers ...
... ... contract partners can now ensure on-time production, gain visibility to production milestones and ... With this cloud-based solution, team members can collaborate on production orders and track ... ...
... ... marketing and product/service innovations. , ... Michigan (PRWEB) May 3, 2010 -- David Hofer has joined Michigan-based ... will also head the recruitment of team members and development of the International Bancard ...
Cached Medicine News:Health News:Surgery for Treatable Dementia Might Also Help in Alzheimer's 2Health News:Surgery for Treatable Dementia Might Also Help in Alzheimer's 3Health News:Study finds cutting colonoscopy preparation from 2 days to 1 day just as effective 2Health News:All Time Medical Has Just Moved To Their New, State-Of-The Art Office Situated In The Heart Of The Business District Of Monsey, N.Y 2Health News:Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution 2Health News:Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution 3Health News:Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution 4Health News:David Hofer Named President of International Bancard Corporation 2
(Date:1/15/2014)... , Jan. 15, 2014 AARP Foundation today announced it ... adults suffering from the severe cold weather that has gripped ... to helping those in need; so to support these emergency ... up to $250,000, which could mean up to $500,000 in ...
(Date:1/15/2014)... January 15, 2014 Shire plc (LSE: SHP, NASDAQ: ... of Fair Trading (OFT) approval condition to the announced tender offer ...   As a result of the waiver, the transaction ... complete the tender offer on January 24, 2014 following the currently ...
(Date:1/15/2014)... Fla. , Jan. 15, 2014  In an unprecedented effort to ... TB in ambulances and other transport vehicles, an advanced and portable ... rescue personnel for the first time. In order ... with these deadly pathogens, West Palm Beach ...
Breaking Medicine Technology:AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 2AARP Foundation Establishes Winter Relief Fund for Older Adults Suffering from the Severe Cold Weather 3Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3Superbugs No Longer Ride In Rescue Vehicles 2
... 2010 At this year,s Annual Meeting of ... Philips Electronics (NYSE: PHG, AEX: PHI) is demonstrating ... can help simplify the clinician and patient experience. ... (Logo: http://www.newscom.com/cgi-bin/prnh/20091127/NY17547LOGO ) ...
... Inovonics ( http://www.inovonics.com ), the industry leader in ... safety applications, today announced the release of the ... specifically to meet the unique needs of senior ... EN1240 offers a significant advancement over other alternative ...
Cached Medicine Technology:Philips Showcases Integrated Radiation Oncology Suite to Simplify Treatment Planning 2Philips Showcases Integrated Radiation Oncology Suite to Simplify Treatment Planning 3Philips Showcases Integrated Radiation Oncology Suite to Simplify Treatment Planning 4Inovonics Delivers Passive Wireless Sensor for Monitoring Senior Care Resident Activity 2Inovonics Delivers Passive Wireless Sensor for Monitoring Senior Care Resident Activity 3Inovonics Delivers Passive Wireless Sensor for Monitoring Senior Care Resident Activity 4
The Sedimat 15 Automated sedrate system provides an accurate ESR result in only 15 minutes. Fast, in-office results (before patient leaves the office) can lead to improved patient therapy....
... Sysmex CA-7000 provides speed and precision ... synonymous with Sysmex technology. With ... throughput of up to 300 samples ... multi-parameter testing. This high performance, ...
... CA-1500 enhances productivity in the laboratory with ... detection methods clotting, chromogenic and immunological ... precise test results every time. With ... and random access, the CA-1500 will provide ...
... is the lancing device that has set ... since 1983. This re-usable lancing device assists ... The auto-Lancet is constructed in the USA ... after day, year after year. It's the ...
Medicine Products: