Navigation Links
Aging cells lose their grip on DNA rogues
Date:1/30/2013

ntial genes are located and closed "heterochromatin" formations around areas with active transposable elements and few desirable genes.

The distinction appeared to become worn in aging, or senescent, cells. In the observations, the chromatin that once was open tended to become more closed and the chromatin that was once closed, tended to become more open.

Working with computational biologist and Nicola Neretti, assistant professor of biology, Sedivy and De Cecco conducted a genome-wide analysis of these differences. The team extracted and then sequenced DNA from young and senescent human fibroblast cells using a technique called FAIRE. Essentially FAIRE uses chemicals such as formaldehyde to separate out DNA that is loosely packed in euchromatin from DNA that is more tightly wound up in heterochromatin.

Then the scientists compared the DNA that was coming from open or closed chromatin formations in the young and senescent cells.

"Given that our genomes contain well over a million copies of transposable elements and that they are very similar to one another, tracking all this mayhem is no easy matter," Neretti said. "Computationally speaking, it's a nightmare."

But Sedivy said results were well worth the effort. In their study not only did they find that the chromatin lockdown was breaking down, but also that the newly freed transposons were taking full advantage.

"I was really surprised to see that first of all these transposable elements start to get expressed and that they actually start moving around [to other regions in the genome]," Sedivy said. "That's really an amazing thing."

How bad and how to stop it?

What's not clear from the study is the relevance of the damage that the cells suffer from the transposable element jailbreak and resulting genetic crime spree. That depends on the timing, which Sedivy's team measured only in approximate terms.

"Is the transposition really bad for
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
2. Social ties have mixed impact on encouraging healthy behaviors in low-income areas
3. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
4. MR enterography is as good or better than standard imaging exams for pediatric Crohns patients
5. Use of dedicated pediatric imaging departments for pediatric CT reduces radiation dose
6. Joslin scientists identify important mechanism that affects the aging process
7. Low-dose whole-body CT finds disease missed on standard imaging for patients with multiple myeloma
8. Staging and risk stratification of thyroid cancer improved with SPECT/CT
9. Study examines necessity of additional imaging in PET/CT oncologic reports
10. Self-Managing COPD Might Pose Risks, Study Suggests
11. CNIO scientists successfully test the first gene therapy against aging-associated decline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aging cells lose their grip on DNA rogues
(Date:11/26/2014)... November 26, 2014 Healthpointe is proud ... Perris , and it will be led by ... in the field of Occupational Medicine and utilizes the ... Medicine specialist delivers quality care for employers and their ... health. , As an Occupational Medicine ...
(Date:11/26/2014)... Recently, Locks-Magnetic.com, a Chinese outstanding Maglocks supplier, is ... on the Internet. It also provides a big discount ... As a leading company in the electronic lock industry, ... buy high quality locks. It can meet the demands ... are not only useful but also affordable. However, inexpensive ...
(Date:11/26/2014)... iFitDress.com, a well-known wedding dress manufacturer and ... 16 cocktail dresses . Included in the new range ... all of these charming outfits are offered at deeply ... has promised that all of the sweet 16 cocktail ... worth mentioning that all of them are set according ...
(Date:11/26/2014)... November 26, 2014 Dr. Rod ... Distinguished Teaching Professor in the Department of Plastic ... facial fat compartments, fat grafting, and modern lift-and-fill ... an annual conference held by the American Society ... of this underlying facial structure were explored in ...
(Date:11/26/2014)... When you,re planning your holiday get-away, don,t forget ... -- such as skiing or hiking, a sports ... fail to take altitude into account when visiting ... of developing fatigue and other symptoms related to ... Melissa Tabor, an assistant professor of sports medicine ...
Breaking Medicine News(10 mins):Health News:Healthpointe now offering Occupational Medicine in their Perris Medical Clinic 2Health News:Healthpointe now offering Occupational Medicine in their Perris Medical Clinic 3Health News:Fresh Products Launched by Famous Company Lock-Magnetic.com 2Health News:iFitDress.com: Trendy Sweet 16 Cocktail Dresses Unveiled 2Health News:Dr. Rod J. Rohrich Discusses Facelifts at ASPS Annual Assembly 2Health News:Dr. Rod J. Rohrich Discusses Facelifts at ASPS Annual Assembly 3Health News:Don't Let High Altitude Ruin Your Holiday Trip 2
... year in Jacksonville,nearly 600 adults experience some form ... to recovery lacked long-term support. Today, Brooks,Rehabilitation celebrated ... Florida created to help people with acquired brain ... The Brain Injury Association of America estimates that ...
... researcher, administrator, and,Chair Emeritus of the University of Louisville,s ... Foundation for,Biomedical Research (FBR) today announced its board of ... chairman of the board. Dr.,Polk succeeds the late Dr. ... years., "I am honored to represent the Foundation ...
... respiratory problems, CDC report says , , WEDNESDAY, Oct. 22 (HealthDay ... has soared 18 percent in the last decade, with an ... the condition, a new federal report says. , In 2007, ... reported to have had a food or digestive allergy in ...
... Oct. 22 Endocare, Inc.,(Nasdaq: ENDO ), an ... invasive technologies for tissue and tumor,ablation, today announced that ... Oppenheimer 19th Annual Healthcare Conference at 1:20,p.m. ET on ... at the,Waldorf Astoria hotel November 3-4 in New York ...
... supplier, DRE adds affordable, professionally refurbished ultrasound machines to its ... ... KY (PRWEB) October 22, 2008 -- DRE Inc. - named ... businesses in Louisville, Ky. — now sells professionally refurbished ...
... allows more efficient use of larger cleanrooms. , ... ... fabricator and installer of cleanrooms and cleanroom equipment announces ... the AireCell line of extrusions. The new extrusion allows greater ...
Cached Medicine News:Health News:Brooks Rehabilitation Opens First Work-Based Brain Injury Rehab Program in Florida 2Health News:The Foundation for Biomedical Research Names Dr. Hiram C. Polk Jr. Chairman of its Board of Governors 2Health News:Food Allergies Up 18% Among U.S. Children 2Health News:Endocare to Present at Oppenheimer 19th Annual Healthcare Conference 2Health News:DRE Medical Equipment Adds Affordable Refurbished Ultrasound Machines to Product Line 2Health News:DRE Medical Equipment Adds Affordable Refurbished Ultrasound Machines to Product Line 3Health News:Gerbig Engineering Introduces 7 " Deep Extrusions for Cleanroom Construction 2
(Date:11/26/2014)... , Nov. 26, 2014  Aethlon Medical, Inc. ... definitive agreement to raise approximately $3.3 million at a ... made by one institutional healthcare focused investor. Each unit consists ... a common share purchase warrant. Each whole warrant entitles ... price of $0.30 for a period of five years ...
(Date:11/26/2014)... , Nov. 26, 2014  Cohen, Placitella ... behalf of investors who purchased Nymox Pharmaceutical Corporation ... during the period from January 31, 2011 through ... whether Nymox and certain of its officers and ... in violation of Sections 10(b) and 20(a) of ...
(Date:11/26/2014)... , Nov. 26, 2014 Lexicon ... announced the completion of previously announced concurrent financing ... After fees and estimated offering expenses, Lexicon anticipates ... transactions.  The transactions consisted of: , ... stock, pursuant to a registration statement that has ...
Breaking Medicine Technology:Aethlon Medical Announces $3.3 Million Equity Investment 2Aethlon Medical Announces $3.3 Million Equity Investment 3Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 2Cohen, Placitella & Roth, PC Investigating Nymox Pharmaceutical Corporation for Failing to Disclose Material Information 3Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3
The pouch is designed to protect the Digitrapper. The pouch strap can be worn on a belt loop or carried in a shoulder strap or backpack configuration....
... catheters are designed using established technology ... following benefits:, ,Working with pH ... where the multi-use catheter is used ... contact to the skin.,NOTE: ,Medtronic pH ...
...
... Designed to accommodate a variety of applications ... the AMAX DestinyPlus is suitable for any ... environment. With a mixed-mode throughput exceeding 95 ... perform a full range of chromogenics, the ...
Medicine Products: