Navigation Links
Aging cells lose their grip on DNA rogues
Date:1/30/2013

ntial genes are located and closed "heterochromatin" formations around areas with active transposable elements and few desirable genes.

The distinction appeared to become worn in aging, or senescent, cells. In the observations, the chromatin that once was open tended to become more closed and the chromatin that was once closed, tended to become more open.

Working with computational biologist and Nicola Neretti, assistant professor of biology, Sedivy and De Cecco conducted a genome-wide analysis of these differences. The team extracted and then sequenced DNA from young and senescent human fibroblast cells using a technique called FAIRE. Essentially FAIRE uses chemicals such as formaldehyde to separate out DNA that is loosely packed in euchromatin from DNA that is more tightly wound up in heterochromatin.

Then the scientists compared the DNA that was coming from open or closed chromatin formations in the young and senescent cells.

"Given that our genomes contain well over a million copies of transposable elements and that they are very similar to one another, tracking all this mayhem is no easy matter," Neretti said. "Computationally speaking, it's a nightmare."

But Sedivy said results were well worth the effort. In their study not only did they find that the chromatin lockdown was breaking down, but also that the newly freed transposons were taking full advantage.

"I was really surprised to see that first of all these transposable elements start to get expressed and that they actually start moving around [to other regions in the genome]," Sedivy said. "That's really an amazing thing."

How bad and how to stop it?

What's not clear from the study is the relevance of the damage that the cells suffer from the transposable element jailbreak and resulting genetic crime spree. That depends on the timing, which Sedivy's team measured only in approximate terms.

"Is the transposition really bad for
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
2. Social ties have mixed impact on encouraging healthy behaviors in low-income areas
3. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
4. MR enterography is as good or better than standard imaging exams for pediatric Crohns patients
5. Use of dedicated pediatric imaging departments for pediatric CT reduces radiation dose
6. Joslin scientists identify important mechanism that affects the aging process
7. Low-dose whole-body CT finds disease missed on standard imaging for patients with multiple myeloma
8. Staging and risk stratification of thyroid cancer improved with SPECT/CT
9. Study examines necessity of additional imaging in PET/CT oncologic reports
10. Self-Managing COPD Might Pose Risks, Study Suggests
11. CNIO scientists successfully test the first gene therapy against aging-associated decline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aging cells lose their grip on DNA rogues
(Date:7/28/2015)... , ... July 28, 2015 , ... Want to improve ... – or in your easy chair? Luckily, there are plenty of back-friendly cardio exercises ... an orthopedic spine surgeon at Atlantic Spine Center . , It’s simply ...
(Date:7/27/2015)... , ... July 28, 2015 , ... Almost a year ... to offer behavioral health counseling for persons who are obese and those who are ... less clear. , That mandate will affect any commercial health plan with a program ...
(Date:7/27/2015)... (PRWEB) , ... July 28, 2015 , ... The ... 2015-2016 inductee into the NAPW VIP Woman of the Year Circle. She is recognized ... over 200 operating Local Chapters, NAPW is the nation’s leading networking organization exclusively for ...
(Date:7/27/2015)... , ... July 27, 2015 , ... The heroin epidemic ... reported WCNC on July 7th. The rate for heroin usage has continued ... gone down considerably, and is a less expensive alternative for those with an addiction ...
(Date:7/27/2015)... (PRWEB) , ... July 27, 2015 , ... Looking to ... smile? Horizon Blue Cross Blue Shield of New Jersey has enhanced its Dental webpage ... take care of their teeth. , “Horizon is committed to offering our 3.8 ...
Breaking Medicine News(10 mins):Health News:Safe Cardio for Back Pain Sufferers 2Health News:Safe Cardio for Back Pain Sufferers 3Health News:How Digital Therapeutics Can Help Payers Out of Regulatory Fix 2Health News:How Digital Therapeutics Can Help Payers Out of Regulatory Fix 3Health News:NAPW Inducts Deana Skidmore, Assistant Director of Nursing at Wilton Meadows Rehablilitation and Health Care Center, Into its VIP Woman of the Year Circle 2Health News:45% Of People Addicted to Heroin Began Addicted to Prescription Medications 2Health News:45% Of People Addicted to Heroin Began Addicted to Prescription Medications 3Health News:Thinking about a Dental Check-up? Check out Horizon Blue Cross Blue Shield of New Jersey’s Enhanced Website for a Dental Download of Helpful Information 2
... reimburses patients and physicians who have been shortchanged ... American Medical Association (AMA), along with the Medical Society ... State Medical Association, claims victory with the settlement agreement ... The $350 million settlement marks the largest monetary settlement ...
... Philadelphia Attorney Stephen Sheller,s Whistleblower Clients Help ... Criminal Fine in Eli Lilly & Company ... 2003 Representing Six Whistleblowers PHILADELPHIA, Jan. 15 ... ("Lilly") will pay federal and state governments ...
... Eli Lilly and Company announced today it has ... pay more than 1.4 billion in criminal and civil ... multiple whistleblower lawsuits that the pharmaceutical giant defrauded Medicare, ... with its market practices for its blockbuster atypical antipsychotic, ...
... transplanted because of the generosity of donors and their familiesPHILADELPHIA, ... kid on the football field, but he spent his life ... graduated high school. For a 16-year-old from Hazleton, Pa. ... certainly unique. But as his father Paul Sr. talked ...
... $515 Million Criminal Fine is Largest Individual Corporate Criminal ... 15 American pharmaceutical giant Eli Lilly and Company ... for promoting its drug Zyprexa for uses not approved ... of Justice announced today. This resolution includes ...
... CINCINNATI, Jan. 15, 2009 The Procter & Gamble,Company ... organizational changes: , -- Mariano ... June 30, 2009, after 33 years of service. He ... 2009, when he will focus on working,closely with his ...
Cached Medicine News:Health News:AMA Claims Victory With Record Breaking Settlement in Case Against Insurer 2Health News:The Largest Pharma Fraud Whistleblower Case in U.S. History Totaling $1.4 Billion 2Health News:The Largest Pharma Fraud Whistleblower Case in U.S. History Totaling $1.4 Billion 3Health News:The Largest Pharma Fraud Whistleblower Case in U.S. History Totaling $1.4 Billion 4Health News:Eli Lilly Pays a Record $1.4 Billion to Settle Federal and State Fraud Investigations into Illegal Zyprexa Off-Label Marketing Practices 2Health News:Eli Lilly Pays a Record $1.4 Billion to Settle Federal and State Fraud Investigations into Illegal Zyprexa Off-Label Marketing Practices 3Health News:Eli Lilly Pays a Record $1.4 Billion to Settle Federal and State Fraud Investigations into Illegal Zyprexa Off-Label Marketing Practices 4Health News:Gift of Life Celebrates 35th Anniversary as National Leader in Organ Donation 2Health News:Gift of Life Celebrates 35th Anniversary as National Leader in Organ Donation 3Health News:Gift of Life Celebrates 35th Anniversary as National Leader in Organ Donation 4Health News:Eli Lilly and Company Agrees to Pay $1.415 Billion to Resolve Allegations of Off-Label Promotion of Zyprexa 2Health News:Eli Lilly and Company Agrees to Pay $1.415 Billion to Resolve Allegations of Off-Label Promotion of Zyprexa 3Health News:Eli Lilly and Company Agrees to Pay $1.415 Billion to Resolve Allegations of Off-Label Promotion of Zyprexa 4Health News:Eli Lilly and Company Agrees to Pay $1.415 Billion to Resolve Allegations of Off-Label Promotion of Zyprexa 5Health News:Eli Lilly and Company Agrees to Pay $1.415 Billion to Resolve Allegations of Off-Label Promotion of Zyprexa 6Health News:Eli Lilly and Company Agrees to Pay $1.415 Billion to Resolve Allegations of Off-Label Promotion of Zyprexa 7Health News:Procter & Gamble Announces Organizational Changes 2
(Date:7/27/2015)... New York , July 27, 2015 ... Market Research "Bionics Market - Global Industry Analysis, Size, Share, ... was valued at USD 7.96 billion in 2014, growing at ... for USD 20.49 billion in 2021. The global ... the number of accidents, which is leading to paralysis or ...
(Date:7/27/2015)... CHICAGO , July 27, 2015 The Physician-Patient ... anniversary. PPAHS posted its first blog on July ... a heart beat? ". This post featured ... heart attack outside of a grocery store in ... a 96-minute CPR marathon involving 20 others, who took turns ...
(Date:7/27/2015)... MENLO PARK, Calif. , July ... (OTCQX: DMPI) ("DelMar" and the "Company"), a biopharmaceutical ... therapies in new orphan drug indications, today announced ... accredited investors for a registered direct placement ("Placement") ... 3.35 million common stock purchase warrants for aggregate ...
Breaking Medicine Technology:Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 2Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 3Global Bionics Market is Expected to Reach USD 20.49 Billion in 2021, Growing at CAGR of 13.2% From 2015 to 2021: Transparency Market Research 4Physician-Patient Alliance for Health & Safety Turns 4 Years Old 2DelMar Pharmaceuticals Announces Financing Update and Initial Subscriptions of $2.0 million in Registered Direct Offering 2DelMar Pharmaceuticals Announces Financing Update and Initial Subscriptions of $2.0 million in Registered Direct Offering 3
... Calif., Aug. 29, 2011 Masimo ... of Health Labor & Welfare (MHLW) and Health Canada regulatory ... to quickly and conveniently measure total hemoglobin (SpHb®), SpO2, perfusion ... Hemoglobin is one of the most commonly ...
... Aug. 29, 2011 /PRNewswire-Asia/ -- Winner Medical Group ... or "the Company"), a leading manufacturer of medical ... 100% natural PurCotton® products in China, today announced ... investors to establish Shenzhen PurCotton E-Commerce Co., Ltd.("PurCotton ...
Cached Medicine Technology:Masimo Pronto-7™ Receives Japanese and Canadian Regulatory Clearances 2Masimo Pronto-7™ Receives Japanese and Canadian Regulatory Clearances 3Masimo Pronto-7™ Receives Japanese and Canadian Regulatory Clearances 4Masimo Pronto-7™ Receives Japanese and Canadian Regulatory Clearances 5Winner Medical's PurCotton E-Commerce Sets Sail 2Winner Medical's PurCotton E-Commerce Sets Sail 3Winner Medical's PurCotton E-Commerce Sets Sail 4