Navigation Links
Aging cells lose their grip on DNA rogues
Date:1/30/2013

ntial genes are located and closed "heterochromatin" formations around areas with active transposable elements and few desirable genes.

The distinction appeared to become worn in aging, or senescent, cells. In the observations, the chromatin that once was open tended to become more closed and the chromatin that was once closed, tended to become more open.

Working with computational biologist and Nicola Neretti, assistant professor of biology, Sedivy and De Cecco conducted a genome-wide analysis of these differences. The team extracted and then sequenced DNA from young and senescent human fibroblast cells using a technique called FAIRE. Essentially FAIRE uses chemicals such as formaldehyde to separate out DNA that is loosely packed in euchromatin from DNA that is more tightly wound up in heterochromatin.

Then the scientists compared the DNA that was coming from open or closed chromatin formations in the young and senescent cells.

"Given that our genomes contain well over a million copies of transposable elements and that they are very similar to one another, tracking all this mayhem is no easy matter," Neretti said. "Computationally speaking, it's a nightmare."

But Sedivy said results were well worth the effort. In their study not only did they find that the chromatin lockdown was breaking down, but also that the newly freed transposons were taking full advantage.

"I was really surprised to see that first of all these transposable elements start to get expressed and that they actually start moving around [to other regions in the genome]," Sedivy said. "That's really an amazing thing."

How bad and how to stop it?

What's not clear from the study is the relevance of the damage that the cells suffer from the transposable element jailbreak and resulting genetic crime spree. That depends on the timing, which Sedivy's team measured only in approximate terms.

"Is the transposition really bad for
'/>"/>

Contact: David Orenstein
david_orenstein@brown.edu
401-863-1862
Brown University
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Vaccine yielded encouraging long-term survival rates in certain patients with NSCLC
2. Social ties have mixed impact on encouraging healthy behaviors in low-income areas
3. Live imaging shows response to cancer drugs can be boosted by altering tumor microenvironment
4. MR enterography is as good or better than standard imaging exams for pediatric Crohns patients
5. Use of dedicated pediatric imaging departments for pediatric CT reduces radiation dose
6. Joslin scientists identify important mechanism that affects the aging process
7. Low-dose whole-body CT finds disease missed on standard imaging for patients with multiple myeloma
8. Staging and risk stratification of thyroid cancer improved with SPECT/CT
9. Study examines necessity of additional imaging in PET/CT oncologic reports
10. Self-Managing COPD Might Pose Risks, Study Suggests
11. CNIO scientists successfully test the first gene therapy against aging-associated decline
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Aging cells lose their grip on DNA rogues
(Date:12/19/2014)... illness-causing E. coli bacteria were found on nearly one-quarter ... new study. Researchers checked cilantro, basil and parsley ... Los Angeles and Orange counties in California, and in ... 24 percent were positive for E. coli. One sample ... Both types of bacteria can cause sometimes serious or ...
(Date:12/19/2014)... The cost of cancer treatment can cause financial stress ... Researchers examined data from 1,000 people in the United ... cancer. Of those patients, almost 900 had finished their ... advanced cancer. Nearly half of the patients said ... was linked with a poorer health-related quality of life. ...
(Date:12/19/2014)... Diet Doc strives to continue to provide ... weight loss by combining scientific fast weight loss ... company understand that remaining committed to a diet can ... and sugars from the diet can cause patients to ... loss goals. , For this reason, Diet Doc ...
(Date:12/19/2014)... December 19, 2014 B. E. Smith, ... healthcare providers, has been retained to lead a national ... Hospital in Franklin, Ind. The top executive search firm ... placed more than 900 healthcare executives into organizations. ... service hospital providing care to the residents of Johnson ...
(Date:12/19/2014)... Mobile Spa, has announced they now have a Virtual ... into a utopia for the Long Island community where the ... Tour showcases the beauty of the Spa On Wheels which ... The Virtual Tour shows viewers each of the rooms in ... Marla Kaplan-Pelle, Director states " It's hard to imagine that ...
Breaking Medicine News(10 mins):Health News:E. Coli Germs Found on Farmers Market Herbs 2Health News:Cancer Treatment Costs Weigh Heavily on Patients, Study Finds 2Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 2Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 3Health News:Diet Doc Incorporates Appetite Zap into their Already Impressive Collection of Diet Products to Jump Start the Metabolism and Burn Fat 4X Faster 4Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:A Virtual Tour Of Hands On Mobile Massage Spa Is Now Available 2Health News:A Virtual Tour Of Hands On Mobile Massage Spa Is Now Available 3
... greatly increases the risk of heart diseases as an adult, according ... heart disease is not how much you weigh now, but how ... with a low birth weight are roughly twice as susceptible to ... an epidemologist at the University of Southampton, and a team at ...
... The right side of the brain helps people recognise ... from the Beth Israel Deaconess Medical Center in Boston ... ,The study joins a growing body of evidence ... in self-awareness.// Studies of self-awareness may provide unique insights ...
... who do not express their requests feel less satisfied with their ... not tell a patient everything on his mind. One may feel ... she may seem rushed, or it may be that the relationship ... as it could be.// ,Researchers at the University of ...
... differences in disease patterns in different mammals - and it ... genes with our primate cousins - yet they rarely get ... dogs do not suffer from high blood pressure, even when ... Professor of Comparative Medicine at the University of Houston and ...
... tool to the field of medicine. An interactive video ... treatment. The days when doctors told you what treatment ... participate in the decision-making process.// But sometimes this is ... new research comes up all the time. ...
... or sleep apnoea has the potential to alter voice characteristics. ... stops many times during the night - is to remodel ... is that the uvula - a flap of tissue at ... ,If the uvula is trimmed - in an operation called ...
Cached Medicine News:Health News:The right is responsible 2
(Date:12/19/2014)... , Dec. 18, 2014 Somewhere between dropping ... health was forgotten. But Audicus , a next-generation ... better this new year. Hearing loss is ... aging population, though it is often unaddressed. Forty-eight million ... has a hearing aid, mainly due to price. Hearing ...
(Date:12/19/2014)... 18, 2014  RESMED INC. (NYSE: RMD ) ... fiscal year 2015 results on Thursday, January 22, 2015, after ... with ResMed,s results will be issued after 1:00 p.m. US ... discuss operating results and future outlook. The earnings ... Time and the live webcast of the call can be ...
(Date:12/19/2014)... has witnessed robust development with the growth pace keeping at ... In 2012, the size of China ... worldwide soaring to 16.3%. It is projected that ... rate by around 20% in the upcoming years and that ... An integrated membrane industrial system has taken shape ...
Breaking Medicine Technology:Audicus Will Help People Resolve to Hear Better in 2015 2ResMed To Announce Second Quarter 2015 Results 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 2Separation Membranes Market (Company, Country & Application) Research Reports for Global and Chinese Regions 3
0.5 mm x 10 mm angled blade with blunt tip. Flat smooth handle with polished finish....
0.5 mm short 90 degree angled tip with black ebonized shaft. Titanium handle with position reference indicator. Shaft length 52 mm, handle length 100 mm....
The popular Bechert nucleus rotator has been modified to have the shaft angled 10 mm from tip to bend for ease of manipulation of the lens nucleus in the anterior chamber. Round knurled handle....
1.0 mm long 120 degree angled tip with black ebonized shaft. Titanium handle with position reference indicator. Shaft length 52 mm, handle length 100 mm....
Medicine Products: