Navigation Links
Advances in delivery of therapeutic genes to treat brain tumors
Date:6/27/2011

New Rochelle, NY, June 27, 2011Novel tools and methods for delivering therapeutic genes to cells in the central nervous system hold great promise for the development of new treatments to combat incurable neurologic diseases. Five of the most exciting developments in this rapidly advancing field are presented in a series of articles in the June issue of Human Gene Therapy, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The articles are available free online at www.liebertpub.com/hum

A review article by Betley and Sternson, "Adeno-Associated Viral Vectors for Mapping, Monitoring, and Manipulating Neural Circuits," highlights the latest genetic tools that are enabling cell type-specific delivery of transgenes for studying the structure and function of neuronal circuits.

Ryu et al. report on the successful use of stem cells derived from human umbilical cord blood to deliver a novel therapeutic geneinterleukin-12to the brain for long-term anti-tumor activity against gliomas, a deadly type of brain tumor. Their innovative strategy is presented in the research report "Gene Therapy of Intracranial Glioma Using Interleukin 12-Secreting Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells."

"High-Density Lipoprotein Facilitates In Vivo Delivery of α-Tocopherol-Conjugated Short-Interfering RNA to the Brain" by Uno et al. describes a combination strategy for dramatically improved delivery of siRNAs to the brain to silence genes involved in neurological disease.

Loss of the neurotrophic factor GDNF contributes to the development of neuropathic pain caused by trauma or neurodegenerative disease. Shi et al. present data to support this link and demonstrate the potential to replace GDNF via intramuscular gene delivery in the article "Glial Cell Line-Derived Neurotrophic Factor Gene Transfer Exerts Protective Effect on Axons in Sciatic Nerve Following Constriction-Induced Peripheral Nerve Injury."

The use of adenoviral vectors as carriers of therapeutic genes to the cerebrospinal fluid has the potential to enable long-term gene expression for the treatment of neurological diseases. In the brief report "Intrathecal Injection of Helper-Dependent Adenoviral Vectors Results in Long-Term Transgene Expression in Neuroependymal Cells and Neurons" Dindot et al. describe the successful use of adenoviral vectors to transduce neuronal cells.

"Treating neurologic diseases with traditional biologic products such as therapeutic proteins has been challenging due to limited access. The use of vectors helps to overcome these barriers," says James M. Wilson, MD, PhD, Editor-in-Chief, and Director of the Gene Therapy Program, Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia.


'/>"/>

Contact: Vicki Cohn
vcohn@liebertpub.com
914-740-2100
Mary Ann Liebert, Inc./Genetic Engineering News
Source:Eurekalert  

Related medicine news :

1. New advances in lipid genetics lead to better detection and prevention of major diseases
2. Led by advances in chemical synthesis, scientists find natural product shows pain-killing properties
3. Society of Interventional Radiology addresses radiation safety, advances best practices
4. Experts to discuss advances in dental sleep medicine treatments for sleep-disordered breathing
5. UT Southwestern research advances fight against kidney cancer
6. Research presented at 2011 GU Cancers Symposium highlights advances in treatment of prostate cancer
7. RIC study suggests researchers are entering a new era of advances in brain research
8. Long-shot discovery may lead to advances in treating anxiety, memory disorders
9. Roundup: 2010 Advances in Heart Disease and Stroke Care
10. Ovarian cancer advances when genes are silenced
11. Blood Cancer Advances May Improve Survival
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Advances in delivery of therapeutic genes to treat brain tumors 
(Date:9/20/2017)... ... September 20, 2017 , ... Houston, Texas, investment firm CORDA ... September 8, and Monday, September 11, off work and rolled up their sleeves to ... heading to local homes to start the process of rebuilding. , CORDA founder Bonner ...
(Date:9/20/2017)... , ... September 20, 2017 , ... “The Foggy Road to Moorwick”: the adventures of ... is the creation of published author, Jeanine Liston, a busy mother of five who used ... “I have been writing this book for over twenty years. It was a way ...
(Date:9/20/2017)... , ... September 20, 2017 , ... “Monique”: is ... uncomfortable situations. “Monique” is the creation of published author, Colleen Crispi, has owned four ... then Crispi has been involved in real estate and cooking. , “The doctor’s ...
(Date:9/19/2017)... ... September 19, 2017 , ... ... addition of strategic marketing leader, Denise Flannery, to its strategic advisory and client ... Management Consultant, Denise will work with clients across different industries to develop and ...
(Date:9/19/2017)... ... September 19, 2017 , ... Peter Chandonait, Abt Associates Principal ... Initiative (PMI) Africa Indoor Residual Spraying (AIRS) Project , has been named the ... to Action Award, a USAID Catalyst Award, recognizes USAID staff and implementing partners ...
Breaking Medicine News(10 mins):
(Date:9/5/2017)... WAYNE, N.J. , Sept. 5, 2017 /PRNewswire/ ... technology, has created a vibrant charitable donation program ... funds and support congenital heart defect research by ... healthcare providers and the general public are encouraged ... and submit the completed artwork to the ...
(Date:9/1/2017)... , Sept. 1, 2017 Michael ... Solutions, Inc , highlights opportunities for growth in his ... report that Marlin Equity is seeking a buyer for ... annual award-winning 22-year-old healthcare solutions Value Added Reseller and ... "As the healthcare market ...
(Date:8/31/2017)... Aug. 31, 2017 PM360,s annual Innovations ... to the latest innovations happening across the industry. Established ... to focus on providing a comprehensive look at the ... covers the most innovative companies, startups, divisions, products, services, ... "Everyone in this industry wants to ...
Breaking Medicine Technology: