Navigation Links
Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
Date:5/15/2008

3.5 hours. In seven out of 20 cases (35 percent), DP-PS correctly predicted the eventual outcome. These results seem to indicate that PS derived from DP model showed better correlation with drug exposure and could predict patient outcome better than Ktrans.

In a separate analysis, the effects of ABT-869 on biomarkers of angiogenesis were evaluated. Correlations of dose and pharmacokinetics of ABT-869, with serum biomarkers, tumor DCE-MRI tracer kinetics, proteinuria and hypertension were assessed. Results appeared to indicate that ABT-869 induced dose-dependent changes in serum biomarkers are consistent with anti-angiogenic activity. However, these serum biomarkers had limited value in predicting safety, i.e., proteinuria or hypertension. The utility of tumor flow and permeability changes on DCE-MRI in predicting proteinuria should be further examined. Updated information will be presented at the ASCO Annual Meeting.

Background on Abbott's Oncology Pipeline

Bcl-2 Family Protein Inhibitors (ABT-263)

Researchers have been interested in the Bcl-2 family of proteins since their role in preventing apoptosis -- the natural process by which damaged or unwanted cells die and are cleared from the body -- was proven more than a decade ago. Discovered by Abbott scientists, ABT-263 restores programmed cell death, a natural mechanism for the elimination of cancerous cells, by inhibiting the function of Bcl-2 proteins.

Bcl-2 proteins play a central role in regulating apoptosis, as well as tumor formation, tumor growth and resistance to treatment. Pioneering work in structural biology at Abbott established how the Bcl-2 family proteins interact with one another, leading researchers to develop a novel compound that causes cancer cells to self-destruct.

ABT-263 is in Phase I/II clinical trials for lymphomas and solid tumors, including small cell lung cancer. Preclinical data has shown that Abbott's Bcl-2 family protein inhibitors bind to Bc
'/>"/>

SOURCE Abbott
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine news :

1. Abbott to Present at Citi Investment Research Global Health Care Conference
2. Abbott to Present at Morgan Stanley Global Healthcare Unplugged Conference
3. Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the Treatment of Rheumatoid Arthritis
4. Abbott Reports Double-Digit Sales and Earnings Growth in First Quarter and Reaffirms Full-Year Growth Outlook
5. Innovative Diagnostic Instrument Introduced by Abbott for Low- to Mid-Volume Laboratory Market Segment
6. Abbott FreeStyle Freedom(R) Lite Blood Glucose Monitoring System Now Available With No Coding for People With Diabetes
7. Abbott Hosts Conference Call for First-Quarter Earnings
8. Takeda, Abbott Announce Plans to Conclude TAP Joint Venture
9. FDA Approves Abbotts FreeStyle Navigator(R) Continuous Glucose Monitoring System
10. Abbott Receives CE Mark for Smaller-Size XIENCE(TM) V Drug Eluting Stent
11. Abbott, Genentech and WEHI Collaborate to Research and Develop New Anti-Cancer Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... ... 02, 2015 , ... Denver-based SlimGenics Weight Control Centers, the ... No. 14 on ColoradoBiz magazine’s Top 100 Woman-Owned Companies list. ColoradoBiz compiles the ... The award identifies outstanding woman-owned businesses that demonstrate excellence and success in the ...
(Date:7/1/2015)... Angeles, CA (PRWEB) , ... July 01, 2015 , ... ... the great outdoors. Yet, in many Middle-Eastern countries like Saudi Arabia and Dubai, the ... to relax in more temperate climates. Celebrity dentist Dr. Sam Saleh of ORA Dentistry ...
(Date:7/1/2015)... ... ... Sir Fazle Hasan Abed, BRAC’s founder and chairperson, was announced as the ... for his outstanding contribution to enhancing the world's production and distribution of food to ... Prize Foundation, announced this year’s winner at a ceremony at the State Department in ...
(Date:7/1/2015)... Seattle, WA (PRWEB) , ... July 01, 2015 ... ... culture war in this land of liberty. Americans have been arguing over laws ... was a particularly contentious period, as a forthcoming historical comparative biography by Cindy ...
(Date:7/1/2015)... ... July 01, 2015 , ... ... today announced that its fifth annual Smile for a Lifetime Foundation (S4L) fundraising ... non-profit organization. In addition to supporting S4L in its mission to provide free ...
Breaking Medicine News(10 mins):Health News:ColoradoBiz Magazine Names SlimGenics #14 on Top 100 Woman-Owned Companies List 2Health News:ColoradoBiz Magazine Names SlimGenics #14 on Top 100 Woman-Owned Companies List 3Health News:Dr. Sam Saleh Invites Vacationing International Patients to Get a Same-Day Hollywood Smile During the July Travel Season 2Health News:Sir Fazle Hasan Abed Receives World Food Prize 2Health News:Sir Fazle Hasan Abed Receives World Food Prize 3Health News:Biography by Cindy Safronoff to be Released July 4 Explores an 1870s Marriage Debate Over Women’s Rights and the Implications of the American Revolution for Sexuality 2Health News:Biography by Cindy Safronoff to be Released July 4 Explores an 1870s Marriage Debate Over Women’s Rights and the Implications of the American Revolution for Sexuality 3Health News:Biography by Cindy Safronoff to be Released July 4 Explores an 1870s Marriage Debate Over Women’s Rights and the Implications of the American Revolution for Sexuality 4Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 2Health News:The Forum Fundraiser Raises $80,000 for the Smile for a Lifetime Foundation 3
... ... every 6 men in the United States (1 in 3 in the African American community), ... by registering for Little Red Door,s Unite 2 Fight Race Against Prostate Cancer. , ... Indianapolis, IN (PRWEB) April 13, 2010 ...
... ... Multiple Sclerosis through Community , ... (PRWEB) April 13, 2010 -- Motivational Speaker/MS Advocate and Author Erin Morrow ... with Multiple Sclerosis. , , ,Published by iUniverse with a forward by Harold ...
... social fear and appear open, friendly to all, researchers ... Children with a rare condition called Williams syndrome appear ... a new study shows. , The finding suggests that ... stereotyping. , French and German researchers examined the behaviors ...
... Alzheimer,s patients with dignity and respect, researchers say ... memory loss can still "remember" feelings associated with happy ... University of Iowa researchers showed clips of happy and ... patients couldn,t remember what they had watched, but they ...
... Americans (96 percent of Republicans, 10 percent of Democrats ... care reform legislation that was signed into law by ... national survey conducted April 6 - 10 by researchers ... Research (CHPPR). Americans 18 to 34 years ...
... TCT 2010 (Transcatheter Cardiovascular Therapeutics) will provide ... in interventional cardiology that will directly affect patient ... interventional cardiology has figured prominently in recent current ... received a heart stent in February at New ...
Cached Medicine News:Health News:Registration Now Open for Little Red Door's Unite 2 Fight Race Against Prostate Cancer Saturday, July 10, 2010 2Health News:Author Erin Morrow Still Releases "Fighting MS: Strength in Numbers" 2Health News:Author Erin Morrow Still Releases "Fighting MS: Strength in Numbers" 3Health News:Kids With Rare Condition Lack Racial Prejudice 2Health News:Even As Memory Fades, Emotions Linger 2Health News:Health care reform 'important' even to those who want new law repealed 2Health News:TCT 2010 to have significant impact on interventional cardiology practices and patient care 2
(Date:7/1/2015)... -- MEI Pharma, Inc. (Nasdaq: MEIP ), an oncology company ... announced today that Daniel P. Gold , Ph.D., President ... Fitzgerald Healthcare Conference on Wednesday, July 8, 2015 at 8:30 ... New York . A live webcast of ... replay will be available approximately one hour after the presentation. ...
(Date:7/1/2015)... Lupin , Strides , ... Sub-licensees to Fourteen Companies     ... of its network of generic manufacturers to 14 companies now ... (ARVs). New companies Lupin and Strides Arcolab recently signed agreements ... MPP licensed from ViiV Healthcare two months after its approval ...
(Date:7/1/2015)... , July 1, 2015  AVACEN, Inc. announced today the ... patent covering the medical technology platform supporting its unique Dry ... Logo - http://photos.prnewswire.com/prnh/20150630/227364LOGO ... methods patent no. 9,066,781 - Methods And Apparatus For Therapeutic ... AVACEN and specific methods of use, referred to by the ...
Breaking Medicine Technology:MEI Pharma to Present at Cantor Fitzgerald Healthcare Conference 2The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 2The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 3AVACEN Medical Patent Issued 2
... Accuray Incorporated (Nasdaq: ARAY ), a global leader ... report results for its third quarter of fiscal 2011, ended ... market closes. A conference call to review the ... will be hosted by Euan S. Thomson, Ph.D., president and ...
... YORK, April 14, 2011 Reportlinker.com announces that a ... North America Dental Devices Market ... North America Dental Devices Market Outlook ... GlobalData,s new report, "North America Dental Devices Market Outlook ...
Cached Medicine Technology:Accuray Incorporated to Report Financial Results for Third Quarter of Fiscal 2011 2Reportlinker Adds North America Dental Devices Market Outlook to 2017 2Reportlinker Adds North America Dental Devices Market Outlook to 2017 3Reportlinker Adds North America Dental Devices Market Outlook to 2017 4Reportlinker Adds North America Dental Devices Market Outlook to 2017 5Reportlinker Adds North America Dental Devices Market Outlook to 2017 6Reportlinker Adds North America Dental Devices Market Outlook to 2017 7Reportlinker Adds North America Dental Devices Market Outlook to 2017 8Reportlinker Adds North America Dental Devices Market Outlook to 2017 9Reportlinker Adds North America Dental Devices Market Outlook to 2017 10Reportlinker Adds North America Dental Devices Market Outlook to 2017 11Reportlinker Adds North America Dental Devices Market Outlook to 2017 12Reportlinker Adds North America Dental Devices Market Outlook to 2017 13
The WatchMate LC model is a cost-effective solution for monitoring a single exit, and provides local notification of an alarm....
The WatchMate MR model displays multiple alarms locally without individual identification, but ID numbers and names can be displayed at a central station. Alarms may be cleared locally under password...
... RoamAlert Integrity system builds on the ... door controllers in the system are ... a standard Windows® operating system, which ... of a personal computer, RoamAlert Integrity ...
... Radianse indoor positioning solution ... of where and when ... flow through care processes. ... provides intelligence that hospitals ...
Medicine Products: