Navigation Links
Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
Date:5/15/2008

3.5 hours. In seven out of 20 cases (35 percent), DP-PS correctly predicted the eventual outcome. These results seem to indicate that PS derived from DP model showed better correlation with drug exposure and could predict patient outcome better than Ktrans.

In a separate analysis, the effects of ABT-869 on biomarkers of angiogenesis were evaluated. Correlations of dose and pharmacokinetics of ABT-869, with serum biomarkers, tumor DCE-MRI tracer kinetics, proteinuria and hypertension were assessed. Results appeared to indicate that ABT-869 induced dose-dependent changes in serum biomarkers are consistent with anti-angiogenic activity. However, these serum biomarkers had limited value in predicting safety, i.e., proteinuria or hypertension. The utility of tumor flow and permeability changes on DCE-MRI in predicting proteinuria should be further examined. Updated information will be presented at the ASCO Annual Meeting.

Background on Abbott's Oncology Pipeline

Bcl-2 Family Protein Inhibitors (ABT-263)

Researchers have been interested in the Bcl-2 family of proteins since their role in preventing apoptosis -- the natural process by which damaged or unwanted cells die and are cleared from the body -- was proven more than a decade ago. Discovered by Abbott scientists, ABT-263 restores programmed cell death, a natural mechanism for the elimination of cancerous cells, by inhibiting the function of Bcl-2 proteins.

Bcl-2 proteins play a central role in regulating apoptosis, as well as tumor formation, tumor growth and resistance to treatment. Pioneering work in structural biology at Abbott established how the Bcl-2 family proteins interact with one another, leading researchers to develop a novel compound that causes cancer cells to self-destruct.

ABT-263 is in Phase I/II clinical trials for lymphomas and solid tumors, including small cell lung cancer. Preclinical data has shown that Abbott's Bcl-2 family protein inhibitors bind to Bc
'/>"/>

SOURCE Abbott
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine news :

1. Abbott to Present at Citi Investment Research Global Health Care Conference
2. Abbott to Present at Morgan Stanley Global Healthcare Unplugged Conference
3. Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the Treatment of Rheumatoid Arthritis
4. Abbott Reports Double-Digit Sales and Earnings Growth in First Quarter and Reaffirms Full-Year Growth Outlook
5. Innovative Diagnostic Instrument Introduced by Abbott for Low- to Mid-Volume Laboratory Market Segment
6. Abbott FreeStyle Freedom(R) Lite Blood Glucose Monitoring System Now Available With No Coding for People With Diabetes
7. Abbott Hosts Conference Call for First-Quarter Earnings
8. Takeda, Abbott Announce Plans to Conclude TAP Joint Venture
9. FDA Approves Abbotts FreeStyle Navigator(R) Continuous Glucose Monitoring System
10. Abbott Receives CE Mark for Smaller-Size XIENCE(TM) V Drug Eluting Stent
11. Abbott, Genentech and WEHI Collaborate to Research and Develop New Anti-Cancer Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/4/2015)... ... ... According to an article published August 18th on Neurology Advisor, ... force that is great enough to cause a traumatic brain injury. This new polymer, ... coaches or officials would instantly see if a player may have suffered a head ...
(Date:9/4/2015)... California (PRWEB) , ... September 04, 2015 , ... The ... behalf of Tanya De La Paz. , Schmidt National Law Group, a leading ... Northern District of California against Bayer Corp., Bayer Essure, Inc., and other Bayer affiliates ...
(Date:9/4/2015)... , ... September 04, 2015 , ... ... Health Products Association (CHPA) joint meeting of its Product, Quality and Manufacturers, Dietary ... waste handling rules constantly evolving in the consumer goods industry, it can be ...
(Date:9/4/2015)... ... September 04, 2015 , ... “Getting away from the daily ... to explore, revitalize and strengthen their ‘couple-ness,’” says Jean Claude Wietzel, general manager ... Seasons Resort Maui, the island’s only Forbes Five Star resort and Travel + Leisure’s ...
(Date:9/4/2015)... ... September 04, 2015 , ... ... taking place in Hollywood, Florida October 9-10, 2015 at the Diplomat Resort & ... 2015 symposium are doctors and researchers at the top of their field and ...
Breaking Medicine News(10 mins):Health News:New Article on Head Injury Detection Technology Highlights Implications for Head Injury Detection in Sports, says The Law Offices of Burg & Brock 2Health News:Schmidt National Law Group Files First Bayer Essure® Lawsuit in California 2Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 2Health News:Inmar Experts To Address OTC Manufacturers’ Session on Hazardous Waste and Handling at CHPA Meeting 3Health News:Couples Season at Four Seasons Resort Maui Begins This Week With Best Hotel Rates of the Year through November 2Health News:Couples Season at Four Seasons Resort Maui Begins This Week With Best Hotel Rates of the Year through November 3Health News:Integrative Healthcare Symposium Focus On: The Microbiome Conference Program Announced 2
... and Chief,Operating Officer Matthew P. Cullen, 52, has been ... Bill Baer, president and,chief executive officer of The Crown ... YMCA does throughout the Metro Detroit,region- building strong kids, ... been a vital part of our great city for ...
... Inc. (NASDAQ: QLTI; TSX:,QLT) announced today that QLT ... asset purchase agreement with Allergan Sales, LLC, a,wholly-owned ... to fully divest QLT,s,worldwide rights to Aczone(R), a ... Canada for the treatment of acne vulgaris. Under ...
... abstract that will be presented on Monday at SLEEP ... Sleep Societies (APSS), finds that poor sleep is a ... authored by Julie L. Elam, of Indiana University, was ... age of 48 years. Seventy-six percent of the ...
... happiness may lower the risk of sleep problems in Caucasian ... a research abstract that will be presented on Monday at ... Sleep Societies (APSS). , The study, authored by Wendy M. ... married women from the Study of Womens Health Across the ...
... Ill. Morningness is a predictor of better grades ... be presented on Monday at SLEEP 2008, the 22nd ... , The study, authored by Kendry Clay, of the ... who were enrolled in psychology classes. The subjects ...
... 9 , - Social Media Will Have ... Years, 2collab ( http://www.2collab.com ), the research ... science, technology and,medical (STM) information, announced today the ... of social media in their professional lives. The,survey, ...
Cached Medicine News:Health News:Cullen Elected to Chairman of YMCA of Metro Detroit - the City's Oldest Not-for-Profit 2Health News:QLT announces agreement to sell Aczone(R) to Allergan for approximately US$150 million 2Health News:QLT announces agreement to sell Aczone(R) to Allergan for approximately US$150 million 3Health News:QLT announces agreement to sell Aczone(R) to Allergan for approximately US$150 million 4Health News:QLT announces agreement to sell Aczone(R) to Allergan for approximately US$150 million 5Health News:Poor sleep a problem in long-term breast cancer survivors 2Health News:More marital happiness = less sleep complaints 2Health News:Morningness a predictor of better grades in college 2Health News:2collab Survey Reveals That Scientists and Researchers are "All Business" With Social Applications 2Health News:2collab Survey Reveals That Scientists and Researchers are "All Business" With Social Applications 3
(Date:9/3/2015)... , Sept. 3,  2015 About ... bio-artificial devices, which are implanted or integrated ... organs. These include artificial heart, kidney, pancreas, ... polymers (polyurethane, polysulfone, and porous polypropylene), biologics, ... artificial organs. These organs are incorporated with ...
(Date:9/3/2015)... About dry eye syndrome Dry eye syndrome usually ... production or quick tear evaporation or deviation in tear ... deficient dry eye and evaporative dry eye. In aqueous ... enough tears, whereas meibomian gland dysfunction results in evaporative ... evaporation and maintain tear stability. The symptoms include pain, ...
(Date:9/3/2015)... Denmark , Sept. 3, 2015 /PRNewswire/ ... a clinical stage biotechnology company that applies ... unmet medical needs, today announced plans to ... 2015 Wells Fargo Healthcare Conference in BostonDate: ... EDTEvent: , Bank of America Merrill Lynch ...
Breaking Medicine Technology:Global Artificial Organ Market 2015-2019 2Global Dry Eye Syndrome Market 2015-2019 2Ascendis Pharma A/S to Present at Three Upcoming Investor Conferences 2
... testing feature single-well ANA screen and ENA ... tests including dsDNA, and 6 individual ENA ... Scl-70 and Jo-1. In addition, our autoimmune ... products for Cardiolipins (IgA, IgG, IgM), Thyroglobulin, ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: