Navigation Links
Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
Date:5/15/2008

a experienced a 20 percent tumor reduction. Lastly, a patient with NK/T cell lymphoma had a 75 percent reduction in tumor measurements. Adverse events included two Grade 3 dose- limiting toxicities (upper respiratory infection (URI) and elevated liver enzymes) and five cases of Grade 3 thrombocytopenia (low-platelet count) without any sign of bleeding.

Reductions in platelet counts were analyzed in the three ongoing Phase I trials as a biomarker of Bcl-2 family protein inhibition. Subjects received doses ranging from 10 mg to 315 mg. The study data demonstrate that ABT-263 induces a transient decrease in circulating platelets via inhibition of Bcl- XL, without decreasing platelet production, confirming on-target activity. At 315 mg, researchers observed a 69 percent reduction in mean platelets from baseline values. Typically, platelet nadir occurred on days three to five with recovery during continued dosing. Tumor regression was observed in six patients, with three patients showing more than 50 percent tumor shrinkage. Adverse events included three dose-limiting toxicities, one Grade 3 URI at 160 mg, one Grade 3 alanine aminotransferase (ALT) elevation at 315 mg and one fatal respiratory failure at 10 mg. Updated information will be presented at the ASCO Annual Meeting.

ABT-869

Twenty-four patients from a completed Phase I trial (ABT-869), which studied three dose levels of ABT-869, were evaluated to compare two different measures of angiogenesis using functional imaging -- the distributed parameter (DP) model and the transfer constant (Ktrans) model. DP is a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) model that enables derivation of blood flow and capillary permeability-surface area product (PS). Tests indicated that time over threshold could be an important predictor of efficacy, and results demonstrated that an appropriate value for the plasma concentration threshold could be 0.08 ug/mL, with time above threshold value of
'/>"/>

SOURCE Abbott
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine news :

1. Abbott to Present at Citi Investment Research Global Health Care Conference
2. Abbott to Present at Morgan Stanley Global Healthcare Unplugged Conference
3. Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the Treatment of Rheumatoid Arthritis
4. Abbott Reports Double-Digit Sales and Earnings Growth in First Quarter and Reaffirms Full-Year Growth Outlook
5. Innovative Diagnostic Instrument Introduced by Abbott for Low- to Mid-Volume Laboratory Market Segment
6. Abbott FreeStyle Freedom(R) Lite Blood Glucose Monitoring System Now Available With No Coding for People With Diabetes
7. Abbott Hosts Conference Call for First-Quarter Earnings
8. Takeda, Abbott Announce Plans to Conclude TAP Joint Venture
9. FDA Approves Abbotts FreeStyle Navigator(R) Continuous Glucose Monitoring System
10. Abbott Receives CE Mark for Smaller-Size XIENCE(TM) V Drug Eluting Stent
11. Abbott, Genentech and WEHI Collaborate to Research and Develop New Anti-Cancer Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/28/2014)... 2014 (HealthDay News) -- Planning on seconds at Thanksgiving ... -- clinically known as gastroesophageal reflux disease (GERD) -- a ... Josephson, an ear, nose and throat specialist at Lenox Hill ... help manage GERD on Thanksgiving: Pace yourself. ... two small meals throughout the day. It,s also a good ...
(Date:11/28/2014)... Not only is the Éminence Organic Skin Care ... and other cancer-causing agents, but they are also proud ... programs that help in the fight against breast cancer. ... incredible, record-breaking contribution of $30,000 through participation in the ... Red Rose Whip Moisturizer and the company’s corporate donation. ...
(Date:11/28/2014)... 28, 2014 An inventor and dental assistant ... a patient’s filling and it was almost impossible to reach. ... light," she said. , The patent-pending Access Light allows for ... to areas of the mouth, as well as avoids harm ... safety. Easy to use and clean, it also helps prevent ...
(Date:11/28/2014)... 28, 2014 Mabel’s Labels , ... lose® and an award-winning company established by four moms, ... Esp, and Tricia Mumby have been honored with a ... with the PROFIT Award for Excellence in Entrepreneurship. , ... and Tricia Mumby) accepted the award on behalf of ...
(Date:11/28/2014)... A newly released article from Community ... influenza virus that will soon be spreading across the United ... begins with a brief explanation of what the influenza virus ... that children under the age of 5, adults over the ... as heart and lung diseases, asthma, or diabetes, are at ...
Breaking Medicine News(10 mins):Health News:Don't Let Chronic Heartburn Spoil Your Thanksgiving Feast 2Health News:Éminence Organic Skin Care Donates Record-breaking $30,000 to Breast Cancer Research 2Health News:Éminence Organic Skin Care Donates Record-breaking $30,000 to Breast Cancer Research 3Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 2Health News:Mabel's Labels’ Co-Founders Named A Winner In The 2014 RBC Canadian Women Entrepreneur Awards Program; A Second-Time Win For The Brand 3Health News:How Flu Vaccines Can Impact Families Is Discussed in New Article from Community Health Center of Snohomish County 2
... , , LOS ANGELES, Sept. 10 ... tune into DietTribe , Lifetime,s reality series about a group of ... two premieres Friday, October 2nd at 9:00pm ET/PT . ... Kaiser return to guide and coach an all-new tribe as they work ...
... , , CHICAGO, Sept. 10 The ... , Is anyone listening? As this debate rages on about ... every day, we do not hear about what is happening to the people ... , Two million people in the U.S. died ...
... , NEW YORK, Sept. 10 , , , What: ... Americans could come down with the swine flu this fall and, ... that by July, more, than ... hospitalized. With fears that swine flu will become a, ...
... , , ... For the 21(st) consecutive year Polaroid, under the new ownership of PLR ... Boston Marathon Jimmy Fund Walk. , , On Sunday, September ... the world, will be there as Boston Marathon Jimmy Fund Walk participants follow ...
... , , ST. LOUIS, ... management, business intelligence and performance management solutions announced that ... portal for BlueAdvantage Administrators of Arkansas to enable greater ... The intranet portal will provide BlueAdvantage employees the ability ...
... flu, H1N1 goes deep into respiratory tract, researchers confirm ... research confirms previous reports that the H1N1 swine flu ... possibly explaining why it,s often more severe in some ... the current pandemic have experienced relatively mild symptoms," Ten ...
Cached Medicine News:Health News:Get Pumped Up for the Return of 'DietTribe' Season Two of Inspirational Lifestyle Series Premieres October 2 on Lifetime Television 2Health News:Get Pumped Up for the Return of 'DietTribe' Season Two of Inspirational Lifestyle Series Premieres October 2 on Lifetime Television 3Health News:Medical Holocaust in U.S.: Who in the Health Cares? 2Health News:Medical Holocaust in U.S.: Who in the Health Cares? 3Health News:Insite Security Hosts Webinar on Swine Flu Preparedness 2Health News:Polaroid(R) Continuing Tradition of Support for Boston Marathon(R) Jimmy Fund(R) Walk 2Health News:Amitech Solutions Selected to Implement SharePoint Portal for BlueAdvantage Administrators of Arkansas 2Health News:Amitech Solutions Selected to Implement SharePoint Portal for BlueAdvantage Administrators of Arkansas 3Health News:Swine Flu Burrows Into Lungs: Study 2
(Date:11/26/2014)...  Aethlon Medical, Inc. (OTCQB:AEMD), announced today that it ... $3.3 million at a price of $0.30 per unit. ... investor. Each unit consists of one common share and ... Each whole warrant entitles the holder to acquire one ... period of five years from closing.  ...
(Date:11/26/2014)... 26, 2014 Lexicon Pharmaceuticals, Inc. (Nasdaq: ... of previously announced concurrent financing transactions resulting in ... estimated offering expenses, Lexicon anticipates net proceeds of ... consisted of: , a public offering ... a registration statement that has been declared effective ...
(Date:11/26/2014)... , November 26, 2014 Investor-Edge has ... VVUS ), Horizon Pharma PLC (NASDAQ: HZNP ... Johnson (NYSE: JNJ ), and Theravance Inc. (NASDAQ: ... can be accessed at: http://investor-edge.com/register . On ... up 0.07%, the Dow Jones Industrial Average edged 0.02% lower, ...
Breaking Medicine Technology:Aethlon Medical Announces $3.3 Million Equity Investment 2Aethlon Medical Announces $3.3 Million Equity Investment 3Lexicon Announces Completion Of $280 Million In Financing Transactions 2Lexicon Announces Completion Of $280 Million In Financing Transactions 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 2Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 3Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 4Pharma Stocks Highlight - VIVUS, Horizon Pharma, Endocyte, Johnson and Johnson, and Theravance 5
... , Increased vaccination ... gaps remain, others must join effort , DAVOS, Switzerland ... announced today that their foundation will commit $10 billion ... deliver vaccines for the world,s poorest countries. , (Photo: ...
... , , REDWOOD CITY, Calif. ... today announced financial results for its fiscal second quarter and six months ... call at 4:30 p.m. Eastern Time to discuss the financial ... quarter, as we continued to transition the sales model for our cardiac ...
Cached Medicine Technology:Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 2Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 3Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 4Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 5Bill and Melinda Gates Pledge $10 Billion in Call for Decade of Vaccines 6Cardica Announces Fiscal 2010 Second Quarter Financial Results 2Cardica Announces Fiscal 2010 Second Quarter Financial Results 3Cardica Announces Fiscal 2010 Second Quarter Financial Results 4Cardica Announces Fiscal 2010 Second Quarter Financial Results 5Cardica Announces Fiscal 2010 Second Quarter Financial Results 6Cardica Announces Fiscal 2010 Second Quarter Financial Results 7Cardica Announces Fiscal 2010 Second Quarter Financial Results 8Cardica Announces Fiscal 2010 Second Quarter Financial Results 9
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: