Navigation Links
Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
Date:5/15/2008

a experienced a 20 percent tumor reduction. Lastly, a patient with NK/T cell lymphoma had a 75 percent reduction in tumor measurements. Adverse events included two Grade 3 dose- limiting toxicities (upper respiratory infection (URI) and elevated liver enzymes) and five cases of Grade 3 thrombocytopenia (low-platelet count) without any sign of bleeding.

Reductions in platelet counts were analyzed in the three ongoing Phase I trials as a biomarker of Bcl-2 family protein inhibition. Subjects received doses ranging from 10 mg to 315 mg. The study data demonstrate that ABT-263 induces a transient decrease in circulating platelets via inhibition of Bcl- XL, without decreasing platelet production, confirming on-target activity. At 315 mg, researchers observed a 69 percent reduction in mean platelets from baseline values. Typically, platelet nadir occurred on days three to five with recovery during continued dosing. Tumor regression was observed in six patients, with three patients showing more than 50 percent tumor shrinkage. Adverse events included three dose-limiting toxicities, one Grade 3 URI at 160 mg, one Grade 3 alanine aminotransferase (ALT) elevation at 315 mg and one fatal respiratory failure at 10 mg. Updated information will be presented at the ASCO Annual Meeting.

ABT-869

Twenty-four patients from a completed Phase I trial (ABT-869), which studied three dose levels of ABT-869, were evaluated to compare two different measures of angiogenesis using functional imaging -- the distributed parameter (DP) model and the transfer constant (Ktrans) model. DP is a dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) model that enables derivation of blood flow and capillary permeability-surface area product (PS). Tests indicated that time over threshold could be an important predictor of efficacy, and results demonstrated that an appropriate value for the plasma concentration threshold could be 0.08 ug/mL, with time above threshold value of
'/>"/>

SOURCE Abbott
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine news :

1. Abbott to Present at Citi Investment Research Global Health Care Conference
2. Abbott to Present at Morgan Stanley Global Healthcare Unplugged Conference
3. Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the Treatment of Rheumatoid Arthritis
4. Abbott Reports Double-Digit Sales and Earnings Growth in First Quarter and Reaffirms Full-Year Growth Outlook
5. Innovative Diagnostic Instrument Introduced by Abbott for Low- to Mid-Volume Laboratory Market Segment
6. Abbott FreeStyle Freedom(R) Lite Blood Glucose Monitoring System Now Available With No Coding for People With Diabetes
7. Abbott Hosts Conference Call for First-Quarter Earnings
8. Takeda, Abbott Announce Plans to Conclude TAP Joint Venture
9. FDA Approves Abbotts FreeStyle Navigator(R) Continuous Glucose Monitoring System
10. Abbott Receives CE Mark for Smaller-Size XIENCE(TM) V Drug Eluting Stent
11. Abbott, Genentech and WEHI Collaborate to Research and Develop New Anti-Cancer Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/20/2014)... RBSEO Services, which has occupied a top ... it provides an affordable website SEO (Search Engine Optimization) ... would benefit those new and old businesses struggling to ... to pay a big amount for their website promotion. ... in top search results for their business keywords and ...
(Date:9/20/2014)... September 20, 2014 The first federal ... now in its third week in the U.S. District ... reports. Court documents indicate that the week opened in ... testimony from a DePuy Orthopaedics vice president, who discussed ... the company’s Pinnacle hip replacement. According to Reuters, the ...
(Date:9/20/2014)... 2014 The children of Branches now ... active play they need. An empty lot at the ... Campus was transformed into a kid-designed playspace in less ... from Branches (@BranchesFL), ESPN (@TeamESPN), Disney (@CitizenDisney), area residents ... a playground is more than a playground. It’s a ...
(Date:9/19/2014)... 2014 “Copay coupons,” a drug manufacturer ... drugs among patients with prescription drug coverage, may now ... new report from the Department of Health and ... anti-kickback laws prohibit suppliers from offering side-payments to increase ... government. , The report highlights that two recent surveys, ...
(Date:9/19/2014)... Dallas, TX (PRWEB) September 19, 2014 ... equipment and solutions, today detailed the key role ... by two-way radios in the healthcare industry. ... operations and patient care – and in emergency ... the difference between life and death,” said Hugh ...
Breaking Medicine News(10 mins):Health News:RBSEO Services Announces Affordable Website SEO Service at Only $175 2Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 2Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 3Health News:Third Week of DePuy Pinnacle Hip Lawsuit Trial Focuses on Clinical Testing of Metal-on-Metal Hip Implant, Wright & Schulte LLC Reports 4Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 2Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 3Health News:Volunteers Improve Miami Kids’ Lives and Futures with Play 4Health News:PCMA: New OIG Report Cites Drug Manufacturer“Copay Coupon” Use in Medicare Part D 2Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 2Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 3Health News:BearCom Releases Guidelines on Using Two-Way Radios to Improve Communications and Enhance Patient Service in Healthcare 4
... show crying patterns that mimic parents, language, study finds ... are just a few days old cry with intonation ... new research shows. , The conclusion drawn by German ... mothers during the last trimester of pregnancy, laying the ...
... , Iowa and national campaign finance watchdogs ask: Who ... Sen. Chuck Grassley (R) has raised $154,350 in campaign ... care interests, including $43,590 from health insurance interests, according ... Campaign Action Fund. Grassley serves as the ranking Republican ...
... ChemSW is pleased to announce their standing in ... that offers quick, confidential performance ratings and comparisons of ... rated vendor overall in their Q3 2009 Customer Satisfaction ... where the customer satisfaction score was the lowest ever ...
... , From their very first days, newborns, cries already bear the ... published online on November 5th in Current Biology , a ... elements of what will be their first language in the womb, ... dramatic finding of this study is that not only are human ...
... VenaCure-EVLT.com ... ... (NASDAQ: ANGO) launched a new Web site at the American College of Phlebology,s 23rd ... of venous disease. It also features content targeted to patients, including a physician locator ...
... of recent hospital patients commissioned by TransUnion found that two-thirds ... their hospital bill while only three in 10 of those ... programs. , The results of the survey are ... healthcare patient payment estimator at the HFMA Revenue Cycle Strategy ...
Cached Medicine News:Health News:Fetus Learns Intonations of Mother's Tongue 2Health News:Fetus Learns Intonations of Mother's Tongue 3Health News:Sen. Grassley Raised More Than $150,000 Over the Summer From Health Care and Insurance Interests 2Health News:ChemSW Rated Top Vendor Overall for Customer Satisfaction in Q3 2009 by VendorRate 2Health News:Babies' language learning starts from the womb 2Health News:New Web Site on Varicose Veins is Launched by AngioDynamics at American College of Phlebology Congress 2Health News:New Web Site on Varicose Veins is Launched by AngioDynamics at American College of Phlebology Congress 3Health News:TransUnion Survey Finds Patients Want More Transparency in Hospital Bills and Knowledge of Charity Care Programs 2Health News:TransUnion Survey Finds Patients Want More Transparency in Hospital Bills and Knowledge of Charity Care Programs 3Health News:TransUnion Survey Finds Patients Want More Transparency in Hospital Bills and Knowledge of Charity Care Programs 4
(Date:9/19/2014)... 2014 UBM Medica US announces that  ... to help oncologists and other clinicians gain a better ... of targeted therapies and immunotherapies, discusses some of the ... Every September, Blood Cancer Awareness Month ... about blood cancers—helping to increase survival rates and improve ...
(Date:9/19/2014)... , Sept. 19, 2014  Pressure BioSciences, ... announced it has received and approved all parts ... instruments and has begun to manufacture the new ... instrument will be ready for shipment by mid-October ... and released at a rate of about one ...
(Date:9/19/2014)... , Sept. 19, 2014  Over 200 runners participated ... to Benefit the Radiation Oncology Institute (ROI), hosted by ... Golden Gate Park in San Francisco.  ... , CEO of Radiation Business Solutions, "but at ... raised over $70,000 for the ROI this year. This ...
Breaking Medicine Technology:OncoTherapy Network Highlights National Blood Cancer Awareness Month 2OncoTherapy Network Highlights National Blood Cancer Awareness Month 3OncoTherapy Network Highlights National Blood Cancer Awareness Month 4Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 2Pressure BioSciences Announces Completion of the First Phase of Its Commercialization Plan for the Barozyme HT48, the Company's Recently Released High Throughput PCT-based Instrument System 3Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 2Fifth Annual 5K Run for the Future to Benefit the Radiation Oncology Institute Breaks Attendance, Donation Records 3
... Pacific Corporation (Nasdaq: APFC ) today reported financial ... September 30, 2010. We provide non-GAAP measures ... reconciliation of the non-GAAP measures to the most directly comparable ... FINANCIAL SUMMARY Year Ended September ...
... (NKI) ( www.neuro-kinetics.com ), manufacturers of noninvasive medical diagnostic ... conditions, was named the 2010 "Manufacturer of the Year ... company said today. The regional business publication ... earlier this month. Watch a video profile of NKI ...
Cached Medicine Technology:American Pacific Reports Fiscal 2010 Results 2American Pacific Reports Fiscal 2010 Results 3American Pacific Reports Fiscal 2010 Results 4American Pacific Reports Fiscal 2010 Results 5American Pacific Reports Fiscal 2010 Results 6American Pacific Reports Fiscal 2010 Results 7American Pacific Reports Fiscal 2010 Results 8American Pacific Reports Fiscal 2010 Results 9American Pacific Reports Fiscal 2010 Results 10American Pacific Reports Fiscal 2010 Results 11American Pacific Reports Fiscal 2010 Results 12American Pacific Reports Fiscal 2010 Results 13American Pacific Reports Fiscal 2010 Results 14American Pacific Reports Fiscal 2010 Results 15American Pacific Reports Fiscal 2010 Results 16American Pacific Reports Fiscal 2010 Results 17American Pacific Reports Fiscal 2010 Results 18American Pacific Reports Fiscal 2010 Results 19American Pacific Reports Fiscal 2010 Results 20American Pacific Reports Fiscal 2010 Results 21American Pacific Reports Fiscal 2010 Results 22American Pacific Reports Fiscal 2010 Results 23Neuro Kinetics Named 'Manufacturer of the Year' 2
... SC Strep A is a rapid point-of-care ... Strep A antigen in throat swab specimens. ... use no mixing, measuring or working ... cassette format and clearly visible result window ...
... A Twist Rapid Test Device (Throat Swab) is ... a patented design to provide convenience to the ... swab chamber, eliminating the need for test tubes ... exhibits a 93% accuracy compared to plate culture, ...
... Since 1994 the CoaguChek System has been ... needed most, at the point of care. , ... for thousands of patients self-testing when monitoring on ... the user to obtain a result from a ...
... Ovulation Tests are qualitative immunoassays for detecting elevated ... procedure is fast and results are easy to ... is darker than the control band, then ovulation ... If the test band does not appear ...
Medicine Products: