Navigation Links
Abbott to Present Data on Novel Cancer Treatments at American Society of Clinical Oncology Annual Meeting
Date:5/15/2008

Studies Show ABT-263 and ABT-869 to be Promising in Targeting Cancer Cells'

Underlying Mechanisms

ABBOTT PARK, Ill., May 15 /PRNewswire-FirstCall/ -- Abbott scientists will highlight the latest clinical trial data of several investigative compounds in the company's oncology pipeline at this year's American Society of Clinical Oncology (ASCO) Annual Meeting, scheduled for May 30 in Chicago. The presentations include ABT-263, a Bcl-2 family protein antagonist, and ABT-869, an oral small molecule that provides simultaneously potent and specific inhibition of the VEGFR and PDGFR families. Both compounds were discovered by Abbott scientists and are being co-developed by Abbott and Genentech. The company's meeting abstracts are available online today at http://www.asco.org.

By targeting a key survival mechanism of cancer cells, Abbott scientists identified ABT-263 as a potent inhibitor of Bcl-2 family proteins. The Bcl-2 family proteins regulate apoptosis (programmed cell death), the natural process by which damaged or unwanted cells die and are cleared from the body. When this process is defective, damaged cells can continue to divide, leading to the formation and growth of tumors. Preclinical studies showed promising activity against chronic lymphocytic leukemia (CLL), lymphomas and small cell lung cancer -- Phase I/II trials are currently underway in these diseases.

Additionally, Abbott scientists are targeting another vital characteristic of cancer cells with ABT-869. In early studies, data have shown that ABT-869 inhibits a distinct set of kinases that are involved in angiogenesis, a process by which tumors gain access to new blood vessels. Inhibition of these kinases may suppress tumor growth by cutting off tumor blood supply. ABT-869 is currently being tested against several tumor types in Phase II clinical trials.

"Researchers from around the world have requ
'/>"/>

SOURCE Abbott
Copyright©2008 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related medicine news :

1. Abbott to Present at Citi Investment Research Global Health Care Conference
2. Abbott to Present at Morgan Stanley Global Healthcare Unplugged Conference
3. Abbott Announces HUMIRA(R) (adalimumab) Approved in Japan for the Treatment of Rheumatoid Arthritis
4. Abbott Reports Double-Digit Sales and Earnings Growth in First Quarter and Reaffirms Full-Year Growth Outlook
5. Innovative Diagnostic Instrument Introduced by Abbott for Low- to Mid-Volume Laboratory Market Segment
6. Abbott FreeStyle Freedom(R) Lite Blood Glucose Monitoring System Now Available With No Coding for People With Diabetes
7. Abbott Hosts Conference Call for First-Quarter Earnings
8. Takeda, Abbott Announce Plans to Conclude TAP Joint Venture
9. FDA Approves Abbotts FreeStyle Navigator(R) Continuous Glucose Monitoring System
10. Abbott Receives CE Mark for Smaller-Size XIENCE(TM) V Drug Eluting Stent
11. Abbott, Genentech and WEHI Collaborate to Research and Develop New Anti-Cancer Drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... October 30, 2014 Don Allred Insurance, ... health insurance plans for North Carolina residents, is excited ... in Burlington’s Holly Hill Mall. The new branch has ... already helping customers through all facets of the insurance ... Allred Insurance spokesman Scott Allred couldn’t be happier with ...
(Date:10/30/2014)... Five months after their expansion, the ... new branding and a website to accompany their recent ... Mepham’s promotion to name partner earlier this year, Hodgkinson ... Mepham’s name and better reflect their combined litigation expertise. ... decision to implement new branding reflects Hodgkinson Street Mepham’s ...
(Date:10/30/2014)... 2014 Paramount Rx, a full-service prescription ... efforts to help people save money through its innovative ... for prescription drugs in the new health care system, ... to bridge the relationship between consumers, businesses and the ... challenges people face today with medical costs is the ...
(Date:10/30/2014)... HealthDay Reporter , WEDNESDAY, Oct. 29, 2014 (HealthDay ... who also have certain heart problems may increase their odds ... , , The therapy in question is called androgen deprivation therapy ... male hormones to prevent the growth of cancer cells, according ... therapy was linked to triple the risk of heart-related death ...
(Date:10/30/2014)... Dennis Thompson HealthDay Reporter ... Ebola outbreak in Liberia -- one of three West African ... Health Organization officials said Wednesday. Dr. Bruce Aylward, WHO,s ... number of burials in Liberia and no increase in laboratory-confirmed ... push to tame the epidemic may be making some progress, ...
Breaking Medicine News(10 mins):Health News:Allred Insurance Satellite Office Grand Opening 2Health News:Hodgkinson Street Mepham Rebrands 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 2Health News:Hormone Therapy May Up Heart-Related Deaths in Some Prostate Cancer Patients 3Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 2Health News:Ebola Outbreak in Liberia May Be Slowing: WHO 3
... ... and Research (CDER) will soon initiate a major enforcement initiative against cosmetics product ... L. England, former 17-year FDA veteran and FDAImports.com, LLC Founder. ... (Vocus) ...
... A ... Officers Association as the 2010 Health Leader of the Year. This is a distinction ... the health of the American people and that of the larger global community. ... San Diego, CA (PRWEB) May ...
... ... It,s 501(c)(3) application is filed, it has a bank account, and it even has ... What it needs now is a logo, and it has launched a nationwide ... The Spice House, singer Gretchen Wilson, and writer Michael Z. Williamson. , ...
... PITTSBURGH, May 23 Young women of reproductive-age are among ... have suggested that during pregnancy women are even more susceptible ... a time when men also are at greater risk. In ... and pregnant. The results were presented today at ...
... ... Moschetti’s collection , ... (Vocus) May 23, 2010 -- Readers will be struck by the illuminative work of a ... of the Prisoner. True to its name, this reflective anthology reveals the profound emotions and ...
... KitPackers®, ... This agreement provides the 3MTM Industrial Adhesives and Tapes Division with custom modification and ... such as epoxies, acrylics, urethanes, and premixed and frozen. , ... Germantown, WI (PRWEB) May 23, ...
Cached Medicine News:Health News:FDA to Take Up Major Enforcement Action Against Cosmetics Manufacturers With Illegal “Anti-Aging” Labeling Claims, According to FDAImports.com, LLC 2Health News:FDA to Take Up Major Enforcement Action Against Cosmetics Manufacturers With Illegal “Anti-Aging” Labeling Claims, According to FDAImports.com, LLC 3Health News:FDA to Take Up Major Enforcement Action Against Cosmetics Manufacturers With Illegal “Anti-Aging” Labeling Claims, According to FDAImports.com, LLC 4Health News:Health Leader of the Year for 2010 - U.S. Senator Daniel K. Inouye 2Health News:Health Leader of the Year for 2010 - U.S. Senator Daniel K. Inouye 3Health News:Health Leader of the Year for 2010 - U.S. Senator Daniel K. Inouye 4Health News:Art Contest for New Charity With A History 2Health News:Art Contest for New Charity With A History 3Health News:Art Contest for New Charity With A History 4Health News:Pregnancy doubles HIV risk in men; first trial of a microbicide in pregnant women 2Health News:Pregnancy doubles HIV risk in men; first trial of a microbicide in pregnant women 3Health News:Pregnancy doubles HIV risk in men; first trial of a microbicide in pregnant women 4Health News:The Heart of the Prisoner Revealed 2Health News:KitPackers Offers 3MTM Repackaging Capability 2
(Date:10/30/2014)... INDIANAPOLIS , Oct. 30, 2014 Today ... published details of its long-standing technology transfer program to ... (MDR-TB). Begun in 2003, the effort included Lilly donating ... manufacturers in China , ... South Africa – all MDR-TB ...
(Date:10/27/2014)... 2014 La enfermedad del reflujo gastroesofágico ... es un problema importante para muchas personas en ... alimentos [2] y hábitos alimentarios [3] ... la GERD. Takeda ha desarrollado la aplicación móvil ... los síntomas del reflujo. (Foto: ...
(Date:10/27/2014)... last few weeks, Ebola has gone from a localized health concern ... crisis when a traveler to United States ... infected. While much of the cable news talk focused ... as electronic health records (EHRs), to help find, combat, and control ... Alison Diana fills in those gaps by explaining how ...
Breaking Medicine Technology:Lilly Shares Insights from Decade-Long Technology Transfer Experience 2Lilly Shares Insights from Decade-Long Technology Transfer Experience 3Lilly Shares Insights from Decade-Long Technology Transfer Experience 4Trate los síntomas del reflujo gracias a la Food4GERD App 2Trate los síntomas del reflujo gracias a la Food4GERD App 3Trate los síntomas del reflujo gracias a la Food4GERD App 4EHRs in the Age of Ebola: Discuss on InformationWeek 2EHRs in the Age of Ebola: Discuss on InformationWeek 3
... , NORTH HOLLYWOOD, Calif., ... ), a leading national hospitalist physician group practice company, announced today ... ACP Hospitalist as one of the 2009 Top Ten ... issue of the magazine. , Dr. Vaidyan has been a practicing ...
... , MOUNTAIN VIEW, Calif., Nov. 24 ... providers of kidney dialysis services and a major sponsor of ... survivor and chef Elias Nasrallah in his effort to support ... built a successful career as a chef for the past ...
Cached Medicine Technology:IPC The Hospitalist Company's Philip Vaidyan, M.D. Named a Top Hospitalist of 2009 2IPC The Hospitalist Company's Philip Vaidyan, M.D. Named a Top Hospitalist of 2009 3Satellite Healthcare and Renal Disease Survivor Elias Nasrallah Join Forces to Support the Homeless This Holiday Season 2
... Rusch Snap-Light™ laryngoscope blades are designed with ... fiber optic bundle can be removed to ... to reach areas. Our unique snap-on mechanism ... bright focused blades are interchangeable with other ...
... high quality fiberoptic system designed to meet ... fiberoptic laryngoscopes. The green color coding identifies ... to interconnect with other green coded systems. ... bright and focused light. The Greenspec pivot ...
Rigid plastic. Single use. Non-Sterile. The disposable laryngoscope blade that fits on a standard handle. Made of extremely rigid plastic. Bright white light out-performs metal blades. Single patient...
... Laryngoscopes are a high quality fiberoptic system ... greater standardization to fiberoptic laryngoscopes. The green ... indicates it's ability to interconnect with other ... offers a cool, bright and focused light. ...
Medicine Products: