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ASU leads $5 million NIH-sponsored research initiative to advance diabetes care and treatment
Date:11/1/2011

alone and correlates with CVD phenotype outcomes has great potential for influencing industry-wide type 2 diabetes drug development decisions."

HbA1c, or hemoglobin A1c, is a form of hemoglobin that is elevated in people with poorly controlled diabetes. In the 6-month life of a red blood cell, blood sugar molecules react with hemoglobin, forming glycated hemoglobin. In individuals with poorly controlled diabetes, the quantities of these glycated hemoglobins are much higher than in healthy people.

Researchers use state-of-the-art technology including protein sequencing by mass spectrometer, an instrument used to determine the composition of a physical sample by generating a spectrum representing the masses of sample components. The team uses mass spectrometers not only to identify new diabetes biomarkers and their functional states, but also to measure the quantity of particular proteins. For example, people with type 2 diabetes may produce too much of a given protein that would normally be present in lower amounts in a healthy individual.

Others collaborators include Chad Borges at Biodesign; Juraj Koska of the Phoenix VA Health Care System; and Serrine Lau, Craig Stump and Yassine Hussein at the University of Arizona's BIO5 Institute.

"The envisioned biomarkers will better predict the onset of cardiovascular disease in the context of type 2 diabetes and help define the optimal therapeutic or pharmaceutical interventions to significantly improve patient outcomes," said Nelson.

The project builds on a pilot project previously supported by NIH. The investigators were also supported by the UA's BIO5 Institute and the Technology and Research Initiative Fund (TRIF) of the ASU's Biodesign Institute. TRIF is a special investment in higher education made possible by state Proposition 301.


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Contact: Joe Caspermeyer
joseph.caspermeyer@asu.edu
480-727-0369
Arizona State University
Source:Eurekalert  

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