Navigation Links
A potentially life-saving protein takes shape
Date:7/2/2013

COLLEGE PARK, MD - A tiny protein called ubiquitin so named because it is present in every cell of living things as dissimilar as hollyhocks and humans - may hold the key to treatment for a variety of diseases from Parkinson's to diabetes. The protein, found in all eukaryotes (organisms with membranous cells), was considered unimportant when it was described in 1975. But scientists now know ubiquitin takes many different forms and is important in basic cellular processes, from controlling cells' circadian clocks to clearing away the harmful build-up of cells found in cancer and other diseases.

To maximize ubiquitin's potential for treating diseases, researchers are working to identify the protein's dizzying array of structures, and to understand each form's function. Ubiquitin forms polymeric chains linked by specific amino acids. Each ubiquitin protein can connect to its neighbor through one of eight different amino acids, and each combination appears to do something different in a normal cell, says University of Maryland structural biologist David Fushman, whose lab studies these ubiquitin chains and their linkages.

Imagine the cell as a dance floor, thronged with proteins seeking partners, says Fushman, who has studied ubiquitin since 2000. When two ubiquitins join through a lysine, "it's like two hands meeting, but with just a single finger touching that's specific to that lysine." The choice of lysine determines the shape of the ubiquitin chain, and probably also determines its function.

Fushman and his colleagues' newly published research focuses on one of the most common and least studied linkages, the polymeric chain formed by the amino acid Lysine-11. The ubiquitin chains linked by Lysine-11 "are directly involved in cell cycle regulation," Fushman says. To turn that knowledge into medically useful information, "we have to understand exactly how they form and with whom they interact."

Most work of this type is
'/>"/>

Contact: Heather Dewar
hdewar@umd.edu
301-405-9267
University of Maryland
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Potentially life-saving cooling treatment rarely used for in-hospital cardiac arrests
2. Immunoglobulins Market to 2019 - Demand in Primary Immunodeficiency And CIDP Potentially Supplemented by Approval for Alzheimers Disease Available at ResearchMoz.us
3. Artificial Ovaries Could Potentially Deliver Hormone Therapy
4. Office workers carry biomarker of potentially harmful flame retardant, study finds
5. Millions of people in Asia potentially exposed to health risks of popular herbal medicines
6. Brain stent offers alternative to shunt for fixing potentially blinding vein narrowing
7. 1 in 4 colonoscopies in Medicare patients found to be potentially inappropriate
8. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
9. Robotic-assisted radical bladder surgery potentially benefits bladder cancer patients
10. Many home couches contain potentially toxic flame retardants
11. ACA: More than a million women could gain access to potentially life saving tests for cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/1/2014)... (PRWEB) September 02, 2014 Top10BestSEOHosting.com is ... recently compared many top web hosting companies and announced ... hosting suppliers in August. , GreenGeeks ( http://www.greengeeks.com/cgi-bin/affiliates/clickthru.cgi?id=seohosts ... from the USA. The company has a lot of ... always get great products at low rates. , ...
(Date:9/1/2014)... was associated with mental health and substance use ... protect teens from the consequences of cyberbullying and ... Author: Frank J. Elgar, Ph.D., of McGill University, ... in 5 adolescents has experienced recent online bullying ... risk of mental health problems in teens as ...
(Date:9/1/2014)... 01, 2014 Liver is the largest organ ... that helps the body in barring itself from poisons, helps ... energy. Liver also plays many important functions such as protein ... , Many illnesses can affect the liver, an organ ... cage on the right side of the abdomen, reducing its ...
(Date:9/1/2014)... The B-cell non-Hodgkin’s Lymphoma (NHL) treatment ... markets (the US, France, Italy, Germany, Spain and the ... by 2018. , The competitive landscape in the B-cell ... and the UK is poised to undergo a dramatic ... four largest B-cell NHL indications, which includes Diffuse Large ...
(Date:9/1/2014)... D.C. (PRWEB) September 01, 2014 The ... pleased to announce that Dawn Bazarko, DNP, MPH, RN, ... Fellows of the American Academy of Nursing. They will ... MBA, RN-BC, CCM, FACHE, whose induction we reported last ... October 18, 2014, during the 2014 American Academy of ...
Breaking Medicine News(10 mins):Health News:The Best Reseller Hosting Suppliers in August Released by Leading Review SiteTop10BestSEOHosting.com 2Health News:Family dinners good for teens' mental health, could protect from cyberbullying 2Health News:Family dinners good for teens' mental health, could protect from cyberbullying 3Health News:Global Liver Diseases and Therapies Market- The Key Basics by Transparency Market Research 2Health News:Global Liver Diseases and Therapies Market- The Key Basics by Transparency Market Research 3Health News:B-cell Non-Hodgkin Lymphoma Treatment Market Value worth $5.4 Billion by 2018 Says a New Report Available at MarketOptimizer.org 2Health News:B-cell Non-Hodgkin Lymphoma Treatment Market Value worth $5.4 Billion by 2018 Says a New Report Available at MarketOptimizer.org 3Health News:B-cell Non-Hodgkin Lymphoma Treatment Market Value worth $5.4 Billion by 2018 Says a New Report Available at MarketOptimizer.org 4Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 2Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 3Health News:Two Additional NAHN Members to be Inducted as Fellows of the American Academy of Nursing 4
... in the early detection of coronary heart disease (CHD) between ... 45-64 have undetected or silent myocardial infarctions, suggesting a general ... a doctors gender may hinder early hinder early diagnosis of ... by Dr Ann Adams of Warwick Medical School at the ...
... indoor mould improves the symptoms of people with asthma. , ... is among the highest in the world, with 260,000 people ... admissions for adults 12 per cent more than anywhere else ... asked patients with asthma living in two areas of South ...
... Memry Corporation,(Amex: MRY ), a leading provider ... announced today that it will release its fiscal,fourth quarter ... 17,after the market closes. The company will host ... of the management team on Tuesday, September 18 at ...
... ... Refined Cats, Palates, CHELMSFORD, Mass., Sept. 5 ... natural food and treats for pets,is launching a NEW offering for ... real,seafood and poultry morsels and an array of fresh fruits and ...
... choices for older Americans, researchers find , WEDNESDAY, Sept. ... that charge higher co-pays for brand name or non-preferred ... peers who have a flat co-pay for all prescription ... a tough decision for older Americans: Spend more or ...
... Medical,Organizations Growing Rapidly with Thousands of Community Members ... introduced Lance Hill,as the new CEO of the ... physicians, researchers, and medical organizations worldwide. Members,use Within3,s ... as a,professional tool, where they can develop their ...
Cached Medicine News:Health News:Research says doctor's gender may hinder early diagnosis of heart disease in women 2Health News:Research says doctor's gender may hinder early diagnosis of heart disease in women 3Health News:Memry Corporation Announces Fiscal Fourth Quarter and 2007 Year End Earnings Release and Conference Call 2Health News:Finicky Felines Award Four Stars to New Wellness(R) Healthy Indulgence Everyday Entrees 2Health News:Finicky Felines Award Four Stars to New Wellness(R) Healthy Indulgence Everyday Entrees 3Health News:High Co-Pays Cause Seniors to Go Without Meds 2Health News:Cleveland-based Health Care Tech Company Within3 Names New CEO 2
(Date:8/29/2014)... -- Research and Markets  has announced the addition of ... report to their offering. The Central Nervous ... largest segments of pharmaceuticals industry. The numbers of CNS disorders ... were unable to meet the market requirements. There has been ... especially over the past two decades. The market for CNS ...
(Date:8/29/2014)... Vittamed Corporation , a neurodiagnostics medical device company based in ... (Teo) Forcht Dagi , MD, DmedSc, MPH, MBA, FACS, FRCSEd ... " Teo Forcht Dagi is an experienced leader ... capital," said Remis Bistras , President and CEO of ... and entrepreneurial expertise to our Board." Dr. Dagi ...
(Date:8/29/2014)... -- Research and Markets has announced the ... 2014-2018" report to their offering. ... results in demyelination, axonal transection, and neurodegeneration. The myelin ... the immune system, which targets neurons within the central ... in which the damage of the myelin sheath causes ...
Breaking Medicine Technology:US CNS Disorders Drug Pipeline Insight 2014 2Vittamed Adds Prominent Neurosurgeon and Venture Capitalist T. Forcht Dagi to Board of Directors 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 2Global Multiple Sclerosis Drugs Market 2014-2018: Key Vendors are Bayer, Biogen Idec, Merck Serono, Novartis and Teva Pharmaceutical 3
... June 29 Noting that only about 200 of the nearly 7,000 ... today called for a Food and Drug Administration (FDA) statement of policy on regulation ... , NORD also urged ... of medicines for rare disorders. , , ...
... , DAYTON and CINCINNATI, Ohio , June 29 ... with Stipkala LLC, was an invited speaker and panel discussion participant at ... in Dayton, Ohio June 16-19, 2010 .  The 2010 ... new technologies in addition to traditional chemical disciplines.   , ...
Cached Medicine Technology:NORD Calls for Statement of Policy on Orphan Drug Development 2Dr. Harry J. Guttman, Esq. Invited Speaker at 2010 Central Regional Meeting of the American Chemical Society 2
... Mini low cost Incubators. Bench top ... excellent incubation results. Aluminum lined chamber ... and I104025 incubators contain removable perforated ... easy decontamination. Thermometer port on top ...
Binocular indirect ophthalmic lenses. Pediatric ophthalmoscopy / vetinary applications....
Binocular indirect ophthalmic lenses. Small pupil diagnosis & treatment....
Binocular indirect ophthalmic lenses. General diagnosis & treatment....
Medicine Products: