Navigation Links
A new soldier in the war on cancer: The blind mole rat

If someone ever calls you a "dirty rat," consider it a compliment. A new discovery published online in the FASEB Journal ( shows that cellular mechanisms used by the blind mole rat to survive the very low oxygen environment of its subterranean niche are the same as those that tumors use to thrive deep in our tissues. The net effect of this discovery is two-fold: first the blind mole rat can serve a "living tumor" in cancer research; andperhaps more importantthat unique gene in the blind mole rat becomes a prime target for new anti-cancer drugs that can "suffocate" tumors.

"President Obama said in his February 24 address to the U.S. Congress that he wants to put an end to cancer, and the boost to basic science in the stimulus package is a great start," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "But if he wants to end the longest ongoing war in U.S. historya War on Cancer we've been fighting since before Nixon declared it in 1971then building on this discovery is a good place to start."

To reach their finding, American and Israeli scientists from the Universities of Illinois and Haifa conducted experiments in multiple groups of "dirty" mole rats and "regular" rats. For each type of animal, a control group was exposed to normal levels of oxygen while the experimental groups were exposed to oxygen levels ranging from 3 percent to 10 percent. In the regular rats exposed to low levels of oxygen, the gene that becomes active to protect their bodies from low oxygen (BNIP3) was shown to be active in heart and skeletal muscles. In the mole rats, however, it was discovered that their version of the BNIP3 gene was much more effective at helping them tolerate low levels of oxygen than the version of the gene in "regular" rats.

"In show biz and politics, people make comebacks all the time," Weissmann added, "but rodents aren't usually that lucky. Since the bubonic plague in the 1300s, the reputation of rats has been in the sink. If the blind mole rat ultimately helps us cure cancer, it will be the greatest comeback of all time in public health and in public relations."


Contact: Cody Mooneyhan
Federation of American Societies for Experimental Biology

Related medicine news :

1. Regional Anesthesia Eases Wounded Soldiers Pain in Iraq and Afghanistan
2. Old Tech Helps Soldiers With New Wound Infection
3. Soldiers' Angels Announces Special Wheelchair Covers for Veterans
4. LegalView Updates Brain Injury Site with Information on TBI Disabled Soldier's Family
5. K-State Psychologist Studies Ways to Improve Soldiers Work-Life Relationship
6. LegalView Brain Injury Site Reports Department of Veteran Affairs Request for Research on TBI and Soldiers
7. National Rehabilitation Hospital Team to Work with US Army to Improve Rehab Care for Wounded Soldiers
8. US soldiers in high-tuberculosis areas face new epidemic: false positives
9. New Veterans Drug Court Focuses on Rehabilitating Our Soldiers Through Mental Health Treatment
10. Soldiers Receive Free Memorial Day Lasik Surgery Before Going to Iraq
11. UVA Health System part of Armed Forces multi-million dollar effort to help soldiers
Post Your Comments:
(Date:11/27/2015)... ... November 27, 2015 , ... According to an article ... American Dental Association meeting in Washington D.C. revolved around the fact that proper dental ... health. The talk stressed the link between periodontal disease (more commonly referred to as ...
(Date:11/27/2015)... , ... November 27, 2015 , ... ... safe and convenient way to dispense prescription medications at home, so he invented ... way to monitor and dispense prescription medications. In doing so, it could help ...
(Date:11/27/2015)... ... November 27, 2015 , ... MPWH, the No.1 Herpes-only dating community in the world, revealed ... 1-1 ). More than 3.7 billion people under the age of 50 – or ... to WHO's first global estimates of HSV-1 infection . , "The data shocks us ...
(Date:11/27/2015)... ... November 27, 2015 , ... ... innovative online platform for mental health and wellness consultation, has collaborated with a ... will bridge the knowledge gap experienced by parents and bring advice from parenting ...
(Date:11/27/2015)... ... 2015 , ... Indosoft Inc., developer and distributor of the ... LTS (Long Term Support) into its Q-Suite 5.10 product line. , Making the ... a version of Asterisk that will receive not only security fixes, but feature ...
Breaking Medicine News(10 mins):
(Date:11/29/2015)... 2015  The GE Health Cloud 1 was unveiled ... North America (RSNA) meeting in ... the new cloud ecosystem and its applications will connect radiologists ... and multidisciplinary teams – both inside and outside the hospital ... of GE. "As the digital industrial leader, we are betting ...
(Date:11/29/2015)... 29, 2015   National Decision Support Company (NDSC) ... base, including notable statewide implementations. As a result, ... ACR Select, more than 1 million times per ... ACR Select provides real-time feedback on the most ... has been implemented at over 100 healthcare systems ...
(Date:11/27/2015)... 27, 2015 --> ... go online. The potential to save costs, improve treatment ... far from fully exploited as yet. Here, particular emphasis ... either via mobile tablet or directly at the patients, ... ) -->      (Photo: ...
Breaking Medicine Technology: