Navigation Links
A new soldier in the war on cancer: The blind mole rat
Date:3/4/2009

If someone ever calls you a "dirty rat," consider it a compliment. A new discovery published online in the FASEB Journal (http://www.fasebj.org) shows that cellular mechanisms used by the blind mole rat to survive the very low oxygen environment of its subterranean niche are the same as those that tumors use to thrive deep in our tissues. The net effect of this discovery is two-fold: first the blind mole rat can serve a "living tumor" in cancer research; andperhaps more importantthat unique gene in the blind mole rat becomes a prime target for new anti-cancer drugs that can "suffocate" tumors.

"President Obama said in his February 24 address to the U.S. Congress that he wants to put an end to cancer, and the boost to basic science in the stimulus package is a great start," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal. "But if he wants to end the longest ongoing war in U.S. historya War on Cancer we've been fighting since before Nixon declared it in 1971then building on this discovery is a good place to start."

To reach their finding, American and Israeli scientists from the Universities of Illinois and Haifa conducted experiments in multiple groups of "dirty" mole rats and "regular" rats. For each type of animal, a control group was exposed to normal levels of oxygen while the experimental groups were exposed to oxygen levels ranging from 3 percent to 10 percent. In the regular rats exposed to low levels of oxygen, the gene that becomes active to protect their bodies from low oxygen (BNIP3) was shown to be active in heart and skeletal muscles. In the mole rats, however, it was discovered that their version of the BNIP3 gene was much more effective at helping them tolerate low levels of oxygen than the version of the gene in "regular" rats.

"In show biz and politics, people make comebacks all the time," Weissmann added, "but rodents aren't usually that lucky. Since
'/>"/>

Contact: Cody Mooneyhan
cmooneyhan@faseb.org
301-634-7104
Federation of American Societies for Experimental Biology
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Regional Anesthesia Eases Wounded Soldiers Pain in Iraq and Afghanistan
2. Old Tech Helps Soldiers With New Wound Infection
3. Soldiers' Angels Announces Special Wheelchair Covers for Veterans
4. LegalView Updates Brain Injury Site with Information on TBI Disabled Soldier's Family
5. K-State Psychologist Studies Ways to Improve Soldiers Work-Life Relationship
6. LegalView Brain Injury Site Reports Department of Veteran Affairs Request for Research on TBI and Soldiers
7. National Rehabilitation Hospital Team to Work with US Army to Improve Rehab Care for Wounded Soldiers
8. US soldiers in high-tuberculosis areas face new epidemic: false positives
9. New Veterans Drug Court Focuses on Rehabilitating Our Soldiers Through Mental Health Treatment
10. Soldiers Receive Free Memorial Day Lasik Surgery Before Going to Iraq
11. UVA Health System part of Armed Forces multi-million dollar effort to help soldiers
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/31/2015)... California (PRWEB) , ... August 31, 2015 , ... ... by host/actor/writer/director/ CSUN psychology professor Luciana Lagana (aka Dr. Luciana) received a ... for Best Web Series, Best Documentary, and Best (Dis)ability Film. Dr. Luciana co-wrote ...
(Date:8/31/2015)... ... August 31, 2015 , ... Wyoming Medical Center, an ... for its Clinical Documentation Improvement (CDI) and medical coding needs. Based on a ... - ezCAC is an enterprise-level coding solution that combines CDI, Coding, Quality and ...
(Date:8/31/2015)... , ... August 31, 2015 , ... With baseball season ... and the World Series will dominate the sports world. Fans desire nothing more than ... to the final series. For children, especially those who are too young to really ...
(Date:8/31/2015)... ... 31, 2015 , ... On Saturday, May 30th, 2015, Best Drug Rehabilitation sponsored ... in Mendon, IL. The purpose behind this concert was to raise money for music ... Best Drug Rehabilitation’s sponsorship of “Music with a Mission” helped with a portion of ...
(Date:8/31/2015)... ... 31, 2015 , ... In preparation for this November’s National Family Caregivers Month, ... sound amplifier, is offering caregivers “7 Reasons to Care about Hearing Health.” The information ... a variety of home healthcare challenges, specifically as they relate to caring for the ...
Breaking Medicine News(10 mins):Health News:Actor/Writer/Director/Psychology Professor Luciana Lagana Receives Three Wins at the 2015 Global Independent Film Awards for the TV Pilot Dr. Luciana on Aging and Falling 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 2Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 3Health News:Wyoming Medical Center Selects ezDI’s CAC/CDI Solution Based on Integrated Healthcare Data Management, Workflow Design and ROI 4Health News:New Children's Baseball Series Offers Young Fans a Way to Celebrate the World Series 2Health News:2015 "Music With A Mission" Sponsor Best Drug Rehabilitation Releases Artist Compilation Video 2Health News:2015 "Music With A Mission" Sponsor Best Drug Rehabilitation Releases Artist Compilation Video 3Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 2Health News:Etymotic Offers Caregivers “7 Reasons to Care about Hearing Health” 3
... that a specialized virus with the ability to reproduce its ... mice and eliminate them. Healthy brain tissue remained virtually untouched, ... of Neuroscience . With more research, the technique could one ... humans. , Most importantly, this study finds that the virus ...
... 19 Accenx Technologies, Inc., a,leading company in ... integration solutions, announced today the launch of their,new ... to their,clients, such as large health systems, hospitals, ... physician outreach programs, and connect,physician practices to RyTRAK ...
... the daughter of,Virginia Kent, Deceased, seeks vindication in ... which was caused by the prescription drug,Rezulin. Michigan,s ... All Rezulin cases in the United States ... 187 cases from Michigan. All Michigan,cases were dismissed ...
... North American Insurance,Leaders, Inc. (Amex: NAO ) ("NAIL"), ... time to consider and vote on the proposed,acquisition of ... of,additional proxies related thereto, its annual meeting of stockholders,originally ... 2:00 p.m. local,time, has been postponed and will now ...
... cold winter day and you will see the water vapor ... a Nobel-Prize-related tool, and you could potentially detect trace amounts ... signs of disease. In a new paper,* a team led ... of the National Institute of Standards and Technology (NIST) and ...
... development of new technologies that demand a,highly-trained workforce and ... provide the backdrop for this historic,undertaking by the nation,s ... a march, rally and press conference on,Wednesday, Feb. 20 ... gather at the Main Entrance to Summit,Medical Center, 350 ...
Cached Medicine News:Health News:Tumor-killing virus selectively targets diseased brain cells 2Health News:New Accenx Physician's Relations Department! Now At Your Service 2Health News:Michigan Resident, Kimberly Kent's Drug Product Liability Case Will Be Argued in the United States Supreme Court on February 25, 2008 2Health News:North American Insurance Leaders, Inc. Postpones Stockholders Meeting 2Health News:Optical 'frequency comb' can detect the breath of disease 2Health News:UHW Kicks Off Contract Campaigns for 75,000 Hospital and Nursing Home Workers in Unprecedented Effort to Raise Quality Statewide 2
(Date:8/31/2015)... 2015  AMRI (NASDAQ: AMRI ) and ... focused on the development, manufacture and marketing of ... The collaboration combines Saneca,s strength in extracting opiates ... and manufacturing controlled substance APIs with AMRI,s U.S. ... into these facilities. The collaboration will also capitalize ...
(Date:8/31/2015)... -- Bionomics Limited (ASX:BNO, ADR:BMICY), a biopharmaceutical company focused ... the treatment of diseases of the central nervous system ... submission has passed review by the US Food and ... 1 clinical trial in patients with metastatic colon cancer ... 31 December 2015. Bionomics, CEO & Managing ...
(Date:8/29/2015)... LONDRES, August 29, 2015 ... para los sistemas de imagen por Ultrasonidos   ... tiempos de examen rápidos y un flujo de trabajo ... diagnóstica en el proceso de detección de Cardiopatías   ... ha anunciado hoy el lanzamiento europeo de HeartModel ...
Breaking Medicine Technology:AMRI Announces Agreement with Saneca Pharmaceuticals, a.s. for Portfolio of Opium-Derived Active Pharmaceutical Ingredients 2AMRI Announces Agreement with Saneca Pharmaceuticals, a.s. for Portfolio of Opium-Derived Active Pharmaceutical Ingredients 3AMRI Announces Agreement with Saneca Pharmaceuticals, a.s. for Portfolio of Opium-Derived Active Pharmaceutical Ingredients 4Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 2Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 3Successful BNC101 IND Submission Paves Way for Development of Promising Cancer Stem Cell Drug Candidate 4Philips presenta HeartModel A.I en el Congreso ESC 2015 2Philips presenta HeartModel A.I en el Congreso ESC 2015 3Philips presenta HeartModel A.I en el Congreso ESC 2015 4Philips presenta HeartModel A.I en el Congreso ESC 2015 5
... true breakthrough in ophthalmic ultrasound, offering an ... capability previously unavailable. See pathology formerly unavailable, ... up to 105db to view vitreous details ... 90db setting - or reduce it to ...
The Ultrasonic BioMicroscope (UBM P40) provides the highest ultrasound resolution for imaging....
PremierEdge Stab Knives - 45....
VISCO SHIELD Viscoelastic. Complete with 23g x 7/8" Thin Wall Cannula....
Medicine Products: