Navigation Links
A new mechanism that contributes to the evolution of cancer
Date:1/31/2013

Cancer arises from the accumulation of mutations and structural changes in chromosomes, which in some cases give rise to combinations that favour the growth or expansion of the disease. In this context, chromosomes tend to lose or duplicate entire regions, although, the mechanisms that initiate these chromosomal abnormalities are not fully understood.

A study published this week in the journal Cell, in which researchers from the Spanish National Cancer Research Centre (CNIO) participated, demonstrates a new mechanism that explains how these changes originate in the chromosomes of tumour cells.

The work, led by André Nussenzweig's group at the National Cancer Institute (NCI, USA), with the participation of CNIO researcher Óscar Fernández‐Capetillo, shows that collisions between the machinery responsible for duplicating the DNA and for transferring this genomic information to the RNA for protein synthesisa phenomenon known as transcriptionare the cause of a very high proportion of the chromosomal alterations found in tumours.

Until now, it was believed that the majority of these problems originated in areas of the genome that were difficult to duplicate and which, therefore, required the completion of the entire S phase of the cell cycle; a stage in which cells duplicate their DNA. Due to this episode, these regions were especially exposed to breaks or aberrations.

The current study reveals that other areas of the genome also existthose that replicate quickly early in S phasethat are prone to breakages. In particular, the researchers demonstrate that this occurs when these DNA regions that replicate, have surrounding genes that are being actively copied to RNA.

"In these cases, the collision between the two machineries, the duplication machine and the transcription machine, can be responsible for generating chromosomal alterations that are deadly for cells," says Fernández‐Cap
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
2. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
3. Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children
4. Scientists discover mechanism that could reduce obesity
5. New mechanism for cancer progression discovered by UNC and Harvard researchers
6. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
7. Mechanism of breathing muscle paralysis in dreaming sleep identified
8. New mechanism of action for PARP inhibitors discovered
9. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
10. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
11. Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2014)... Nancy Chiaravalloti, PhD, of Kessler Foundation was named ... Jersey City, New Jersey. Dr. Chiaravalloti spoke on April ... the topic of "Treating Cognitive Deficits Following Neurological Illness ... be a part of the long legacy of the ... Chiaravalloti. "The field of rehabilitation research is a rewarding ...
(Date:4/24/2014)... yeast is giving scientists a better understanding of drug ... illness world-wide. , When two or more medications ... or enhance the effectiveness of the other. Similarly, ... types of interactions are a major cause of illness ... on the practical scope of drug studies in humans. ...
(Date:4/24/2014)... ,Take me out to the ballgame, doesn,t exactly ... The more likely culprits include French fries, soda and ... children who play youth baseball, eating unhealthy food during ... according to researchers at Wake Forest Baptist Medical Center. ... Childhood Obesity , found that high-calorie snacks and ...
(Date:4/24/2014)... be boring and irrelevant, could offer an alternative to ... Dr Milena Furtado, and her team from the Australian ... heart cell fibroblast is a close relative to a ... , In research published today in Circulation Research ... unique cells due to their genetic program, and will ...
(Date:4/24/2014)... than to receive at least if you,re an adolescent ... study found that 15- and 16-year-olds who find pleasure in ... are less likely to become depressed than those who get ... for themselves. , The researchers detail their findings in the ... The study focused on the ventral striatum, a brain region ...
Breaking Medicine News(10 mins):Health News:Kessler Foundation scientist named 63rd Mendel Lecturer by St. Peter's University 2Health News:Large-scale identification and analysis of suppressive drug interactions 2Health News:Take the bat, leave the candy 2Health News:Boring cells could hold the key to heart disease 2Health News:Study: Altruistic adolescents less likely to become depressed 2
... should,we die? Finding grace in life and death is an eternal ... Finding Grace on a Less Traveled Road is both an autobiography, ... a journey through the life of,a cancer physician who learns early, ... suffering. It is through the author,s own,understanding of what it means ...
... workers, sit-in shifted,national attention to the plight of laid-off workers, ... nightmarish loss of health,coverage benefits in layoffs and should know ... of Outten & Golden LLP. , ... the New York office of Outten &,Golden LLP which represents ...
... WEST PALM BEACH, Fla., Dec. 10 The Cosmetic ... for core cosmetic,physicians and their office staff will begin ... meeting has seen strong attendance and industry sponsorship.,According to ... the meeting,is recognized as the essential meeting for specialists ...
... New York and Wisconsin Among States with Hurdles Ahead, ... , NASHVILLE, Tenn., Dec. ... market intelligence, reports that states will face pressure to ... as commercially-insured members lose their jobs or come off ...
... Skilled Nursing Facilities , , ... 18-month selection process, a proven commitment to clinical quality ... (EMR) throughout Metropolitan Jewish Health System,s (Metropolitan) skilled nursing ... Metropolitan, a nationally recognized nonprofit organization, operates Metropolitan Jewish ...
... contracting portfolio, e-commerce exchange and clinical services , ... ... that Jordan Health Systems in Plymouth, Massachusetts has selected Broadlane as ... services to help manage its approximate $35 million in annual ...
Cached Medicine News:Health News:Finding Grace on a Less Traveled Road: A Cancer Doctor Reflects on Living and Dying 2Health News:Chicago Sit-In Highlights Laid-Off Workers, Employers' Obligations, and WARN Act, According to Outten & Golden LLP 2Health News:Chicago Sit-In Highlights Laid-Off Workers, Employers' Obligations, and WARN Act, According to Outten & Golden LLP 3Health News:Economic Downturn Means Increased Demands on Budget-Challenged State Health Coverage Initiatives 2Health News:Economic Downturn Means Increased Demands on Budget-Challenged State Health Coverage Initiatives 3Health News:Metropolitan Jewish Health System Awards Electronic Medical Records Contract to SigmaCare(R) 2Health News:Metropolitan Jewish Health System Awards Electronic Medical Records Contract to SigmaCare(R) 3Health News:Jordan Health Systems Selects Broadlane to Provide Comprehensive Supply Chain Services 2Health News:Jordan Health Systems Selects Broadlane to Provide Comprehensive Supply Chain Services 3
(Date:1/14/2014)... HARRISBURG, Pa. , Jan. 14, 2014 Dynamic Healthcare ... ("GMH"), announced today that it acquired Progressive Home Medical Equipment, ... January 7, 2014. The terms of the acquisition were not ... medical equipment ("DME") company providing a wide range of sleep, ...
(Date:1/14/2014)... 2014 Animal Emergency Critical Care, a LifeCentre partner practice, located ... is the first in Loudoun County ... Dr. Susan M. Barnes , Medical Director, is a well-seasoned ... Cole Taylor , are avid scuba divers. "As altitude skiers ...
(Date:1/14/2014)... CLEVELAND , Jan. 14, 2014 NineSigma ... will hold its Innovation Leadership Summit , May ... in Cleveland Ohio . ... innovators and organizations committed to breakthrough achievements through open ...
Breaking Medicine Technology:Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 2Dynamic Healthcare Services Completes Progressive Home Medical Equipment of Clarion, PA Investment 3Hyperbaric Veterinary Medicine (hvm) Announces Animal Emergency Critical Care Installs A Small Animal Hyperbaric Chamber 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 2Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 3Expect the Unexpected from Leading Global Innovators at NineSigma Leadership Summit, Sharing Winning Strategies to Advance Innovation 4
... HARBIN, China , July 6 ... WKBT) ("Weikang" or the,"Company"), a leading developer, manufacturer and ... pharmaceuticals and other,health and nutritional products in the ... participate in the Global Hunter 2010 China Conference,on ...
... WARSAW, Ind. , July 6 Zimmer Holdings, Inc. (NYSE: ... earnings conference call will be broadcast live over the Internet on Thursday, ... release detailing the quarterly results will be made available at 7:00 a.m. ... , , ...
Cached Medicine Technology:Weikang Bio-Technology to Present at Global Hunter 2010 China Conference on July 13, 2010 2Weikang Bio-Technology to Present at Global Hunter 2010 China Conference on July 13, 2010 3Zimmer Holdings Announces Live Audio Webcast and Conference Call of Second Quarter 2010 Results 2
The Becton™ Colles Fracture Plate has proven clinical outcomes and has excellent patient acceptance compared to external fixation. It provides a cost effective treatment option through a simple...
X-Hair Trephines...
Coronet Donor Punch Set - Unique design providing precise control and full visualization throughout the procedure. Corneal marking pen included....
Stainless Steel. Sterile. 2 pieces/box...
Medicine Products: