Navigation Links
A new mechanism that contributes to the evolution of cancer
Date:1/31/2013

Cancer arises from the accumulation of mutations and structural changes in chromosomes, which in some cases give rise to combinations that favour the growth or expansion of the disease. In this context, chromosomes tend to lose or duplicate entire regions, although, the mechanisms that initiate these chromosomal abnormalities are not fully understood.

A study published this week in the journal Cell, in which researchers from the Spanish National Cancer Research Centre (CNIO) participated, demonstrates a new mechanism that explains how these changes originate in the chromosomes of tumour cells.

The work, led by André Nussenzweig's group at the National Cancer Institute (NCI, USA), with the participation of CNIO researcher Óscar Fernández‐Capetillo, shows that collisions between the machinery responsible for duplicating the DNA and for transferring this genomic information to the RNA for protein synthesisa phenomenon known as transcriptionare the cause of a very high proportion of the chromosomal alterations found in tumours.

Until now, it was believed that the majority of these problems originated in areas of the genome that were difficult to duplicate and which, therefore, required the completion of the entire S phase of the cell cycle; a stage in which cells duplicate their DNA. Due to this episode, these regions were especially exposed to breaks or aberrations.

The current study reveals that other areas of the genome also existthose that replicate quickly early in S phasethat are prone to breakages. In particular, the researchers demonstrate that this occurs when these DNA regions that replicate, have surrounding genes that are being actively copied to RNA.

"In these cases, the collision between the two machineries, the duplication machine and the transcription machine, can be responsible for generating chromosomal alterations that are deadly for cells," says Fernández‐Cap
'/>"/>

Contact: Nuria Noriega
nnoriega@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Singapore scientists led by A*STARs GIS identify 4 mechanisms that contribute to gastric cancers
2. Cancer scientists determine mechanism of 1 of the most powerful tumor-suppressor proteins, Chd5
3. Research sheds new light on mechanisms of T-ALL, a form of leukemia that primarily affects children
4. Scientists discover mechanism that could reduce obesity
5. New mechanism for cancer progression discovered by UNC and Harvard researchers
6. Novel mechanism through which normal stromal cells become cancer-promoting cells identified
7. Mechanism of breathing muscle paralysis in dreaming sleep identified
8. New mechanism of action for PARP inhibitors discovered
9. Mechanism found for destruction of key allergy-inducing complexes, Stanford researchers say
10. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
11. Scientist receives $2.8 Million to study cell signaling mechanism and develop potential therapeutics
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 2014 — A team from the Broad Institute, ... of California, Santa Cruz, was awarded one of ... Pilot contracts with the goal of building a ... Cancer Genome Atlas (TCGA) and other datasets by ... in one cloud environment. This co-location will enable ...
(Date:10/31/2014)... At the start of 2014, numerous news ... monoxide poisoning in their homes. Now, as 2015 (and ... Missouri-based heating and cooling company is taking a more ... the home heating season with the assurance that their ... Nov. 1, 2014, E and Q Heating and Cooling ...
(Date:10/31/2014)... apnea may make it hard for you to remember simple ... your house keys, a small study suggests. Tests on ... -- called spatial memory -- was impaired when sleep apnea ... of sleep weren,t affected. REM sleep is the deepest level ... for the first time that sleep apnea, an increasingly common ...
(Date:10/31/2014)... lab device to give cancer researchers an unprecedented microscopic ... spread through the body, causing more than 90 percent ... tumor cells travel, the device could uncover new ways ... the university,s Whiting School of Engineering and its Institute ... new system recently in the journal Cancer Research ...
(Date:10/31/2014)... scientists have found a drug combination that can trigger ... the way for new treatments, according to research that ... (NCRI) Cancer Conference in Liverpool next week*. , When ... chain of events culminating in self destruction. But cancer ... immortal. This means that cells grow out of control ...
Breaking Medicine News(10 mins):Health News:Broad Institute, Univ. of California team awarded NCI Cancer Genomics Cloud Pilot contract 2Health News:Broad Institute, Univ. of California team awarded NCI Cancer Genomics Cloud Pilot contract 3Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 2Health News:Many Homeowners Missing Key Safety Risks with Home Heating;Missouri-based Company E and Q Announces New Safety Check 3Health News:Sleep Apnea May Steal Some of Your Memory: Study 2Health News:Viewing cancer on the move: New device yields close-up look at metastasis 2Health News:Viewing cancer on the move: New device yields close-up look at metastasis 3Health News:Scientists trigger self-destruct switch in lung cancer cells 2
... America, Inc. (OTC Bulletin Board: CBAI), the umbilical cord blood ... ) focused on bringing the life saving potential of ... announce that between February 15, 2009, and today, it has ... percent. This follows the announcement on Feb. 12, 2009 ...
... Stars Perform to Raise Awareness of Neurological DiseaseEAST RUTHERFORD, N.J., April ... Foundation: WHO: Anthony Galde of Wicke ... Research Foundation WHAT: Curtain Call for a Caus ... & the Dystonia Medical Research Foundation host the 2nd Annual ...
... The United States Marine Corps launches its inaugural ... city opens its doors to the nearly 2,000 Marines ... Chicagoland area. "Established to recognize the contributions of ... which they came, Marine Week also showcases the rich ...
... arthritis (RA) is a systemic disease or an autoimmune disorder ... the thin layer of cells called the synovium that lines ... are swollen joints and crippling stiffness, particularly of the hands ... and also impedes mobility and quality of life. RA cannot ...
... vaccines and critical-care biopharmaceuticals announces exclusive sanofi pasteur Fluzone® agreement for ... ... (Vocus) April 6, 2009 -- As a trusted partner ... is pleased to announce that sanofi pasteur has named FFF the ...
... Lens Boot Camp™ - a first-of-its-kind training program to help refractive ... that its first boot camp session will be held on June ... ... Camarillo, CA (PRWEB) April 6, 2009 -- Premium Lens Boot Camp™ ...
Cached Medicine News:Health News:Cord Blood Announces $1.75 Million Reduction in Long Term Debt 2Health News:Broadway Comes to New Jersey 2Health News:Marine Corps Launches Inaugural Marine Week in Chicago, May 11-17 2Health News:Marine Corps Launches Inaugural Marine Week in Chicago, May 11-17 3Health News:Rheumatoid Arthritis Therapeutics in Thailand 2Health News:Rheumatoid Arthritis Therapeutics in Thailand 3Health News:FFF Named the Exclusive Distributor of Fluzone for GPOs & Announces New Fluzone Return Policy 2Health News:Premium Lens Boot Camp™ Helps Refractive Surgeons Grow Their Premium IOL Practice 2
(Date:10/31/2014)... 30, 2014 Electronic prescribing or ... of prescription related information between prescriber, dispenser ... a physician and nurse practitioner to transmit ... error occurs during pharmacy operations. E-Prescribing system ... provides complete medical lists, conducts all security ...
(Date:10/31/2014)... Oct. 31, 2014  AbbVie (NYSE: ... third quarter ended Sept. 30, 2014. ... of our business with double-digit growth from HUMIRA ... grew nearly 14 percent in the quarter excluding ... executive officer, AbbVie.  "We exceeded our outlook for ...
(Date:10/30/2014)... MAHWAH, N.J. , Oct. 30, 2014 ... PGA TOUR and Champions Tour, is rounding out its ... Cup Championship in Scottsdale, AZ. ... PGA TOUR and Champions Tour that the brand has ... destination designed to educate golf fans on the importance ...
Breaking Medicine Technology:E-Prescribing Market - Global Industry Analysis, Size, Share, Growth, Trends and Forecast, 2013 - 2019 2AbbVie Reports Third-Quarter 2014 Financial Results 2AbbVie Reports Third-Quarter 2014 Financial Results 3AbbVie Reports Third-Quarter 2014 Financial Results 4AbbVie Reports Third-Quarter 2014 Financial Results 5AbbVie Reports Third-Quarter 2014 Financial Results 6AbbVie Reports Third-Quarter 2014 Financial Results 7AbbVie Reports Third-Quarter 2014 Financial Results 8AbbVie Reports Third-Quarter 2014 Financial Results 9AbbVie Reports Third-Quarter 2014 Financial Results 10AbbVie Reports Third-Quarter 2014 Financial Results 11AbbVie Reports Third-Quarter 2014 Financial Results 12AbbVie Reports Third-Quarter 2014 Financial Results 13AbbVie Reports Third-Quarter 2014 Financial Results 14AbbVie Reports Third-Quarter 2014 Financial Results 15AbbVie Reports Third-Quarter 2014 Financial Results 16AbbVie Reports Third-Quarter 2014 Financial Results 17AbbVie Reports Third-Quarter 2014 Financial Results 18AbbVie Reports Third-Quarter 2014 Financial Results 19AbbVie Reports Third-Quarter 2014 Financial Results 20AbbVie Reports Third-Quarter 2014 Financial Results 21AbbVie Reports Third-Quarter 2014 Financial Results 22AbbVie Reports Third-Quarter 2014 Financial Results 23AbbVie Reports Third-Quarter 2014 Financial Results 24Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 3Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 4
... Show Increased Enzyme Levels in Two Most ... /PRNewswire/ -- Amicus,Therapeutics, a biopharmaceutical company developing ... a range of human genetic diseases, announced ... preclinical studies of,Plicera(TM) (isofagomine tartrate, AT2101) for ...
... the Targeted,Anticancer Therapies (TAT 2007) and the ... Phase 1 Trial Design, SOUTH SAN FRANCISCO, ... Inc. , presented,non-clinical data on its development-stage ... on targeted anticancer,medicines. Findings from in vitro ...
Cached Medicine Technology:Amicus Therapeutics Presents Preclinical Data from Studies of,Plicera for Gaucher Disease 2Amicus Therapeutics Presents Preclinical Data from Studies of,Plicera for Gaucher Disease 3Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor,Data Showing Broad Anti-Tumor Activity, Dosing Flexibility 2Sunesis Pharmaceuticals Presents SNS-314 Aurora Kinase Inhibitor,Data Showing Broad Anti-Tumor Activity, Dosing Flexibility 3
Cordis DUCOR Catheters are available in a broad variety of French sizes and configurations. These catheters combine an atraumatic tip with either a braided or non-braided body....
The advanced center-of-the-arc system allows an infinite choice of trajectories. The system's lightweight durable frame provides accuracy, simplicity, patient mobility and accessibility....
The CRW system epitomizes simplicity, quality assurance, and versatility....
Used for complex diagnostic and interventional procedures....
Medicine Products: