Navigation Links
46 gene sequencing test for cancer patients on the NHS
Date:3/25/2013

opsies in the hospital lab's workflow.

The next-generation DNA sequencing method detected all the mutations the conventional method did; it detected new mutations the conventional method didn't; and detected mutations present at much lower levels in the samples. The time taken for the 46 gene test also fitted into the standard turnaround time for samples at the lab.

There is definite benefit in screening some of the 46 genes included in the test; there is probable or likely clinical benefit in screening some of the others; mutations in further genes might be important in some cancers but not others; and the other genes, we don't know as yet. But having this information means researchers can investigate whether a mutation has biological significance.

'We can keep data, bank it and link it with anonymised clinical data on patients' cancers for future research,' explains Dr Schuh.

The test looks for mutations in 'hotspot' regions of each gene areas where mutations are more likely to occur. This does mean the test may miss up to 5% of mutations, as they can occur elsewhere, but this is still significantly better than the 'false negative' rate using current methods.

It can also detect mutations present in only 5% of the tumour cells present in a sample. This is much lower than is possible currently, and is important in being able to capture information from cells present in only small numbers in a tumour, but which are still important in driving cancer growth.

Having shown that it is possible to introduce the 46 gene test as an NHS service, the researchers are now moving on to investigate the potential of a test that will sequence 150 genes. The team will use the test first of all with 500 existing samples from patients taking part in cancer clinical trials to be able to compare the results retrospectively with information from the trials. They will then use the test with 1000 new cancer biopsies to better underst
'/>"/>

Contact: Press Office
press.office@admin.ox.ac.uk
44-018-652-80530
University of Oxford
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Eurofins MWG Operon launches SmartSeq -- An innovative DNA sequencing solution for premixed samples
2. Human bacteria sequencing project involving CU raises $340,000 online
3. Gene sequencing project mines data once considered junk for clues about cancer
4. Genomic sequencing identifies mutant drivers of common brain tumor
5. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
6. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
7. Surprising findings from NHLBI Exome Sequencing Project reported
8. NIH uses genome sequencing to help quell bacterial outbreak in Clinical Center
9. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
10. Gene sequencing project identifies potential drug targets in common childhood brain tumor
11. Voices Against Brain Cancer Comments on Link Between Cell Phone Use and Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... Jerusalem, April 22, 2014 -- In parallel with modern man ... of humans with whom we lived side by side, such ... Yet only Homo sapiens survived. What was it ... The truth is that little is known about our unique ... it contributed to the fact that we are the only ...
(Date:4/22/2014)... exposed to trauma, illness, alcohol or other drug abuse, ... brain cells that can go awry and activate conditions ... of autism. , Until now, it has been unclear ... a developing brain. Past studies have shown that when ... abuse or she experiences some trauma or illness, her ...
(Date:4/22/2014)... be influenced by low exposure to testosterone in the ... how men,s testosterone levels may be determined before they ... of the hormone than others is important because testosterone ... the hormone have been linked to obesity, diabetes and ... responsible for producing testosterone in adults known as ...
(Date:4/22/2014)... stroke intervention researchers have been informed that the National ... National Institutes of Health, will award an $8 million ... of an experimental drug for stroke. , The ... tissue plasminogen activator, or rtPA the "clot-busting" drug ... In laboratory rodent studies, 3K3A-APC, used in combination with ...
(Date:4/22/2014)... 22, 2014) Older parents are more likely to ... (ASD) than are younger parents. A recent study from ... in Philadelphia and Karolinska Institute in Sweden provides more ... varies between mothers, and fathers, ages, and found that ... and intellectual disability is larger for older parents., In ...
Breaking Medicine News(10 mins):Health News:What gave us the advantage over extinct types of humans? 2Health News:Life stressors trigger neurological disorders, researchers find 2Health News:$8 million NIH grant will fund multicenter clinical trial of stroke intervention drug 2Health News:$8 million NIH grant will fund multicenter clinical trial of stroke intervention drug 3Health News:Child's autism risk accelerates with mother's age over 30 2Health News:Child's autism risk accelerates with mother's age over 30 3
... Sint Antonius Hospital in Nieuwegein, the Netherlands say that ... air and belch more frequently, air swallowing does not ... to test whether air swallowing had any role in ... esophagus of 12 people with GERD and 12 healthy ...
... new study says that drinking alcohol is linked to ... of drinking//. ,"Social drinking builds social capital," ... Jose State University. "Social drinkers are out networking, ... result in bigger paychecks." ,The researchers said that ...
... Rosiglitazone, an oral drug used to reduce the amount of sugar ... a study.// ,Type 2 diabetes occurs when people cannot ... is the essential hormone that helps sugars to be turned into ... regulate their use of glucose are at high risk of Type ...
... — the grocery store — can help improve and ... a new study conducted in the Marshall// Islands. By ... habits, the researchers were able to foster an increase ... ,“Diet-related chronic diseases are at epidemic proportions, ...
... already suffered a stroke could run a further risk of ... findings of a new study. Recurrent// strokes could also disable ... Ruland, of the University at Chicago said” Stroke incidence and ... whites. Part of this risk may be explained by a ...
... confirmed in Wisconsin, the outbreak of the disease is ... One person has succumbed to the disease in the ... of the 30 cases have needed hospital admission and ... the patients are women. ,The places ...
Cached Medicine News:Health News:‘Healthy Stores’ Program Boosts Demand for Better Food in Marshall Islan 2
(Date:1/15/2014)... 2014  Humberto C. Antunes,  Galderma  worldwide CEO, will receive ... Journal of Drugs in Dermatology (JDD) at the ... event is January 17-20, 2014, at the Omni Orlando Resort at ... The ODAC is a distinguished event that delivers ...
(Date:1/15/2014)... Ky. , Jan. 15, 2014  Manufacturers, suppliers ... must be able to protect their most important ... http://photos.prnewswire.com/prnh/20130716/CL46586LOGO ) Because of ... it steadfastly remains one of the most litigious ...
(Date:1/15/2014)... Jan. 15, 2014 Tegra Medical is very pleased to ... as its new Chief Executive Officer.  Mark was promoted from ... has overseen the company,s four facilities in Massachusetts ... Mr. King joined Tegra Medical in 2012 with 20+ years ...
Breaking Medicine Technology:Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 2Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 3Galderma's global leader honored with a "Lifetime in Dermatology Achievement Award" by Journal of Drugs in Dermatology 4Intellectual Property Insurance for Medical-related Products and Services 2Tegra Medical Appoints New Chief Executive Officer 2Tegra Medical Appoints New Chief Executive Officer 3
Lorgnette pinhole occluder...
Double Ended Occluders...
Designed to provide occlusion while permitting observation of the eye. Helpful to determine if only one eye is deviating. Approximately 9 inches long....
Long handle occluders are approximately 9 inches long....
Medicine Products: