Navigation Links
46 gene sequencing test for cancer patients on the NHS
Date:3/25/2013

towards verifying the use of a test involving 150 genes.

Having a diagnostic test or 'panel' that can screen for mutations in multiple genes at once will be important for access to all the new cancer drugs that are coming along.

'It will be very difficult to manage in NHS diagnostic labs without gene panels,' explains Dr Schuh. 'Currently, new cancer drugs tend to get approved alongside a diagnostic test specific to that drug which can determine which patients will benefit. But as more and more drugs like this come along, we can't possibly run all the many different separate tests this could mean. We need one test for a range of drugs.'

Dr Taylor adds: 'We wanted a test that would use the latest DNA sequencing techniques to detect a wide range of mutations in a wide range of genes. A test that would be able to cover more cancers and more treatments, all for a similar cost to conventional methods.'

The test is run on a next generation sequencing platform from Life Technologies Corporation, called the Ion Personal Genome Machine (PGM(TM)). The test and accompanying software have been substantially modified as requested by the Oxford team to fulfil diagnostic standards in their lab.

This work was co-funded by the Technology Strategy Board, the UK's innovation agency, through a grant to the NIHR Oxford BRC, Life Technologies Corporation, AstraZeneca, and Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies.

As part of the test development, the Oxford team looked to improve the initial sample preparation in the lab, and to provide the software and infrastructure support to handle and analyse the amount of information involved. Most importantly, the Oxford group has carried out tests and comparisons to verify the robustness of the technique with cancer biopsies direct from patients.

The team compared the new 46 gene test against conventional techniques for 80 consecutive cancer bi
'/>"/>

Contact: Press Office
press.office@admin.ox.ac.uk
44-018-652-80530
University of Oxford
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Eurofins MWG Operon launches SmartSeq -- An innovative DNA sequencing solution for premixed samples
2. Human bacteria sequencing project involving CU raises $340,000 online
3. Gene sequencing project mines data once considered junk for clues about cancer
4. Genomic sequencing identifies mutant drivers of common brain tumor
5. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
6. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
7. Surprising findings from NHLBI Exome Sequencing Project reported
8. NIH uses genome sequencing to help quell bacterial outbreak in Clinical Center
9. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
10. Gene sequencing project identifies potential drug targets in common childhood brain tumor
11. Voices Against Brain Cancer Comments on Link Between Cell Phone Use and Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Two Kansas State University biochemists have discovered a ... for Staphylococcus aureus , a pathogenic bacterium that ... year. , Brian Geisbrecht, professor of biochemistry and molecular ... S. aureus , which is the cause of ... scientific journal Proceedings of the National Academy of ...
(Date:9/2/2014)... Vertebral invasive compression fractures called spine fractures, ... our spine suffers crack or gets deformed. Vertebral compression ... with osteoporosis or low bone density. Though osteoporosis is ... metastatic tumors and extensive trauma such as an accident, ... lead to such fractures. , The placement of such ...
(Date:9/2/2014)... 02, 2014 HMP Communications Holdings ... is proud to announce the acquisition of Nutrition411.com ... designed for healthcare professionals who integrate diet and nutrition ... access to:, , Late-breaking news related ... topic centers for diabetes, oncology, renal disease, wound care, ...
(Date:9/2/2014)... As an industry transformation expert, it was ... predict change. Fortunately for him, that valuable skill has stuck ... that are eager for change — such as the hearing ... market indicated it was ripe for better customer service, better ... a result, he took matters into his own hands and ...
(Date:9/2/2014)... New research involving mice suggests that the key to ... medicine cabinet. In a report published in the ... that macrophages from the lungs of old mice had ... from young mice, but these changes were reversed by ... consequences on immune function," said Joanne Turner, Ph.D., a ...
Breaking Medicine News(10 mins):Health News:Biochemists find new treatment options for staph infections, inflammatory diseases 2Health News:An Overview of the Minimally Invasive Vertebral Compression Fracture Repair Market by Transparency Market Research 2Health News:An Overview of the Minimally Invasive Vertebral Compression Fracture Repair Market by Transparency Market Research 3Health News:HMP Communications Holdings, LLC, Acquires Nutrition411.com 2Health News:David Sapio Launches Zounds Hearing Franchise 2
... Vitamin D, but be Careful Not to Burn Cautions Tanning ... Indoor Tanning Association (ITA) is encouraging beach goers to tan ... good health, overexposure to UV light can be a dangerous ... order for tanners to get all the benefits of UV ...
... 16 , WHO: Nancy Floyd Haworth Foundation (Breast cancer Education and, ... 18th annual Breast Cancer Luncheon and 3 FREE Educational Seminars, WHEN: Saturday, ... 9:00 AM--12 Noon: 3 FREE ... choose two you wish to attend. Call (505) 265-6343 to reserve your seat.) ...
... Nuclear Cardiology and Cardiac CT, is taking place in ... the ESC Working Group on Nuclear Cardiology and Cardiac ... and the American Society of Nuclear Cardiology (ASNC), now ... Nuclear Cardiology and Cardiac CT through practice, education and ...
... high-density genome wide analysis of participants in the Alzheimer,s ... complete and that data will be shared with scientists ... data will be used by researchers to search for ... which currently affects up to 5 million people in ...
... has workers looking over their shoulders according to ... of U.S. workers said their work atmosphere felt ... Tell It Now(SM) survey released by ComPsych today. ... "panicky." ComPsych Corporation is the world,s largest provider ...
... Physicians to E-Prescribing as First Step Toward Connected ... -- A new public/private partnership called PaperFree ... launched a plan to jump-start America,s electronic health ... 100 "electronic healthcare ambassadors" with a goal to ...
Cached Medicine News:Health News:Indoor Tanning Association Promotes Responsible Tanning for Spring Breakers 2Health News:Breast Cancer Awareness Event Including Free Educational Seminars 2Health News:Cardiac imaging highlighted at Biennial ICNC-9 2Health News:Cardiac imaging highlighted at Biennial ICNC-9 3Health News:Cardiac imaging highlighted at Biennial ICNC-9 4Health News:Alzheimer's Disease Neuroimaging Initiative announces completion of genome-wide analysis 2Health News:Alzheimer's Disease Neuroimaging Initiative announces completion of genome-wide analysis 3Health News:Work Atmosphere Is Worried, Panicky, Say Majority of U.S. Employees 2Health News:Tampa Bay Becomes First Community to Jump-Start America's E-Health Revolution 2Health News:Tampa Bay Becomes First Community to Jump-Start America's E-Health Revolution 3Health News:Tampa Bay Becomes First Community to Jump-Start America's E-Health Revolution 4Health News:Tampa Bay Becomes First Community to Jump-Start America's E-Health Revolution 5Health News:Tampa Bay Becomes First Community to Jump-Start America's E-Health Revolution 6Health News:Tampa Bay Becomes First Community to Jump-Start America's E-Health Revolution 7
(Date:9/2/2014)... 2014  BioSpecifics Technologies Corp. (NASDAQ: BSTC ), ... as XIAFLEX ® in the U.S. and XIAPEX ® ... Tom Wegman , will present at the following upcoming investor ... & Renshaw 16 th Annual Global Investment ... September 9, 2014 at 9:10 a.m. EDT , ...
(Date:9/2/2014)... SAN DIEGO , Sept. 2, 2014 /PRNewswire/ ... an oncology company focused on the clinical development ... it has completed enrollment in a randomized Phase ... candidate Pracinostat in combination with azacitidine in patients ... (MDS). The multi-center, placebo-controlled, double-blind study enrolled a ...
(Date:9/2/2014)... ANTONIO , Sept. 2, 2014 ... medical technology company focused on innovating lifesaving devices ... the appointment of Dr. Gabriele Niederauer , ... and CEO. Following the recent closure of Series ... Mark for the Surfacer™ Inside-Out Access Catheter System, ...
Breaking Medicine Technology:BioSpecifics Technologies Corp. Announces Presentations at Upcoming Investor Conferences 2MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 2MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 3MEI Pharma Completes Enrollment In Randomized Phase II Clinical Trial Of Pracinostat In Front Line Myelodysplastic Syndrome 4Bluegrass Vascular Technologies Names Dr. Gabriele Niederauer President And CEO 2
... THOUSAND OAKS, Calif., Sept. 24 Amgen (Nasdaq: ... EPOGEN® and PROCRIT® (Epoetin alfa) vials are being voluntarily ... as a precaution.  The product that is being recalled ... barely visible in most cases. The lamellae result from ...
... Pharmasset, Inc. (Nasdaq: VRUS ) announces that management ... September 27-28, 2010 at the New York Palace Hotel, New ... will provide an overview of the company at the JMP ... To access a simultaneous webcast of Mr. Price,s ...
Cached Medicine Technology:Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 2Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 3Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 4Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 5Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 6Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 7Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 8Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 9Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 10Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 11Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 12Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 13Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 14Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 15Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 16Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 17Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 18Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 19Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 20Amgen Initiates Voluntary Nationwide Recall of Certain Lots of EPOGEN® and PROCRIT® (Epoetin alfa) 21Pharmasset to Present at the JMP Healthcare Conference 2Pharmasset to Present at the JMP Healthcare Conference 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: