Navigation Links
46 gene sequencing test for cancer patients on the NHS
Date:3/25/2013

towards verifying the use of a test involving 150 genes.

Having a diagnostic test or 'panel' that can screen for mutations in multiple genes at once will be important for access to all the new cancer drugs that are coming along.

'It will be very difficult to manage in NHS diagnostic labs without gene panels,' explains Dr Schuh. 'Currently, new cancer drugs tend to get approved alongside a diagnostic test specific to that drug which can determine which patients will benefit. But as more and more drugs like this come along, we can't possibly run all the many different separate tests this could mean. We need one test for a range of drugs.'

Dr Taylor adds: 'We wanted a test that would use the latest DNA sequencing techniques to detect a wide range of mutations in a wide range of genes. A test that would be able to cover more cancers and more treatments, all for a similar cost to conventional methods.'

The test is run on a next generation sequencing platform from Life Technologies Corporation, called the Ion Personal Genome Machine (PGM(TM)). The test and accompanying software have been substantially modified as requested by the Oxford team to fulfil diagnostic standards in their lab.

This work was co-funded by the Technology Strategy Board, the UK's innovation agency, through a grant to the NIHR Oxford BRC, Life Technologies Corporation, AstraZeneca, and Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies.

As part of the test development, the Oxford team looked to improve the initial sample preparation in the lab, and to provide the software and infrastructure support to handle and analyse the amount of information involved. Most importantly, the Oxford group has carried out tests and comparisons to verify the robustness of the technique with cancer biopsies direct from patients.

The team compared the new 46 gene test against conventional techniques for 80 consecutive cancer bi
'/>"/>

Contact: Press Office
press.office@admin.ox.ac.uk
44-018-652-80530
University of Oxford
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Eurofins MWG Operon launches SmartSeq -- An innovative DNA sequencing solution for premixed samples
2. Human bacteria sequencing project involving CU raises $340,000 online
3. Gene sequencing project mines data once considered junk for clues about cancer
4. Genomic sequencing identifies mutant drivers of common brain tumor
5. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
6. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
7. Surprising findings from NHLBI Exome Sequencing Project reported
8. NIH uses genome sequencing to help quell bacterial outbreak in Clinical Center
9. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
10. Gene sequencing project identifies potential drug targets in common childhood brain tumor
11. Voices Against Brain Cancer Comments on Link Between Cell Phone Use and Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/30/2015)... Alexandria, VA (PRWEB) May 30, 2015 ... Research Foundation interviewed Dr. Charles Simone and Dr. ... Medicine, during its ‘Meet the Mesothelioma Experts’ series. ... interviews focusing on mesothelioma centers of excellence. Drs. ... Foundation’s executive director, Mary Hesdorffer, with whom they ...
(Date:5/30/2015)... May 30, 2015 Responding to surging ... travelers who experienced OGAWA products while abroad, OGAWA-engineered massage ... , A leader in the Asian health and ... designer, researcher, developer and manufacturer of health and wellness ... craftsmanship of their products, health enthusiasts in Asia and ...
(Date:5/30/2015)... Cyclist Barry Haarde will commence ... World 2015: Piles of Miles” near San Francisco, ... hemophilia and encourage individuals to support needy hemophilic ... One Life supports nearly 1,200 impoverished children and ... direct sponsorships, scholarships and micro-enterprise grants. Hemophilia is ...
(Date:5/30/2015)... The iconic American actor, and host of “In ... segment on Medical Malpractice. This segment of “In America” ... health care field. , According to the Bureau of ... were filed, roughly only 20% of them made it ... while the remaining 30% were tossed out. (Source: ...
(Date:5/30/2015)... Venus Viva has proven to work ... deep wrinkles, stretch marks, pigmentation irregularities, and uneven texture ... Dr. F. Victor Rueckl of Lakes Dermatology in Las ... Las Vegas. This body image solution combines NanoFractional Radio ... delivers proven results through a skin heating process that ...
Breaking Medicine News(10 mins):Health News:Interview with Mesothelioma Experts, Drs. Simone and Alley Now Available on Demand 2Health News:Award-winning OGAWA Massage Chairs Finally Available for purchase in North America. 2Health News:Award-winning OGAWA Massage Chairs Finally Available for purchase in North America. 3Health News:Barry Haarde Cycles 4,000 Miles Across the USA for Hemophilia 2Health News:Announcing Ground-Breaking Technology for Anti-Aging, FDA Approved, Venus Viva. 2Health News:Announcing Ground-Breaking Technology for Anti-Aging, FDA Approved, Venus Viva. 3
... study shows that people with a low potassium intake are ... Previous research has suggested that reduced quantities of potassium in ... focus on potassium is, perhaps, a new one - for ... intake low to avoid stroke. But sodium and potassium chemistry ...
... heart improves function in patients with advanced heart failure. Researchers ... failure, the heart enlarges and is unable to effectively pump ... too. Heart failure is a progressive condition, with no cure ... with medication. ,However, a new cardiac support device ...
... eases hand spasticity among stroke survivors. Spasticity in the limbs ... much disability,// because it interferes with activities like getting dressed ... a substance that relieves muscle tightness - may help with ... botulinum toxin (also known as botox) in stroke, a group ...
... new study, the the functionality of lungs can be well ... our early days. Scientists have long known a test called ... an effective measure of lung function and predictor of morbidity ... investigators have speculated factors like exposure to tobacco smoke during ...
... works better than relaxation in lessening the symptoms of ... of 120 patients diagnosed with fibromyalgia, a painful muscular ... the patients were initiated to routine sessions of graded ... ,After three months, more of those in the exercise ...
... research it is found that an enzyme that rectifies ... reducing a person's susceptibility to diseases such as hemophilia, ... Wales and the University of Edinburgh in Scotland have ... mutations that can lead to diseases. ,Different combinations ...
Cached Medicine News:
(Date:5/29/2015)... 29, 2015 Research and ... of the "Surgical/Operating Microscopes Market by Application ... report to their offering.      ... market is poised to reach $806.6 million by ... CAGR of 12.3% from 2015 to 2020. , ...
(Date:5/29/2015)... 29, 2015  Eli Lilly and Company (NYSE: ... announced that they have entered into a clinical trial ... AstraZeneca,s investigational anti-PD-L1 immune checkpoint inhibitor, MEDI4736, in combination ... antiangiogenic cancer medicine. The planned study will assess the ... tumors. The Phase I study is expected ...
(Date:5/28/2015)... Ind. , May 28, 2015 Zimmer ... that it has finalized agreements with buyers to divest ... Zimmer® Unicompartmental High-Flex Knee System assets, Biomet Discovery® Elbow ... agreements are in furtherance of Zimmer,s pending acquisition of ... Zimmer continues to work constructively with the Bureau ...
Breaking Medicine Technology:Surgical/Operating Microscopes Market by Application & End User - Global Forecast to 2020 for the $806 Million Industry 2Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 2Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 3Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 4Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 5Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 6Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 7Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 8Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 9Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 10Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 11Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 12Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 13Lilly and AstraZeneca to Collaborate on Immuno-Oncology Combination Clinical Trial in Solid Tumors 14Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 2Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 3Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 4Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 5Zimmer Announces Agreements in Furtherance of Pending Biomet Merger 6
... Inc. (Nasdaq: NUVA ), a medical device company ... for the spine, announced today that Kevin O,Boyle, Chief ... the Oppenheimer 20th Annual Healthcare Conference at The Waldorf ... November 3, 2009. , A live webcast of the ...
... your stomach, relieve your wallet , YONKERS, N.Y., Oct. ... us may suffer from occasional heartburn, a new Best Buy Drugs ... don,t need an expensive drug like Nexium, the "purple pill," for ... to identify "Best Buys" based on safety, effectiveness, and price for ...
Cached Medicine Technology:NuVasive to Present at the Oppenheimer 20th Annual Healthcare Conference 2NuVasive to Present at the Oppenheimer 20th Annual Healthcare Conference 3Consumer Reports Health: Americans With Heartburn Paying Too Much Green For Nexium's 'Purple Pill' 2Consumer Reports Health: Americans With Heartburn Paying Too Much Green For Nexium's 'Purple Pill' 3
... Since 1991 Intersurgical Incorporated ... filters, heat and moisture ... therapy products, hand-held nebulizers ... of accessories and connectors ...
The Pall High Performance HME is a high efficiency heat and moisture exchanger, indicated to protect patients against the potential risks of ventilation with dry and cold gases....
Passive heat and moisture exchangers for respiratory applications....
Ballard trach care HMES and filters, tv 1500, HME with built-in flex tube...
Medicine Products: