Navigation Links
46 gene sequencing test for cancer patients on the NHS
Date:3/25/2013

towards verifying the use of a test involving 150 genes.

Having a diagnostic test or 'panel' that can screen for mutations in multiple genes at once will be important for access to all the new cancer drugs that are coming along.

'It will be very difficult to manage in NHS diagnostic labs without gene panels,' explains Dr Schuh. 'Currently, new cancer drugs tend to get approved alongside a diagnostic test specific to that drug which can determine which patients will benefit. But as more and more drugs like this come along, we can't possibly run all the many different separate tests this could mean. We need one test for a range of drugs.'

Dr Taylor adds: 'We wanted a test that would use the latest DNA sequencing techniques to detect a wide range of mutations in a wide range of genes. A test that would be able to cover more cancers and more treatments, all for a similar cost to conventional methods.'

The test is run on a next generation sequencing platform from Life Technologies Corporation, called the Ion Personal Genome Machine (PGM(TM)). The test and accompanying software have been substantially modified as requested by the Oxford team to fulfil diagnostic standards in their lab.

This work was co-funded by the Technology Strategy Board, the UK's innovation agency, through a grant to the NIHR Oxford BRC, Life Technologies Corporation, AstraZeneca, and Janssen Research & Development, LLC, one of the Janssen Pharmaceutical Companies.

As part of the test development, the Oxford team looked to improve the initial sample preparation in the lab, and to provide the software and infrastructure support to handle and analyse the amount of information involved. Most importantly, the Oxford group has carried out tests and comparisons to verify the robustness of the technique with cancer biopsies direct from patients.

The team compared the new 46 gene test against conventional techniques for 80 consecutive cancer bi
'/>"/>

Contact: Press Office
press.office@admin.ox.ac.uk
44-018-652-80530
University of Oxford
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Eurofins MWG Operon launches SmartSeq -- An innovative DNA sequencing solution for premixed samples
2. Human bacteria sequencing project involving CU raises $340,000 online
3. Gene sequencing project mines data once considered junk for clues about cancer
4. Genomic sequencing identifies mutant drivers of common brain tumor
5. High-throughput sequencing shows potentially hundreds of gene mutations related to autism
6. Johns Hopkins scientists pair blood test and gene sequencing to detect cancer
7. Surprising findings from NHLBI Exome Sequencing Project reported
8. NIH uses genome sequencing to help quell bacterial outbreak in Clinical Center
9. New Stanford method enables sequencing of fetal genomes using only maternal blood sample
10. Gene sequencing project identifies potential drug targets in common childhood brain tumor
11. Voices Against Brain Cancer Comments on Link Between Cell Phone Use and Brain Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/28/2015)... Malaysia (PRWEB) February 28, 2015 The ... all across Malaysia into one platform and gears towards ... , A series of group talks in smaller ... like Nation Building, Education, Personal Development, Leadership, Entrepreneurship, Healthcare, ... and raise awareness of Malaysian youths. , ...
(Date:2/28/2015)... Gerald “Solutionman” Haman surveyed over 10,000 people ... innovative thinking. “The #1 block was lack of ... reports Haman, who created the Thinkubator Innovation Studio in ... that they did not have enough time for innovative ... stimulate innovation. , Solutionman’s monthly “Accelerating Innovation Training” workshops ...
(Date:2/28/2015)... (PRWEB) February 28, 2015 March—also ... good time to remind ourselves and others that ... say Atlantic NeuroSurgical Specialists (ANS). , Concussions are ... account for 75% of TBIs. There are 1.6-3.8 ... may sound benign, but it is a brain ...
(Date:2/28/2015)... A study out of the University of ... for the treatment of a hereditary ocular condition that ... by Dr. Robert MacLaren, professor of ophthalmology at the ... Journal on January 16, 2014 , the study treated ... that mostly affects men and leads to the degeneration ...
(Date:2/28/2015)... 28, 2015 National Sales ... sales, marketing and supply chain management for consumer ... is bringing its award winning solutions for thinning-damaged ... products are specifically created to combat thinning-damaged hair. ... is committed to marrying science with nature to ...
Breaking Medicine News(10 mins):Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 2Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 3Health News:My Mobile University Appointed Learning Partner for the Upcoming MCA’S First Youth Empowerment Conference Held in Malaysia on March 28, 2015 4Health News:New Survey Reveals “Lack of Time” Is the Number #1 Barrier to Innovative Thinking 2Health News:New Survey Reveals “Lack of Time” Is the Number #1 Barrier to Innovative Thinking 3Health News:Atlantic NeuroSurgical Specialists (ANS) Focus on National Brain Injury Awareness Month to Educate the General Public on Head Trauma 2Health News:Atlantic NeuroSurgical Specialists (ANS) Focus on National Brain Injury Awareness Month to Educate the General Public on Head Trauma 3Health News:New Gene Therapy Procedure Could Hold Key to Preventing Blindness for Certain Patients 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 2Health News:BIOTA Botanicals Brings Thinning-Damaged Hair Solutions to the Hair Care Aisle at Walgreens 3
... 12 InfuSystem Holdings, Inc.,(OTC Bulletin Board: INHI; ... and associated clinical services, today announced,financial results and ... of,2008., Mr. Steve Watkins, chief executive officer, ... first full quarter of operations as a stand-alone,public ...
... Medical Association (AVMA) has revised its policy on ... additional guidance,for managing pain associated with these procedures. ... not dictate that practitioners use any,particular method of ... recommendations for consideration by practitioners when they work,with ...
... The American Veterinary,Medical Association (AVMA) has reinforced its ... and other equines by approving a,new policy on the ... the AVMA Executive Board on April 12, 2008,states that ... opposes the,use of double-deck trailers to transport equines. The ...
... Regulatory Authority Over Tobacco, WASHINGTON, May 9 ... country, today announces their,support of H.R. 1108, "The ... gives FDA regulatory authority over tobacco products., ... this year.,H.R. 1108 has broad bi-partisan support and ...
... N.H., May 12 Atrium Medical Corporation ... and precautionary recall of,selected lots of HYDRAGLIDE(TM) ... Atrium heparin-coated Hydraglide Thoracic,Catheters were manufactured with ... chondroitin sulfate (OSCS). The patient risk associated,with ...
... community observes,the destructive aftermath of the world,s second ... mounting frustration over getting humanitarian aid,for cyclone victims, ... been proactive-and more importantly, successful-in initiating,medical care at ... 100,000 people,are assumed dead. AMIMA has funded the ...
Cached Medicine News:Health News:InfuSystem Holdings Provides Business Update and Comments on First Quarter 2008 Financial Results 2Health News:InfuSystem Holdings Provides Business Update and Comments on First Quarter 2008 Financial Results 3Health News:InfuSystem Holdings Provides Business Update and Comments on First Quarter 2008 Financial Results 4Health News:InfuSystem Holdings Provides Business Update and Comments on First Quarter 2008 Financial Results 5Health News:InfuSystem Holdings Provides Business Update and Comments on First Quarter 2008 Financial Results 6Health News:InfuSystem Holdings Provides Business Update and Comments on First Quarter 2008 Financial Results 7Health News:InfuSystem Holdings Provides Business Update and Comments on First Quarter 2008 Financial Results 8Health News:InfuSystem Holdings Provides Business Update and Comments on First Quarter 2008 Financial Results 9Health News:Revised AVMA Policy on Castrating and Dehorning Cattle Provides Additional Guidance for Managing Pain 2Health News:AVMA Opposes Use of Double-Deck Trailers for Transporting Horses and Other Equines 2Health News:Atrium Initiates Voluntary Recall Action Regarding HYDRAGLIDE(TM) Brand Heparin-Coated Thoracic Drainage Catheters Used for Autotransfusion During Cardiopulmonary Bypass Surgery 2Health News:Alumni Myanmar Institutes of Medicine Association (AMIMA) Races Time to Help Cyclone Victims 2
(Date:2/27/2015)... and JERUSALEM , Feb. 27, 2015 ... octreotide capsules, its lead product for the orphan condition ... Series E financing round. Participants in the financing included ... an undisclosed blue chip public investment fund, as well ... Health Ventures, Abingworth and ARCH Venture Partners. ...
(Date:2/26/2015)... 2015 RnRMarketResearch.com adds Corneal ... report to its store. This report p provides ... The report "Corneal Ulcers - Pipeline Review, H2 ... for Corneal Ulcers. Corneal Ulcers are primarily result ... viral infections & fungal infections. The symptoms of ...
(Date:2/26/2015)... 2015  Today the National Safety Council ... physical side effects of pain medications , ... Vicodin and Oxycontin, are safer options than over-the-counter pain ... painkillers than on heroin and cocaine combined," said ... "Yet, these medications are marketed as the Cadillac option ...
Breaking Medicine Technology:Chiasma Announces Completion of $70 Million Series E Financing 2Chiasma Announces Completion of $70 Million Series E Financing 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 2Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 3Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 4Corneal Ulcers Therapeutics Companies and Drugs Pipeline H2 2014 Review Research Report 5National Safety Council: Opioid prescription painkillers have hidden, deadly side effects 2
... 2011 Men and women infected with HIV reduced ... partners through initiation of oral antiretroviral therapy (ART), according ... by the HIV Prevention Trials Network (HPTN), a global ... cutting-edge biomedical, behavioral, and structural interventions. ...
... Inc. (OTC/BB: TBIO) today announced the following Webcast:What: ... Business Update Conference CallWhen: , Thursday, May 12, 2011 ... Live over the Internet -- Simply log on to ... 402-452-5400 To access the call via telephone, call 800-895-0198 ...
Cached Medicine Technology:Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052) 2Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052) 3Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052) 4Initiation of Antiretroviral Treatment Protects Uninfected Sexual Partners from HIV Infection (HPTN Study 052) 5Reminder: Transgenomic to Hold First Quarter Financial Results Conference Call Today 2
The Easy Wrap Apron is now available with an attached Thyroid Collar. The Thyroid Collar is held on with velcro so it adjusts to fully protect the neck. This Apron with Collar is available in 5mm lea...
The NexGen CR femoral component is intended for patients who, in the physician's judgement, have good bone stock and whose ligaments provide adequate mediolateral, anteroposterior, and varus/valgus s...
... The Genesis Total Knee System provides the ... fit each patient. Not the other way ... modules, articular inserts and patellar components allow ... certainty. And you do it all with ...
... a new implant. It's a new material, ... debris can be greatly reduced . The ... needs of the nickel-sensitive patient. Hardness, lubricity ... Oxinium is available in our two already ...
Medicine Products: