Navigation Links
2-step immunotherapy attacks advanced ovarian cancer
Date:1/31/2013

endritic cell vaccine created from tissue in the patients' own tumor, which was stored at time of surgery. All of these women's cancers had progressed on standard of care chemotherapy.

In the first segment of the study, the team prepared an individualized dendritic cell vaccine for each patient. They harvested dendritic cells from each patient using apheresis, the same process volunteers go through when they donate platelets or other blood products such as those collected for stem cell transplants. Kandalaft and colleagues then exposed each patient's dendritic cells to tumor extract produced from the woman's own tumor, which teaches the dendritic cells who the enemy is. After this priming, the investigators vaccinated each patient with her own dendritic cells and gave them a combination chemotherapy regimen of bevacizumab and cyclophosphamide. Because dendritic cells are like the generals of the immune system, they then induce other immune cells to take up the fight.

Of the six patients who received the dendritic cell vaccine, four developed an anti-tumor immune response, indicating that the approach was working. One of those patients had no measurable disease at study entry because all of it had been successfully removed during surgery. She remains in remission today, 42 months following vaccine treatment. The other three who had an immune response to the vaccine still had residual disease and went on to the second segment of treatment.

The team harvested T cells from each of these three women. Using a technique developed at Penn, they grew the cells in the laboratory, expanding their numbers exponentially, and then reintroduced them into each patient after she underwent a lymphodepleting chemotherapy regimen. Because the T cells had already been trained by the dendritic cell vaccine to attack the tumor cells, the adoptive T cell transfer amplifies the anti-tumor immune response.

Two of the women showed a restored immune respon
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. 12-Step Meetings May Help Teens Beat Alcohol, Drug Abuse
2. Immunotherapy reduces allergic patients sensitivity to peanuts
3. Sublingual immunotherapy shows promise as treatment for peanut allergy
4. Moffitt researchers say effective immunotherapy for melanoma hinges on blocking suppressive factors
5. Antibodies reverse type 1 diabetes in new immunotherapy study
6. Immunotherapy for elderly cancer patients finds new promise in drug combination
7. Toward a better cyanide antidote for terrorist attacks and other mass casualty events
8. New Guidelines Seek to Streamline Care for Worst Heart Attacks
9. Penn research reveals new aspect of platelet behavior in heart attacks: Clots can sense blood flow
10. Study Tallies Economic Fallout From Workers Heart Attacks
11. Decline in incidence of heart attacks appears associated with smoke-free workplace laws
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... (PRWEB) October 01, 2014 ... networking and relationship-marketing firm, announced today the ... Executive® and Project of the Year Awards ... makers representing organizations in financial services, commercial, ... large-scale technology endeavors that address key issues ...
(Date:10/1/2014)... October 01, 2014 Beverly Hills licensed ... Mojas is celebrating 20 years of private practice in ... of people to achieve greater joy and fulfillment in ... of warning signs and suggestions for anyone who suspects ... explains: “Believe it or not, it’s not always ...
(Date:10/1/2014)... (PRWEB) October 01, 2014 NoteSwift Inc., ... EHR versions 10.0, 12.1 and 13.0. NoteSwift is the ... as commands to navigate and document clinical information at ... provider spends creating a patient note by more than ... of the major pain points providers state impedes EHR ...
(Date:10/1/2014)... in Bahir Dar, Ethiopia, at the occasion of ... gathered some 150 African and international leishmaniasis experts, ... safety and efficacy monitoring plan, carried out ... Sudan, Uganda, and Ethiopia, were presented to key ... to treatment of kala-azar with the combination of ...
(Date:10/1/2014)... 01, 2014 Dr. Saj Jivraj, one ... prosthodontists, is traveling to Chennai, India, tomorrow to speak ... 2 and 3. , Dr. Jivraj is founder of ... Oxnard, Calif., and one of the world’s foremost prosthodontists, ... replacement. He is speaking to the Indian Society of ...
Breaking Medicine News(10 mins):Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 2Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 3Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 4Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 5Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 6Health News:T.E.N. Announces Nominees for the 2014 ISE® North America Awards; People’s Choice Award voting now open to industry at large 7Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 2Health News:Prominent Beverly Hills Psychologist Dr. Kathleen Mojas Celebrating 20 Years in Private Practice Identifies Common Warning Signs That You May Be In a Toxic Relationship. 3Health News:NoteSwift Joins Allscripts Developer Program 2Health News:NoteSwift Joins Allscripts Developer Program 3Health News:Results of large-scale roll out of combination treatment for kala-azar in Eastern Africa 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 2Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 3Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 4Health News:One of Woodland Hills’ Top Cosmetic Dentists Speaking to Indian Society of Oral Implantologists Tomorrow 5
... directs the University of Southern California Center for ... to evaluate robots as exercise coaches for adults of ... The effort, entitled "Robot Motivator: Towards Adaptive Health ... of virtual social characters on people,s motivation to exercise. ...
... , , - ... 41% from 31% in Q3 2008 , - Q3 2009 Operating ... 2009 Pre-tax Income Increases 168% from same period in 2008 , ... LWAY ), makers of the nutritious, probiotic dairy beverage called kefir, ...
... of this group with better preventive care, , THURSDAY, Nov. ... health measures can prolong lives, but only 25 percent of ... getting these recommended screenings, a new report shows. , Prepared ... and the American Medical Association, the report also lays out ...
... no more likely to have post-operative complications than those ... uterine fibroids, according to a study at Henry Ford ... fibroids, leaving the uterus intact and preserving the ability ... obese patient can present difficulties for the most experienced ...
... ... in Buffalo, NY, launched their revitalized and interactive website Monday, November 16, 2009. The ... . The project was initiated to provide users with an enhanced shopping and ordering ... (PRWEB) November 18, ...
... MELVILLE, N.Y., Nov. 19 Long Island IVF, a full ... patients achieve successful pregnancies, is now offering a new program ... treatment. Through this program and a partnership with In Vitro ... amount of money couples pay for their comprehensive treatment plans ...
Cached Medicine News:Health News:Lifeway Foods Reports Record 3rd Quarter 2009 Revenues and Earnings Results 2Health News:Lifeway Foods Reports Record 3rd Quarter 2009 Revenues and Earnings Results 3Health News:Lifeway Foods Reports Record 3rd Quarter 2009 Revenues and Earnings Results 4Health News:Lifeway Foods Reports Record 3rd Quarter 2009 Revenues and Earnings Results 5Health News:Lifeway Foods Reports Record 3rd Quarter 2009 Revenues and Earnings Results 6Health News:Lifeway Foods Reports Record 3rd Quarter 2009 Revenues and Earnings Results 7Health News:Lifeway Foods Reports Record 3rd Quarter 2009 Revenues and Earnings Results 8Health News: Too Few Older Adults Get Recommended Screenings 2Health News: Too Few Older Adults Get Recommended Screenings 3Health News:Patient's weight not linked to success of fibroid surgery 2Health News:Great Customer Service Just Got Better as Emedco Announces the Launch of their Completely Updated and Enhanced Website 2Health News:Great Customer Service Just Got Better as Emedco Announces the Launch of their Completely Updated and Enhanced Website 3Health News:Long Island IVF to Offer IVF Financial Share Program, Limiting Costs and Providing Refunds if IVF is Not Successful 2
(Date:10/1/2014)... , Oct. 1, 2014 The ... available. Interested parties can learn about the ... Health is supporting the health care continuum ... . Photo- http://photos.prnewswire.com/prnh/20140930/149504-INFO ... financials and the chief executive officer,s letter ...
(Date:10/1/2014)... NOTTINGHAM, England , Oct. 1, 2014 /PRNewswire/ ... announced that its subsidiary, Molecular Profiles Ltd., is set ... the annual CPhI/ICSE Worldwide event in Paris ... with the rapid development of both standard and complex ... platform, which incorporates the company,s existing formulation and analytical ...
(Date:10/1/2014)... MIAMI , Oct. 1, 2014 NeuroCall, ... Commission accreditation for its Telestroke and Teleneurology services. Dr. ... of NeuroCall, commented, "We are extremely proud that our ... Commission, as we continue to provide lifesaving support and ... of affiliated hospitals throughout the United States ...
Breaking Medicine Technology:Cardinal Health 2014 Digital Report to Shareholders Now Available 2Columbia Laboratories' UK Subsidiary To Launch New Development Platform At CPHI 2Columbia Laboratories' UK Subsidiary To Launch New Development Platform At CPHI 3NeuroCall Awarded Joint Commission Accreditation 2
... HOLON, Israel, September 13, 2011 ... modular,   mobile and home-based telemedicine   and telecare ... provider of solutions for personal safety, aged care and ... New Zealand and Australia. Based on Aerotel,s ...
... 13, 2011 Reportlinker.com announces that ... available in its catalogue: ... BRICS (Brazil, Russia, India, China, South ... http://www.reportlinker.com/p0611595/Orthopedic-Accessories-Market-Outlook-in-BRICS-Brazil-Russia-India-China-South-Africa-to-2017.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Orthopedic Orthopedic ...
Cached Medicine Technology:Aerotel and Elemental Technologies Launch New Location-Based Personal Safety Service in Australia and New Zealand 2Aerotel and Elemental Technologies Launch New Location-Based Personal Safety Service in Australia and New Zealand 3Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 2Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 3Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 4Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 5Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 6Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 7Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 8Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 9Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 10Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 11Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 12Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 13Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 14Orthopedic Accessories Market Outlook in BRICS (Brazil, Russia, India, China, South Africa) to 2017 15