Navigation Links
2-step immunotherapy attacks advanced ovarian cancer
Date:1/31/2013

endritic cell vaccine created from tissue in the patients' own tumor, which was stored at time of surgery. All of these women's cancers had progressed on standard of care chemotherapy.

In the first segment of the study, the team prepared an individualized dendritic cell vaccine for each patient. They harvested dendritic cells from each patient using apheresis, the same process volunteers go through when they donate platelets or other blood products such as those collected for stem cell transplants. Kandalaft and colleagues then exposed each patient's dendritic cells to tumor extract produced from the woman's own tumor, which teaches the dendritic cells who the enemy is. After this priming, the investigators vaccinated each patient with her own dendritic cells and gave them a combination chemotherapy regimen of bevacizumab and cyclophosphamide. Because dendritic cells are like the generals of the immune system, they then induce other immune cells to take up the fight.

Of the six patients who received the dendritic cell vaccine, four developed an anti-tumor immune response, indicating that the approach was working. One of those patients had no measurable disease at study entry because all of it had been successfully removed during surgery. She remains in remission today, 42 months following vaccine treatment. The other three who had an immune response to the vaccine still had residual disease and went on to the second segment of treatment.

The team harvested T cells from each of these three women. Using a technique developed at Penn, they grew the cells in the laboratory, expanding their numbers exponentially, and then reintroduced them into each patient after she underwent a lymphodepleting chemotherapy regimen. Because the T cells had already been trained by the dendritic cell vaccine to attack the tumor cells, the adoptive T cell transfer amplifies the anti-tumor immune response.

Two of the women showed a restored immune respon
'/>"/>

Contact: Holly Auer
holly.auer@uphs.upenn.edu
215-349-5659
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. 12-Step Meetings May Help Teens Beat Alcohol, Drug Abuse
2. Immunotherapy reduces allergic patients sensitivity to peanuts
3. Sublingual immunotherapy shows promise as treatment for peanut allergy
4. Moffitt researchers say effective immunotherapy for melanoma hinges on blocking suppressive factors
5. Antibodies reverse type 1 diabetes in new immunotherapy study
6. Immunotherapy for elderly cancer patients finds new promise in drug combination
7. Toward a better cyanide antidote for terrorist attacks and other mass casualty events
8. New Guidelines Seek to Streamline Care for Worst Heart Attacks
9. Penn research reveals new aspect of platelet behavior in heart attacks: Clots can sense blood flow
10. Study Tallies Economic Fallout From Workers Heart Attacks
11. Decline in incidence of heart attacks appears associated with smoke-free workplace laws
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Omar Ahmad Barrada, a junior at Milton Hershey ... Congress of Future Medical Leaders in Boston, Mass. The ... highest achieving high school students.” , “I’m excited to ... and learn better study habits,” said Omar. “The event ... can ask the surgeons questions.” , The goal is ...
(Date:5/22/2015)... PITTSBURGH, Pa (PRWEB) May 22, 2015 ... Network (AHN) today announced a new partnership to ... program for the region. The initiative includes a new ... BodyStage live demonstration theater, and a new traveling ... in the fall of 2015. , Designed to ...
(Date:5/22/2015)... 22, 2015 Coco Libre, the Official Coconut ... World Record at the 104th running of the race. On ... luge served 315 people in one hour—one person about every ... is so true to the heart of the Bay Area, ... ice luge to the finish line only made sense,” said ...
(Date:5/22/2015)... York, NY (PRWEB) May 22, 2015 Medivo, ... entitled “Positivity Rates and Genotype Results in ‘Baby Boomers’ ... Results from a Nationwide Lab Test Database” at Digestive Disease ... by Medivo’s Clinical Affairs and Analytics team members Carol Smyth, ... MD; and Andrea Parker, MSI, along with Nancy Reau, MD ...
(Date:5/22/2015)... 2015 Ticket Down is a reputable source ... NHL Eastern Conference Finals Tickets . All seating for ... in the ticket listing. , For the first time ... top of the Eastern Conference. One of the original franchises ... ups and downs over the years, but the excitement level ...
Breaking Medicine News(10 mins):Health News:Milton Hershey School Student Chosen for Congress of Future Medical Leaders 2Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 2Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 3Health News:Carnegie Science Center, Allegheny Health Network Partner to Create BodyTech 4Health News:Coco Libre Ice Luge Sets New World Record at Bay to Breakers 2Health News:Medivo Study Finds HCV Positivity Rates are 250% Higher Among Baby Boomers 2Health News:Cheap Lightning vs Rangers NHL Eastern Conference Finals Tickets: Ticket Down Slashes Ticket Prices on New York Rangers vs Tampa Bay Lightning Eastern Conference Playoffs 2Health News:Cheap Lightning vs Rangers NHL Eastern Conference Finals Tickets: Ticket Down Slashes Ticket Prices on New York Rangers vs Tampa Bay Lightning Eastern Conference Playoffs 3
... cause of 90 percent of the world’s lung cancer ... cigarettes they smoke per day are exposed to lower ... However, the reduction in the amount or concentration of ... to the reduction in cigarettes smoked. ,Researchers from ...
... shows only 7 percent of diabetics take the ... blood vessel problems. Researchers stressed continued negligence by ... retinopathy, neuropathy, nephropathy, coronary heart disease, stroke, and ... adults, ages 20 years or older, who had ...
... that causes excessive absence from work. Many doctors recommend an ... to normal activity levels. But many people with lower back ... new study suggests people with low back pain can benefit ... among the employees of an airline company in the Netherlands. ...
... 7 million patients suffering from chronic angina report limitations ... to three times more frequently than the general population. ... despite current treatments, such as myocardial revascularization -- a ... and is done largely to prevent angina -- and ...
... is an infection of the central nervous system caused ... the most common type of acquired epilepsy around the ... about 400,000 people. ,New research shows an antiparasitic ... a common parasite. ,Researchers speculated treatment with the ...
... study finds the abilities required for success in school ... workplace.// ,The idea that one’s cognitive abilities predict ... been controversial. Many people believe what is needed for ... academic success. Scientists from the University of Illinois tested ...
Cached Medicine News:Health News:Reducing Number Of Cigarettes Not Enough 2Health News:New Medication May Decrease The Frequency Of Angina Attacks 2
(Date:5/22/2015)... NEW YORK , May 22, 2015 /PRNewswire/ ... segment of the $13 billion global cardiac rhythm ... Kalorama Information.  Kalorama found that Medtronic, St. Jude ... Medical) command 80% of this market segment. The ... Management Device Markets , uses 2015 as a ...
(Date:5/22/2015)... 2015  RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX), a clinical-stage ... regeneration, today announced that J.J. Finkelstein , chief ... corporate overview at two upcoming investor conferences. ... th Annual Microcap Conference on Thursday May 28, ... at 11:00 am EDT.  A webcast will be available ...
(Date:5/22/2015)... KING OF PRUSSIA, Pa. , May 22, 2015 ... CSL Behring its 2015 Corporate Leadership Award as ... science and improving the care of the bleeding disorders community.  ... and Managing Director, CSL Limited, during the NHF Annual Spring ... May 21. "The National Hemophilia Foundation is dedicated ...
Breaking Medicine Technology:Kalorama: Top Companies Dominate Cardiac Defibrillator Market 2Kalorama: Top Companies Dominate Cardiac Defibrillator Market 3Kalorama: Top Companies Dominate Cardiac Defibrillator Market 4RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 2National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 3National Hemophilia Foundation Honors CSL Behring with Corporate Leadership Award 4
... Pacira Pharmaceuticals, Inc., an emerging specialty pharmaceutical ... Phase 3 bunionectomy study to evaluate the efficacy ... (bupivacaine extended-release liposome injection) is being presented in ... Annual Meeting of the Orthopaedic Research Society held ...
... As the first major medical center in North ... clinical practice groups, UT Southwestern Medical Center today applauded ... providers across the nation to embrace new health care ... goal of  "meaningful use" of electronic health records (EHR) ...
Cached Medicine Technology:Pacira Pharmaceuticals Presents New Data from EXPAREL Phase 3 Study at Orthopaedic Research Society's 57th Annual Meeting 2Pacira Pharmaceuticals Presents New Data from EXPAREL Phase 3 Study at Orthopaedic Research Society's 57th Annual Meeting 3UT Southwestern to Accelerate its Early Leadership in Using Electronic Health Records to Improve Patient Care 2
... information that every intern needs from ... the neurologic history and physical examination, ... and diagnostic tools, and clinical information ... ataxia, acute vision loss, headache, movement ...
The Nervous System Flash Cards product uses the time tested content and images from BryanEdwards.com and displays the necessary images to demonstrate the nervous system....
... Reviews enable all those involved with healthcare ... the very latest evidence in their field ... harder each year as the volume of ... by delivering the best single source available ...
This handy quick reference is a pragmatic guide to the pathophysiology, diagnosis, and management of cardiovascular disease....
Medicine Products: