Navigation Links
11 new genetic susceptibility factors for AD discovered through the largest study
Date:10/27/2013

of the nation's researchers working on the genetics of AD as well as many investigators and resources of the 29 NIA funded Alzheimer Disease Centers.

"This study clearly demonstrates that there really is strength in numbers to identify genes that individually have a small effect on risk of Alzheimer's," said Farrer. "But it's not the magnitude of the odds ratio that's really important. Each gene we implicate in the disease process adds new knowledge to our understanding of disease mechanism and provides insight into developing new therapeutic approaches, and ultimately these approaches may be more effective in halting the disease since genes are expressed long before clinical symptoms appear and brain damage occurs," he added.

"This landmark international effort has uncovered new pathways and new genes in old pathways that are definitely associated with Alzheimer dementia, but we need to do much work to better understand how exactly these genes work in health and disease, and to perhaps make drugs from these genes and molecules," said Seshadri. "We will continue to mine these results for new insights, even as we include more patients and use new technologies like whole genome sequencing to find more new pathways and genes," she added.

"Alzheimer's is a complex and devastating disorder, and if we are to reach our goal of finding effective therapies to treat it, then collaboration is key," said Neil Buckholtz, PhD, NIA Division of Neuroscience Director. "IGAP's sharing of DNA samples, data sets and scientific insights proves that team concept, and NIA is gratified to have provided the infrastructure and support needed to move the team forward."


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Head, Body Lice Are Genetically Very Similar
4. Certain Genetic Regions May Be Tied to Osteoporosis
5. Study of half siblings provides genetic clues to autism
6. Genetic variants, tobacco exposure and lung cancer risk
7. Research Gets Closer to Genetic Roots of Glaucoma
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
10. Some women may be genetically predisposed to smoking-related hot flashes
11. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... Spring, Maryland, USA (PRWEB) October 20, 2014 ... or to track interventions? Here comes a wonderful app ... mobile app development company helped its client ... Intervention more efficiently. The app is designed for iOS ... and iPod touch. This app is optimized for iPhone ...
(Date:10/19/2014)... The leading review website, Top10BestSEOHosting.com, has recently ... are the best Dedicated Server Hosting suppliers. Their ... to buy high quality hosting and save money ... of Top10BestSEOHosting.com says, “We believe that iPage and ... A lot of the global clients enjoy using ...
(Date:10/19/2014)... October 19, 2014 Dr. Babatunde Osotimehin, ... welcomes news of a ceasefire agreement that is expected ... 200 girls who were kidnapped from the north-eastern Nigerian ... in captivity long enough, and it is high time ... stated Dr. Osotimehin. , "We owe it to these ...
(Date:10/19/2014)... 20, 2014 Having been working in the ... knowledge of customer needs. According to James, one of the ... dazzling sequins, or with high-low skirts that add beauty to ... demand. Recently, LunaDress has unveiled its new selection of 2014 ... the company’s brand new items are available in over 20 ...
(Date:10/19/2014)... Recently, Fancyflyingfox.com, an innovative company that provides many kinds ... designs of 2014 mother of the bride dresses ... offered with big discounts, up to 70% off. All ... enjoy this special offer. , Owing to the ... one of the leading brands in the global market. ...
Breaking Medicine News(10 mins):Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 2Health News:Metassessor App Launched: an RTI tool for Teachers & Parents 3Health News:Top10BestSEOHosting.com Considers iPage And GreenGeeks As The Best Dedicated Server Hosting Suppliers 2Health News:2014 Long Prom Dresses From LunaDress Now Available In Over 20 Popular Designs 2Health News:Fancyflyingfox.com Updates Its Website With New Mother Of The Bride Dresses For 2014 2
... By Alan Mozes HealthDay Reporter , WEDNESDAY, ... suicide risk appears to be significantly higher among people ... The latest observation seems to confirm the findings of ... fully explained relationship between higher than average suicide rates ...
... hemorrhagic fever in humans, has no known cure or vaccine. ... scientists has uncovered a family of small molecules which appear ... inhibit its entry into human cells. The results are ... and are now online. Previous studies have shown ...
... Inserm research team in Toulouse, led by Dr Stein ... working with the "Modelling tissue and nociceptive stress" Host ... illusions described by many patients under regional anaesthetic. In ... Anesthesiology , the researchers demonstrated that anaesthetising an arm ...
... News) -- Many U.S. transplant surgeons unnecessarily shun organs ... safeguards that would protect and inform transplant recipients, a ... in the nation "overreacted" to a 2007 case in ... organs from a single donor unknowingly infected with HIV, ...
... January 20, 2011) Cancer scientists led by ... and collaborators at St Jude Children,s Research Hospital (Memphis) ... cells that carry them are organized in a more ... published today in Nature (DOI:10.1038/nature09733), challenge the ...
... By Charnicia Huggins HealthDay Reporter , ... tongue piercing as a form of self-expression, know that ... metal or plastic makes a difference when it comes ... collect more bacteria than plastic studs, potentially increasing the ...
Cached Medicine News:Health News:High Altitude Linked to Higher Suicide Risk -- Again 2Health News:High Altitude Linked to Higher Suicide Risk -- Again 3Health News:High Altitude Linked to Higher Suicide Risk -- Again 4Health News:Small molecules may prevent ebola infection 2Health News:How does anesthesia disturb self-perception? 2Health News:Cancer scientists discover genetic diversity in leukemic propagating cells 2Health News:Cancer scientists discover genetic diversity in leukemic propagating cells 3Health News:Metal Tongue Piercings Linked to Raised Infection Risks 2Health News:Metal Tongue Piercings Linked to Raised Infection Risks 3
(Date:10/17/2014)... N.C. , Oct. 17, 2014  Training ... is a critical success factor in today,s highly ... develop market research organizations that effectively and efficiently ... specialty or service area. Effective ... value and earn recognition from internal clients by ...
(Date:10/17/2014)... -- Research and Markets  has announced the ... of China Dialysis Market, 2014-2018" report to ... 2013 version, this update Report provides detailed analysis ... the relevant effect in recent three years, and ... it analyzes Chinese private-owned hemodialysis services. In the ...
(Date:10/17/2014)... BALTIMORE, Md. , Oct. 17, 2014 /PRNewswire-USNewswire/ ... Center for Medical Technology Policy: The ... from the FDA, public and private payers, medical ... representatives, clinicians, and other experts January 12, 2015 ... effectiveness and value of weight loss treatments.  Participants ...
Breaking Medicine Technology:Effective Training Programs for Market Research Groups can Boost Overall Organizational Success 2Research and Development Prospect of China Dialysis Market, 2014-2018 2Research and Development Prospect of China Dialysis Market, 2014-2018 3Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2
... 24, 2012 BioNeutral Group, Inc. (OTCBB: BONU), ... jointly announced today a collaborative research and revenue ... trial Ygiene 206, a detergent cleaner, 90-second disinfectant ... new formulations designed for rapid cleaning and sterilization ...
... HILLS, Calif., Jan. 24, 2012  LoneStar Heart Inc., based ... Coats, M.D., and Mark Maciejewski to the company,s board ... chairman of the board for LoneStar Heart; Frank Ahmann, ... Cohen, chief executive officer of Vessix Vascular, Inc.; and ...
Cached Medicine Technology:BioNeutral and Barnabas Health to Collaborate for Surgical Instrument Sterilization 2BioNeutral and Barnabas Health to Collaborate for Surgical Instrument Sterilization 3LoneStar Heart Inc. Names Andrew J. Coats, M.D., and Mark Maciejewski to Its Board of Directors 2LoneStar Heart Inc. Names Andrew J. Coats, M.D., and Mark Maciejewski to Its Board of Directors 3
... VISION is Guidant's first cobalt chromium stent ... MINI VISION to have remarkably thin struts ... creating a highly deliverable stent. Less metal, ... outcomes in small vessel treatment. The Guidant ...
... an ophthalmologic medical device designed for the ... to -3.00 diopters.* When placed in the ... optical zone, the product reshapes the anterior ... composed of two prescription inserts, each having ...
... Aerotels Heartline™ system is winning the hearts ... world. "Remaining calm are the operative words ... At the same time they and their ... to any change in their heart condition ...
... Weights offer the physician a new approach to ... paralysis. The weight simply uses gravity to gently ... down, or when the eyelid muscle is relaxed. ... a variety of skin tone colors to match ...
Medicine Products: