Navigation Links
11 new genetic susceptibility factors for AD discovered through the largest study
Date:10/27/2013

(Boston)-- The largest international study ever conducted on Alzheimer's disease (AD), the I-GAP (International Genomics Alzheimer's Project) consortium has identified 11 new regions of the genome involved in the onset of this neurodegenerative disease. This study gives an overview of the molecular mechanisms underlying the disease, opening up to a better understanding of the pathophysiology of AD. These results detailed currently in Nature Genetics, could not have been obtained without this unique worldwide collaborative effort.

Since 2009, 10 genes for Alzheimer's disease have been identified. However, much of the individual susceptibility to develop the disease remains unexplained. So in February 2011, the leaders of the four largest international research consortia on the genetics of AD joined forces to accelerate the discovery of new genes. Supported in part by the National Institute on Aging (NIA) and other components of the National Institutes of Health (NIH), in less than three years, the IGAP program identified more genes than had been identified over the previous 20 years. They collected genetic data on 74,076 patients and controls from 15 countries and were able to discover 11 new genes in addition to those already known, and identify 13 other genes, yet to be validated.

These 11 new confirmed genes may open new avenues to understanding the causes of AD. For example, one of the most significant associations was found in the region HLA-DRB5/DRB1 major histocompatibility complex. This finding is interesting in several ways. First, it strongly suggests the involvement of the immune system in AD. In addition, this same region has also been associated with two other neurodegenerative diseases, one known to have an immune mechanism, multiple sclerosis and another not previously thought to have a major immune component, Parkinson's disease.

Some of the newly associated genes confirm biological pathways known to be involv
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Head, Body Lice Are Genetically Very Similar
4. Certain Genetic Regions May Be Tied to Osteoporosis
5. Study of half siblings provides genetic clues to autism
6. Genetic variants, tobacco exposure and lung cancer risk
7. Research Gets Closer to Genetic Roots of Glaucoma
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
10. Some women may be genetically predisposed to smoking-related hot flashes
11. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/1/2015)... ... 01, 2015 , ... Sir Fazle Hasan Abed, BRAC’s founder and chairperson, was ... has been recognised for his outstanding contribution to enhancing the world's production and distribution ... the World Food Prize Foundation, announced this year’s winner at a ceremony at the ...
(Date:7/1/2015)... , ... July 01, 2015 , ... ... devoted exclusively to funding innovative lymphoma research and serving the lymphoma community through ... announced that they will welcome four new members to their industry leading Scientific ...
(Date:7/1/2015)... ... July 01, 2015 , ... DIC Corporation today announced the ... natural blue food coloring. Construction of the plant, which is located on the ... began in May 2014. After commissioning, commercial production is expected to begin in ...
(Date:7/1/2015)... ... July 01, 2015 , ... OncLive® will ... of America (HCA), as it further expands its Strategic Alliance Partnership Program for ... this new partnership, OncLive’s editorial and marketing teams will collaborate with Sarah Cannon ...
(Date:7/1/2015)... ... ... The 28th annual Charity Horse Show hosted by the Mid-South Horse Show ... in Pugh Bourne Park, 343 Oakfield Road. The event will again benefit Youth Town. ... a silent auction and concessions. , Horses and riders from around the country will ...
Breaking Medicine News(10 mins):Health News:Sir Fazle Hasan Abed Receives World Food Prize 2Health News:Sir Fazle Hasan Abed Receives World Food Prize 3Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 2Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 3Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 4Health News:Lymphoma Research Foundation Welcomes New Scientific Advisory Board Members 5Health News:DIC Strengthens Its Position as the Global Leader for Natural Blue Food Coloring 2Health News:DIC Strengthens Its Position as the Global Leader for Natural Blue Food Coloring 3Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 2Health News:OncLive® Welcomes Sarah Cannon Cancer Network to Its Strategic Alliance Partnership Program 3
... , Recent CBO analysis understates key factors ... new actuarial analysis by Oliver Wyman, Inc. finds that average ... 54 percent higher than they are today five years after ... Care Act (PPACA), excluding the impact of medical inflation. ...
... ... HPV test, not by Pap test – HiFi DNA Tech sues FDA on December 11 ... ... Gynecologists has confirmed that the invasive cancer workup procedure, also known as colposcopic biopsy, ...
... , MUNICH, Germany, PARSIPPANY, N.J. ... one Enterprise Image Intelligence® company, and Visage Imaging® Inc., ... PME) announced today that they have entered into a ... for the clinical and preclinical imaging domain. , The ...
... , CHAPEL HILL, N.C., Dec. 3 To ... has created a named award for a long-serving employee, ... inaugural Pauline Muhuhu Leadership Award, with a small cash prize, ... week. , With the annual award, IntraHealth seeks to ...
... ... space, announced that international medical quality authority, Dr. David Jaimovich, has joined its Medical ... ... leading global healthcare company specializing in the emerging medical travel space, announced that international ...
... also find that children exposed to smoke are at risk ... Add colorectal cancer to the list of malignancies caused by ... two. , And other studies are providing more bad news ... in the December issue of Epidemiology, Biomarkers & Prevention ...
Cached Medicine News:Health News:New Actuarial Analysis Shows Senate Bill Would Significantly Raise Premiums 2Health News:New Actuarial Analysis Shows Senate Bill Would Significantly Raise Premiums 3Health News:New Actuarial Analysis Shows Senate Bill Would Significantly Raise Premiums 4Health News:Harmful Procedures on Young Women Caused by Outdated HPV test, not by Pap Test 2Health News:Visage Imaging and Definiens Announce Partnership 2Health News:Visage Imaging and Definiens Announce Partnership 3Health News:Inaugural 'Health Worker Leadership Award' Honors Kenyan Midwife, IntraHealth Senior Leader 2Health News:Former Chief Medical Officer of Joint Commission International Joins Satori World Medical's Medical Quality Advisory Board 2Health News:Former Chief Medical Officer of Joint Commission International Joins Satori World Medical's Medical Quality Advisory Board 3Health News:Former Chief Medical Officer of Joint Commission International Joins Satori World Medical's Medical Quality Advisory Board 4Health News:Smoking Exposure Now Linked to Colon, Breast Cancers 2Health News:Smoking Exposure Now Linked to Colon, Breast Cancers 3Health News:Smoking Exposure Now Linked to Colon, Breast Cancers 4
(Date:7/1/2015)... Lupin , Strides ... MPP Sub-licensees to Fourteen Companies     ... expansion of its network of generic manufacturers to 14 companies ... antiretrovirals (ARVs). New companies Lupin and Strides Arcolab recently signed ... the MPP licensed from ViiV Healthcare two months after its ...
(Date:7/1/2015)... July 1, 2015  Celsion Corporation (NASDAQ: CLSN ... Michael H. Tardugno , Chairman, President and CEO, ... Healthcare Conference on Wednesday, July 8, 2015, at 4:15 ... Parker Meridien Hotel located at 119 W. 56th Street, ... A copy of the presentation will be available ...
(Date:7/1/2015)... July 1, 2015 Egalet Corporation (Nasdaq: ... pharmaceutical company focused on developing, manufacturing and marketing ... Radie , president and chief executive officer, is ... He will provide an update on Egalet,s marketed ... Nasal Spray, approved product OXAYDO ™ (oxycodone ...
Breaking Medicine Technology:The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 2The Medicines Patent Pool Increases its Generic Manufacturing Network to Ramp-Up Production of Low Cost Antiretrovirals (ARVs) 3Celsion Corporation to Present at Cantor Fitzgerald's Inaugural Healthcare Conference on July 8, 2015 2Egalet to Present at Upcoming Conferences This Summer 2Egalet to Present at Upcoming Conferences This Summer 3
... First Totally Noninvasive Cardiovascular Monitor... -- AMSTERDAM, November 18, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we need to grab ...
... 2010 Royal Philips Electronics (NYSE: PHG, AEX: ... of neonatal medical equipment, announced today that they ... a more complete portfolio of perinatal care solutions. ... home monitoring, neonatal incubators and warmers, jaundice management, ...
Cached Medicine Technology:BMEYE Receives FDA Clearance to Launch ccNexfin, the First Totally Noninvasive Cardiovascular Monitor With BP, CO, and Masimo Rainbow SET(R) Technology in the United States 2BMEYE Receives FDA Clearance to Launch ccNexfin, the First Totally Noninvasive Cardiovascular Monitor With BP, CO, and Masimo Rainbow SET(R) Technology in the United States 3BMEYE Receives FDA Clearance to Launch ccNexfin, the First Totally Noninvasive Cardiovascular Monitor With BP, CO, and Masimo Rainbow SET(R) Technology in the United States 4BMEYE Receives FDA Clearance to Launch ccNexfin, the First Totally Noninvasive Cardiovascular Monitor With BP, CO, and Masimo Rainbow SET(R) Technology in the United States 5BMEYE Receives FDA Clearance to Launch ccNexfin, the First Totally Noninvasive Cardiovascular Monitor With BP, CO, and Masimo Rainbow SET(R) Technology in the United States 6BMEYE Receives FDA Clearance to Launch ccNexfin, the First Totally Noninvasive Cardiovascular Monitor With BP, CO, and Masimo Rainbow SET(R) Technology in the United States 7BMEYE Receives FDA Clearance to Launch ccNexfin, the First Totally Noninvasive Cardiovascular Monitor With BP, CO, and Masimo Rainbow SET(R) Technology in the United States 8Philips and Atom Medical Corporation Announce Strategic Alliance to Provide a Complete Neonatal and Perinatal Offering 2Philips and Atom Medical Corporation Announce Strategic Alliance to Provide a Complete Neonatal and Perinatal Offering 3
... complete imaging access, with nearly 100 percent ... imaging C-Arms can pan from head to ... patient. Anesthesiologists will appreciate this table for ... construction, and ease of operation. The key ...
...
LiquichekCardiac Markers Plus Control LT is a premium, comprehensive cardiac assessment control with many analytes and long stability....
Liquichek Autoimmune Controls are individual controls for monitoring the performance of autoimmune assays....
Medicine Products: