Navigation Links
11 new genetic susceptibility factors for AD discovered through the largest study
Date:10/27/2013

(Boston)-- The largest international study ever conducted on Alzheimer's disease (AD), the I-GAP (International Genomics Alzheimer's Project) consortium has identified 11 new regions of the genome involved in the onset of this neurodegenerative disease. This study gives an overview of the molecular mechanisms underlying the disease, opening up to a better understanding of the pathophysiology of AD. These results detailed currently in Nature Genetics, could not have been obtained without this unique worldwide collaborative effort.

Since 2009, 10 genes for Alzheimer's disease have been identified. However, much of the individual susceptibility to develop the disease remains unexplained. So in February 2011, the leaders of the four largest international research consortia on the genetics of AD joined forces to accelerate the discovery of new genes. Supported in part by the National Institute on Aging (NIA) and other components of the National Institutes of Health (NIH), in less than three years, the IGAP program identified more genes than had been identified over the previous 20 years. They collected genetic data on 74,076 patients and controls from 15 countries and were able to discover 11 new genes in addition to those already known, and identify 13 other genes, yet to be validated.

These 11 new confirmed genes may open new avenues to understanding the causes of AD. For example, one of the most significant associations was found in the region HLA-DRB5/DRB1 major histocompatibility complex. This finding is interesting in several ways. First, it strongly suggests the involvement of the immune system in AD. In addition, this same region has also been associated with two other neurodegenerative diseases, one known to have an immune mechanism, multiple sclerosis and another not previously thought to have a major immune component, Parkinson's disease.

Some of the newly associated genes confirm biological pathways known to be involv
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Head, Body Lice Are Genetically Very Similar
4. Certain Genetic Regions May Be Tied to Osteoporosis
5. Study of half siblings provides genetic clues to autism
6. Genetic variants, tobacco exposure and lung cancer risk
7. Research Gets Closer to Genetic Roots of Glaucoma
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
10. Some women may be genetically predisposed to smoking-related hot flashes
11. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/23/2014)... 2014 The European Bio fertilizers Market ... Europe with analysis and forecast of revenue. The bio ... around $ 2,566.4 million in 2012 to $4,582.2 million ... to 2017. , Browse through the TOC of the ... of the in-depth analysis provided. , http://www.micromarketmonitor.com/market/europe-bio-fertilizer-4637178345.html ...
(Date:7/23/2014)... "I wanted a better way to keep ... blood sugar, blood pressure and pulse rate," said an inventor ... to carry along a bunch of different devices, so I ... the Master III to make it easier to monitor health ... unit. The accessory enables the user to have more control ...
(Date:7/23/2014)... class of drugs commonly used to lower cholesterol levels, ... according to a new study in Gastroenterology ... American Gastroenterological Association. Obese patients experienced the greatest level ... received statins had a 43 percent reduction in the ... study author Hashem B. El-Serag, MD, MPH, from the ...
(Date:7/23/2014)... suffered repeated blows to the head during their careers ... suggest the athletes had a disease called chronic traumatic ... might be able to detect CTE in its earliest ... Engineering News (C&EN) , the weekly news magazine of ... Wolf, a senior editor at C&EN, explains that many ...
(Date:7/23/2014)... 23, 2014 According to a new ... Form Factor (Integrated Circuit IP, SOC IP), Design Architecture ... Geography and Verification IP - Forecast & Analysis to ... expected to grow at a CAGR of 12.6% from ... , Browse more than 76 market data tables with ...
Breaking Medicine News(10 mins):Health News:Europe Bio Fertilizer Market is Expected to Reach $4,582.2 Million in 2017 - New Report by MicroMarket Monitor 2Health News:Europe Bio Fertilizer Market is Expected to Reach $4,582.2 Million in 2017 - New Report by MicroMarket Monitor 3Health News:Europe Bio Fertilizer Market is Expected to Reach $4,582.2 Million in 2017 - New Report by MicroMarket Monitor 4Health News:Statin use decreases the risk of Barrett's esophagus 2Health News:Semiconductor IP Market Estimated to Reach $5.63 Billion by 2020 – New Report by MarketsandMarkets 2Health News:Semiconductor IP Market Estimated to Reach $5.63 Billion by 2020 – New Report by MarketsandMarkets 3Health News:Semiconductor IP Market Estimated to Reach $5.63 Billion by 2020 – New Report by MarketsandMarkets 4Health News:Semiconductor IP Market Estimated to Reach $5.63 Billion by 2020 – New Report by MarketsandMarkets 5Health News:Semiconductor IP Market Estimated to Reach $5.63 Billion by 2020 – New Report by MarketsandMarkets 6
... , THURSDAY, Sept. 23 (HealthDay News) -- Distracted driving fatalities ... space of three years, according to new U.S. government research ... in car accidents from 2001 to 2007, the researchers estimated. ... rose 28 percent in just three years, from 4,572 in ...
... Bloomberg Faculty of Nursing professor, Dr. Diane Doran, was ... help protect the safety of over 900,000 Canadians who ... The Canadian Patient Safety Institute and its partners ... competition drawing some of Canada,s leading healthcare researchers. The ...
... Gordon HealthDay Reporter , THURSDAY, Sept. 23 (HealthDay ... was living his boyhood dream. He,d just been plucked ... on the courts of the National Basketball Association,s Dallas Mavericks, ... a local tournament. But a small on-court collision with ...
... A concerted effort to boost research on women,s health over ... and reduced deaths among women due to cardiovascular disease, breast ... Institute of Medicine. The effort has yielded less but ... and osteoporosis on women, added the committee that wrote the ...
... the University of California, San Diego School of Medicine ... UCSD Cancer Center, has been named the 2010 recipient ... the Metastasis Research Society, an international, non-profit organization that ... at a recent joint meeting of the MRS and ...
... Estonia (September 23, 2010) At an international gathering of ... Vaccine Foundation announced it will initiate a clinical trial of ... researchers at Saint Louis University in St. Louis, Missouri, USA. ... on TB Vaccine Development. Building on more than ...
Cached Medicine News:Health News:Texting Taking a Deadly Toll on Roads 2Health News:Texting Taking a Deadly Toll on Roads 3Health News:$1 million awarded to Bloomberg Faculty of Nursing-led research team 2Health News:Experimental Leukemia Drug Proves a Slam Dunk 2Health News:Experimental Leukemia Drug Proves a Slam Dunk 3Health News:Experimental Leukemia Drug Proves a Slam Dunk 4Health News:Increased attention to women's health research has yielded gains on some important conditions, but progress lags on others 2Health News:Increased attention to women's health research has yielded gains on some important conditions, but progress lags on others 3Health News:David Cheresh receives top award for cancer metastasis research 2Health News:New TB vaccine enters clinical testing 2
(Date:7/23/2014)... YORK , July 23, 2014 ... Beach, Fla. , is an emerging player ... diagnostic systems for bio-threat detection and rapid medical ... called M-BAND (Microfluidic Bio-agent Autonomous Networked Detector), was ... Homeland Security ("DHS") Science & Technology directorate, and ...
(Date:7/23/2014)... July 23, 2014  Researchers from the North American ... elevates calcium levels too high, 1 putting ... problems. Women close to menopause are commonly ... to prevent diseases such as osteoporosis, to which they ... women determine how much calcium they typically get through ...
(Date:7/23/2014)... This September leading clinicians in orthodontics and ... for DOCtalk 2014 —a "Dynamic Orthodontic ... and private practitioner Dr. David Sarver , DOCtalk ... clinical and practice management efficiency and high quality patient ... to welcome fresh thinking and join a community of ...
Breaking Medicine Technology:PositiveID Analyst Inspection: Emerging Contender in BioThreat Detection - First Ever Revenue Guidance and Backlog Position Company for Increased Visibility and Traction - by SmallCapTraders.com 2Women Taking Too Much Calcium Create Health Risk 22014 DOCtalk Registration Now Open 22014 DOCtalk Registration Now Open 3
The BARDEX I.C. Catheter represents Bard's newest technology in providing protection against NUTI....
Used for injection into urethral strictures, bladder neck contracture, and the bladder wall. Supplied sterile in peel-open packages. Intended for one-time use....
... a minimally invasive tension-free sling specifically ... resulting from urethral hypermobility (Type II) ... TF Kit is designed to accommodate ... Supplied sterile in peel-open packages. ...
... Used to dilate the ... medium to assess possible submucosal ... a topical anesthetic in the ... passage by, or dislodgment of ...
Medicine Products: