Navigation Links
11 new genetic susceptibility factors for AD discovered through the largest study
Date:10/27/2013

(Boston)-- The largest international study ever conducted on Alzheimer's disease (AD), the I-GAP (International Genomics Alzheimer's Project) consortium has identified 11 new regions of the genome involved in the onset of this neurodegenerative disease. This study gives an overview of the molecular mechanisms underlying the disease, opening up to a better understanding of the pathophysiology of AD. These results detailed currently in Nature Genetics, could not have been obtained without this unique worldwide collaborative effort.

Since 2009, 10 genes for Alzheimer's disease have been identified. However, much of the individual susceptibility to develop the disease remains unexplained. So in February 2011, the leaders of the four largest international research consortia on the genetics of AD joined forces to accelerate the discovery of new genes. Supported in part by the National Institute on Aging (NIA) and other components of the National Institutes of Health (NIH), in less than three years, the IGAP program identified more genes than had been identified over the previous 20 years. They collected genetic data on 74,076 patients and controls from 15 countries and were able to discover 11 new genes in addition to those already known, and identify 13 other genes, yet to be validated.

These 11 new confirmed genes may open new avenues to understanding the causes of AD. For example, one of the most significant associations was found in the region HLA-DRB5/DRB1 major histocompatibility complex. This finding is interesting in several ways. First, it strongly suggests the involvement of the immune system in AD. In addition, this same region has also been associated with two other neurodegenerative diseases, one known to have an immune mechanism, multiple sclerosis and another not previously thought to have a major immune component, Parkinson's disease.

Some of the newly associated genes confirm biological pathways known to be involv
'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. IntegraGen launches ARISk test, a genetic screening tool for autism in high-risk children
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Head, Body Lice Are Genetically Very Similar
4. Certain Genetic Regions May Be Tied to Osteoporosis
5. Study of half siblings provides genetic clues to autism
6. Genetic variants, tobacco exposure and lung cancer risk
7. Research Gets Closer to Genetic Roots of Glaucoma
8. Moffitt researcher awarded GE grant to develop tool to detect breast cancer metastasis genetic risks
9. Genetically modified T cell therapy shown to be safe, lasting in decade-long study of HIV patients
10. Some women may be genetically predisposed to smoking-related hot flashes
11. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... January 22, 2015 The City of West Hollywood ... a.m., to commemorate the 42nd anniversary of the Supreme Court decision ... “It’s been 42 years since the Roe vs. Wade decision and ... as present as ever,” said City of West Hollywood Councilmember Abbe ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 The Incredible Bulk ... Ben Pakulski to increase lean muscle by up to 30lbs ... caught the attention of HealthyandFitZone.com’s Stan Stevenson, prompting an investigative ... it is a step-by-step, scientific diet formula that allows the ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 Juvent Sports ... at the 2015 PGA Merchandise Show to bestow a ... incredible female amateur golfer, Arlene McKitrick. The award commemorated ... amateur golf tournament win. She won her first amateur ...
(Date:1/22/2015)... Carinsurancesavings.biz has released a new blog post presenting the ... , Purchasing an accidental death and dismemberment rider for ... of rider provides benefits if the insured dies in an ... form of life insurance. , AD&D is not expensive ...
(Date:1/22/2015)... (PRWEB) January 22, 2015 IsoComforter, Inc. has ... machine with patented IsoTube design to treat specific body parts ... the most progressive and easy to use patented cold therapy ... and sports related orthopedic and muscle injuries. IsoComforter has ...
Breaking Medicine News(10 mins):Health News:The Incredible Bulk: Review Examining Ben Pakulski’s Brand New Bulking Muscle Building Diet Program Released 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Accidental Death and Dismemberment Insurance Can Be Purchased at Low Prices Online 2Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2
... The Cystic Fibrosis Foundation announced today that VX-770, an ... in CF, showed promising results in an ongoing Phase ... mutation of CF. The drug is being developed by ... for 14 days showed significant improvements in several key ...
... improved access to health education and benefits for ... seniors in communities across America, ... in Washington, D.C., CVS/pharmacy and the National Council on Aging,(NCOA) ... health and well-being of older Americans. Their joint,"Prescription for Better ...
... Recognizes Visionary Advocate, LOS ANGELES, March 27 ... Gregg Gonsalves has been selected as the,first-ever recipient of ... An AIDS activist for 17 years, Gonsalves has played ... and improve access to,lifesaving drugs. He is currently based ...
... women die from breast cancer each year because current ... fail to stem the disease, warns Breast Cancer Campaign ... research published today, 56 of the UKs most influential ... and priorities for the greatest potential impact on patients. ...
... Poll: Teens Still Feel Targeted By Tobacco Advertising and ... Kids across Virginia,will rally against tobacco on April ... the 13th annual Kick Butts Day, sponsored by the,Campaign ... the,nation (for a list of local events, go to, ...
... VANCOUVER, March 27 /PRNewswire-FirstCall/ - CRH Medical Corporation,(CRM:TSX-V) announced ... in Denver, CO. This Center is the Company,s first ... CRH has targeted for expansion. The,opening of the Denver ... According to the National Institute of Health, the ...
Cached Medicine News:Health News:Cystic Fibrosis Foundation announces positive early results for phase 2 clinical trial of VX-770 2Health News:CVS/pharmacy and the National Council on Aging Extend 'Prescription for Better Health' Partnership 2Health News:CVS/pharmacy and the National Council on Aging Extend 'Prescription for Better Health' Partnership 3Health News:AIDS Activist Gregg Gonsalves Receives $100,000 Leadership Award 2Health News:AIDS Activist Gregg Gonsalves Receives $100,000 Leadership Award 3Health News:Too many women still dying from breast cancer, says charity 2Health News:Virginia Kids 'Kick Butts' on April 2 2Health News:Virginia Kids 'Kick Butts' on April 2 3Health News:CRH Medical Corporation opens new center in Denver, Colorado 2
(Date:1/23/2015)... JUNCTION, N.J. , Jan. 23, 2015  CytoSorbents ... company commercializing its CytoSorb® extracorporeal cytokine adsorber to ... patients, announced the receipt of $385,642, net of ... participant of the Technology Business Tax Certificate Transfer ...
(Date:1/23/2015)... , Jan. 23, 2015 Gem Pharmaceuticals announced ... have been enrolled into the Company,s Phase 2 clinical ... safety of Gem,s lead compound, GPX-150 (an investigational medication), ... or metastatic disease. Logo - http://photos.prnewswire.com/prnh/20150123/170966LOGO ...
(Date:1/23/2015)... 2015 Tianyin Pharmaceutical Inc. (NYSE Amex: ... development and sale of patented biopharmaceutical medicine, modernized traditional ... (API) today announced the business and development progress at ... 1. Following the September 2014 JCM application (No. 51268) ...
Breaking Medicine Technology:CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 2CytoSorbents Receives $385,000 in Non-Dilutive Funding from the New Jersey Technology Business Tax Certificate Transfer Program 3Gem Pharmaceuticals Announces Enrollment of Initial Patients in its Phase 2 Clinical Trial to Assess the Efficacy and Safety of GPX-150 in Sarcoma Patients 2TPI's JCM Updates on Import Registration for International Clients 2TPI's JCM Updates on Import Registration for International Clients 3TPI's JCM Updates on Import Registration for International Clients 4
... 2011 Progressive Medical, Inc., a leading pharmacy benefit ... compensation and no-faulty auto industries, has named Kevin Banion ... current role as president of Progressive Medical. This strategic ... that David Bianconi recently announced that he will serve ...
... Jan. 19, 2011 QBC Diagnostics is pleased to ... breakthrough product that can easily upgrade any compound light ... Advance builds on the proven success of the ParaLens ... LED fluorescence microscopy to thousands of labs around the ...
Cached Medicine Technology:Kevin Banion Named CEO of Progressive Medical, Inc. 2QBC Diagnostics Announces the Availability of the ParaLens Advance LED Fluorescence Microscopy Attachment 2
... Featured Products are kept ... and are offered as ... regular or extra long ... with insulation, flush ports, ...
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
... The Featured Products ... at Mediflex and are ... modular in regular or ... come equipped with insulation, ...
... The 5mm AEM Laparoscopic Instruments incorporate a ... Instruments are shielded and monitored to prevent ... the instrument caused by insulation failure or ... The protective shield built into all AEM ...
Medicine Products: