The European Prospective Investigation into Cancer and Nutrition (EPIC) study is a Europe-wide prospective cohort study of the relationships between diet and cancer, as well as other chronic diseases, such as cardiovascular disease. With over half a million participants, it is the largest study of diet and disease to be undertaken.
EPIC is coordinated by the International Agency for Research on Cancer (IARC), part of the World Health Organization, and funded by the 'Europe Against Cancer' programme of the European Commission as well as multiple nation-specific grants and charities.
521,457 healthy adults, mostly aged 35-70 years, were enrolled in 23 centres in ten European countries: Denmark (11%), France (14%), Germany (10%), Greece (5%), Italy (9%), The Netherlands (8%), Norway (7%), Spain (8%), Sweden (10%) and the United Kingdom (17%). One UK centre (Oxford) recruited 27,000 vegetarians and vegans; this subgroup forms the largest study of this dietary group. Recruitment to the study took place between 1993 and 1999, and follow up is planned for at least ten years, with repeat interview/questionnaires every three to five years. The main prospective data collected are standardised dietary questionnaires (self administered or interview based), seven-day food diaries, blood samples and anthropometric measurements, such as body mass index and waist-to-hip ratio. Additionally, the GenAir case-control study is studying the relationship of passive smoking and air pollution with cancers and respiratory diseases.
Up to 2004, there were over 26,000 new cases of cancer recorded among participants, with the most common being cancers of the breast, colorectum, prostate and lung. Current analyses are focusing particularly on stomach, colorectal, breast, prostate and lung cancers. The different dietary patterns in the different countries should enable reliable associations to be made between particular diets and cancers. The analysis of stored blood samples should also allow dissection of genetic factors involved in cancers, as well as the effects of hormones and hormone-like factors.
- Consumption of fibre, fish, milk and cheese reduce risk of colorectal cancer, while red and processed meat increase risk
- Consumption of fruit and vegetables does not affect risk of breast or prostate cancer
- Bingham SA, Day NE, Luben R, et al. Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational study. Lancet (2003) 361: 1496-1501 PubMed
- Gonzalez CA, Jakszyn P, Pera G, et al. Meat intake and risk of stomach and esophageal adenocarcinoma within the European Prospective Investigation Into Cancer and Nutrition (EPIC). J. Natl Cancer Inst. (2006) 98: 345-354
- Khaw KT, Bingham S, Welch A, et al. Relation between plasma ascorbic acid and mortality in men and women in EPIC-Norfolk prospective study: a prospective population study. European Prospective Investigation into Cancer and Nutrition. Lancet (2001) 357: 657-663 PubMed
- Miller AB, Altenburg HP, Bueno-de-Mesquita B, et al. Fruits and vegetables and lung cancer: Findings from the European Prospective Investigation into Cancer and Nutrition. Int. J. Cancer (2004) 108: 269-276 PubMed
- Norat T, Bingham S, Ferrari P, et al. Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutrition. J. Natl Cancer Inst. (2005) 97: 906-916
(Date:4/22/2014)... of all lung cancers are small cell lung ... resistance to chemotherapy. However, researchers at Virginia Commonwealth ... into the mechanisms leading to this resistance that ... work primarily by mediating B-cell lymphoma 2 (Bcl-2) ... death. Depending on their function, this family of ...
(Date:4/22/2014)... The International Communication Association will hold its ... The theme of the 2014 conference will explore ... and digital society. , Featuring over 2,300 academic ... Communication scholars representing over 40 countries, the ICA ... in the world. This year,s conference features sessions ...
(Date:4/22/2014)... release is available in German . ... important intracellular signaling molecules, but their mode of action ... of cellular function and behavior, while at high concentrations ... and DNA. To analyze how redox signaling unfolds in ... microscopy technique has been developed jointly by the teams ...
(Date:4/22/2014)... (SALT LAKE CITY)A computational tool developed at the University ... with unknown gene mutations in three separate cases, U ... new study in The American Journal of Human ... Re-ranking tool), identifies undiagnosed illnesses and unknown gene mutations ... proteins that code for genes are made, in individual ...
(Date:4/22/2014)... demonstrated the first size-based form of chromatography that ... living cells. This unique physical approach to probing ... whether a cell lives or dies, remains normal ... conventional microscopy. , "We,ve developed membrane-embedded nanodot array ... probe and manipulate membrane assemblies, including signaling clusters, ... Breaking Medicine News(10 mins):Health News:Scientists pinpoint protein that could improve small cell lung cancer therapies 2Health News:International Communication Association to hold Annual Conference in Seattle, Washington 2Health News:Neuroimaging: Live from inside the cell 2Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 2Health News:Applying math to biology: Software identifies disease-causing mutations in undiagnosed illnesses 3Health News:First size-based chromatography technique for the study of livi 2Health News:First size-based chromatography technique for the study of livi 3
Other medicine definitionOther Tags
... benefit from a shunt used for less common brain ... -- Some people with Alzheimer,s disease may be helped ... less common neurological condition, new research suggests. , The ... cerebrospinal fluid builds up in the ventricles, or cavities, ...
... Jefferson University have found that colonoscopy preparation drugs administered ... to those given the night before and the morning ... side effects such as abdominal pain, sleep loss and ... compared results between 116 colonoscopy patients given a split ...
... ... near some of the best hospitals and clinics in the world. , ... Monsey, NY (PRWEB) May 4, 2010 -- The new All Time ... , ,"We were physically bound by how many people we were able to hire. We literally ...
... An enchanted estate ... laidback escape, in total peace. , , ... May 1, 2010 -- What is Euterpini? , , ,Eight typical local villas, the so-called dammusi, that ... the western side of the island of Pantelleria , and named after local plants and flowers ...
... ... contract partners can now ensure on-time production, gain visibility to production milestones and ... With this cloud-based solution, team members can collaborate on production orders and track ... ...
... ... marketing and product/service innovations. , ... Michigan (PRWEB) May 3, 2010 -- David Hofer has joined Michigan-based ... will also head the recruitment of team members and development of the International Bancard ...Cached Medicine News:Health News:Surgery for Treatable Dementia Might Also Help in Alzheimer's 2Health News:Surgery for Treatable Dementia Might Also Help in Alzheimer's 3Health News:Study finds cutting colonoscopy preparation from 2 days to 1 day just as effective 2Health News:All Time Medical Has Just Moved To Their New, State-Of-The Art Office Situated In The Heart Of The Business District Of Monsey, N.Y 2Health News:Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution 2Health News:Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution 3Health News:Life Science Contract Manufacturing Gains Predictable On-Time Production with TraceLink's Production Tracking Solution 4Health News:David Hofer Named President of International Bancard Corporation 2