Navigation Links
Central tolerance


Central tolerance is the mechanism by which newly developing T cells and B cells are rendered non-reactive to self.[1] The process is required due to the random generation of receptor specificities that occurs during T cell and B cell differentiation, whereby a proportion of the cells generated are self-reactive (recognise the component self antigens of the host).

In mammals the process occurs in the thymus (T cells)[2][3] and bone marrow (B cells), when maturing lymphocytes are exposed to self antigens. Self antigens are present in both organs due to endogenous expression within the organ and importation of antigen due to circulation from peripheral sites. In the case of T cell central tolerance, additional sources of antigen are made available in the thymus by the action of the transcription factor AIRE.

After exposure to self antigens, T cells and B cells become immunologically tolerant (non-reactive) in a number of ways :

Genetic defects in these processes lead to autoimmunity, such as in the human syndromes APS-1 and IPEX.

References

  1. ^ http://www-immuno.path.cam.ac.uk/~immuno/part1/lec11/lec11_97.html
  2. ^ Sprent J, Kishimoto H (2001). "The thymus and central tolerance". Philos Trans R Soc Lond B Biol Sci 356 (1409): 609-16. PMID 11375064.
  3. ^ Hogquist K, Baldwin T, Jameson S (2005). "Central tolerance: learning self-control in the thymus". Nat Rev Immunol 5 (10): 772-82. PMID 16200080.
  4. ^ Halverson R, Torres R, Pelanda R (2004). "Receptor editing is the main mechanism of B cell tolerance toward membrane antigens". Nat Immunol 5 (6): 645-50. PMID 15156139.

'"/>


(Date:5/28/2015)... Optimity Advisors ( Optimity ) ... of care for healthcare organizations worldwide – today ... help operationalize contracting and engagement models. As part ... series of seven “ OrangePapers” that provide ... is a strategy, operations and information technology advisory ...
(Date:5/28/2015)... what your racquet can do for you but what kind ... the launch of their new digital campaign, HEAD introduces trick ... unique skill to HEAD Pro Players and consumers around the ... demonstrates how to gain more control over the racquet and ... tennis enthusiasts everywhere to join the show. , The digital ...
(Date:5/28/2015)... 2015 Although many people have resigned ... their slow metabolism for life, never being able to ... true. There are methods to jump start the metabolism. ... low-carbohydrate, low-fat and no-fat foods, cleverly worded to lure ... times the foods contain hidden ingredients and hidden ...
(Date:5/28/2015)... Aureus Medical Group (web: aureuslocumtenens.com), a national leader ... that it will participate as an exhibitor at the ... be held June 9-14, 2015 in New Orleans, Louisiana. ... and exhibits with products and services. , Representatives ... be available to speak with attendees about its full ...
(Date:5/28/2015)... 28, 2015 JJ Mowder-Tinney, PT, PhD, NCS, ... New York Physical Therapy Association (NYPTA) by the Delegation at ... member of the NYPTA. At the National level, she ... Section Research Committee and an abstract reviewer for the Neurology ... been a member of the Program committee since 2010 and ...
Breaking Medicine News(10 mins):Health News:Optimity Advisors Now Offers Outcomes Based Contracting Services to Support Engagement Model For New Healthcare Innovative Models of Care 2Health News:Tennis Artist Baffles Novak Djokovic - HEAD Launches Trick Shot Campaign “Frame & Play” 2Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 2Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 3Health News:As Part of their Comprehensive Weight Loss Program, Diet Doc Now Teaches Patients how to Identify Hidden Carbohydrates for Safe, Fast and Long Term Weight Loss Success 4Health News:Healthcare Staffing Leader, Aureus Medical Group, to Exhibit at the American Association of Nurse Practitioners’ 2015 National Conference 2
... 2 Responding to increased attention about clinical productivity ... Centric, Inc. ( www.usercentric.com ) - a ... a new service for the healthcare industry called ... providers. Among the technologies targeted for these service ...
... of a naturally fluorescent molecule found in all living ... according to bioengineers. , NADH, or nicotinamide adenine dinucleotide, ... for the functioning of an enzyme -- found mostly ... or mitochondria. It fuels a series of biochemical reactions ...
... Acquisition of BiotelCONSHOHOCKEN, Pa., April 2 CardioNet, Inc. ... technology company with an initial focus on the diagnosis ... into the cardiac clinical research services business and the ... The two companies entered into a binding definitive merger ...
... WASHINGTON, April 2 The following is a statement from ... (TFAH) in response to the release of the new report ... by the Robert Wood Johnson Foundation Commission to Build a ... healthy as he or she can be. And every ...
... of the Country,s Largest e-Prescribing Initiatives Drives Industry-leading Prescriber ... you recently went to your doctor and received a ... the rule. That,s right, in New Jersey more and ... pad in favor of e-prescribing technology that is improving ...
... PHILADELPHIA, April 2 John K. Davis, II has ... at the American Board of Internal Medicine (ABIM), effective ... will work closely with senior management and the Board ... operational oversight for the development and implementation of information ...
Cached Medicine News:Health News:User Centric Offers New Service, Usability Diagnostics, to Measure HIT Usability 2Health News:User Centric Offers New Service, Usability Diagnostics, to Measure HIT Usability 3Health News:Naturally fluorescent molecules may serve as cancer biomarker 2Health News:Naturally fluorescent molecules may serve as cancer biomarker 3Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 2Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 3Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 4Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 5Health News:CardioNet Expands Product Offering and Launches Clinical Research Services 6Health News:Trust for America's Health Supports Recommendations from Robert Wood Johnson Foundation Commission to Build a Healthier America 2Health News:Trust for America's Health Supports Recommendations from Robert Wood Johnson Foundation Commission to Build a Healthier America 3Health News:Horizon Blue Cross Blue Shield of New Jersey and CVS Caremark Reach 5.5 Million e-Prescriptions 2Health News:Horizon Blue Cross Blue Shield of New Jersey and CVS Caremark Reach 5.5 Million e-Prescriptions 3Health News:Horizon Blue Cross Blue Shield of New Jersey and CVS Caremark Reach 5.5 Million e-Prescriptions 4Health News:John K. Davis, II to Join the American Board of Internal Medicine as Chief Information Officer 2
Other medicine definitionOther Tags