Navigation Links
Cachexia


Name of Symptom/Sign:
Cachexia
Classifications and external resources
ICD-10 R64
ICD-9 799.4

Cachexia (pronounced [kəˈkɛksiə]) is loss of weight, muscle atrophy, fatigue, weakness and significant loss of appetite in someone who is not actively trying to lose weight. It can be a sign of various underlying disorders; when a patient presents with cachexia, a doctor will generally consider the possibility of cancer, certain infectious diseases (e.g. tuberculosis, AIDS) and some autoimmune disorders. Cachexia physically weakens patients to a state of immobility stemming from loss of appetite, asthenia, and anemia, and response to standard treatment is usually poor.

Contents

Disease settings

Cachexia is often seen in end-stage cancer, and in that context is called "cancer cachexia". It was also prevalent in AIDS patients before the advent of triple-therapy for that condition; now it is seen less frequently in those countries where such treatment is available. In those patients who have Congestive Heart Failure, there is also a cachectic syndrome. Also, a cachexia co-morbidity is seen in patients that have any of the range of illnesses classified as "COPD" (Chronic obstructive pulmonary disease), particularly emphysema.

In each of these settings there is full-body wasting, which hits the skeletal muscle especially hard, resulting in muscle atrophy.

Mechanism

The exact mechanism in which these diseases cause cachexia is poorly understood, but there is probably a role for inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) -which is also nicknamed cachexin for this reason-, Interferon gamma (IFNɣ), and Interleukin 6 (IL-6), as well as the tumor secreted proteolysis inducing factor (PIF).

Related malnutrition syndromes are kwashiorkor and marasmus, although these do not always have an underlying causative illness; they are most often symptomatic of severe malnutrition.

Those suffering from the eating disorder anorexia nervosa appear to have high plasma levels of ghrelin. Ghrelin levels are also high in patients who have cancer-induced cachexia (Garcia et al 2005).

See also

External links


'"/>


(Date:2/19/2019)... ... February 19, 2019 , ... ClearHealth Quality ... Foley & Lardner LLP, as Recognized Consultants. The CHQI Recognized Consultant Program trains ... pursuing CHQI accreditation. , Ms. Wein and Mr. Einhorn are part of ...
(Date:2/19/2019)... ... , ... According to a recent study by Columbia University, more than 40% ... and only 26% of widows return to their pre-loss level of life satisfaction, according ... of the most tragic events that one can face. Consequently, many look for a ...
(Date:2/19/2019)... ... February 19, 2019 , ... K.J. Kidd, a Missouri native born and raised ... Opportunity”: an autobiographical work offered to encourage other women to be proactive about their ... shares, “On September 28th of 2013, I spent my entire morning walking up and ...
(Date:2/19/2019)... GREENWOOD VILLAGE, Colo. (PRWEB) , ... February 19, 2019 , ... ... online Group Supervision Program for occupational therapists beginning March 2019. The focus ... to share and discuss challenging client cases. The new Group Supervision Programs will be ...
(Date:2/17/2019)... ... February 18, 2019 , ... ... Seal of Approval® for Health Care Staffing Services Certification. The certification demonstrates Highland ... , “Highland Medical Group is pleased to receive certification from The Joint Commission, ...
Breaking Medicine News(10 mins):
Other medicine definition