Navigation Links
Cachexia


Name of Symptom/Sign:
Cachexia
Classifications and external resources
ICD-10 R64
ICD-9 799.4

Cachexia (pronounced [kəˈkɛksiə]) is loss of weight, muscle atrophy, fatigue, weakness and significant loss of appetite in someone who is not actively trying to lose weight. It can be a sign of various underlying disorders; when a patient presents with cachexia, a doctor will generally consider the possibility of cancer, certain infectious diseases (e.g. tuberculosis, AIDS) and some autoimmune disorders. Cachexia physically weakens patients to a state of immobility stemming from loss of appetite, asthenia, and anemia, and response to standard treatment is usually poor.

Contents

Disease settings

Cachexia is often seen in end-stage cancer, and in that context is called "cancer cachexia". It was also prevalent in AIDS patients before the advent of triple-therapy for that condition; now it is seen less frequently in those countries where such treatment is available. In those patients who have Congestive Heart Failure, there is also a cachectic syndrome. Also, a cachexia co-morbidity is seen in patients that have any of the range of illnesses classified as "COPD" (Chronic obstructive pulmonary disease), particularly emphysema.

In each of these settings there is full-body wasting, which hits the skeletal muscle especially hard, resulting in muscle atrophy.

Mechanism

The exact mechanism in which these diseases cause cachexia is poorly understood, but there is probably a role for inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) -which is also nicknamed cachexin for this reason-, Interferon gamma (IFNɣ), and Interleukin 6 (IL-6), as well as the tumor secreted proteolysis inducing factor (PIF).

Related malnutrition syndromes are kwashiorkor and marasmus, although these do not always have an underlying causative illness; they are most often symptomatic of severe malnutrition.

Those suffering from the eating disorder anorexia nervosa appear to have high plasma levels of ghrelin. Ghrelin levels are also high in patients who have cancer-induced cachexia (Garcia et al 2005).

See also

External links


'"/>


(Date:8/31/2014)... 31, 2014 Asked to offer ... between "Bioavailability" and "absorption," Dr. Priya Khan, Director ... great interest. "Bioavailability" and "absorption" are possibly ... the supplement industry, second perhaps only to the ... and absorption, while related, are not the same. ...
(Date:8/31/2014)... Top10BestSEOHosting.com, a reliable review website, has recently ... FatCow, Arvixe and Hostgator are the best ASP.NET hosting ... hosting companies in the world, but good suppliers are ... a reliable ASP.NET server than running a Linux server, ... believe that FatCow, Arvixe and Hostgator are the most ...
(Date:8/31/2014)... (PRWEB) August 31, 2014 Ticket Down ... Bolivia tickets at Dick’s Sporting Goods Park in suburban ... a plethora of games against other international teams on USA ... Cup, Mexico brought a new soccer coach aboard, Miguel Herrera, ... In the build-up before the World Cup in Brazil, the ...
(Date:8/31/2014)... 2014 NutriGold announces that its ... organic fruits and berries, has been approved ... tested, including purity and label claims. , ... Acid from genetically modified and chemically produced corn ... process involves the use of a genetically modified ...
(Date:8/31/2014)... 01, 2014 Market Research Report ... 2009-2019 is a professional and in-depth market survey ... The report firstly reviews the basic information of ... manufacturing technology. , The report then explores global ... listing their product specification, capacity, production value, and ...
Breaking Medicine News(10 mins):Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 2Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 3Health News:Bioavailability Vs Absorption - NutriGold Publishes Tips to Help Consumers Make Informed Decisions for Their Health 4Health News:Best ASP.NET Hosting Award for August 2014 Released By Top10BestSEOHosting.com 2Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 2Health News:Mexico vs. Bolivia Tickets at Dick’s Sporting Goods Park in Commerce City (Denver), CO: Ticket Down Slashes Ticket Prices on Mexico vs. Bolivia Exhibition Game 3Health News:NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval 2Health News:NutriGold’s Organic Wholefood-Sourced Vitamin C Gets ConsumerLab’s Seal of Approval 3Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 2Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 3Health News:Cell Harvesting System Industry for Global and Chinese Market Forecasts to 2019 in New Research Report Available at ReportsnReports.com 4
... AVIV, Israel, Sept. 16 The Company hereby,notifies that the ... Haft Trusts Company Ltd. ("Ziv Haft") as the trustee for,the ... Series C Notes of the,Company. The appointment of Ziv Haft ... Company Ltd., is effective as of September 8,2008, ...
... Rashad Travels to P.A.D. ,Hot Spots, During P.A.D. ... -, NEW YORK, Sept. 16 According to research,conducted ... of P.A.D. "Hot Spots" as the city with the highest ... doubles the risk of,having a heart attack or stroke and ...
... 16 JumpStart Inc., the,Northeast Ohio venture development ... and ideas, today announced the close,of an equity ... a,developer of a proprietary non-invasive ocular glucose measurement ... based, in part, on,patented technology developed at the ...
... Sept. 16 Particle Sciences, Inc.,announces the issuing ... for,increasing the density of sintered metal products. The ... a way that decreases needed,injection forces, decreases lubricant ... based on a proprietary coating,applied to the powders ...
... the European GMES Programme (Global Monitoring for Environment and ... President Gnter Verheugen announced the name today at the ... at the forum as the second flagship of the ... GMES 2008 forum is organised in the framework of ...
... Awarded the Prestigious Award for Strong Market Share Growth, ... , ... Scottsdale, Ariz ... __title__ Vulnerability Management Solutions], Inc., a leading global security ...
Cached Medicine News:Health News:First-Ever National Ranking of 'Hot Spots' for Peripheral Artery Disease (P.A.D.) Identifies Cities With Higher Risk of Heart Attack and Stroke 2Health News:First-Ever National Ranking of 'Hot Spots' for Peripheral Artery Disease (P.A.D.) Identifies Cities With Higher Risk of Heart Attack and Stroke 3Health News:First-Ever National Ranking of 'Hot Spots' for Peripheral Artery Disease (P.A.D.) Identifies Cities With Higher Risk of Heart Attack and Stroke 4Health News:First-Ever National Ranking of 'Hot Spots' for Peripheral Artery Disease (P.A.D.) Identifies Cities With Higher Risk of Heart Attack and Stroke 5Health News:Freedom Meditech Receives JumpStart Investment 2Health News:Freedom Meditech Receives JumpStart Investment 3Health News:Particle Sciences Develops Methods for Increasing Quality of Sintered Metal Products and for Coating Surfaces with Metal Oxide Films 2Health News:Kopernikus, observing our planet for a safer world 2Health News:Lumension Security Receives Frost & Sullivan 2008 Global Market Penetration Leadership Award 2Health News:Lumension Security Receives Frost & Sullivan 2008 Global Market Penetration Leadership Award 3Health News:Lumension Security Receives Frost & Sullivan 2008 Global Market Penetration Leadership Award 4Health News:Lumension Security Receives Frost & Sullivan 2008 Global Market Penetration Leadership Award 5
Other medicine definitionOther Tags