Navigation Links
Cachexia


Name of Symptom/Sign:
Cachexia
Classifications and external resources
ICD-10 R64
ICD-9 799.4

Cachexia (pronounced [kəˈkɛksiə]) is loss of weight, muscle atrophy, fatigue, weakness and significant loss of appetite in someone who is not actively trying to lose weight. It can be a sign of various underlying disorders; when a patient presents with cachexia, a doctor will generally consider the possibility of cancer, certain infectious diseases (e.g. tuberculosis, AIDS) and some autoimmune disorders. Cachexia physically weakens patients to a state of immobility stemming from loss of appetite, asthenia, and anemia, and response to standard treatment is usually poor.

Contents

Disease settings

Cachexia is often seen in end-stage cancer, and in that context is called "cancer cachexia". It was also prevalent in AIDS patients before the advent of triple-therapy for that condition; now it is seen less frequently in those countries where such treatment is available. In those patients who have Congestive Heart Failure, there is also a cachectic syndrome. Also, a cachexia co-morbidity is seen in patients that have any of the range of illnesses classified as "COPD" (Chronic obstructive pulmonary disease), particularly emphysema.

In each of these settings there is full-body wasting, which hits the skeletal muscle especially hard, resulting in muscle atrophy.

Mechanism

The exact mechanism in which these diseases cause cachexia is poorly understood, but there is probably a role for inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) -which is also nicknamed cachexin for this reason-, Interferon gamma (IFNɣ), and Interleukin 6 (IL-6), as well as the tumor secreted proteolysis inducing factor (PIF).

Related malnutrition syndromes are kwashiorkor and marasmus, although these do not always have an underlying causative illness; they are most often symptomatic of severe malnutrition.

Those suffering from the eating disorder anorexia nervosa appear to have high plasma levels of ghrelin. Ghrelin levels are also high in patients who have cancer-induced cachexia (Garcia et al 2005).

See also

External links


'"/>


(Date:11/23/2014)... (PRWEB) November 23, 2014 More than ... month in a federal litigation involving Byetta lawsuits ( ... medications, Bernstein Liebhard LLP reports. , A Case ... over a class of Type 2 diabetes medications referred ... the U.S. District Court, Southern District of California, where ...
(Date:11/23/2014)... November 23, 2014 The FDA is ... Common, **FDAnews On-Demand Webinar**, Dec. 11, 2014 ? Any ... The FDA’s focus on promotional activities is no longer ... Now they're looking at websites, Twitter, journal articles, TV ... for Thursday, Dec. 11, for On-Demand access to Timothy ...
(Date:11/23/2014)... 23, 2014 Today Zane Benefits, ... small businesses, announced their new on demand webinar ... Employer-Provided Health Insurance. , According to ... financial risk facing most American families. It is ... and large, when it comes to recruiting and ...
(Date:11/22/2014)... 2014 PrettyTailor , an outstanding ... new big promotion. Customers can buy new dresses at ... can visit its website. , As a matter of ... dresses. It mainly provides four types of wedding outfits, ... flower girl dresses. It also provides a variety of ...
(Date:11/22/2014)... BambooFlooringChina.com is a famous brand in the bamboo ... collection of bamboo mats ; the new models are ... , According to the sales manager of BambooFlooringChina.com, Bamboo ... highly renewable resource. Their bamboo mats are 100% made from ... from natural bamboo with caramel bamboo strips. , ...
Breaking Medicine News(10 mins):Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 2Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 3Health News:California Federal Court Overseeing Byetta Lawsuits, Other Incretin Mimetic Claims Adds New Cases in November, Bernstein Liebhard LLP Reports 4Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 2Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 3Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 4Health News:FDAnews Announces The FDA is Watching: What Twitter, Tradeshows and TV Have in Common, On-Demand Webinar, Dec. 11, 2014 5Health News:Zane Benefits, Inc. Announces New Webinar on The End of Employer-Provided Health Insurance Now Available On-Demand! 2Health News:Customers Are Welcome to Shop at PrettyTailor.com 2Health News:Trendy Bamboo Mats Online Now By BambooFlooringChina.com 2
... , BOSTON, Sept. 15 The ... America (HFSA) today featured a discussion surrounding the Physical Exam, ... H. Drazner, Cardiologist, Internist and Associate Professor at the University ... of the history and physical examination (H&P) when diagnosing patients ...
... , , , A new ... enables patients to keep better track of their prescription medications and dosage ... never have to worry about forgetting to take their prescription drugs again. ... /PRNewswire-USNewswire/ -- Prescription medications are widely used in ...
... , , , ... Sept. 15 NewCardio, Inc., (OTC Bulletin Board: NWCI) a ... Ph.D., NewCardio,s Chief Technical Officer and Vice-President of Research and ... (EMBS) 2009 Professional Career Achievement Award. The award honored Dr. ...
... , , WAYNE, ... Inc. and Onyx Pharmaceuticals, Inc. (Nasdaq: ONXX ) ... Nexavar((R)) (sorafenib) tablets across tumor types - as a single ... presented at the joint 15th European CanCer Organisation (ECCO) and ...
... , , , ... is intensifying its seasonal influenza public education initiative to urge families to ... campaign aims to ensure Americans get immunized against seasonal influenza, which each ... virus and its related complications. , , The ...
... ... was recently named to the advisory board for PerfectServe, a healthcare communications company. ... physician practices and hospitals nationwide. , ... Knoxville, Tenn. (PRWEB) September 15, 2009 -- Judy ...
Cached Medicine News:Health News:The History and Physical Examination Discussed During Annual Meeting 2Health News:The History and Physical Examination Discussed During Annual Meeting 3Health News:Patients Get Free Text or Email Prescription Medication Reminders From FreeRxReminder.com 2Health News:Patients Get Free Text or Email Prescription Medication Reminders From FreeRxReminder.com 3Health News:Dr. Dorin Panescu, NewCardio's Chief Technology Officer, Awarded Professional Career Achievement Award by the IEEE Engineering in Medicine and Biology Society 2Health News:Dr. Dorin Panescu, NewCardio's Chief Technology Officer, Awarded Professional Career Achievement Award by the IEEE Engineering in Medicine and Biology Society 3Health News:Dr. Dorin Panescu, NewCardio's Chief Technology Officer, Awarded Professional Career Achievement Award by the IEEE Engineering in Medicine and Biology Society 4Health News:Dr. Dorin Panescu, NewCardio's Chief Technology Officer, Awarded Professional Career Achievement Award by the IEEE Engineering in Medicine and Biology Society 5Health News:Bayer and Onyx Announce Nexavar Data Presentations at the Joint 15th European CanCer Organisation (ECCO) and 34th European Society for Medical Oncology (ESMO) Multidisciplinary Congress 2Health News:Bayer and Onyx Announce Nexavar Data Presentations at the Joint 15th European CanCer Organisation (ECCO) and 34th European Society for Medical Oncology (ESMO) Multidisciplinary Congress 3Health News:Bayer and Onyx Announce Nexavar Data Presentations at the Joint 15th European CanCer Organisation (ECCO) and 34th European Society for Medical Oncology (ESMO) Multidisciplinary Congress 4Health News:Bayer and Onyx Announce Nexavar Data Presentations at the Joint 15th European CanCer Organisation (ECCO) and 34th European Society for Medical Oncology (ESMO) Multidisciplinary Congress 5Health News:Bayer and Onyx Announce Nexavar Data Presentations at the Joint 15th European CanCer Organisation (ECCO) and 34th European Society for Medical Oncology (ESMO) Multidisciplinary Congress 6Health News:American Lung Association's Faces of Influenza Campaign Stresses the Importance of Seasonal Influenza Vaccination 2Health News:American Lung Association's Faces of Influenza Campaign Stresses the Importance of Seasonal Influenza Vaccination 3Health News:American Lung Association's Faces of Influenza Campaign Stresses the Importance of Seasonal Influenza Vaccination 4Health News:American Lung Association's Faces of Influenza Campaign Stresses the Importance of Seasonal Influenza Vaccination 5Health News:Judy Benjamin Named to PerfectServe Advisory Board 2
Other medicine definitionOther Tags