Navigation Links
Autoimmune regulator


Autoimmune Regulator
Identifiers
Symbol AIRE
Alt. Symbols AIRE1, APECED, APS1, APSI, PGA1
Entrez 326
HUGO 360
OMIM *607358
RefSeq NM_000383.1
UniProt CAA08759
Other data
Locus Chr. 21 q22.3

The Autoimmune Regulator, abbreviated AIRE, is a human gene which is expressed in the thymus. It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self.

It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis.[1] AIRE is expressed primarily in the thymus.

A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients.[2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus.[3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.[4]

References

  1. ^ OMIM. [1]
  2. ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409.
  3. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Within the Thymus by the Aire Protein. Science 298 (5597), 1395-1401
  4. ^ Liston, A. et al. (2003) Aire regulates negative selection of organ-specific T cells. Nat Immunol 4 (4), 350-354

External links


'"/>


(Date:4/24/2017)... , ... April 24, 2017 , ... ... rising prescription opioid overdose deaths now claim the lives of 62 Americans each ... case filings against drug manufacturers, distributors, pharmacies and prescribers by more than half.(2) ...
(Date:4/24/2017)... ... April 24, 2017 , ... Rod Burkett, CEO of ... News website. , Rod has been at the forefront of Gardant since it was ... CEO, Rod has overseen the opening of more than 40 new senior living communities. ...
(Date:4/24/2017)... ... April 24, 2017 , ... Come to PAINWeekEnd (PWE) Tampa on ... Blvd, for an educational and exciting 2-day program. , An attendee at a ... before they approach patients” about the course entitled Ain't Misbehavin': Decreasing and Managing Pain ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... that over the last decade, student well-being has seriously declined. "When disenfranchised youth ... formal education, join the Islamic State to turn the historic multi-ethnic and multi-religious ...
(Date:4/24/2017)... ... April 24, 2017 , ... “The Saint with Trin, and Omega ... Omega Station” is the creation of published author, Chris Jackson. Chris Jackson grew ... works in the Dallas Independent School District teaching English. He is heavily involved in ...
Breaking Medicine News(10 mins):
Other medicine definition