Navigation Links
Autoimmune regulator


Autoimmune Regulator
Identifiers
Symbol AIRE
Alt. Symbols AIRE1, APECED, APS1, APSI, PGA1
Entrez 326
HUGO 360
OMIM *607358
RefSeq NM_000383.1
UniProt CAA08759
Other data
Locus Chr. 21 q22.3

The Autoimmune Regulator, abbreviated AIRE, is a human gene which is expressed in the thymus. It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self.

It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis.[1] AIRE is expressed primarily in the thymus.

A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients.[2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus.[3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.[4]

References

  1. ^ OMIM. [1]
  2. ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409.
  3. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Within the Thymus by the Aire Protein. Science 298 (5597), 1395-1401
  4. ^ Liston, A. et al. (2003) Aire regulates negative selection of organ-specific T cells. Nat Immunol 4 (4), 350-354

External links


'"/>


(Date:7/22/2014)... a popular supplier of wedding dresses and special occasion gowns ... party dresses to its product category. Additionally, the supplier ... its website. As a special offer, all customers who place ... discounted rate, up to 54% off. , A lot of ... marketing specialist believes the new white party dresses will be ...
(Date:7/22/2014)... As one alternative to surgery, a handful ... now reduce or in some cases eliminate dark eye ... buying guide to help buyers find products to remove ... This guide is meant for both women and men ... circles that can appear. While some people inherit this ...
(Date:7/22/2014)... July 23, 2014 Marietta, Georgia and surrounding ... homes. In an efforts to lower population of needy ... from the Tigg Neuter Project have joined forces. Local ... All proceeds will be presented to the Tigg Neuter ... animal clinic family are excited to attend and host the ...
(Date:7/22/2014)... (PRWEB) July 22, 2014 DocbookMD ... process of deploying one of the largest physician-centric mobile ... ( MHMD ) in Houston. , Created by Austin-based ... the DocbookMD application will be embedded into MHMD’s Accountable ... searched for the best technology to put this capability ...
(Date:7/22/2014)... 22, 2014 Obtaining a bachelor’s degree ... veterans who have hands-on medical experience. The School of ... today announced the launch of an accelerated nursing degree ... The new program, the UNCG Veterans Access Program (VAP), ... 24 veterans. With some prior college credit, veterans who ...
Breaking Medicine News(10 mins):Health News:Elegant White Party Dresses Now Provided by Distinguished Company iFitDress.com 2Health News:Remove Dark Circles Under Eyes: New Cosmetic Buying Guide Released Online for Men and Women 2Health News:Marietta Vet Clinic Hosts 2014 Dog Days of Summer Pet Rescue Event 2Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 2Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 3Health News:Memorial Hermann Physician Network Launches Physician Mobile Communication Solution Throughout Houston 4Health News:UNCG School of Nursing Fast-Tracks Medically Trained Veterans 2
... to help spread awareness of Foundation,s mission and servicesSHORT ... Reeve Foundation, the national, non-profit organization dedicated to finding ... the lives of people living with paralysis, announced today ... popular show "Brothers and Sisters," has been named a ...
... people over 20 now have the condition, while 30% are ... The most recent analysis of data on diabetes in the ... 20 and older have the condition, 40 percent of whom ... diagnosed patients than noted in a previous study, although the ...
... A three-year award from the U.S. Department ... Affairs to Georgetown University,s Institute for Reproductive Health ... and Massachusetts to offer the Standard Days Method, ... developed by Institute researchers. , In addition to ...
... D.Sc., co-founder and CEO of Arobella Medical, LLC, a ... fundamentals of ultrasound assisted wound treatment at the 1st ... Congres in Paris, France on January 19, 2009. ... low frequency, therapeutic ultrasound and wound healing.In his presentation, ...
... the common cardiac drug clopidogrel following a heart attack ... if they are also taking widely used acid-lowering medications ... in CMAJ has found ( http://www.cmaj.ca/cgi/rapidpdf/cmaj.082001 ). ... of heart attack patients aged 66 years and older, ...
... 28 McGraw-Hill Professional, a leading global provider ... communities, and JAMA, the world,s most widely circulated ... launch of a new state-of-the-art digital resource, JAMAevidence. ... educators, and clinicians with the fundamental tools required ...
Cached Medicine News:Health News:Dave Annable Named Christopher & Dana Reeve Foundation Ambassador 2Health News:Diabetes Keeps Rising Among U.S. Adults 2Health News:Diabetes Keeps Rising Among U.S. Adults 3Health News:Bringing easy-to-use, effective natural family planning to American women 2Health News:Arobella Medical CEO Speaks at International Wound Care Conference in Paris 2Health News:Proton pump inhibitors increase risk of heart attacks for patients on common cardiac drug 2Health News:McGraw-Hill Professional and JAMA Launch New Online Evidence-Based Medicine, Clinical and Educational Resource 2Health News:McGraw-Hill Professional and JAMA Launch New Online Evidence-Based Medicine, Clinical and Educational Resource 3
Other medicine definitionOther Tags