Navigation Links
Autoimmune regulator

Autoimmune Regulator
Symbol AIRE
Alt. Symbols AIRE1, APECED, APS1, APSI, PGA1
Entrez 326
HUGO 360
OMIM *607358
RefSeq NM_000383.1
UniProt CAA08759
Other data
Locus Chr. 21 q22.3

The Autoimmune Regulator, abbreviated AIRE, is a human gene which is expressed in the thymus. It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self.

It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis.[1] AIRE is expressed primarily in the thymus.

A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients.[2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus.[3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.[4]


  1. ^ OMIM. [1]
  2. ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409.
  3. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Within the Thymus by the Aire Protein. Science 298 (5597), 1395-1401
  4. ^ Liston, A. et al. (2003) Aire regulates negative selection of organ-specific T cells. Nat Immunol 4 (4), 350-354

External links


(Date:10/8/2015)... , ... October 08, 2015 , ... ... 632-9525 ext. 130 , Oakland Zoo Hosts Weekend of Happy Halloween Themed Activities ... experience called, Family Sundown SPOOKfari . The program is designed include outdoor ...
(Date:10/8/2015)... ... October 08, 2015 , ... ... for the fifth consecutive year. The Philadelphia 100® has been the hallmark of ... the Wharton Small Business Development Center, The Entrepreneurs' Forum of Greater Philadelphia and ...
(Date:10/8/2015)... ... 08, 2015 , ... Daniel S. Herman, Director and Informatics ... by the Healthcare Information and Management Systems Society (LFHIMSS) for his long-term service ... Board of Directors advances members to this status who have been thought leaders ...
(Date:10/8/2015)... ... October 08, 2015 , ... Western ... launched Advanced Training Programs through VirtualU@WesternU, a distance learning Continuing Education and ... VirtualU@WesternU offer an entirely new generation of live patient, hands-on learning for ...
(Date:10/8/2015)... ... , ... HIMSS will dig deep into one of the most pressing issues ... , to be held at the Westin Copley Place in Boston on November 5-6, ... Bates, CIO and SVP of Brigham and Women’s Hospital, as keynote speakers, the solutions-driven ...
Breaking Medicine News(10 mins):
... , , ... ) announced today that it has named Andrew J. Sussman, M.D., ... health clinic subsidiary, and as Senior Vice President/Associate Chief Medical Officer ... be responsible for all clinical services and daily operations for MinuteClinic,s ...
... ... ... hundreds of dollars on new digital hearing aids need look no further. ... utilizes a nationwide network of more than 1,200 professionals and offers discounts on a wide ...
... , MAITLAND, Fla. , July 28 ... treatment for infants with plagiocephaly and other head shape abnormalities, opened ... The Center currently also has offices in the Baltimore and Dallas ... orthoses, also commonly referred to as a cranial helmets or headbands. ...
... REDWOOD CITY, Calif., July 28 Genomic Health, Inc. (Nasdaq: ... call and webcast on Tuesday, August 4, 2009 at 4:30 p.m. Eastern ... and webcast will follow the release of the second quarter financial results ... , To access the live conference call on August ...
... , , , , ... for Rainbow Hospice and Palliative Care at the historic ... Tickets are limited to the first 1,500 people. Tickets for the event, billed as ... food stations, are just $75. Grammy nominated band and Villa Park natives the ...
... Increases 2009 Guidance for Eligard(R) Sales and Adjusted EBITDA , ... QLTI ; TSX: QLT) ("QLT" or the "Company") ... 30, 2009. Unless specified otherwise, all amounts are in U.S. ... pleased to report another strong financial quarter, with robust Eligard(R) ...
Cached Medicine News:
Other medicine definitionOther Tags