Navigation Links
Autoimmune regulator


Autoimmune Regulator
Identifiers
Symbol AIRE
Alt. Symbols AIRE1, APECED, APS1, APSI, PGA1
Entrez 326
HUGO 360
OMIM *607358
RefSeq NM_000383.1
UniProt CAA08759
Other data
Locus Chr. 21 q22.3

The Autoimmune Regulator, abbreviated AIRE, is a human gene which is expressed in the thymus. It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self.

It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis.[1] AIRE is expressed primarily in the thymus.

A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients.[2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus.[3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.[4]

References

  1. ^ OMIM. [1]
  2. ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409.
  3. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Within the Thymus by the Aire Protein. Science 298 (5597), 1395-1401
  4. ^ Liston, A. et al. (2003) Aire regulates negative selection of organ-specific T cells. Nat Immunol 4 (4), 350-354

External links


'"/>


(Date:12/6/2018)... ... December 06, 2018 , ... Tea infusions made ... faster than the drug most commonly used against the ailment—and with no adverse ... The study’s authors, including a professor and two research associates at Worcester Polytechnic ...
(Date:12/5/2018)... DALLAS, Texas (PRWEB) , ... December 05, 2018 ... ... proved its leading SkinPen Precision device is setting a new standard as the ... Aesthetics Everything win. , Each year this award is presented at the renowned ...
(Date:12/5/2018)... ... 05, 2018 , ... Northeast Delta Human Services Authority will ... Monroe Baptist Church, 210 Finks Hideaway Rd, Monroe, LA 71203. , The training ... educate and equip faith leaders to address substance abuse prevention, support and recovery ...
(Date:12/5/2018)... FORT COLLINS, Colo. (PRWEB) , ... December 05, 2018 , ... ... protocol as gum disease treatment and LAPIP™ protocol for ailing dental implants in the ... with a minimally invasive treatment proven to regenerate the bone and tissues lost to ...
(Date:12/5/2018)... ... December 05, 2018 , ... Definitive Healthcare ... market, announced today that it was ranked #184 on Deloitte’s Technology Fast 500 ... highest growth in the fields of technology, media, telecommunications, life science, and energy ...
Breaking Medicine News(10 mins):
Other medicine definition