Navigation Links
Autoimmune regulator

Autoimmune Regulator
Symbol AIRE
Alt. Symbols AIRE1, APECED, APS1, APSI, PGA1
Entrez 326
HUGO 360
OMIM *607358
RefSeq NM_000383.1
UniProt CAA08759
Other data
Locus Chr. 21 q22.3

The Autoimmune Regulator, abbreviated AIRE, is a human gene which is expressed in the thymus. It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self.

It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis.[1] AIRE is expressed primarily in the thymus.

A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients.[2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus.[3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.[4]


  1. ^ OMIM. [1]
  2. ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409.
  3. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Within the Thymus by the Aire Protein. Science 298 (5597), 1395-1401
  4. ^ Liston, A. et al. (2003) Aire regulates negative selection of organ-specific T cells. Nat Immunol 4 (4), 350-354

External links


(Date:11/26/2014)... November 26, 2014 For its ... published The AIS Report on Blue Cross and Blue ... Inc. on the varied strategies the two Blues plans ... compliance with treatments for sleep apnea, ranging from brick-and-mortar ... because it’s linked to increased rates of a variety ...
(Date:11/26/2014)... 2014 GI for Life announced today, ... in prices of their popular nutritional supplements: ColoVite ... . Discounts of 40% will be offered for ... Life’s proprietary ColoVite supplement is a scientifically formulated vitamin ... health. One easy-to-take colon vitamin with ALL the nutrients ...
(Date:11/26/2014)... 2014 Anthropologists have identified concrete ... and stopping Ebola, improve international support, and pave ... in West Africa. , The report, “Strengthening ... Anthropologists Offer Insights,” will be made public during ... Association (AAA), Fri., Dec. 5, 11 a.m., at ...
(Date:11/26/2014)... For those with a New Year’s resolution ... BODYPUMP™ classes at the University of Colorado Anschutz Health ... looking for. The 45- 60 minute classes have just started ... Center fitness club memberships. , LES MILLS BODYPUMP™ exercise classes ... are aimed at fast results , By focusing on ...
(Date:11/26/2014)... of the most important and vital decisions a woman ... choosing the ideal wedding dress and bridesmaid dresses. ... quality outfits. Today, has unveiled its new range ... suitable bridesmaid gowns here at discount prices. , Formal ... and highlight all their most beautiful features while drawing ...
Breaking Medicine News(10 mins):Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 2Health News:AIS Newsletter Reports on Strategies Blues Plans Are Implementing to Combat Sleep Apnea 3Health News:GI For Life Slashes Prices by 40% on Liposomal Vitamin D3 and ColoVite Colon Health Formula for a Limited Time 2Health News:Anthropologists Release Recommendations, Better Practices to Contain Ebola 2Health News:Anthropologists Release Recommendations, Better Practices to Contain Ebola 3Health News:LES MILLS BODYPUMP™ classes come to the University of Colorado Anschutz Health and Wellness Center 2Health News:Royal Blue Bridesmaid Dresses Now Are Available for Christmas at 2
... YORK, April 15 An internationally-known brand name,New York ... Bruce,of Wellness" by Shape magazine, Susan Powter,s "Stop the ... personal story of losing over,l30 pounds as a single ... and fitness industry forever. Now, recently returned to public,life ...
... YARDLEY, Pa., April 15 Breakaway Technologies, Inc.,(BTI), ... that 2008 marks its 10th anniversary. BTI has ... 10 years., "Breakaway was founded to provide ... problems, whether they needed a technology or a,business ...
... diuretics more than double risk for fractures, study finds ... drugs commonly prescribed to treat heart failure and hypertension, ... men, says a U.S. study. , Researchers evaluated 3,269 ... examination between 2000 and 2002, with a follow-up visit ...
... and CAMARILLO, Calif., April 15 IBM (NYSE:,IBM) ... today announced GSMS will be ready to comply ... GSMS is using,IBM technology to manage serialized drug ... The California Board of Pharmacy recently gave ...
... Adults with Autism and Other ... ... annual,in-store fundraising and awareness campaign to bring new hope and,opportunities to ... of dollars to fund Easter Seals, autism and,disability services, provide job ...
... 15, 2008 -- Results of a phase IV, open ... subcutaneous Rebif (interferon beta-1a) provide clinical evidence that the ... months of continued therapy in patients with relapsing-remitting multiple ... April 2008 issue of the Current Medical Research and ...
Cached Medicine News:Health News:Susan Powter The Politics of Stupid: The Cure for Obesity 2Health News:Breakaway Technologies Celebrates 10 Years in Business 2Health News:Heart Failure Drugs Linked to Hip Bone Loss in Older Men 2Health News:Golden State Medical Supply Selects IBM Technology to Comply With California Prescription Drug Pedigree Regulations 2Health News:Golden State Medical Supply Selects IBM Technology to Comply With California Prescription Drug Pedigree Regulations 3Health News:Safeway's In-Store Disabilities Campaign to Benefit Easter Seals 2Health News:Study shows that high-dose, high-frequency interferon produces no additional benefit 2
Other medicine definitionOther Tags