Navigation Links
Autoimmune regulator

Autoimmune Regulator
Symbol AIRE
Alt. Symbols AIRE1, APECED, APS1, APSI, PGA1
Entrez 326
HUGO 360
OMIM *607358
RefSeq NM_000383.1
UniProt CAA08759
Other data
Locus Chr. 21 q22.3

The Autoimmune Regulator, abbreviated AIRE, is a human gene which is expressed in the thymus. It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self.

It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis.[1] AIRE is expressed primarily in the thymus.

A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients.[2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus.[3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.[4]


  1. ^ OMIM. [1]
  2. ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409.
  3. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Within the Thymus by the Aire Protein. Science 298 (5597), 1395-1401
  4. ^ Liston, A. et al. (2003) Aire regulates negative selection of organ-specific T cells. Nat Immunol 4 (4), 350-354

External links


(Date:4/14/2014)... Scientists found that the molecule, called microRNA 135b, is ... to drive the growth of bowel cancers. , Drugs ... of multiple cancer-causing mutations at once, while tests for ... the researchers believe. , The research was carried out ... Institute of Cancer Research, London, the University of Glasgow ...
(Date:4/14/2014)... evidence that antibiotics can contribute to obesity. ... Antimicrobial Agents and Chemotherapy suggests that ... had significant changes in their gut microbiota. ... Aix-Marseille University, Marseille, France, followed 48 patients who ... for Q fever, and 34 control subjects. Nearly ...
(Date:4/14/2014)... decade Chang Lu, associate professor of chemical engineering at ... of tools to efficiently analyze living cells. The long-term ... range of diseases. , In his lab , ... features for examining molecular events inside cells. These devices ... a low number of cells. , Based on their ...
(Date:4/14/2014)... domestic abuse is closely linked to postpartum mental ... (PTSD), in mothers. The research also found that ... mental health problems. The work was done by ... University and the University of British Columbia. , ... partner abuse physical, psychological and sexual ...
(Date:4/13/2014)... expert task force has created a new definition for ... this brain disease. The study published in Epilepsia ... the International League Against Epilepsy (ILAE), provides a greater ... with two unprovoked seizures, and those with one unprovoked ... recurrence. , The 2005 report by the ILAE ...
Breaking Medicine News(10 mins):Health News:'MicroRNA' could be key target for bowel cancer treatment 2Health News:Long-term antibiotic treatment for Q fever causes weight gain 2Health News:Efficient analysis of small quantity of cells improves chances to understand disease 2Health News:Study links domestic abuse to mental health problems in new mothers 2Health News:New clinical definition for epilepsy improves diagnosis accuracy 2
... Niederer / Cariani /,Lindsay, a leading, national executive and ... joined the San Francisco office. Mr. Joyce,will help lead ... throughout the United States., Mr. Joyce brings a ... a range of complex businesses -- large and small,public ...
... data showing first increase in U.S.,teen pregnancy rates, ... in teen pregnancy rates in the United States over ... This unwelcome,development should not come as a surprise since ... last decade -- the decline in sexual,initiation and more ...
... American Society of,Hematology (ASH), the world,s largest professional ... Congressmen and a,hematologist for promoting biomedical research and ... in conjunction with the Society,s,49th Annual Meeting in ... Markey (D-MA) will both,receive ASH,s Award for Public ...
... in Montreal and Boston have identified a potential ... syndrome is a common side-effect of anti-retroviral medications ... of the HIV Metabolic Clinic at the McGill ... Director at the Massachusetts General Hospital Program in ...
... air pollution, especially diesel exhaust , , WEDNESDAY, Dec. 5 ... the health damage done by automotive air pollution, especially ... period of improving air quality in Switzerland, which started ... measurable benefits in lung function for adults as they ...
... Pa., Dec. 5 Eastern Insurance,Holdings, Inc. (Nasdaq: ... of directors has authorized a $0.05 per share quarterly ... stock, payable,December 28, 2007 to shareholders of record at ... is the parent company of Eastern Life and Health ...
Cached Medicine News:Health News:Dennis Joyce Joins Executive and Board Search Firm Hodge / Niederer / Cariani / Lindsay 2Health News:ASH Honors Two Congressmen and NIDDK Director for their Public Service and Leadership in Hematology 2Health News:Major breakthrough toward the treatment of HIV/HAART-associated Lipodystrophy Syndrome 2Health News:Cleaner Air Leads to Healthier Lungs 2Health News:Cleaner Air Leads to Healthier Lungs 3Health News:Eastern Insurance Holdings, Inc. Announces Quarterly Dividend 2Health News:Eastern Insurance Holdings, Inc. Announces Quarterly Dividend 3
Other medicine definitionOther Tags