Navigation Links
Autoimmune regulator


Autoimmune Regulator
Identifiers
Symbol AIRE
Alt. Symbols AIRE1, APECED, APS1, APSI, PGA1
Entrez 326
HUGO 360
OMIM *607358
RefSeq NM_000383.1
UniProt CAA08759
Other data
Locus Chr. 21 q22.3

The Autoimmune Regulator, abbreviated AIRE, is a human gene which is expressed in the thymus. It causes transcription of a wide selection of organ-specific genes. This reduces the threat of autoimmunity occurring by allowing the elimination of autoreactive T cells by the process of negative selection if they are too reactive to self.

It is mutated in the rare autoimmune syndrome Autoimmune Polyendocrinopathy Syndrome type 1 (APS-1), also known as Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED). Disruption of AIRE results in the development of a range of autoimmune diseases, the most common clinical conditions in the syndrome are hypoparathyroidism, primary adrenocortical failure and chronic mucocutaneous candidiasis.[1] AIRE is expressed primarily in the thymus.

A gene knockout of the murine homolog Aire has created a transgenic mouse model to study the mechanism of disease in human patients.[2] Research on the knockout mouse has demonstrated that Aire functions through initiating the transcription of a diverse set of self-antigens, such as insulin, in the thymus.[3] This expression then allows maturing thymocytes to become tolerant towards peripheral organs, thereby suppressing autoimmune disease.[4]

References

  1. ^ OMIM. [1]
  2. ^ Ramsey, C. et al. (2002) Aire deficient mice develop multiple features of APECED phenotype and show altered immune response. Hum Mol Genet 11 (4), 397-409.
  3. ^ Anderson, M.S. et al. (2002) Projection of an Immunological Self-Shadow Within the Thymus by the Aire Protein. Science 298 (5597), 1395-1401
  4. ^ Liston, A. et al. (2003) Aire regulates negative selection of organ-specific T cells. Nat Immunol 4 (4), 350-354

External links


'"/>


(Date:9/1/2015)... ... ... The Jerry Segal Classic to benefit the patients of Magee Rehabilitation Hospital ... Lafayette Hill, PA. Over the past 26 years, the Classic, organized by the Friends ... to support patients and their families during their time at Magee Rehabilitation Hospital. ...
(Date:9/1/2015)... (PRWEB) , ... September 01, 2015 , ... With former ... Engineering and Math) disciplines since its inception more than 35 years ago. A pilot ... students and their teachers - and, not just those intent on pursuing careers in ...
(Date:9/1/2015)... ... September 01, 2015 , ... e-Spirit Inc., a leading ... the FirstSpirit Content Management System with new capabilities and enhancements designed to support ... companies will be well on their way to achieving digital transformation with less ...
(Date:9/1/2015)... York, New York (PRWEB) , ... September 01, 2015 , ... ... Zecurion Zlock Mac , its groundbreaking new version of endpoint DLP developed specifically ... of Zlock Mac, in which more than 100 IT and information security professionals had ...
(Date:9/1/2015)... Boston, MA (PRWEB) , ... September 01, 2015 , ... ... the little-known and incurable disease, facioscapulohumeral muscular dystrophy (FSHD), will be the beneficiary of ... has the same mission – to raise awareness of the FSH Society and further ...
Breaking Medicine News(10 mins):Health News:The 26th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 2Health News:The 26th Jerry Segal Classic Returns to Benefit Patients of Magee Rehabilitation Hospital 3Health News:Inmar Announces Program to Fuel Student Passion for STEM – with an Unconventional Twist 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 2Health News:e-Spirit boosts Corporate Content Cloud initiative with release of FirstSpirit 5.2 3Health News:Zecurion Announces Endpoint Security for Mac 2Health News:FSH Society Beneficiary of Variety of Fall Fundraising Events 2Health News:FSH Society Beneficiary of Variety of Fall Fundraising Events 3
... -- Cancer patients are often faced with many difficult-to-understand ... even mean the difference between life and death. ... use plain language in explaining the options, advised ... the University of Michigan Medical School and a researcher ...
... -- The American College of Physicians (ACP) and the ... commend the Centers for Medicare and Medicaid Services on ... "The American College of Physicians believes that the ... the kind of personalized and coordinated care that patients ...
... the blind to "see" with their hands, bodies or ... $2 million award from the National Science Foundation (NSF) ... and Georgia Institute of Technology (Georgia Tech). The ... Innovation" program, will fund a multidisciplinary team investigating devices ...
... Brain tumor specimens taken from neurosurgery cases at the University ... a new window on the transformation that occurs as healthy ... help identify new drugs to target oligodendroglioma, a common type ... generally most treatable. Any potential drugs identified will have to ...
... HIV prevention trial evaluating two antiretroviral (ARV)-based approaches for preventing ... of one of two different ARV tablets or of a ... tablets from the study. The decision to discontinue use of ... study data concluded that the trial will not be able ...
... Annual Meeting of the American Physical Society,s (APS) Division ... compelling presentations from across the physical sciences, engineering, and ... massive stars; the quirks of flying; why coffee spills; ... among plants. The meeting will take place ...
Cached Medicine News:Health News:Cancer Patients Should Ask Doctors to Use Simple Terms 2Health News:Consumers and physicians together applaud Comprehensive Primary Care Initiative 2Health News:City College of New York-led research could lead to wearable sensors for the blind 2Health News:City College of New York-led research could lead to wearable sensors for the blind 3Health News:How normal cells become brain cancers 2Health News:Major HIV prevention trial in women to drop oral tenofovir arm 2Health News:Major HIV prevention trial in women to drop oral tenofovir arm 3Health News:Major HIV prevention trial in women to drop oral tenofovir arm 4Health News:Major HIV prevention trial in women to drop oral tenofovir arm 5Health News:APS Division of Fluid Dynamics meeting: Highlights and media registration 2Health News:APS Division of Fluid Dynamics meeting: Highlights and media registration 3Health News:APS Division of Fluid Dynamics meeting: Highlights and media registration 4Health News:APS Division of Fluid Dynamics meeting: Highlights and media registration 5
Other medicine definitionOther Tags