Navigation Links
Arterial stiffness


Arteries stiffen as a consequence of age and atherosclerosis. The two leading causes of death in the developed world, myocardial infarction and stroke, are both a direct consequence of atherosclerosis and increased arterial stiffness is associated with an increased risk of cardiovascular events. The World Health Organisation predicts that by 2010 cardiovascular disease will also be the leading killer in the developing world and represents a major global health problem.

Arterial stiffness

Once considered by the ancient Greeks as inert conduits within which air flowed, William Harvey is generally credited with being the first to describe the circulation of the blood through arteries. The circulation of blood depends on the contraction of the heart. When the heart contracts it generates a pulse or energy wave that travels through the circulation. The speed of travel of this pulse wave (pulse wave velocity) is related to the stiffness of the arteries. Other terms that are used to described the mechanical properties of arteries include elastance, or the reciprocal (inverse) of elastance, compliance. The relationship between arterial stiffness and pulse wave velocity (PWV) was first predicted by Thomas Young in his Croonian Lecture of 1808 (Young T: On the function of the heart and arteries: The Croonian lecture. Phil Trans Roy Soc 1809;99:l-31), but is generally described by the Moens-Korteweg equation (Nichols WW, O'Rourke MF. Vascular impedance. In: McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. 4th ed. London, UK: Edward Arnold; 1998:54–97, 243–283, 347–395.) or the Bramwell-Hill equation (Bramwell JC, Hill AV. The velocity of the pulse wave in man. Proc R Soc Lond (Biol) 1922;93:298-306).Typical values of PWV in the aorta range from approximately 5m/s to >15m/s.

Measurement of aortic PWV provides some of the strongest evidence concerning the prognostic significance of large artery stiffening. Increased aortic PWV has been shown to predict cardiovascular and in some cases all cause mortality in individuals with end stage renal failure (Blacher et al.,Circulation. 1999; 99: 2434–2439), hypertension (Laurent et al., Hypertension. 2001; 37: 1236–1241), diabetes mellitus (Cruickshank et al., Circulation. 2002; 106: 2085–2090) and in the general population (Mattace-Raso et al. Circulation. 2006;113:657-663, Hansen et al., Circulation. 2006;113:664-670.). However, at present, the role of measurement of PWV as a general clinical tool remains to be established.


'"/>


(Date:2/26/2015)... 2015 Catalent Pharma Solutions, ... technologies and development solutions for drugs, biologics ... several expanded capabilities within its European Clinical ... implemented in response to increased customer demand ... of highly-potent or temperature-sensitive investigational medical products ...
(Date:2/26/2015)... 26, 2015 Participants in the ... Working? What’s Not? What’s New? ,” will learn ... to achieve strong outcomes for duals-plan members and ... in the implementation phase of programs for Medicare-Medicaid ... Which ones need to be implemented in the ...
(Date:2/26/2015)... NJ (PRWEB) February 26, 2015 The ... reopening of their newly renovated office in Lawrenceville, NJ. ... Reproductive Science Center of New Jersey’s physicians, and NJ ... and patient care in the areas of infertility and ... for having excellent success rates and providing current, high ...
(Date:2/26/2015)... 26, 2015 Software and Cybersecurity ... Position and Best Practices for Compliance, **Presented by ... MD, http://www.fdanews.com/SoftwareAndCybersecurity , This workshop — ... has been specifically designed to provide attendees with ... assure medical device software safety. , In fact, ...
(Date:2/26/2015)... Michigan (PRWEB) February 26, 2015 A ... procedures that accomplish two different things—but they can be ... blending a tummy tuck with liposuction, Michigan’s Dr. Pramit ... which he's seen grow in popularity by 50 percent ... Why are more patients seeking to combine the two? ...
Breaking Medicine News(10 mins):Health News:Catalent Expands European Clinical Packaging Capabilities, Highlighting Growing Industry Need for Specialty Handling 2Health News:Catalent Expands European Clinical Packaging Capabilities, Highlighting Growing Industry Need for Specialty Handling 3Health News:Upcoming AIS Virtual Conference Will Explain What Is and Is Not Working in Medicare-Medicaid Dual Eligibles Programs 2Health News:RSCNJ Is Celebrating the Reopening of Their Newly Renovated Office 2Health News:RSCNJ Is Celebrating the Reopening of Their Newly Renovated Office 3Health News:FDAnews New Workshop — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, April 14-15 2Health News:FDAnews New Workshop — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, April 14-15 3Health News:FDAnews New Workshop — Software and Cybersecurity Risk Management for Medical Devices: Understanding the FDA’s Position and Best Practices for Compliance, April 14-15 4Health News:Dr. Pramit Malhotra Reports a Rise in Patients Combining Liposuction and Tummy Tuck in Michigan, Citing the “Power LipoTuck” 2Health News:Dr. Pramit Malhotra Reports a Rise in Patients Combining Liposuction and Tummy Tuck in Michigan, Citing the “Power LipoTuck” 3
... more than 33,000 Americans per year, experts say , , ... they,ve spotted several potential new drug targets for the ... by a bacterial infection that enters the bloodstream, is ... tens of thousands of Americans a year. , In ...
... of Minnesota School of Public Health and the University ... programs prior to sixth grade, when nearly one in ... that adolescents who already use alcohol are less receptive ... earlier ages, specifically between third and fifth grade, would ...
... Riverview Medical,Center, located in Red Bank, ... the J.D. Power and Associates Distinguished Hospital,Program(SM). ... Riverview,Medical Center to provide an "outstanding emergency ... The service excellence distinction was determined ...
... and supplement manufacturers are often at odds, they,don,t ... half the,physicians on the Harvard Men,s Health Watch ... years, Harvard Men,s Health Watch has,also endorsed these ... they won,t hurt. However, the March 2008 issue ...
... The Association for Professionals in Infection Control and ... selected by Blue Shield of California Foundation (BSCF) ... healthcare-associated infections (HAIs). , APIC will join BSCF ... Foundations innovative California Healthcare-Associated Infection Prevention Initiative to ...
... the ,I ... in the Kitchen(TM), Campaign, NEW YORK, Feb. 27 /PRNewswire-FirstCall/-- ... involves using 70 percent,store-bought items and 30 percent homemade items ... Unknown to most, Lee,s signature,style was strongly influenced by her ...
Cached Medicine News:Health News:Research May Yield New Weapons Against Sepsis 2Health News:U of Minn researchers find primary alcohol prevention programs are needed for 'tweens' 2Health News:J.D. Power and Associates Reports: Riverview Medical Center Recognized for Providing an Emergency Department Experience 2Health News:J.D. Power and Associates Reports: Riverview Medical Center Recognized for Providing an Emergency Department Experience 3Health News:It's Time to Reassess the Value, Safety of Multivitamin Use, Says Harvard Men's Health Watch 2Health News:Celebrity Chef Sandra Lee Offers Recipes and Shortcuts in the Kitchen to People with Rheumatoid Arthritis 2Health News:Celebrity Chef Sandra Lee Offers Recipes and Shortcuts in the Kitchen to People with Rheumatoid Arthritis 3Health News:Celebrity Chef Sandra Lee Offers Recipes and Shortcuts in the Kitchen to People with Rheumatoid Arthritis 4Health News:Celebrity Chef Sandra Lee Offers Recipes and Shortcuts in the Kitchen to People with Rheumatoid Arthritis 5Health News:Celebrity Chef Sandra Lee Offers Recipes and Shortcuts in the Kitchen to People with Rheumatoid Arthritis 6
Other medicine definitionOther Tags