Navigation Links
Arterial stiffness


Arteries stiffen as a consequence of age and atherosclerosis. The two leading causes of death in the developed world, myocardial infarction and stroke, are both a direct consequence of atherosclerosis and increased arterial stiffness is associated with an increased risk of cardiovascular events. The World Health Organisation predicts that by 2010 cardiovascular disease will also be the leading killer in the developing world and represents a major global health problem.

Arterial stiffness

Once considered by the ancient Greeks as inert conduits within which air flowed, William Harvey is generally credited with being the first to describe the circulation of the blood through arteries. The circulation of blood depends on the contraction of the heart. When the heart contracts it generates a pulse or energy wave that travels through the circulation. The speed of travel of this pulse wave (pulse wave velocity) is related to the stiffness of the arteries. Other terms that are used to described the mechanical properties of arteries include elastance, or the reciprocal (inverse) of elastance, compliance. The relationship between arterial stiffness and pulse wave velocity (PWV) was first predicted by Thomas Young in his Croonian Lecture of 1808 (Young T: On the function of the heart and arteries: The Croonian lecture. Phil Trans Roy Soc 1809;99:l-31), but is generally described by the Moens-Korteweg equation (Nichols WW, O'Rourke MF. Vascular impedance. In: McDonald's Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles. 4th ed. London, UK: Edward Arnold; 1998:54–97, 243–283, 347–395.) or the Bramwell-Hill equation (Bramwell JC, Hill AV. The velocity of the pulse wave in man. Proc R Soc Lond (Biol) 1922;93:298-306).Typical values of PWV in the aorta range from approximately 5m/s to >15m/s.

Measurement of aortic PWV provides some of the strongest evidence concerning the prognostic significance of large artery stiffening. Increased aortic PWV has been shown to predict cardiovascular and in some cases all cause mortality in individuals with end stage renal failure (Blacher et al.,Circulation. 1999; 99: 2434–2439), hypertension (Laurent et al., Hypertension. 2001; 37: 1236–1241), diabetes mellitus (Cruickshank et al., Circulation. 2002; 106: 2085–2090) and in the general population (Mattace-Raso et al. Circulation. 2006;113:657-663, Hansen et al., Circulation. 2006;113:664-670.). However, at present, the role of measurement of PWV as a general clinical tool remains to be established.


'"/>


(Date:7/31/2014)... “Bivalent, Heteronomy and Natural Killer Cells?” opened ... bands ~ homeostatic CS science is the answer.” , ... new on the Bryan William Brickner Blog, ten ... cannabinoid system (CS). The line-up links to PubMed articles ... directly on homeostasis, two each on the central nervous, ...
(Date:7/31/2014)... In its latest blog post, Best ... having family close by during a stay in rehab can ... is successful, is focusing on nine secrets that addicts don’t ... that they can spot an addict from a mile away, ... best Drug Rehabilitation’s CEO Per Wickstrom . “However, take ...
(Date:7/31/2014)... 2014 Continuing Education Company Inc ... Clinical Issues in Primary Care Continuing Medical ... at the Wailea Beach Marriott Resort and Spa on ... been developed for today's Primary Care practitioners. In 5 ... says Barbara Lyons, VP Education. , The agenda for ...
(Date:7/30/2014)... Denver, Colorado (PRWEB) July 30, 2014 ... the skiers wearing orange vests emblazoned with “Blind Skier.” ... Colorado slopes through Foresight Ski Guides , a ... with visually impaired and blind participants (VIPs) for snow ... interested in guiding can learn more and pick up ...
(Date:7/30/2014)... DC (PRWEB) July 31, 2014 ... health care environment more responsive to an increasingly ... years of experience and scholarly expertise to the ... the health care professions: "Diversity and Cultural Competence ... 2013). Janice L. Dreachslin, PhD, a professor in ...
Breaking Medicine News(10 mins):Health News:Homeostatic Cannabinoid Science ~ Publius’ July Roundup on the Bryan William Brickner Blog 2Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 2Health News:Latest Best Drug Rehabilitation Blog Posts Focuses on Nine Secrets Addicts Don’t Want Others to Know 3Health News:Clinical Issues in Primary Care Continuing Medical Education (CME) Conference - October 13-17, 2014 in Maui, Hawaii - Agenda Released 2Health News:Clinical Issues in Primary Care Continuing Medical Education (CME) Conference - October 13-17, 2014 in Maui, Hawaii - Agenda Released 3Health News:Colorado Non-Profit Foresight Ski Guides Seeking Applications for Blind and Visually Impaired Skiers and Guides for Vail Ski Season 2Health News:NLN CEO Co-Authors Textbook to Advance Diversity and Cultural Competence Across Health Care Professions 2Health News:NLN CEO Co-Authors Textbook to Advance Diversity and Cultural Competence Across Health Care Professions 3
... Chase, MD Postmenopausal women who have higher testosterone levels ... resistance and the metabolic syndrome compared to women with ... for publication in The Endocrine Society,s Journal of ... is an important step, say researchers, in understanding the ...
... ... and Total Health the all-natural herbal Nutraceutical Company together for the health of our ... ... Association and Registry (ACTHA) announced today that Total Health Enhancement Corp. ...
... ... Scrubs& Beyond shipped directly to their home or work! , ... Brentwood, MO (PRWEB) November 4, 2009 -- Medical professionals ... to their home or work! Orders will ship via SmartPost, which is a collaboration between ...
... Due to the increasing complexities of treating digestive diseases, ... enhanced abilities and experiences in specific disease areas or ... to a "Report of the Multisociety Task Force on ... the achievements of trainees based on specific defined competencies ...
... Nov. 3 Robbins & Myers, Inc. (NYSE: RBN ... Annual Industrial Conference on November 11, 2009. Representing the ... Officer, and Christopher M. Hix, Vice President and Chief Financial ... from 8:20-8:50 a.m., CT, at the Four Seasons Hotel in ...
... of Hematology (ASH) is honoring two prominent hematologists with ASH ... in the training and career development of hematologists early in ... MD, will receive their awards during the 51st ASH Annual ... receiving the Mentor Award for Basic Science, is the David ...
Cached Medicine News:Health News:Postmenopausal women with higher testosterone levels 2Health News:American Competitive Trail Horse Association Announces Total Health Enhancement Corp. as a Sponsor Member 2Health News:Smart Post Brings Scrubs & Beyond to Canadian Doorsteps 2Health News:Gastroenterology/hepatology societies release report evaluating fellowship training curriculum 2Health News:Gastroenterology/hepatology societies release report evaluating fellowship training curriculum 3Health News:The American Society of Hematology to honor inspirational hematologists with Mentor Awards 2
Other medicine definitionOther Tags