Navigation Links
Anterior mediastinal mass


Anterior mediastinal compartment, also known as anterosuperior compartment, is anterior to the pericardium. Masses in this area is more likely to be malignant than those in other compartments (1) Most common masses found here include thymomas, germ cell tumors, lymphomas, thyroid tissue, and parathyroid lesions.

Thymoma

Main article: thymoma

Most common primary anterior mediastinal tumor (20%) in adults but rarely seen in children. It can be classified as lymphocytic, epithelial, or spindle cell histologies, but this is not very significant clinically (2). Tonofibrils seen under electron microscopy can differentiate thymoma from other tumors such as carcinoid, Hodgkin's, and seminoma. Patients are usually asymptomatic but can present with myasthenia gravis-related symptoms, substernal pain, dyspnea, or cough. Invasive tumors can produce compression effects such as superior vena cava syndrome. (3,4) Thymomas are diagnosed with CT or MRI revealing mass in anterior mediastinum. Therapy in stage I tumors consists of surgical ressection with good prognosis. Stage II-III requires maximal resection possible followed by radation. Stage IV disease requires addition of cisplatin-based chemotherapy in addition to those in stage II and III. For those with invasive thymoma, treatment is based on induction chemotherapy, surgical resection, and post-surgical radiation. 5-year survival for invasive thymoma is between 12-54% regardless of any myasthenia gravis symptoms (5,6).

Lymphoma

Main article: lymphoma

Secondary most common primary anterior mediastinal mass in adults. Most are seen in the anterior compartment and rest are seen in middle compartment. Hodgkin's usually present in 40-50's with nodular sclerosing type (7), and non-Hogdkin's in all age groups. Can also be primary mediastinal B cell lymphoma with poor prognosis (8,9). Common symptoms include fever, weight loss, night sweats, and compressive symptoms such as pain, dyspnea, wheezing, SVC syndrome, pleural effusions (10,11). Diagnosis usually by CT showing lobulated mass. Confirmation done by tissue biopsy of accompanying nodes if any, mediastinoscopy, mediastinotomy, or thoracotomy. FNA biopsy usually not adequate. (12,13,14) Treatment of mediastinal Hodgkin's involves chemotherapy and/or radiation. 5 year survival is now around 75%. Mediastinal non-Hodgkin's only has median survival of 13 months even with chemotherapy and radiation. (15) Large-cell type may have somewhat better prognosis. Surgery is generally not performed because of invasive nature of tumor.


'"/>


(Date:8/20/2014)... Salt Lake City, Utah (PRWEB) August 20, 2014 ... House Awning & Canvas Products, announces the availability ... extension of the company’s ordering capabilities aims to ... features Sugar House Awning’s complete line of canvas ... most major brands including Bryant, Lennox, Rheem, Payne, ...
(Date:8/20/2014)... 2014 Recently, UWDress.com, the distinguished wedding ... of birthday party dresses for girls . According ... well-designed and exquisitely handmade by experienced specialists. Now, they ... off. , The company’s new items come in various ... knee length frocks, long elegant backless gowns and so ...
(Date:8/20/2014)... Top10BestSEOHosting.com is a website dedicated to ... It is headed by a team of experts ... research-based information and factual studies about the newest ... market. , Recently, Top10BestSEOHosting.com has compared many ... and Bluehost are the most recommended suppliers ...
(Date:8/20/2014)... Park Avenue Dental, a leading Florida-based dental ... top graduate of the University of Detroit School of ... website through an ultra-informative blog focused on dental tips ... the blog page is chock full of topics that ... concentrating on important dental care tips including ...
(Date:8/20/2014)... 20, 2014 Today, Zane Benefits, ... publication of a new eBook, Affordable Care Act ... business owners feel uncertain about how the ACA ... their bottom line. , The new eBook outlines ... businesses navigate their upcoming health insurance decisions. , ...
Breaking Medicine News(10 mins):Health News:Air Conditioner Covers for Most A/C Units Now Available Online at Coolercovers.com and Amazon.com 2Health News:Air Conditioner Covers for Most A/C Units Now Available Online at Coolercovers.com and Amazon.com 3Health News:Cheap Birthday Party Dresses for Girls Now Available at UWDress.com 2Health News:New Reviews For Linux Web Hosting Suppliers Announced By Top10BestSEOHosting.com 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 3
... injection into a collection of nerves in the neck ... frequency of debilitating hot flashes and night awakenings associated ... published online today by The Lancet Oncology and appearing ... dysfunctions often plague breast cancer survivors, especially those who ...
... WASHINGTON, May 14 The following was,released by the ... Obama:, "NARAL Pro-Choice America PAC Is Excited To ... 2008. Sen. Obama Has A Fully Pro-Choice,Record, And We ... Champion For,Women,s Reproductive Rights." (NARAL Website, "Elections," http://www.naral.org, ...
... Center, Emory University, have discovered the first conclusive ... aged nonhuman primate. The unprecedented finding, described in ... Neurology, has the potential to move the scientific ... neurodegenerative diseases, such as Alzheimer,s disease, are uniquely ...
... Mergent, Inc., administrator for the,HealthShares(TM) Indexes, a ... Traded Funds, today announced the following,changes with effect ... 19, 2008:,Genzyme Corporation (Nasdaq: GENZ ) will ... Index, Ligand Pharmaceuticals Inc.,(Nasdaq: LGND ) will ...
... They contain same toxins as cigarettes, but users think ... News) -- The increasing use of waterpipes, or ... public health problem, according to a Virginia Commonwealth University ... and the smoke is cooled by passing through a ...
... can lead to muscle spasms, fever, sweating and nausea, ... A commonly used migraine medication may cause so-called serotonin ... in the May 15 issue of the New ... and the U.S. Food and Drug Administration detail 11 ...
Cached Medicine News:Health News:'Cool' new treatment for hot flashes in breast cancer survivors 2Health News:'Cool' new treatment for hot flashes in breast cancer survivors 3Health News:NARAL'S CHOICE: Is Anyone Surprised About Out-of-the-Mainstream NARAL's Choice of Barack Obama for President? 2Health News:NARAL'S CHOICE: Is Anyone Surprised About Out-of-the-Mainstream NARAL's Choice of Barack Obama for President? 3Health News:Researchers find first conclusive evidence of Alzheimer's-like brain tangles in nonhuman primates 2Health News:Researchers find first conclusive evidence of Alzheimer's-like brain tangles in nonhuman primates 3Health News:Mergent, Inc. Announces Changes to the HealthShares(TM) Composite Index, HealthShares(TM) Dermatology and Wound Care Index and HealthShares(TM) Orthopedic Repair Index 2Health News:Mergent, Inc. Announces Changes to the HealthShares(TM) Composite Index, HealthShares(TM) Dermatology and Wound Care Index and HealthShares(TM) Orthopedic Repair Index 3Health News:Waterpipe Smoking in Colleges Could Become Public Health Problem 2Health News:Migraine Medications May Cause 'Serotonin Syndrome' 2Health News:Migraine Medications May Cause 'Serotonin Syndrome' 3
Other medicine definitionOther Tags