Navigation Links
Anterior mediastinal mass


Anterior mediastinal compartment, also known as anterosuperior compartment, is anterior to the pericardium. Masses in this area is more likely to be malignant than those in other compartments (1) Most common masses found here include thymomas, germ cell tumors, lymphomas, thyroid tissue, and parathyroid lesions.

Thymoma

Main article: thymoma

Most common primary anterior mediastinal tumor (20%) in adults but rarely seen in children. It can be classified as lymphocytic, epithelial, or spindle cell histologies, but this is not very significant clinically (2). Tonofibrils seen under electron microscopy can differentiate thymoma from other tumors such as carcinoid, Hodgkin's, and seminoma. Patients are usually asymptomatic but can present with myasthenia gravis-related symptoms, substernal pain, dyspnea, or cough. Invasive tumors can produce compression effects such as superior vena cava syndrome. (3,4) Thymomas are diagnosed with CT or MRI revealing mass in anterior mediastinum. Therapy in stage I tumors consists of surgical ressection with good prognosis. Stage II-III requires maximal resection possible followed by radation. Stage IV disease requires addition of cisplatin-based chemotherapy in addition to those in stage II and III. For those with invasive thymoma, treatment is based on induction chemotherapy, surgical resection, and post-surgical radiation. 5-year survival for invasive thymoma is between 12-54% regardless of any myasthenia gravis symptoms (5,6).

Lymphoma

Main article: lymphoma

Secondary most common primary anterior mediastinal mass in adults. Most are seen in the anterior compartment and rest are seen in middle compartment. Hodgkin's usually present in 40-50's with nodular sclerosing type (7), and non-Hogdkin's in all age groups. Can also be primary mediastinal B cell lymphoma with poor prognosis (8,9). Common symptoms include fever, weight loss, night sweats, and compressive symptoms such as pain, dyspnea, wheezing, SVC syndrome, pleural effusions (10,11). Diagnosis usually by CT showing lobulated mass. Confirmation done by tissue biopsy of accompanying nodes if any, mediastinoscopy, mediastinotomy, or thoracotomy. FNA biopsy usually not adequate. (12,13,14) Treatment of mediastinal Hodgkin's involves chemotherapy and/or radiation. 5 year survival is now around 75%. Mediastinal non-Hodgkin's only has median survival of 13 months even with chemotherapy and radiation. (15) Large-cell type may have somewhat better prognosis. Surgery is generally not performed because of invasive nature of tumor.


'"/>


(Date:4/14/2014)... orphaned by HIV/AIDS in South Africa may provide insight ... behavior issues in other areas of the world, which ... that could lead to successful interventions. , A ... United Nations mentions that due to the HIV/AIDS pandemic, ... African, children are at an increased risk for mental ...
(Date:4/14/2014)... A new study shows that moderate to severe ... risk of stroke, cancer and death. , Results of ... to severe obstructive sleep apnea were four times more ... times more likely to have a stroke (HR = ... (HR = 3.4), and 2.5 times more likely to ...
(Date:4/14/2014)... Dallas study involving serious youth offenders, the answer to one ... seven years: "How long do you think you,ll live?", According ... offending over time., Author Dr. Alex Piquero said the study ... of them offend at very high rates and commit more ... much later in life offend much less., "In a lot ...
(Date:4/14/2014)... with symptoms increasing dramatically during some of the most important ... has found. , Depressive symptoms increased on average by 68 ... young men, who were around 25 years old when they ... their children. The results of the study were published April ... is the first to identify when young fathers are at ...
(Date:4/14/2014)... Lower weight babies and babies who aren,t breastfed ... risk of developing chronic inflammation and related health ... study. , "There were good reasons to hypothesize ... inflammation in adulthood," says Thomas McDade (Northwestern University), ... in the Child & Brain Development program. "It ...
Breaking Medicine News(10 mins):Health News:Researchers identify children with emotional behavior difficulties 2Health News:Researchers identify children with emotional behavior difficulties 3Health News:Study links severe sleep apnea to increased risk of stroke, cancer and death 2Health News:UT Dallas study: Youth who fail to envision future commit more crimes 2Health News:Young dads at high risk of depression, too 2Health News:Low birth weight, less breastfeeding create later health risks 2
... Quality,Forum (NQF) announced today that Baylor Health Care ... National Quality Healthcare Award. The award,recognizes exemplary healthcare ... quality improvement in healthcare, and is,presented in partnership ... NQF National Quality Healthcare Award will be presented ...
... the state and ... in rural ... Shield,in Indiana announced the expansion of its Hoosier Healthwise network of,hospitals ... than 123,000 enrollees in the Hoosier Healthwise Medicaid,Managed Care program., ...
... MGT Capital Investments, Inc. (AMEX:,MGT), a holding ... sector, today announced that its subsidiary, Medicexchange ... the Chinese online business,Maydeal.com., The acquisition ... and offline business offerings in China.,The combined ...
... medicine may not be accurate, study finds , , ... of Web pages devoted to breast cancer contain inaccurate ... are 15 times more likely to make misleading claims ... , Moreover, standard measures of quality developed to assess ...
... KENSINGTON, Md., Feb. 11 "Psoriasis Cure,Now," a ... the,National Institutes of Health (NIH) for delivering a ... year 2007. Psoriasis research has,traditionally been underfunded at ... risen 159% (before inflation), but psoriasis and psoriatic,arthritis ...
... Continued Improvements in Medical Loss Ratio, SAN JUAN, ... GTS ), the largest managed care company in,Puerto Rico, ... income of $58.5 million and EPS of $2.15 for ... in net realized and unrealized,gains) reflecting the Company,s strong ...
Cached Medicine News:Health News:National Quality Forum Names Baylor Health Care System Winner of 2008 NQF National Quality Healthcare Award 2Health News:Anthem Blue Cross and Blue Shield Expands Network of Hospitals to Serve Hoosier Healthwise Members 2Health News:Anthem Blue Cross and Blue Shield Expands Network of Hospitals to Serve Hoosier Healthwise Members 3Health News:MGT Capital Investments, Inc. Announces Subsidiary's Preliminary Agreement to Acquire Maydeal.com 2Health News:Most Breast Cancer Web Pages Contain Reliable Information 2Health News:Psoriasis Cure Now Applauds Record Government Psoriasis Research Funding 2Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 2Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 3Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 4Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 5Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 6Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 7Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 8Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 9Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 10Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 11Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 12Health News:Triple-S Management Corporation Reports Record Consolidated Operating Income, Net Income and EPS for 2007 13
Other medicine definitionOther Tags