Navigation Links
Anterior mediastinal mass


Anterior mediastinal compartment, also known as anterosuperior compartment, is anterior to the pericardium. Masses in this area is more likely to be malignant than those in other compartments (1) Most common masses found here include thymomas, germ cell tumors, lymphomas, thyroid tissue, and parathyroid lesions.

Thymoma

Main article: thymoma

Most common primary anterior mediastinal tumor (20%) in adults but rarely seen in children. It can be classified as lymphocytic, epithelial, or spindle cell histologies, but this is not very significant clinically (2). Tonofibrils seen under electron microscopy can differentiate thymoma from other tumors such as carcinoid, Hodgkin's, and seminoma. Patients are usually asymptomatic but can present with myasthenia gravis-related symptoms, substernal pain, dyspnea, or cough. Invasive tumors can produce compression effects such as superior vena cava syndrome. (3,4) Thymomas are diagnosed with CT or MRI revealing mass in anterior mediastinum. Therapy in stage I tumors consists of surgical ressection with good prognosis. Stage II-III requires maximal resection possible followed by radation. Stage IV disease requires addition of cisplatin-based chemotherapy in addition to those in stage II and III. For those with invasive thymoma, treatment is based on induction chemotherapy, surgical resection, and post-surgical radiation. 5-year survival for invasive thymoma is between 12-54% regardless of any myasthenia gravis symptoms (5,6).

Lymphoma

Main article: lymphoma

Secondary most common primary anterior mediastinal mass in adults. Most are seen in the anterior compartment and rest are seen in middle compartment. Hodgkin's usually present in 40-50's with nodular sclerosing type (7), and non-Hogdkin's in all age groups. Can also be primary mediastinal B cell lymphoma with poor prognosis (8,9). Common symptoms include fever, weight loss, night sweats, and compressive symptoms such as pain, dyspnea, wheezing, SVC syndrome, pleural effusions (10,11). Diagnosis usually by CT showing lobulated mass. Confirmation done by tissue biopsy of accompanying nodes if any, mediastinoscopy, mediastinotomy, or thoracotomy. FNA biopsy usually not adequate. (12,13,14) Treatment of mediastinal Hodgkin's involves chemotherapy and/or radiation. 5 year survival is now around 75%. Mediastinal non-Hodgkin's only has median survival of 13 months even with chemotherapy and radiation. (15) Large-cell type may have somewhat better prognosis. Surgery is generally not performed because of invasive nature of tumor.


'"/>


(Date:10/30/2014)... Florida (PRWEB) October 30, 2014 Timothy, ... visit to Pompano Beach firefighters, showing that you are ... , Timothy met firefighters Tracey and Carl at ... Galuppi’s Restaurant and the Pompano Beach Chamber of Commerce. ... the fire truck, letting Timothy wear his real fireman’s ...
(Date:10/30/2014)... San Diego, Calif. (PRWEB) October 30, 2014 ... no longer mutually exclusive concepts in the medical-grade ... focusing on the development of uniquely potent topical ... Skin Health System ( http://www.RefinitySkinScience.com ) with patented ... highest available glycolic acid concentrations (50% and 70%) ...
(Date:10/30/2014)... Paramount Rx, a full-service prescription benefits manager ... help people save money through its innovative discount card ... drugs in the new health care system, the Paramount ... the relationship between consumers, businesses and the pharmacy industry. ... face today with medical costs is the rising price ...
(Date:10/30/2014)... Tara Haelle HealthDay ... -- More than 100 genes have been identified that ... report. And researchers say they are on their ... may contribute to the disorder. Autism spectrum disorders ... and social difficulties and repetitive behaviors. An estimated one ...
(Date:10/30/2014)... Dr. Joseph Furlin MD, a certified obstetrician and gynecologist, ... OB GYN in Melrose Park, IL and OB ... information about each of the care services and practice areas ... English and Spanish. The navigation of the website is ... provide Dr. Furlin’s patients with important information regarding his care ...
Breaking Medicine News(10 mins):Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 2Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 3Health News:4-year-old InstaKNOT CEO Honors Local Firefighters with Community Support 4Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 2Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 3Health News:Cosmederm Redefines Peel Science Standard with Launch of Refinity® Skin Health System 4Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 2Health News:Paramount Rx Discount Card Program Provides Valuable Resources in Midst of Current Health Care Reform 3Health News:Discovery of 100-Plus Genes Tied to Autism May Improve Treatments 2Health News:Discovery of 100-Plus Genes Tied to Autism May Improve Treatments 3Health News:Dr. Joseph Furlin Launches New Website with Information about Care Services 2
... myocardial perfusion imaging is common, and in many patients is ... a study in the November 17 issue of JAMA ... is being presented at the American Heart Association,s annual meeting. ... years, but along with the potential benefits has come an ...
... the gradual accumulation in the brain of amyloid-beta peptide which is ... protein known as APP, which is found in three forms. Most ... disease does not distinguish between the different forms of the ... Chemistry , show that amyloid beta peptide is actually created mainly ...
... Reporter , SUNDAY, Nov. 14 (HealthDay News) -- Moderate drinking ... than not drinking at all, according to a trio of ... in Chicago. Not only did male coronary bypass ... was also boosted by a cocktail now and then. ...
... , SUNDAY, Nov. 14 (HealthDay News) -- ... the brain alter how they view themselves and others, ... aptitude for introspection, researchers say. Georgetown University Medical ... of the five scattered brain regions that comprise what,s ...
... of adult smokers dramatically decreased during the past three ... more quitting and fewer picking up the habit, according ... Sessions 2010. The Minnesota Heart Survey, a population-based, serial ... between 3,000 and 6,000 participants in each of its ...
... do not get enough sleep have higher levels of ... researchers have found. Data from a recent study ... the American Heart Association Scientific Sessions in Chicago by ... School of Medicine. The results come from surveying ...
Cached Medicine News:Health News:Common for patients to undergo multiple cardiac imaging tests, with high cumulative radiation dose 2Health News:Common for patients to undergo multiple cardiac imaging tests, with high cumulative radiation dose 3Health News:'Magic number' 695 opens up new areas for Alzheimer's research 2Health News:A Little Alcohol May Help the Heart: Studies 2Health News:A Little Alcohol May Help the Heart: Studies 3Health News:Brain Organizes Itself for Introspection as Children Age: Study 2Health News:Smoking among some adults dropped dramatically in past three decades 2Health News:Smoking among some adults dropped dramatically in past three decades 3Health News:Smoking among some adults dropped dramatically in past three decades 4Health News:Smoking among some adults dropped dramatically in past three decades 5Health News:Smoking among some adults dropped dramatically in past three decades 6Health News:Poor sleep quality increases inflammation, community study finds 2Health News:Poor sleep quality increases inflammation, community study finds 3
Other medicine definitionOther Tags