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Researchers report major advance in gene therapy technique

MADISON Despite a roller-coaster ride of ups and downs during the past 15 years, gene therapy has continued to attract many of the worlds brightest scientists. They are tantalized by the enormous potential that replacing missing genes or disabling defective ones offers for curing diseases of many kinds.

One group, consisting of researchers from the
Full article >>> The research has exciting near-term implications for muscle and blood vessel disorders in particular.

Duchennes muscular dystrophy, for example, is a genetic disease characterized by a lack of muscle-maintaining protein called dystrophin. Inserting genes that produce dystrophin into muscle cells could override the defect, scientists theorize, ensuring that the muscles with the normal gene......

Full article >>> he leg muscles in healthy animals, with minimal side effects. We detected gene expression in all leg muscle groups, and the DNA stayed in muscle cells indefinitely, notes Wolff.

In addition, the scientists were able to perform multiple injections without damaging the veins. The ability to do repeated injections has important implications for muscle diseases since to cure them, a high perc......

Full article >>> to concentrate on veins. Injecting any substance into arteries carries a degree of risk since, unlike veins, only one artery feeds a whole limb, notes Wolff.

In a related procedure, they experienced excellent results with high-pressure injection of genes into the tail veins of rodents, a technique that yielded extensive gene expression in the animals livers.

We think the genes tr......

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'"/> By WTN News 06/03/04

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