Navigation Links
Quantitation of Cabergoline at Extremely Low Plasma Concentrations with ,,, a Triple Quadrupole Mass Spectrometer

lysis of drug combination products. Typically, method development is biased towards optimizing the detection limit for the lower concentration analyte, sacrificing detector saturation of the higher concentration analytes. Since linear range of the high concentration analyte is compromised, sample dilution and subsequent analysis becomes unavoidable; this contributes considerably to overall sample analysis time and, thus, does not lend itself to highthroughput applications. Hence, the extended linear dynamic range of the TSQ Quantum is extremely beneficial in these situations.

Conclusions

The TSQ Quantum operated at unit resolution shows tremendous utility in the development of highly sensitive detection methods for ergoline derivatives such as cabergoline. Sensitivity on the TSQ Quantum is ~20 times better than that reported on the TSQ 7000 while only requiring a fraction of the sample previously used. Furthermore, analysis of low plasma concentrations of cabergoline was performed in a complex, minimally treated plasma matrix. The broad dynamic range of the TSQ Quantum, coupled with the excellent precision and accuracy in unit resolution, is of particular importance for applications where detector saturation is typically encountered. The broad dynamic range, therefore, allows for easy development of methods suitable for the analysis of drugs administered at any given dose (low and high), for drugs and their metabolites, and for drug combination products. For these reasons, the TSQ Quantum should find widespread use in the development of sensitive, simple, fast, accurate, and rugged methods for many pharmacokinetic applications.

References

1. Andreotti AC, Pianezzola E, Persiani S, Pacciarini MA, Strolin Benedetti M, Pontiroli, AE. J. Clin. Endoc
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8

Related biology technology :

1. Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine in Bovine Plasma using the TSQ Quantum Mass Spectrometer
2. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
3. Comparison of Different Methods of mRNA Quantitation
4. Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer
5. Quantitation of RNA for Hybridization Blots Using the VersaFluor Fluorometer
6. Quantitation of Lymphangiogenesis Using the iCycler iQ Real-Time PCR Detection System and Scorpions Detection System, Rev A
7. Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A
8. Benchmark Plus Microplate Reader: Quantitation of Protein Concentration Using Two Different Colorimetric Assay Kits, Rev A
9. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
10. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
11. Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System
Post Your Comments:
(Date:4/24/2015)... Seoul Semiconductor announced the expansion of its ... lighting market. In recent months, there have ... emerging markets such as Russia, South America, and ... such as streetlight and area lighting, tunnel lighting, ... in 2005 the Acrich technology from Seoul Semiconductor ...
(Date:4/23/2015)... , April 23, 2015 BioTE Medical ... his book "Age Healthier Live Happier - Avoiding Over-Medication ... the Age Management Medicine Group Conference at JW Marriott ... 2015. ",Age Healthier Live Happier, is a ... avoid over-medication and searching for a higher quality of ...
(Date:4/23/2015)... 23, 2015  Cryoport, Inc. (OTCBB: CYRX) ("Company"), ... for the life sciences industry, today announced that ... solutions within the animal husbandry market by signing ... support the shipment of equine semen for artificial ... Stallions. Animal husbandry is a multi-billion ...
(Date:4/23/2015)... April 23, 2015  Metanome, Inc., an industry ... company has changed its name to Diversigen, Inc.  ... as the single commercial source for the myriad ... on the diverse opportunities of the microbiome.  From ... accepts – including those that are difficult to ...
Breaking Biology Technology:Acrich Technology from Seoul Semiconductor Adopted in Installations Worldwide 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 2Release and Book Signing of BioTE Medical President Gary Donovitz M.D. 'Age Healthier Live Happier' at Age Management Medicine Group (AMMG) Conference 3Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 2Cryoport to Support the Equine Animal Husbandry Market Through Agreement with Yancey Farms 3Metanome Announces Corporate Name Change to Diversigen 2
... Draper Laboratory, in conjunction with the National Academy of Engineering (NAE), ... about the impact engineers have had on our daily lives, and ... awarded "Engineering,s Nobel" since 1989. , ... Cambridge, MA ...
... Inc. (Nasdaq: SVNT ) today announced the ... Vice President, Chief Financial Officer & Treasurer. Mr. ... Savient,s Chief Financial Officer, effective immediately. "We are ... Vice President of Corporate Finance and Controller, David will ...
... SAN DIEGO, Feb. 12 Volcano Corporation,(Nasdaq: ... sales of,products for the diagnosis and treatment of coronary ... participating in the Roth Capital Partners,21st Annual Growth Stock ... The presentation by Scott Huennekens, president and chief ...
Cached Biology Technology:New Educational Website Celebrates the Accomplishments of Engineers 2Savient Announces Appointment of David Gionco as Chief Financial Officer 2Savient Announces Appointment of David Gionco as Chief Financial Officer 3Savient Announces Appointment of David Gionco as Chief Financial Officer 4Volcano Corporation Presentation at Roth Capital Partners Conference to Be Webcast 2
(Date:3/24/2015)... , Mar. 24, 2015 Research and Markets ... of the "Global Iris Recognition Market 2015-2019" ... the Global Iris Recognition market to grow at a ... This report covers the present scenario and the ... the period 2015-2019. To calculate the market size, the ...
(Date:3/24/2015)... 24, 2015   Crossmatch ™, a leading ... that its U.are.U ® 4500 Fingerprint Readers ... Bros . to achieve PCI compliance for Point-of-Sale ... to the POS terminal, protecting the retailer and ... breaches. With one-third of worldwide ...
(Date:3/23/2015)... , March 23, 2015  In the 2014 fiscal ... case conviction losses. This figure accounts for a fraction ... to The Nilson Report, exceeds $11 billion globally. The ... after a crime has occurred. Investor Mark Saint ... expert Joe Paolella partnered to administer the ...
Breaking Biology News(10 mins):Global Iris Recognition Market 2015-2019 with 3M Cogent, Bioenable Technologies, Cross Match Technology, Iris ID Systems & Safran Dominating 2Crossmatch Fingerprint Readers Help Retailer Prevent Data Breaches at Point-of-Sale 2Polygraph Test Now Used to Protect Investors From Fraud 2Polygraph Test Now Used to Protect Investors From Fraud 3
... - A Purdue University study shows dairy has an advantage ... Connie Weaver, distinguished professor and head of the food and ... dry milk were longer, wider, more dense and stronger than ... carbonate is the most common form of calcium used in ...
... biologist Dr. Gary G. Borisy, director and CEO of ... The National Academy of Sciences (NAS), an honorific society ... The achievement, considered one of the highest honors in ... Academy,s 146th annual meeting in Washington, D.C. Dr. Borisy ...
... calve from the northern front of the Wilkins Ice Shelf ... follows the collapse three weeks ago of the ice bridge ... The ice bridge, which effectively formed a barrier pinning ... Shelf, collapsed on 5 April removing about 330 sq km ...
Cached Biology News:Purdue study finds dairy better for bones than calcium carbonate 2MBL director and CEO and cell biology pioneer Gary Borisy elected to National Academy of Sciences 2MBL director and CEO and cell biology pioneer Gary Borisy elected to National Academy of Sciences 3Satellite imagery shows fragile Wilkins Ice Shelf destabilized 2
Recommended for use as a cell culture substratum at 0.1-0.2 mg/cm 2 or 5-10 μl/cm 2 . Optimal concentration depends on cell type as well as the application or research objectives. Type B...
... The Eclipse is a state-of-the-art separation ... Fractionation (AFFF) technique. The Eclipse integrates easily ... DAWN, miniDAWN Tristar, as well as the ... size and molar mass distributions of the ...
... for determining the absolute count of CD34+ ... peripheral blood samples, and leukapheresis samples. These ... cell count and a total CD45 (leucocyte) ... use in the BD Procount progenitor cell ...
... Protein A and, until recently, no readily available ... purification. Standard methods for IgM purification generally are ... for removing all of the major impurities present ... Pierce has developed an easy-to-use affinity matrix and ...
Biology Products: