Navigation Links
Quantitation of Cabergoline at Extremely Low Plasma Concentrations with ,,, a Triple Quadrupole Mass Spectrometer

d enrichment of the analyte concentration, and a large injection volume (150 L) representing 75% of the extracted sample.[6] In contrast, using the TSQ Quantum, superior cabergoline sensitivity was achieved with minimally-treated samples and a much smaller injection volume (5 L). Thus, the detection limit for cabergoline on the TSQ Quantum is almost 20 times lower than that attained on the TSQ 7000.[6,8,11] The calibration curve for cabergoline obtained on the TSQ Quantum shows a linear dynamic range covering 5 orders of magnitude (1 x 105) with a correlation coefficient of R > 0.999 using a weighting factor of 1/x (Figure 4). Intra-assay accuracy and precision was evaluated for n >= 5 samples at each calibration level. The accuracy and precision numbers obtained over this extended linear dynamic range are shown in Table 1. The LLOQ (50 fg on column) had an accuracy (%RE) and precision (%CV) of 13.6% and 9.3% respectively. The %RE and %CV for all the other calibration levels (0.5 pg to 5000 pg on column) ranged from -7.5% to 1.6% and 0.5 to 8.4%, respectively. The linear dynamic range for the TSQ Quantum is considerably broader than that achievable on the TSQ 7000 (which was less than 2 orders of magnitude for this assay).[6,7] The significance of this extended linear dynamic range is that a single method can now be developed for cabergoline for application in both low and high dose pharmacokinetic analyses.

It is typical for the response of older generation mass spectrometers to be nonlinear and/or for detector saturation to occur for linear dynamic ranges as low as 3 orders of magnitude. This is particularly problematic for assays where drugs and their metabolites are present in vastly different concentrations and for the ana
'"/>

Source:


Page: All 1 2 3 4 5 6 7 8

Related biology technology :

1. Bioanalytical Method Intraday Validation for the Quantitation of Paroxetine in Bovine Plasma using the TSQ Quantum Mass Spectrometer
2. Quantitation of the Protein MIA as a Marker for Chondrocytes in Research Samples
3. Comparison of Different Methods of mRNA Quantitation
4. Quantitation of DNA for Automated Sequencing Using the VersaFluor Fluorometer
5. Quantitation of RNA for Hybridization Blots Using the VersaFluor Fluorometer
6. Quantitation of Lymphangiogenesis Using the iCycler iQ Real-Time PCR Detection System and Scorpions Detection System, Rev A
7. Quantitation of GAD67 Gene Expression in Prefrontal Cortex of Schizophrenia Patients Using the iCycler iQ Detection System and Molecular Beacons, Rev A
8. Benchmark Plus Microplate Reader: Quantitation of Protein Concentration Using Two Different Colorimetric Assay Kits, Rev A
9. A Robust LC/MS/MS Method for the Quantitation of Very Long Chain Fatty Acids for Research into the Characterization of Peroxisomal Disorders
10. A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)
11. Separation and Quantitation of R and S Enantiomers using Normal Phase Chromatography on an API 3000 LC/MS/MS System
Post Your Comments:
(Date:7/29/2015)... , July 29, 2015  Indivior PLC (LON: INDV) ... naloxone nasal spray was accepted and received Priority Review ... the treatment of opioid overdose. This naloxone nasal spray ... formulated for optimal absorption into the nasal mucosa. 1 ... training so individuals may be better equipped to help ...
(Date:7/29/2015)... CITY , July 29, 2015 /PRNewswire/ - Aeterna ... today announced it has selected an optimized Erk ... milestone in the development of a new class ... MAPK pathway represents a prime target for therapeutic ... antitumor activities and survival benefits for B-Raf and ...
(Date:7/29/2015)... ... July 29, 2015 , ... Available in select ... Contouring Bi-Gel, a nighttime-specific product that targets fat cells for extreme contouring action. ... to enter fat cells, inhibiting the formation of new fat. Upon waking CHRONODIET ...
(Date:7/29/2015)... ... July 29, 2015 , ... ... making good progress in evaluating the full range of capabilities of its unique ... tissue stem cells perform the day-to-day renewal and repair of normal tissues and ...
Breaking Biology Technology:Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 2Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 3Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 4Indivior PLC Announces FDA Acceptance of Naloxone Nasal Spray New Drug Application With Priority Review 5Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 2Aeterna Zentaris Announces Optimized Erk Inhibitor Compounds For Further Development 3Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 2Phytocéane introduces CHRONO NIGHT Express Contouring Bi-Gel 3Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 2Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 3Asymmetrex Plans to Report Results From Adult Stem Cell Technology Development Milestone Studies At End of Summer 4
... today announced it,has received 510(k) clearance from the ... CO-OX, a portable blood gas analyzer that brings ... commercial release,of the instrument to soon follow., ... ABL80 FLEX CO-OX accurately measures pH, blood gases, ...
... up on their recently announced partnership, Grid Dynamics and GridGain teamed ... Amazon EC2. , ... San Francisco, CA (PRWEB) August ... Dynamics and GridGain teamed up to develop the largest publicly known ...
... DIEGO, Aug. 1 Anadys Pharmaceuticals,Inc. (Nasdaq: ANDS ... Bank of,America 2008 Specialty Pharmaceuticals Conference on Friday, August ... conference is being held at the,Southampton Inn in Long ... Chief Executive Officer of Anadys,Pharmaceuticals, Inc., will present an ...
Cached Biology Technology:New CO-oximetry Module for the ABL80 FLEX Blood Gas Analyzer 2Grid Dynamics Demonstrates Linear Scalability up to 512 Nodes with GridGain Software on Amazon EC2 Cloud 2Grid Dynamics Demonstrates Linear Scalability up to 512 Nodes with GridGain Software on Amazon EC2 Cloud 3Anadys Pharmaceuticals to Present at the Bank of America 2008 Specialty Pharmaceuticals Conference 2
(Date:7/7/2015)... 2015 Research and ... of the "Capacitive Fingerprint Sensors Patent Landscape" ... this date, fingerprint sensing technology is the most ... are well developed. This patent landscape focuses on ... The domain of capacitive fingerprint sensors is closely ...
(Date:7/2/2015)... , June 25, 2015 ... addition of the "Next Generation Biometrics Market by ... 2020" report to their offering. The ... Billion by 2020, at a CAGR of 17.9% between ... the leading application for the market. Safran SA ...
(Date:6/29/2015)... Research and Markets( http://www.researchandmarkets.com/research/zj7h4f/latin_america ) has ... Sensors Market - Growth, Trends & Forecasts (2014-2020)" ... Biomedical Sensors market is estimated at $0.65 billion by ... 2014-2020 The near future will bring Biomedical ... each individual. These sensors can be set to trigger ...
Breaking Biology News(10 mins):Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 2Next Generation Biometrics Market 2015 - Global Forecast to 2020 with Safran, NEC, 3M Cogent, Fujitsu & Suprema Dominating the $24 Billion Market 3Latin America Biomedical Sensors Market Report 2015-2020 2
... of researchers has shown that female kittens consume more food ... with entire littermates. This research was conducted at the WALTHAM ... Petcare brands such as WHISKAS and ROYAL CANIN. In ... consumed more food than their entire littermates for an 18 ...
... some strains of algae, when starved of nutrients, quickly build ... discovery lay dormant until people began to search in earnest ... 2000s, algal fuel production enjoyed a tremendous vogue, as scientists ... "pond scum" to oil. But a recent wave of bankruptcies ...
... October 2011, Christian Sonne, Senior Scientist at Aarhus University, defends ... University of Copenhagen. "The accumulated industrial chemicals cause diseases ... immediate deaths. On the other hand, the toxins damage the ... and not least their reproductive systems. However, the harm suffered ...
Cached Biology News:New research from WALTHAM demonstrates the importance of portion control for maintaining healthy body weight in neutered female kittens 2WUSTL wins $ 2.2 million US Department of Energy grant to build a fuel producing bacterium 2WUSTL wins $ 2.2 million US Department of Energy grant to build a fuel producing bacterium 3WUSTL wins $ 2.2 million US Department of Energy grant to build a fuel producing bacterium 4
3M Imidazole Solution 125 ml...
Rabbit polyclonal to NCoR2, prediluted ( Abpromise for all tested applications). entrezGeneID: 9612 SwissProtID: Q9Y618...
...
... Anti-Clusterin α chain (human), clone 41D ... Immunogen : Native clusterin purified ... pH 7.4, 0.15M NaCl and 0.05% ... on RIPA lysates from HeLa cells ...
Biology Products: