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Quantitation of Cabergoline at Extremely Low Plasma Concentrations with ,,, a Triple Quadrupole Mass Spectrometer

Nicola Hughes,1 Antony Harvey,2 Witold Winnik,3 Jean-Jacques Dunyach,2 Maan Amad,2 Maurizio Splendore,2 and Gary Paul3

1Biovail Contract Research,Toronto,Ontario,Canada;
2Thermo Finnigan,San Jose,CA,USA;
3Thermo Finnigan,Somerset, NJ,USA

Systemic Plasma Analysis

The data presented here was acquired on a Thermo Finnigan TSQ Quantum mass spectrometer

Overview

Quantitation of low plasma concentrations of the pharmaceutical cabergoline is performed to demonstrate the sensitivity and selectivity of the TSQ Quantum mass spectrometer. Samples with analyte concentrations ranging five orders of magnitude are analyzed to demonstrate precision and accuracy over a linear dynamic range suitable for pharmacokinetic applications. Analysis of 50 fg of cabergoline on column in minimally treated plasma samples is performed to demonstrate the sensitivity, ruggedness, and practicality of the bioanalytical method in a complex matrix.

Introduction

Pharmaceuticals with potent activity achieve their desired therapeutic effects when administered at low doses. Consequently, their systemic plasma levels are extremely low and require highly sensitive techniques for detection. Cabergoline, a synthetic ergoline derivative with a powerful dopaminergic activity, is usually administered in 0.25 mg, biweekly doses, yielding plasma concentrations in the pg/mL level.[1,2]

A variety of analytical methods have been employed to quantify low levels of cabergoline in plasma; these include high performance liquid chromatography (HPLC), radioimmunassay (RIA), and liquid chromatogra
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