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Conclusions
Oragene is a non-invasive DNA self-collection kit that can be used by
untrained study subjects, including children and the elderly. The median
DNA yield from Oragene/saliva samples is 110 g. This is significantly
higher than other oral collection methods.
References
1. Cozier, Y., Palmer, J., and Rosenberg, L. (2003) Comparison of Methods
for Collection of DNA Samples by Mail in the Black Womens Health Study.
AEP. 14, 117-122.
2. Harty, L., Garcia-Closas, M., Rothman, N., Reid, Y., Tucker, M., and Hartge, P. (2000) Collection of buccal cell DNA using treated cards. Cancer Epidemiology, Biomarkers & Prevention. 9, 501506.
3. Montserrat, G., Egan, K., Abruzzo, J., Newcomb, P., Titus-Ernstoff, L., Franklin, T., et al. (2001) Collection of genomic DNA from adults in epidemiological studies by buccal cytobrush and mouthwash. Cancer Epidemiology, Biomarkers & Prevention. 10, 687-696.
4. Le Marchand, L., Lum-Jones, A., Saltzman, B., Visaya, V., Nomura, A., and Kolonel, L. (2001) Feasibility of collecting buccal cell DNA by mail in a cohort study. 10, 701-703.
5. DNA Genotek Technical Bulletin PR003 Sept 30, DNA Quantifi cation Using the Fluorescence/DNase (F/D) Assay. 2004.
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