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A new LC/MS/MS Research Method for Rapid Quantitation of Five Immunosuppressant Drugs, including Mycophenolic Acid (MPA)

p> Rapid. It is suitable for quantifying either MPA, and/or the other immunosuppressant drugs (CsA, TAC, SIR, EVE).

Flexible. With the same hardware setting and configuration, the method can handle whole blood, for CsA, TAC, SIR, and EVE and plasma for MPA and MPAG.

Accurate. MPAG, usually present at significant concentrations, does not interfere with the MPA quantitation results.

Fully under control of the Analyst acquisition software. All the peripheral modules are under control of the fullinclusive Acquisition Method.

Effective in reducing the solvent consumption. The programmed operation of the LC peripheral units enables the high flow-rate regime in the firstdimension LC just for the time needed for the sample clean up.

References

1. Applied Biosystems Application, Publication: MS-AP234.

2. T. Koal, M. Deters, B. Casetta, and V. Kaever, J. Chromatogr B, 805 (2004) 215-222.

3. B. Atcheson, P.J. Taylor, D.W. Mudge, D.W. Johnson, I. Pillans, and S.E.Tett. J. Chromatogr, B. Analyt Technol Biomed Life Sci, Jan 2004; 799(1): 157-63.

4. F. Streit, M. Shipkova, V.W. Armstrong, and M. Oellerich, Clinical Chemistry 50:1 152159 (2004).

5. T.M. Annesley, L.T. Clayton, Clinical Chemistry 51:5 872877 (2005).

Acknowledgements

Applied Biosystems/MDS SCIEX acknowledges our collaborators, Jan Lembke and Uta Ceglarek of the Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Leipzig (Germany), Bruno Casetta of Applied Biosystems Monza (Milano- Italy), and Daniel Blake of Applied Biosystems, Warrington (UK) for providing the method, samples, and data for this application note.


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