In independent research, Texas Fertility Center physicians concluded that the progesterone vaginal ring is effective for luteal phase supplementation in IVF, regardless of the duration or cause of infertility.
Progesterone, a hormone naturally produced to nourish and prepare the uterine lining, has a critically important role in helping to sustain pregnancy. During the in vitro fertilization process, the cells that make progesterone are removed from the ovarian follicles along with the eggs. Fertility specialists must then prescribe progesterone to supplement the significantly reduced amount of progesterone produced by a woman’s ovaries after IVF egg retrieval.
Progesterone delivered vaginally now represents over 65 percent of all IVF-related progesterone usage in the US. The multi-center study that TFC participated in demonstrated – for the first time - that the new vaginal progesterone-secreting ring works as well as the leading vaginal gel.
Comparing the New Vaginal Ring to Gels and Injections
1. Vaginal progesterone gel: Less painful and easier to administer than injections, once or twice daily dosing, may be messy, and due to potential leakage, may not provide a full dose with every application.
2. Progesterone vaginal ring: The flexible silicone product, inserted into the vagina, contains a micronized progesterone formulated to allow for weekly dosing. Although it occasionally caused mild discomfort, it was generally well tolerated by study participants.
3. Progesterone injections: Administered once or twice daily. Very painful and potentially may cause injection site inflammation or infection. Serum prog
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