Navigation Links
University of Colorado Cancer Center Study Finds That Body's Ibuprofen, SPARC, Reduces Inflammation and Thus Bladder Cancer Development and Metastasis
Date:1/16/2013

AURORA, Colo. (PRWEB) January 16, 2013

Cancer researchers are increasingly aware that in addition to genetic mutations in a cancer itself, characteristics of the surrounding tissue can promote or suppress tumor growth. One of these important tissue characteristics is inflammation – most cancers prosper in and attach to inflamed tissue and so many cancers have developed ways to create it.

A University of Colorado Cancer Center study published today in the Journal of Clinical Investigation shows that the protein SPARC (Secreted Protein Acidic and Rich in Cysteine) acts much like an anti-inflammatory drug, attempting to heal tissues inflamed by tumors. Likewise, cancers – for example, bladder cancer in this study – have developed ways to turn off the production of SPARC, thus allowing growth and metastasis, especially to the lung where bladder cancer is frequently fatal.

"In fact, we show the effects of SPARC go beyond even this anti-inflammatory role. Additionally, the protein is involved in disallowing migrating cancer cells from attaching at possible metastasis sites and stopping the production of new blood vessels needed to feed tumor tissue," says Dan Theodorescu, MD, PhD, director of the University of Colorado Cancer Center and the study's senior author.

The study started by evaluating SPARC levels in human bladder cancer samples. In less aggressive cancers, both the tumor and the surrounding tissue made SPARC. In more aggressive cancers, it was just the surrounding tissue that made SPARC – the aggressive tumor itself had suppressed production of the protein. In these human bladder cancer tumors, more SPARC was associated with longer survival.

This distinction between SPARC made in the tumor and SPARC made in the surrounding tissue largely explains previous work that found high SPARC in aggressive tumors and so suggested a possible tumor-promoting role for the protein. Instead, it
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2

Related biology technology :

1. Rice University discovers that graphene oxide soaks up radioactive waste
2. Carin Grings remains identified by researchers at Uppsala University
3. Nanonex Delivered Advanced Nanoimprint Tool NX-B200 to Swinburne University of Technology, Australia
4. University of Pennsylvania Purchases Nanonex Advanced Nanoimprint Tool NX-2600 BA
5. Eqalix Enters Sponsored Research Agreement with Temple University
6. Bed Bugs Find Their Way to University of Washington and Hastings-on-Hudson Libraries; Bed Bug Control 911 Advises Use of Bed Bug Spray to Effectively Clear the Pests Away
7. University of College London Hospitals (UCLH) Selects GEO SCAN Medical as New Standard of Care for the Detection and Treatment of Prostate Cancer
8. iLab Solutions Core Facility Management Software Named a University Business Magazine 2012 Readers’ Choice Top Product
9. Ben-Gurion University awarded $6.5 million grant to develop nano thin infrared night vision glasses
10. IntelliCell BioSciences Announces Research Agreement with the New Jersey Center for Biomaterials at Rutgers-The State University of New Jersey
11. Moscow State University Hospital Selects Ekahau RTLS to Improve Operations and Patient Safety
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/14/2014)... Boston, MA (PRWEB) January 14, 2014 iLab ... Michelle Detwiler as the new Director of Product Strategy. In ... as well as iLab sub-teams to guide in the development ... that iLab provides the maximum possible benefit to the scientific ...
(Date:1/14/2014)... Rockville, MD (PRWEB) January 14, 2014 ... dedicated to developing innovative information technology solutions for ... other health care stakeholders, announced today the signing ... the US Food and Drug Administration (FDA). ...
(Date:1/14/2014)... 14, 2014 Kerr Corporation, a leading manufacturer ... additional how-to information about dual arch impressions on its dental ... Arch Impressions,” the blog entry serves up a list of ... a step-by-step demonstration by Dr. David Little as he crafts ...
(Date:1/14/2014)... Research Triangle Park, NC (PRWEB) January 14, 2014 ... diagnostic company focusing on ultra-sensitive POC diagnostic platforms and novel ... on their first round of financing netting a total of ... first outside equity capital in the company. This group of ...
Breaking Biology Technology:iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Global Record Systems Announces Research Collaboration Agreement with FDA to Create a Novel “Big Data” Paradigm for Collection of Patient Safety and Outcomes Information 2BioMedomics, Inc. Closes $690K Round of Financing 2
... ancient and proud history of interstate sports rivalries (especially ... this past New Years Day, the rivalry generates nasty ... marijuana have in common? They both get smoked in ... another interstate rivalry. This one is of keen interest ...
... -RedPrairie announced Wednesday it will support American Musical ... of supply chain execution solutions. AMS , ... a customer distribution network next year and develop ... and enterprise vision products. , ,AMS was ...
... a calm before the storm. The plans are set, the ... spent in quiet preparations by a group of outstanding companies ... producer of the event, I'm bound by the rules that ... at the conference on February 15. And as DEMO has ...
Cached Biology Technology:For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 2For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 3For Now, Michigan Can Celebrate $150 Million Entrepreneurial VC Fund 4The Calm Before the Storm: Hot New Firms and Technologies 2The Calm Before the Storm: Hot New Firms and Technologies 3
(Date:4/23/2014)... read quickly. It involves visual searching for clues ... sentences. Similarly to humans, biological systems are sometimes ... Genes that need to be read quickly are ... the easier it will be to read them ... (IGC, Portugal) and Centre for Molecular and Structural ...
(Date:4/22/2014)... team of Yale researchers will lead a five-year, $3 ... rain events is affecting the transport of dissolved organic ... they say could alter the chemical composition and water ... With funding from the National Science Foundation,s MacroSystems Biology ... across the watershed, which begins in Canada and runs ...
(Date:4/22/2014)... Consortium Ltd.,s nanotechnology expert will present a poster ... at the 7th International Nanotoxicology Congress to ... , Dr. Monita Sharma will outline a strategy consistent ... of Sciences, " Toxicity Testing in the 21st Century: ... of non-animal methods involving human cells and cell lines ...
Breaking Biology News(10 mins):Cell division speed influences gene architecture 2Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3
... SPRING HARBOR, N.Y. A new book, ... CSHL,s mix of historic and modern buildings and the striking ... preservationist and tree enthusiast Elizabeth L. Watson, who, together with ... in various homes on the picturesque grounds of CSHL for ...
... ARGONNE, Ill. (June 9, 2008) The Institute for Genomics ... Department of Energy,s (DOE) Argonne National Laboratory and the University ... enhanced ability to sequence genomes more quickly and broadly. ... by searching only on the fairway, but not the rough," ...
... HARBOR, N.Y. The appointment of James Watson ... set off an explosive development of research at Cold ... wisely teams of investigators with diverse scientific interests. ... by the scientists involved tell the stories of research ...
Cached Biology News:Argonne-University of Chicago joint venture bolsters genomic sequencing capabilities 2Watson-inspired innovation in research at Cold Spring Harbor Laboratory 2
... Yeast ProtoArray high-density functional protein microarray is ... elucidation of proteinprotein interactions on a proteome ... cerevisiae open reading frames (ORFs) expressed as ... on a 1 inch x 3 inch ...
... is a compact, versatile system that simultaneously ... or 24-well microplates into a solid filter ... scintillation and gamma counter. The FilterMate is ... applications such as cell proliferation, receptor binding, ...
... Corning single use spatulas have been designed ... They are for those interested in eliminating ... spatulas. Each spatula is individually packaged, RNase/DNase ... number is a new product number, created ...
... Competitor Assay Kits are ideal for ... binding compounds using fluorescence polarization (FP) ... of glutathione transferase to the ligand ... [PR-LBD(GST)] and a proprietary, fluorescently-tagged progesterone ...
Biology Products: