Navigation Links
University of Colorado Cancer Center Review Shows Long-term Side-effects of New, Targeted Therapies in Pediatric Cancer Patients
Date:2/7/2013

Aurora, COLO (PRWEB) February 07, 2013

A University of Colorado Cancer Center review published this week in the journal Lancet Oncology describes possible long-term side-effects of new, targeted therapies in pediatric cancer patients: what we don’t know may hurt us.

“As pediatricians who treat kids with cancer, we expect the side-effects of traditional chemotherapies: low white blood count, infections, even long-term heart trouble or infertility. But there’s the impression that these new, molecularly targeted agents are much less toxic. That may be true, especially in adult patients, but until we have more information about the long-term effects of these therapies in children, we need to be careful about how and when we prescribe them,” says Chris Porter, MD, CU Cancer Center investigator and assistant professor of Pediatrics at the University of Colorado School of Medicine.

Already we know that molecularly targeted therapies may stunt the growth of pediatric patients, delay puberty or speed the onset of diabetes. And researchers are just now starting to ask about additional, sometimes unforeseen side-effects, potentially including more subtle issues such as neurocognitive, balance and motor defects.

“The growth of cancer cells isn’t that different than the growth of a 7-pound baby into a 210-pound teenage linebacker. Now, you shut down these growth pathways in an adult and it might not be a big deal, but you shut down these same pathways at a critical time in childhood development and you can have real problems,” says Lia Gore, MD, CU Cancer Center investigator and associate professor of Pediatrics and Medical Oncology at the CU School of Medicine.

The practical problem is this: FDA approval of many of these drugs for adult use allows physicians to prescribe the same drugs for pediatric use. Many are pills – orally administered, outpatient treatments that make it difficult to recognize and track p
'/>"/>

Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Page: 1 2

Related biology technology :

1. Elsevier and Kanazawa University in Japan Collaborate to Map Universitys Research Performance
2. Two University of Colorado Cancer Center Studies Show that Silibinin, Found in Milk Thistle, Protects Against UV-Induced Skin Cancer
3. WaferGens MyDesign Open Platform Facilitates Rapid Development of a Proprietary Prostate Cancer Diagnostic Panel in the Lab of Dr. Arul Chinnaiyan at the University of Michigan Cancer Center
4. NextBio Teams With Emory University and the Aflac Cancer Center to Improve Outcomes for Children with Medulloblastoma
5. Notre Dame to be part of $194 million university research center network
6. University of Minnesota awarded $28 million grant to lead microelectronics development
7. Krishagni Enables University of New South Wales (Australia) to Adopt caTissue Plus
8. University of Colorado Cancer Center Study Finds That Body's Ibuprofen, SPARC, Reduces Inflammation and Thus Bladder Cancer Development and Metastasis
9. Rice University discovers that graphene oxide soaks up radioactive waste
10. Carin Grings remains identified by researchers at Uppsala University
11. Nanonex Delivered Advanced Nanoimprint Tool NX-B200 to Swinburne University of Technology, Australia
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... , ... July 03, 2015 , ... Cuvettes have been used in countless labs for ... to find the cuvette they needed. As expected, this was a daunting and tiring ... wrong part because they were not able to navigate the complex catalog structure. , Now ...
(Date:7/2/2015)... ... 2015 , ... Sleepless nights will become obsolete as Luzi , a ... campaign on June 23. Sound sleepers and the sleep deprived both will love Luzi ... while the integration of the Bluetooth speaker, alarm clock and ability to charge various ...
(Date:7/1/2015)... , July 1, 2015   Decision Resources ... cited advantages of Otezla are its oral administration, ... as reported by surveyed rheumatologists. Otezla was the ... the treatment of active psoriatic arthritis in ... standard of care includes conventional oral treatments including ...
(Date:7/1/2015)... HAMILTON, Bermuda , July 1, 2015 /PRNewswire/ ... biopharmaceutical company focused on the treatment of dementia, ... investor briefing on July 22 at 5:45 p.m. ... at the Alzheimer,s Association International Conference 2015 (AAIC). ... following remarks: , Dr. Lawrence ...
Breaking Biology Technology:New Cuvette E-Commerce Website Launched by FireflySci 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 2Luzi Smart Lamp Recently Launched Indiegogo Campaign 3Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 2Surveyed Rheumatologists Report That Otezla's Oral Administration is its Single Greatest Advantage Over Currently Available Treatment Options 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3
... ... premixed formulation, DEERFIELD, Ill., ... U.S. Food and Drug Administration (FDA) has approved a,new premixed ... Discovered and developed by Astellas,Vaprisol, an arginine vasopressin (AVP) receptor ...
... Halozyme Therapeutics,Inc. (Nasdaq: HALO ), a biopharmaceutical company ... it will present at three upcoming investor conferences:, ... Hyatt Regency in La,Jolla, Calif. on Monday, October 27, ... -- Oppenheimer,s 19th Annual Healthcare Conference to be held ...
... Pharmaceuticals,Inc. (Nasdaq: ARNA ) announced today that the ... on October 28, 2008 at 2:00 p.m.,Pacific Time (5:00 ... La,Jolla, California. Jack Lief, Arena,s President and Chief Executive,Officer, ... including its,clinical development and discovery programs., A live ...
Cached Biology Technology:FDA Approves Astellas' Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia 2FDA Approves Astellas' Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia 3FDA Approves Astellas' Vaprisol(R) (Conivaptan Hydrochloride Injection) Premixed in 5% Dextrose for the Treatment of Hyponatremia 4Halozyme Therapeutics to Present at Upcoming Investor Conferences 2Arena Pharmaceuticals to Present at the BIOCOM Investor Conference 2Arena Pharmaceuticals to Present at the BIOCOM Investor Conference 3
(Date:6/23/2015)... RALEIGH, N.C. , June 23, 2015 /PRNewswire/ ... technology, today announced the results of a recent ... unmatched accuracy on the wrist during activity. In ... biometric technology was compared along with the Apple ... for accurately measuring heart rate during activity. The ...
(Date:6/18/2015)... OXFORD, Conn. , June 18, 2015 NXT-ID, ... biometric authentication company focused on the growing mobile commerce market ... of a featured segment on "Money on the Mark", scheduled ... York City June 20 th . ... interview will be from 7:00 to 8:00pm EST. NXT-ID, Inc.,s ...
(Date:6/17/2015)... 2015  Synaptics Inc. (NASDAQ: SYNA ), ... that Xiaomi, one of the world,s largest mobile ... ® family of capacitive touchscreen solutions and ... for its latest smartphones, the Xiaomi Mi Note ... in-cell display solutions and DDICs in discrete display ...
Breaking Biology News(10 mins):Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 2Valencell Delivers Breakthrough Heart Rate Accuracy on the Wrist 3NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 2Synaptics Touchscreen and Display Driver IC Solutions Power Xiaomi's Latest Flagship Smartphones 3
... that broadens our understanding of time perception in the ... the bumble bee, can estimate the duration of time ... of behavior, the more sophisticated ability to estimate the ... only in humans and other vertebrates. , The ...
... of Florida scientists have delivered a gene through an eggshell ... blind. , The finding, reported Tuesday (May 23) in the ... a similar treatment can be developed for an incurable form ... to the photoreceptor cells in the retinas of an avian ...
... at UT Southwestern Medical Center have identified a group ... in the embryonic stages of development, a discovery that ... , "We engineered a fruit fly so that the ... new type of malformation, completely unexpectedly," said Dr. Eric ...
Cached Biology News:UF scientists restore sight to chickens with blinding disease 2UF scientists restore sight to chickens with blinding disease 3UT Southwestern researchers find gene mutation that leads to 'broken hearts' 2
... The Rapid-Screen cDNA Library Panels were designed ... three sets of PCRs to identify the ... is performed in a 96-well "Master Plate," ... 5,000 clones. Having identified the positive well(s) ...
... Kit, designed for use with Ciphergens ... of amyloid peptides more straightforward and ... neuroscience proteomics applications - Monitor beta-amyloid ... beta-amyloid peptide levels with disease progression ...
... new Finnigan Pocket Surveyor software provides ... existing Finnigan Surveyor HPLC Systems. The ... running the popular Windows Pocket PC ... ability to connect directly to their ...
Reported to support murine B lymphocytes, hematopoietic tissue from bone marrow, B cells stimulated with lipopolysaccharide, T lymphocytes, and a variety of hybrid cells....
Biology Products: