Navigation Links
UCLA researchers further refine 'NanoVelcro' device to grab single cancer cells from blood
Date:2/25/2013

f the cancer type and the various genetic characteristics of a patient's specific cancer.

Improving the NanoVelcro device

Tseng's team now reports that they have improved the NanoVelcro chip by replacing its original non-transparent silicon nanowire substrate inside with a new type of transparent polymer nanofiber-deposited substrate, allowing the device's nanowires to better "grab" cancer cells as blood passes by them.

Tseng and his colleagues were able to pick single CTCs immobilized on the new transparent substrate by using a miniaturized laser beam knife, a technique called laser micro-dissection, or LMD.

The researchers' paper on their improvement to the chip was published online Feb. 22 in the peer-reviewed journal Angewandte Chemie and is featured on the cover of the journal's March 2013 print issue.

"This paper summarizes a major milestone in the continuous development of NanoVelcro assays pioneered by our research group," Tseng said. "We now can not only capture cancer cells from blood with high efficiency but also hand-pick single CTCs for in-depth characterization to provide crucial information that helps doctors make better decisions."

Testing the improvements on melanoma

Using the new assay on patients' blood containing circulating melanoma cells (CMCs), Tseng's team was able to isolate and preserve single CMCs. Melanoma is a deadly type of skin cancer that is prone to spreading quickly throughout the body. The ability to capture and preserve single CMCs allows doctors to analyze melanoma cells' DNA structure, determine the genetic characteristics of the patient's cancer and confirm that the circulating cells remain genetically similar to the tumor they came from.

The preservation of single captured CMCs in this proof-of-concept study also allowed researchers to conduct an analysis called single-cell genotyping to find within the cell a specifi
'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Penn researchers develop protein passport that help nanoparticles get past immune system
2. Researchers nanoweld by applying light to aligned nanorods in solid materials
3. Researchers create semiconductor nano-shish-kebabs with potential for 3-D technologies
4. Researchers invent acoustic-assisted magnetic information storage
5. INRS researchers at the Global Young Academy
6. SPIE Photonics West is Still ‘the Place to Meet’ for Researchers, Developers, and Suppliers of Ubiquitous Technology
7. Researchers create building block of quanutm networks
8. Boston College researchers unique nanostructure produces novel plasmonic halos
9. EMBL-EBI researchers make DNA storage a reality
10. Researchers create method for more sensitive electrochemical sensors
11. Sustainable Valley Technology Group Provides Technology Innovation Grant To Help Researchers & Start-Ups With Funding, Business Support, Equipment & Facilities
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... MA (PRWEB) December 18, 2014 Reports ... in the United States suffer from one or more ... asthma, or cancer. Medication can address some of these ... daily activities that many sufferers face. While implanted nerve ... and stimulate the whole nerve, which can induce side ...
(Date:12/19/2014)... With only 2 weeks left of ... Sartorius Biohit products . The product specials include Buy ... Pipette Trade-in Program, and free pipette tips. , Sartorius ... the world. They are ideal for lab technicians performing ... ,     Full volume range of 0.1 uL to ...
(Date:12/19/2014)... , Dec. 18, 2014 Relmada Therapeutics, Inc. ... the treatment of chronic pain, announced the results of ... "This was a transformational year in Relmada,s history ... for our company," said Sergio Traversa , chief ... have executed on key financial, human resource and clinical ...
(Date:12/17/2014)... 2014 Achim Noack has been named ... Group. In this position, Noack will assist Jerry Stoller, ... develop marketing strategy and supervise global marketing management and ... has tremendous knowledge and experience in the crop protection ... experience and innovative thinking will be a great asset ...
Breaking Biology Technology:Draper Wins GSK Funding for Smaller, Smarter Implantable Devices 2Major Pipette Distributor Pipette.com Announces Sartorius Year End Specials 2Relmada Therapeutics Announces Results of Annual Shareholders Meeting 2Achim Noack Joins Stoller Group as Global Vice President of Marketing and Administration 2
... , , , , , , , ... 4308 915.021 11/1999 , , , , , , ... Cell line , NIH 3T3, mouse embryo, ... Plasmid pEGFP-N1 (in bidistilled H 2 O), , , ...
... Multiporator / Electroporator 2510 , , , , , , , ... Protocol No. 4308 915.522 03/2002 , , ... , , Microorganism , ... Cell type , Bacteria, gram positive, , ...
... Electroporator 2510 , , , , , , , , ... Protocol No. 4308 915.523 03/2002 , , , , ... , Microorganism , Mycobacterium avium, ... Bacteria, gram positive, , , ...
Cached Biology Technology:NIH 3T3 2Mycobacterium smegmatis 2Mycobacterium avium 2
(Date:12/17/2014)... Va. , Dec. 15, 2014 ... to make it easier to detect and prevent ... Today the agency started performing an ... capability will validate the authenticity of purchased microcircuits ... The new quality control measures will be conducted ...
(Date:12/17/2014)... -- Automation is fundamentally transforming the travel experience and ... borders. Over the past decade, ePassports, biometric readers, ... to self process through border control via eGates ... increasing number of airports, seaports, and land borders ... Maxine Most , Principal at Acuity Market ...
(Date:12/11/2014)... , Dec. 10, 2014  That blood pressure plays ... a while. Hypertension – the medical term for high blood ... early 1800s, and the inflatable cuff that,s used in measuring ... however, mean there,s nothing new about hypertension, its triggers and ... beliefs about the condition and the best ways to treat ...
Breaking Biology News(10 mins):Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 2Defense Logistics Agency Launches DNA Marking Capability to Strengthen Microcircuit Supply Chain 3Automated Border Control (ABC) Transforms the Global Travel Experience With More Than 2500 ABC eGates and APC Kiosks Deployed In Airports, Seaports, and Land Borders Worldwide 2Research points to need for new approaches to treatment of high blood pressure 2Research points to need for new approaches to treatment of high blood pressure 3Research points to need for new approaches to treatment of high blood pressure 4
... fish hatched at Michigan State University has a new look. A ... a number of improvements on the fish, including the ability to ... The fish now has the ability to glide through the water ... that can aid in the cleaning of our lakes and rivers. ...
... NEW YORK January 16, 2013 EcoHealth Alliance, a ... issues, released new research on Ebola virus in fruit bats ... a monthly publication by the Centers for Disease Control and ... in 4% of the 276 bats scientists screened in Bangladesh. ...
... start at the launch pad or even in orbit. They ... instruments that promise to expand our view and understanding of ... lay the groundwork for the Aerosol-Cloud-Ecosystem (ACE) mission, a satellite ... to learn about clouds and aerosols," said ACE science lead ...
Cached Biology News:New robotic fish glides indefinitely 2Recent study suggests bats are reservoir for ebola virus in Bangladesh 2PODEX experiment to reshape future of atmospheric science 2PODEX experiment to reshape future of atmospheric science 3PODEX experiment to reshape future of atmospheric science 4PODEX experiment to reshape future of atmospheric science 5
5X StabilCoat Immunoassay Stabilizer is a 5X concentrate solution of StabilCoat Immunoassay Stabilizer. The shelf-life of 5X StabilCoat Immunoassay Stabilizer is 2 years when stored at 4C. Product ...
... A three-color reagent kit for determining the ... peripheral blood samples, mobilized peripheral blood samples, ... provide a total nucleated cell count and ... kit is designed for use in the ...
... Mouse monoclonal [RET-P1] to Rhodopsin Rhodopsin ... pigment in mammals, birds, amphibians, and reptiles. ... photoreceptor cells in the retina. ... retina. Specificity: This antibody ...
... a trademark of Merck KGaA. Physical form: Solution in ... 2 mM MgCl 2 , and 20 mM NaCl ... sperm DNA to acid-soluble oligonucleotides equivalent to a ΔA ... 8.0 at 37 C (reaction volume 2.625 ml). Assay: ...
Biology Products: