This release is available in German.
Many scientists are working feverishly to develop reliable but simple methods for the production of tiny particles with defined size and shape that are covered with special regular patterns in two or three dimensions and at both the nano- and the microscale. These miniature objects have countless applications in modern technology, from diagnostic systems to the generation of artificial tissues to improved data storage. A team headed by Edwin L. Thomas and Patrick S. Doyle at MIT in Cambridge, Massachusetts (USA) has now developed a new method for the large-scale synthesis of three-dimensionally patterned polymer particles with morphological characteristics in the submicrometer range. As described in the journal Angewandte Chemie, with the use of stop-flow interference lithography, the team has even been able to produce Janus particles, microparticles with two chemically different hemispheres.
Our new method is a combination of phase mask interference lithography and mirofluidic flow lithography, unifying the strengths of these two methods, explain the researchers. Liquid precursors of a polymer whose formation is induced by light are introduced into a microfluidic system (a system of channels that are just a few micrometers wide). The bottom portion of the device is a phase mask with a periodic surface structure. This arrangement is irradiated through a transparency mask that defines the shape of the resulting particles. In a test sample these were triangles with sides of 60 m. Once the parallel light rays pass through the strictly periodic surface structure of the phase mask, the result is a complex three-dimensional distribution of light intensity within the liquid (interference). In regions of high intensity, the polymer precursors are cross-linked to form three-dimensional structures in a solid hydrogel. In this way, the rese
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