Navigation Links
Two-faced miniatures
Date:11/15/2007

This release is available in German.

Many scientists are working feverishly to develop reliable but simple methods for the production of tiny particles with defined size and shape that are covered with special regular patterns in two or three dimensions and at both the nano- and the microscale. These miniature objects have countless applications in modern technology, from diagnostic systems to the generation of artificial tissues to improved data storage. A team headed by Edwin L. Thomas and Patrick S. Doyle at MIT in Cambridge, Massachusetts (USA) has now developed a new method for the large-scale synthesis of three-dimensionally patterned polymer particles with morphological characteristics in the submicrometer range. As described in the journal Angewandte Chemie, with the use of stop-flow interference lithography, the team has even been able to produce Janus particles, microparticles with two chemically different hemispheres.

Our new method is a combination of phase mask interference lithography and mirofluidic flow lithography, unifying the strengths of these two methods, explain the researchers. Liquid precursors of a polymer whose formation is induced by light are introduced into a microfluidic system (a system of channels that are just a few micrometers wide). The bottom portion of the device is a phase mask with a periodic surface structure. This arrangement is irradiated through a transparency mask that defines the shape of the resulting particles. In a test sample these were triangles with sides of 60 m. Once the parallel light rays pass through the strictly periodic surface structure of the phase mask, the result is a complex three-dimensional distribution of light intensity within the liquid (interference). In regions of high intensity, the polymer precursors are cross-linked to form three-dimensional structures in a solid hydrogel. In this way, the researchers were able to give the triangular particles a knobby, lattice-like structure.

Because this method works continuously, it can attain a very high throughput: Liquid flows in and polymerizes to form particles that are immediately rinsed away when the next portion of liquid followsall in less than a second. In contrast to other techniques, the liquid does not need to be deposited in an even layer on a support and developed stepwise.

In addition, within a microchannel, it is possible to allow two different liquids to flow side by side without mixing. If the transparency mask is adjusted so that the light irradiates a region around the boundary between the two liquids, the process results in Janus particles with two chemically different hemispheres.


'/>"/>

Contact: Edwin L. Thomas
elt@mit.edu
617-253-6901
Wiley-Blackwell
Source:Eurekalert

Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2016)... , June 23, 2016  Blueprint Bio, a company ... to the medical community, has closed its Series A ... Nunez . "We have received a commitment ... capital we need to meet our current goals," stated ... us the runway to complete validation on the current ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
(Date:6/23/2016)... , June 22, 2016  Amgen (NASDAQ: ... of the QB3@953 life sciences incubator to ... health. The shared laboratory space at QB3@953 was created ... a key obstacle for many early stage organizations - ... of the sponsorship, Amgen launched two "Amgen Golden Ticket" ...
(Date:6/22/2016)... 22, 2016 Research and Markets has announced ... report to their offering. ... from $29.3 billion in 2013. The market is expected to grow ... 2015 to 2020, increasing from $50.6 billion in 2015 to $96.6 ... during the forecast period (2015 to 2020) are discussed. As well, ...
Breaking Biology Technology:
(Date:5/20/2016)... , May 20, 2016  VoiceIt is ... partnership with VoicePass. By working together, ... experience.  Because VoiceIt and VoicePass take slightly different ... engines increases both security and usability. ... excitement about this new partnership. "This ...
(Date:5/12/2016)... 2016 WearablesResearch.com , a brand of ... results from the Q1 wave of its quarterly wearables ... consumers, receptivity to a program where they would receive ... insurance company. "We were surprised to see ... Michael LaColla , CEO of Troubadour Research, "primarily because ...
(Date:5/3/2016)...  Neurotechnology, a provider of high-precision biometric identification ... Identification System (ABIS) , a complete system for ... can process multiple complex biometric transactions with high ... face or iris biometrics. It leverages the core ... MegaMatcher Accelerator , which have been used in ...
Breaking Biology News(10 mins):