Navigation Links
Transplanted brain cells in monkeys light up personalized therapy
Date:3/14/2013

MADISON For the first time, scientists have transplanted neural cells derived from a monkey's skin into its brain and watched the cells develop into several types of mature brain cells, according to the authors of a new study in Cell Reports. After six months, the cells looked entirely normal, and were only detectable because they initially were tagged with a fluorescent protein.

Because the cells were derived from adult cells in each monkey's skin, the experiment is a proof-of-principle for the concept of personalized medicine, where treatments are designed for each individual.

And since the skin cells were not "foreign" tissue, there were no signs of immune rejection potentially a major problem with cell transplants. "When you look at the brain, you cannot tell that it is a graft," says senior author Su-Chun Zhang, a professor of neuroscience at the University of Wisconsin-Madison. "Structurally the host brain looks like a normal brain; the graft can only be seen under the fluorescent microscope."

Marina Emborg, an associate professor of medical physics at UW-Madison and the lead co-author of the study, says, "This is the first time I saw, in a nonhuman primate, that the transplanted cells were so well integrated, with such a minimal reaction. And after six months, to see no scar, that was the best part."

The cells were implanted in the monkeys "using a state-of-the-art surgical procedure" guided by an MRI image, says Emborg. The three rhesus monkeys used in the study at the Wisconsin National Primate Research Center had a lesion in a brain region that causes the movement disorder Parkinson's disease, which afflicts up to 1 million Americans. Parkinson's is caused by the death of a small number of neurons that make dopamine, a signaling chemical used in the brain.

The transplanted cells came from induced pluripotent stem cells (iPS cells), which can, like embryonic stem cells, develop into virtually a
'/>"/>

Contact: Su-Chun Zhang
szhang4@wisc.edu
608-265-2543
University of Wisconsin-Madison
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Stem Cells Show Promise in Extending Transplanted Kidneys’ Survival Time
2. Magnet helps target transplanted iron-loaded cells to key areas of heart
3. NSBRI Funds Cerebrotech to Accelerate Development of Brain Monitoring Device
4. Study: Brain Imaging After Mild Head Injury/Concussion Can Show Lesions
5. Enhanced brain acetate metabolism may reward heavy drinkers
6. Ectopic eyes function without connection to brain
7. Blueprint for an artificial brain
8. Amarantus BioScience and Banyan Biomarkers to Present Poster of MANF Data at The 3rd Annual Traumatic Brain Injury Conference
9. Brain Research Foundation 2013 Scientific Innovations Awards To Dr. Jean Hebert and Dr. Brian Litt
10. Society for Brain Mapping and Therapeutics endorse President Obamas support for Human Brain Mapping research; nominating him for prestigious Pioneer in Healthcare Policy Award
11. Fighting disease deep inside the brain
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/21/2014)... tension to a chain of carbon atoms can turn ... to Rice University scientists. , Stretching the material known ... atoms -- by just 3 percent can begin to ... useful for mechanically activated nanoscale electronics and optics. , ... his colleagues appears in the American Chemical Society journal ...
(Date:7/21/2014)... Sleep disturbances such as insomnia, hypersomnia, ... depression. According to a study published by the ... of depressed patients have insomnia symptoms, and hypersomnia ... adults and 10% of older patients, with a ... have a major impact on quality of life, ...
(Date:7/18/2014)... Mich. , July 18, 2014  Neogen Corporation ... Stephen Snyder , Neogen,s chief operating officer and president, ... he will work as a consultant going forward on ... Snyder has been in this position since September ... fulfilled by James Herbert , who has been ...
(Date:7/18/2014)... Hungary & Cambridge, MA (PRWEB) July 18, 2014 ... , headquartered in Budapest with US offices in ... HLA™ - a combination Assay and Software product ... (NGS), for use on the Illumina® MiSeq sequencing ... through collaboration with The Children’s Hospital of Philadelphia ...
Breaking Biology Technology:Carbyne morphs when stretched 2Carbyne morphs when stretched 3Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 2Open Label Data on Enhanced Sleep Released by JayMac Pharmaceuticals, LLC 3Omixon Launches Holotype HLA for NGS-based HLA Genotyping 2Omixon Launches Holotype HLA for NGS-based HLA Genotyping 3
... on Growth Opportunities, NEW YORK, May 30 ... and CEO Charles O. Holliday, Jr., said the,company ... macro trends related to food, safety and security, ... company," Holliday said at the,Sanford Bernstein Strategic Decisions ...
... (Nasdaq:,PCOP), an innovator in the discovery and development ... is implementing the next,step in its ongoing effort ... later-stage discovery programs. This effort includes an immediate,workforce ... of positions as well as a decrease in ...
... 2b Clinical Trial Sites in ... ... today announced that PTC124, the company,s orally delivered,investigational new drug for the ... at Myology 2008, the Third,Annual Congress of Myology, on Friday, May 30 ...
Cached Biology Technology:DuPont Well Positioned for Long-Term Growth in Agricultural Productivity, Safety and Security, Renewable Energy 2DuPont Well Positioned for Long-Term Growth in Agricultural Productivity, Safety and Security, Renewable Energy 3Pharmacopeia Advances Strategic Plan to Focus Resources on Development and Later-Stage Discovery Programs 2Pharmacopeia Advances Strategic Plan to Focus Resources on Development and Later-Stage Discovery Programs 3Pharmacopeia Advances Strategic Plan to Focus Resources on Development and Later-Stage Discovery Programs 4PTC124 Featured at Third Annual Congress of Myology 2PTC124 Featured at Third Annual Congress of Myology 3PTC124 Featured at Third Annual Congress of Myology 4
(Date:7/21/2014)... a professor of entomology and cooperating faculty ... the University of California, Riverside, has been awarded the ... of Chemical Ecology ( ISCE ). , Awarded first ... the society,s highest honor. It is awarded annually to ... the study of chemicals that mediate interactions between living ...
(Date:7/21/2014)... BLOOMINGTON, Ind. -- Want to conserve water and save ... Indiana University researcher and published in the current issue ... "The Water Short List: The Most Effective Actions U.S. ... households can reduce water use substantially by simple actions ... habits involving water consumption. While the suggestions may be ...
(Date:7/21/2014)... and cheating in science are among the topics ... mycology experts in Montreal at the three International ... 27 to August 1, 2014. Some 2,000 participants ... the 14th International Congress of Bacteriology and Applied ... Eukaryotic Microbiology, and the 16th International Congress of ...
Breaking Biology News(10 mins):UC Riverside entomologist receives international honor for chemical ecology contributions 2Researchers provide guide to household water conservation 2Researchers provide guide to household water conservation 3Montreal hosts International Union of Microbiology Societies congresses 2
... The mating habits of marine turtle may help to ... new research led by the University of Exeter. Published today ... Royal Society B , the study shows how the mating ... helping them deal with the fact that global warming is ...
... the world,s orchids, not all forests are equal. In a ... Molecular Ecology , Smithsonian ecologists revealed that an orchid,s fate ... Roughly 10 percent of all plant species are orchids, ... loss has rendered many threatened or endangered. This is partly ...
... whale species commands global attention as a result of ... fate of smaller marine mammals is less understood, specifically ... dolphins, porpoises, manatees, and other warm-blooded aquatic species are ... on the issue, researchers from the Wildlife Conservation Society ...
Cached Biology News:Turtles' mating habits protect against effects of climate change 2Fungi-filled forests are critical for endangered orchids 2Marine mammals on the menu in many parts of world 2Marine mammals on the menu in many parts of world 3
Ultra Pure Grade. Used in conjunction with IPTG to identify bacterial colonies that contain recombinant plasmids by blue/white selection. X-Gal forms an intense blue precipitate in the presence of be...
Request Info...
4-Hydroxy-3-nitrophenylacetyl hapten is conjugated to SSA (Sheep serum albumin) lysine through amide bonds. This product is homologous to NP-BSA....
Human Aminopeptidase P2/XPNPEP2 Affinity Purified PAb ENTREZ GeneID: 7512...
Biology Products: