Navigation Links
Transition in cell type parallels treatment response, disease progression in breast cancer
Date:1/31/2013

A process that normally occurs in developing embryos the changing of one basic cell type into another has also been suspected of playing a role in cancer metastasis. Now a study from Massachusetts General Hospital (MGH) Cancer Center researchers has associated this process, called epithelial-mesenchymal transition or EMT, with disease progression and treatment response in breast cancer patients. The report also identifies underlying mechanisms that someday may become therapeutic targets.

"Until now, EMT had only been modeled in experimental systems, but its clinical relevance was uncertain. Now we show that it can be detected in samples from breast cancer patients and that the tumor cells oscillate between these two states" says Shyamala Maheswaran, PhD, of the MGH Cancer Center, co-corresponding author of the report in the Feb. 1 issue of Science. "We find that the EMT state of breast cancer cells evolves in response to therapy and to disease recurrence, pointing to involvement of this mechanism in tumor spread and invasiveness."

Epithelial tissues line most bodily surfaces and cavities, and epithelial cells closely adhere to each other. During development, some epithelial cells develop traits of mesenchymal cells, including the ability to migrate to other parts of the embryo, establish themselves and develop into organs or other types of tissue. Several studies have suggested that a transition from epithelial to mesenchymal cell type is also involved with cancer metastasis, which involves tumor cells' migration to and invasion of other sites in the body, but identifying EMT stages of tissues has been challenging.

The MGH investigators developed a new assay that determines EMT stage by screening tumor samples for seven epithelial markers and three mesenchymal markers. In primary tumor samples from several breast cancer patients including samples of estrogen-receptor/progesterone-receptor-positive, HER2-positive
'/>"/>

Contact: Katie Marquedant
kmarquedant@partners.org
617-726-0337
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. Topological transitions in metamaterials
2. Study Shows Transition to Practice Programs Get Nurses Employed
3. Innosight Announces Leadership Transition
4. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
5. Roche Signs Agreement with PTC Therapeutics to Advance Treatment for Spinal Muscular Atrophy (SMA)
6. Nutra Pharma Announces Publication of a New Mechanism Study of Alpha-Cobratoxin in the Treatment of Pain
7. Emerging Lymphoma and Myeloma Treatments Focus on Improving Individual Patient Response
8. Intravenous Remodulin Approved for the Treatment of Pulmonary Arterial Hypertension in Most of the European Union
9. Baxter Initiates Phase I Clinical Trial of Longer-acting Recombinant FVIII Treatment for Hemophilia A
10. SFJ Pharma Ltd. II, Announces Agreement With Pfizer to Develop Axitinib for Adjuvant Treatment of Renal Cell Carcinoma
11. MarketsandMarkets: Global Seed Treatment Market worth $3430.3 Million by 2016
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/31/2014)... 30, 2014 Two separate delegations ... hosted by Charm Sciences at its Andover, Massachusetts ... in the US, the participants discussed international systems ... management, and process verification, and received hands-on technical ... was the first visit to the United States ...
(Date:10/31/2014)... 2014 This is a professional ... Biocides industry. The report provides basic biocides information, ... structure as well as industry overview. This research ... market as well as Global industry analysis covering ... on the Chinese biocides industry covers ...
(Date:10/31/2014)... ENVIRON , an international environmental, ... Dr. Harvey Clewell III has rejoined the firm ... with senior professionals in ENVIRON’s Health Sciences practice. ... The Hamner Institutes for Health Sciences (The Hamner) ... is Director, Center for Human Health Assessment. , ...
(Date:10/31/2014)... 31, 2014  Atlanta-based Intellimedix could make a ... onset of Ebola by suggesting a new, computational ... Tech,s Center for Computational Systems Biology have spent ... alternative uses for existing drugs through systematic repurposing, ... the bout against Ebola. Logo ...
Breaking Biology Technology:Charm Sciences Hosts Executives from Latin America for Dairy Safety Executive Seminar 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 2Biocides Market for International & Chinese Regional Development Analysis Now Available at DeepResearchReports.com 3Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 2Internationally recognized health scientist Dr. Harvey Clewell renews association with ENVIRON 3Atlanta-Based Intellimedix May Help Solve Ebola With Computer Algorithms 2
... 1, 2012   Reportlinker.com announces that a ... its catalogue: Cell ... http://www.reportlinker.com/p0203537/Cell-Therapy---Technologies-Markets-and-Companies.html#utm_source=prnewswire&utm_medium=pr&utm_campaign=Biological_Therapy This ... and methods, which have already started to ...
... Force Research Laboratory in Dayton, Ohio, has experimentally confirmed ... foretold a pair of interesting properties about nanotube growth: ... of its growth, and that armchair nanotubes should grow ... toward defining all the mysteries inherent in what Yakobson ...
... , Graphene leaves a rather modest impression at a ... ordered in a mono-layered "carpet". Yet, what makes graphene ... This property is particularly useful in the development of ... and transform it into electrical signals. Graphene,s ...
Cached Biology Technology:Cell Therapy - Technologies, Markets and Companies 2Cell Therapy - Technologies, Markets and Companies 3Cell Therapy - Technologies, Markets and Companies 4Cell Therapy - Technologies, Markets and Companies 5Cell Therapy - Technologies, Markets and Companies 6Cell Therapy - Technologies, Markets and Companies 7Cell Therapy - Technologies, Markets and Companies 8Cell Therapy - Technologies, Markets and Companies 9Cell Therapy - Technologies, Markets and Companies 10Cell Therapy - Technologies, Markets and Companies 11Cell Therapy - Technologies, Markets and Companies 12Cell Therapy - Technologies, Markets and Companies 13Cell Therapy - Technologies, Markets and Companies 14Cell Therapy - Technologies, Markets and Companies 15Cell Therapy - Technologies, Markets and Companies 16Rice professor's nanotube theory confirmed 2Rice professor's nanotube theory confirmed 3Ultra-fast photodetector and terahertz generator 2
(Date:10/29/2014)... compete with members of their own species. However, ... into their competitive ability. Some individuals are highly ... resources, while others seem to avoid competition, instead ... are left over for them. Moreover, the degree ... to fluctuate considerably over time. A theoretical study ...
(Date:10/29/2014)... A new study on a large cohort of kidney ... architecture of the disease -- and reveals an apparent ... kidney cancer, particularly in Romania. , The research, by ... University and Genome Quebec Innovation Centre in Montreal, underscores ... aristolochic acid. The compound, found in plants of the ...
(Date:10/28/2014)... North America, Europe and China have published a paper ... Sciences that reveals important details about key transitions ... From strange and exotic algae, mosses, ferns, trees and ... and vegetables we eat and the ornamental plants adorning ... a billion years of history., "Our study generated DNA ...
Breaking Biology News(10 mins):Evolution of competitiveness 2Evolution of competitiveness 3Study sheds light on genetic architecture of kidney cancer 2Study sheds light on genetic architecture of kidney cancer 3New study uses DNA sequences to look back in time at key events in plant evolution 2New study uses DNA sequences to look back in time at key events in plant evolution 3
... Two nurses have won recognition as emerging leaders in ... for Nursing Informatics (ANI) to participate in a jointly ... based on a number of criteria, including a mid-level ... current license to practice as a registered nurse, and ...
... An orchid researcher based on the island of Reunion in ... Botanic Gardens, Kew (RBG Kew) has used motion sensitive night ... functioning as a pollinator of flowering plants. Not only is ... a member of the Orthoptera order of insects who ...
... STATION - Mango. If you know little about this fruit, ... colon and breast cancer cells in the lab. ... food scientists, who examined the five varieties most common in ... Though the mango is an ancient fruit heavily consumed in ...
Cached Biology News:2 nurses emerge as leaders in informatics 2First known instance of a cricket as an orchid pollinator captured on film by Kew scientist 2Mango effective in preventing, stopping certain colon, breast cancer cells 2
Screening test for the detection of Salmonella sp. by means of DNA amplification, subsequent molecular hybridization and detection on a microtitre plate....
... Application: The simple three step procedure ... can be completed in one day. The ... greater than 80%. , Features and Benefits: ... be cloned into any expression vector , ...
... 96- or 384-well PCR plates Dimples on both ... 96-tube plates End tabs on Thermo-Mat™ 384 fit ... Efficient sealing is achieved with either Thermo-Mat™ 96 or ... hot lid thermal cyclers Fully autoclavable ...
... Streptavidin-HRP Systems provide rapid, precise localization ... in frozen or paraffin-embedded tissue, cytospins ... also facilitate double or triple labeleing ... simultaneously with primary antibodies of different ...
Biology Products: