Navigation Links
Tissue development 'roadmap' created to guide stem cell medicine
Date:8/14/2014

tures

CellNet applies network biology to discover the complex network of genes that are turned on or off in an engineered cell, known as the cell's Gene Regulatory Network or GRN. It then compares that network to the cell's real-life counterpart in the body, as determined from public genome databases. Through this comparison, researchers can rigorously and reliably assess:

  • the quality of induced pluripotent stem cells (iPS cells) made by reprogramming blood cells or skin cells
  • the quality of specialized cells—such as liver, heart, muscle, brain or blood cells—made from either iPS cells or embryonic stem cells
  • the quality of specialized cells made from other specialized cells (such as liver cells made directly from skin cells)
  • what specific improvements need to be made to the engineering process.

"CellNet will also be a powerful tool to advance synthetic biology—to engineer cells for specific medical applications," says James Collins, PhD, Core Faculty member at the Wyss Institute and the William F. Warren Distinguished Professor at Boston University, co-senior investigator on one of the studies.

Putting CellNet to the test

The researchers—including co-first authors Patrick Cahan, PhD and Samantha Morris, PhD, of Boston Children's, and Hu Li, PhD, of the Mayo Clinic, first used CellNet to assess the quality of eight kinds of cells created in 56 published studies.

In a second study, they applied CellNet's teachings to a recurring question in stem cell biology: Is it feasible to directly convert one specialized cell type to another, bypassing the laborious process of first creating an iPS cell? This study looked at two kinds of directly converted cells: liver cells made from skin cells, and macrophages made
'/>"/>

SOURCE Boston Children's Hospital
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. New method for producing precursor of neurons, bone and other important tissues from stem cells
2. BioStorage Technologies Partners with Susan G. Komen for the Cure Tissue Bank at IU Simon Cancer Center to Raise Money and Awareness for Breast Cancer Research
3. U.S. Tissue Engineering Markets
4. Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference
5. IntelliCell BioSciences Announces Collaborative Agreement with the University of Florida on Stem Cell and Tissue Repair Research
6. Beike Earns AABB Accreditation for Cord Blood and Cord Tissue Banking
7. AllCells Introduces Autoimmune Diseased Cells and Tissue Products
8. Will new methods that increase blood flow to bone implants improve viability of engineered bone tissue?
9. Precisely engineering 3-D brain tissues
10. The Alliance for Regenerative Medicine forms Tissue Engineering and Biomaterials Committee
11. Krishagni Enables University of New South Wales (Australia) to Adopt caTissue Plus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/30/2014)... The severe flooding that devastated a wide swath of ... the bridges, roads and other infrastructure had been upgraded ... University of Colorado Denver. , "People need to understand ... PhD, associate professor of structural engineering at the CU ... author the study. "There is an assumption that a ...
(Date:10/27/2014)... Kalorama Information says that PCR is demonstrating ... the United States and is the ... said the FDA,s Emergency Use Authorization (EUA) to authorize the ... detection of the Ebola virus was an indication that ... the IVD industry and its biennial survey on diagnostics ...
(Date:10/27/2014)... 2014 Pressure BioSciences, Inc. (OTCQB: PBIO) ... the development and sale of high pressure-based sample ... today announced that Professor Ruedi Aebersold ... reproducible, and robust method to allow – for ... on small needle biopsy samples by mass spectrometry ...
(Date:10/25/2014)... The report “Adipic Acid Market by ... Global Trends & Forecast to 2019” report analyzes ... drivers, opportunities, and trends in different regions. , ... spread through 217 slides and in-depth TOC on ... to 2019”., http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , Early buyers will ...
Breaking Biology Technology:CU Denver study says upgrading infrastructure could reduce flood damage 2Kalorama: PCR The Go-to Test in Ebola Fight 2Kalorama: PCR The Go-to Test in Ebola Fight 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 2Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 3Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 4Breakthrough Method to Permit Quantification of Thousands of Proteins in Needle Biopsy Samples in 12 hours Presented at Major International Scientific Meeting; Method Enabled by Pressure BioSciences' PCT Sample Preparation Platform 5Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4
... that going from a positive to a negative is a ... scientists from the National Institute of Standards and Technology (NIST) ... extended the reach of their novel microfluidic system for analyzing ... how the system, meant to analyze real-world, crude mixtures such ...
... help resolve the public debate over America,s future light source ... compact fluorescent lamp. It could be neither. ... new breed of light emitting diode, or LED, that conjures ... an article in the current online issue of the journal ...
... Ariz., Aug. 31, 2011 SynCardia Systems, Inc. ( www.syncardia.com ... today that it has launched company pages on Facebook ... to educate a larger audience about the world,s only FDA, ... have been more than 950 implants of the Total Artificial ...
Cached Biology Technology:Researchers expand capabilities of miniature analyzer for complex samples 2Manufacturing method paves way for commercially viable quantum dot-based LEDs 2Manufacturing method paves way for commercially viable quantum dot-based LEDs 3SynCardia Goes Social on Facebook, Twitter and LinkedIn 2SynCardia Goes Social on Facebook, Twitter and LinkedIn 3SynCardia Goes Social on Facebook, Twitter and LinkedIn 4
(Date:10/28/2014)... of Health (NIH) announced awards to expand the ... National Center for Advancing Translational Sciences (ORDR-NCATS) collaborative ... the network, physician scientists at 22 consortia will ... clinical research and investigate new treatments for patients ... by $29 million in fiscal 2014 funding from ...
(Date:10/27/2014)... researchers have delivered a scientific one-two punch with a ... self-assemble via their sticky ends. , Collagen is the ... bone and the fibrous tissues that support cells and ... better synthetic collagen for tissue engineering and cosmetic and ... has been studying synthetic collagen for a decade, teasing ...
(Date:10/27/2014)... 27, 2014) — Recent breakthroughs may pave the ... infected by parasitic helminths. These flatworms, including tapeworms ... and blood flukes (schistosomes), infect more than 300 ... life years lost due to chronic illness and ... , professor of microbiology, immunology, and tropical medicine, ...
Breaking Biology News(10 mins):NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 2NIH's ORDR-NCATS RDCRN & NICHD awards U54 cooperative agreement for natural history study 3'Sticky' ends start synthetic collagen growth 2'Sticky' ends start synthetic collagen growth 3GW researcher adapting breakthrough technologies to combat parasitic worm infections 2
... of the brain are over-stimulated and this leads to ... this process was finally shown last year to be ... stroke. But very few targets for drugs to block ... detailed study, researchers have discovered a previously missing link ...
... an evolutionary geneticist at Fred Hutchinson Cancer Research Center who ... with opposing functions that drives evolutionary change has been ... is among 27 of the nation,s top biomedical scientists to ... more than 1,100 applicants. , "HHMI has a very ...
... Solanaceaea flowering plant family with some species producing foods ... effect against Parkinson,s disease. The study appearing today in ... American Neurological Association and Child Neurology Society, suggests that ... nicotine, such as peppers and tomatoes, may reduce risk ...
Cached Biology News:Researchers discover a missing link in signals contributing to neurodegeneration 2Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator 2Fred Hutch evolutionary geneticist Harmit Malik selected as an HHMI investigator 3Could eating peppers prevent Parkinson's? 2
Rabbit anti MMP-13, Hinge Region MMP-13 Hinge Region...
Mouse monoclonal [SIT-01] to SIT ( Abpromise for all tested applications). entrezGeneID: 27240 SwissProtID: Q9Y3P8...
Anti-MMP-25 (Membrane-type MMP-6, Mt6MMP), hinge region; rabbit host...
D4-GDI rabbit polyclonal antibody...
Biology Products: