Navigation Links
Tissue development 'roadmap' created to guide stem cell medicine
Date:8/14/2014

tures

CellNet applies network biology to discover the complex network of genes that are turned on or off in an engineered cell, known as the cell's Gene Regulatory Network or GRN. It then compares that network to the cell's real-life counterpart in the body, as determined from public genome databases. Through this comparison, researchers can rigorously and reliably assess:

  • the quality of induced pluripotent stem cells (iPS cells) made by reprogramming blood cells or skin cells
  • the quality of specialized cells—such as liver, heart, muscle, brain or blood cells—made from either iPS cells or embryonic stem cells
  • the quality of specialized cells made from other specialized cells (such as liver cells made directly from skin cells)
  • what specific improvements need to be made to the engineering process.

"CellNet will also be a powerful tool to advance synthetic biology—to engineer cells for specific medical applications," says James Collins, PhD, Core Faculty member at the Wyss Institute and the William F. Warren Distinguished Professor at Boston University, co-senior investigator on one of the studies.

Putting CellNet to the test

The researchers—including co-first authors Patrick Cahan, PhD and Samantha Morris, PhD, of Boston Children's, and Hu Li, PhD, of the Mayo Clinic, first used CellNet to assess the quality of eight kinds of cells created in 56 published studies.

In a second study, they applied CellNet's teachings to a recurring question in stem cell biology: Is it feasible to directly convert one specialized cell type to another, bypassing the laborious process of first creating an iPS cell? This study looked at two kinds of directly converted cells: liver cells made from skin cells, and macrophages made
'/>"/>

SOURCE Boston Children's Hospital
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. New method for producing precursor of neurons, bone and other important tissues from stem cells
2. BioStorage Technologies Partners with Susan G. Komen for the Cure Tissue Bank at IU Simon Cancer Center to Raise Money and Awareness for Breast Cancer Research
3. U.S. Tissue Engineering Markets
4. Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference
5. IntelliCell BioSciences Announces Collaborative Agreement with the University of Florida on Stem Cell and Tissue Repair Research
6. Beike Earns AABB Accreditation for Cord Blood and Cord Tissue Banking
7. AllCells Introduces Autoimmune Diseased Cells and Tissue Products
8. Will new methods that increase blood flow to bone implants improve viability of engineered bone tissue?
9. Precisely engineering 3-D brain tissues
10. The Alliance for Regenerative Medicine forms Tissue Engineering and Biomaterials Committee
11. Krishagni Enables University of New South Wales (Australia) to Adopt caTissue Plus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/1/2015)... UT (PRWEB) April 01, 2015 ... allowing Biosearch to make, use, market and sell ... also licenses CoPrimers™ technology to Biosearch for its ... design greatly reduces the occurrence of primer-dimers, without ... in increased sensitivity and lower test prices. ...
(Date:4/1/2015)... MANCHESTER, N.H. , April 1, 2015 ... conference, IGNITE: The Business of Better Medicine . ... necessary business knowledge to develop a thriving and fulfilling ... at the Omni La Costa Resort and Spa, the ... where attendees can expect to accomplish key projects and ...
(Date:4/1/2015)... GAITHERSBURG, Md. , April 1, 2015  VLP ... biotechnology company focusing on the research and development of ... based upon a novel and proprietary vaccine technology, today ... the Institute of Tropical Medicine at Nagasaki ... The collaboration will facilitate VLP,s research and development of ...
(Date:4/1/2015)... -- Goldman Small Cap Research, a stock market research ... announced today that it has issued a new article ... traded clinical stage biotechnology company focused on developing and ... sponsored research article, along with disclosures and disclaimers, or ... www.GoldmanResearch.com .  In the article on ...
Breaking Biology Technology:Biosearch and Co-Diagnostics Sign Cooperative Primers Agreement 2Biosearch and Co-Diagnostics Sign Cooperative Primers Agreement 3Emerson Ecologics Announces First Annual Conference for Integrative Healthcare Practitioners 2Emerson Ecologics Announces First Annual Conference for Integrative Healthcare Practitioners 3VLP Therapeutics Enters Collaboration with Institute of Tropical Medicine, Nagasaki University 2VLP Therapeutics Enters Collaboration with Institute of Tropical Medicine, Nagasaki University 3Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 2Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 3Flurry of Biotech Mergers and Acquisitions Bodes Well for PharmaCyte Biotech 4
... 2 Researchers at Fred Hutchinson Cancer,Research Center have ... the first systematic surveillance program of men with prostate,cancer ... to wait and when,to treat the disease. The project ... Institute., Peter Nelson, M.D., of the Hutchinson Center,s ...
... Roche is pleased to announce that,Grace Ju, Ph.D., research ... an "Outstanding Woman of Science" by the New Jersey,Association ... Thank You,Research Gala held May 1 at the Bridgewater ... at this year,s event, which is also,marking the 20th ...
... Motion Preservation, MARQUETTE, Mich., May 2 ... devices, announced today the,successful human implantation of its ... Arthroplasty Device. The surgeries were,performed by Drs. Hansen ... China, on,patients with degenerative disc disease (DDD) otherwise ...
Cached Biology Technology:When to Wait and When to Treat? New Program Will Search for Biomarkers in Men With Prostate Cancer to Help Find an Answer 2When to Wait and When to Treat? New Program Will Search for Biomarkers in Men With Prostate Cancer to Help Find an Answer 3Roche Research Director Grace Ju Hailed as NJABR 'Outstanding Woman of Science' 2Roche Research Director Grace Ju Hailed as NJABR 'Outstanding Woman of Science' 3Pioneer(R) Surgical Technology Announces First Human Implants of its NuNec(TM) Cervical Arthroplasty Device 2
(Date:3/10/2015)... -- Transforming How We Look at Medicine ... Human Space Flight" by Michael A. Schmidt ... was recently featured by Springer Science Media, highlighting the most ... Specifically, "Personalized Medicine in Human Space Flight" was among ... and 2014 from Springer in the journal Metabolomics ...
(Date:3/10/2015)... Conn. , March 10, 2015  NXT-ID, ... ("NXT-ID" or the "Company"), a biometric authentication company ... the company,s Wocket™ smart wallet has been named ... by Rethink Modern. Rethink Modern ( ... and innovative items for your home and lifestyle that have ...
(Date:3/4/2015)... Research and Markets ( http://www.researchandmarkets.com/research/48tj8z/global_biometrics ... "Global Biometrics Market Forecast and Opportunities, 2020" ... for biometric authentication systems is projected to grow ... The driving forces for this highly ... projects and constant development in technology. In 2014, ...
Breaking Biology News(10 mins):"Personalized Medicine in Human Space Flight" Listed Among Most Influential Papers of 2013 and 2014 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 2NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 3NXT-ID's Wocket Smart Wallet Named Number One Best Tech Gift for 2015 by Rethink Modern 4Global Biometrics Market Forecast and Opportunities, 2020 2Global Biometrics Market Forecast and Opportunities, 2020 3
... Montreal, QC (CNW) February 17, 2010 A Discussion ... in knowledge creation over the past three decades in ... extracted from the Web of Science (Thomson Reuters) database ... to 2009), the paper examines the effects of geopolitical ...
... and people alike face critical choices as they ... babies--or many small, poorly-provisioned ones. Different species make ... of life forms: Darwin,s "endless forms most beautiful. ... the Smithsonian Tropical Research Institute argues that these ...
... biological sciences, mankind has struggled to comprehend the relationships ... arthropods. Now, a team of researchers, including Dr. Joel ... Museum of Los Angeles County (NHM), has finished a ... arthropods, answering many questions that defied previous attempts to ...
Cached Biology News:Wall, war, wealth: 30 years of science 2Stress and trade-offs explain life's diversity: New Smithsonian model 2Where did insects come from? 2Where did insects come from? 3
The thermal printer, 120 V, is used to record fluorescence data acquired with the VersaFluor fluorometry systems. The printer includes a cable and power adaptor....
The Sony UPD895 printer is used to print data captured with the Gel Doc XR and ChemiDoc XRS gel documentation systems as well as the VersaDoc imaging systems....
This thermal printer, 120 V, provides a permanent record of the preprogrammed method and run data for the PROTEAN IEF cell. Includes cable and power adaptor....
... to purify genomic DNA from plants in 96 well ... a deep well plate using large zirconia beads optimized ... velocity plate shaker (available through Mo Bio). Cells are ... spin filter plate. The DNA is washed and then ...
Biology Products: