Navigation Links
Tissue development 'roadmap' created to guide stem cell medicine
Date:8/14/2014

tures

CellNet applies network biology to discover the complex network of genes that are turned on or off in an engineered cell, known as the cell's Gene Regulatory Network or GRN. It then compares that network to the cell's real-life counterpart in the body, as determined from public genome databases. Through this comparison, researchers can rigorously and reliably assess:

  • the quality of induced pluripotent stem cells (iPS cells) made by reprogramming blood cells or skin cells
  • the quality of specialized cells—such as liver, heart, muscle, brain or blood cells—made from either iPS cells or embryonic stem cells
  • the quality of specialized cells made from other specialized cells (such as liver cells made directly from skin cells)
  • what specific improvements need to be made to the engineering process.

"CellNet will also be a powerful tool to advance synthetic biology—to engineer cells for specific medical applications," says James Collins, PhD, Core Faculty member at the Wyss Institute and the William F. Warren Distinguished Professor at Boston University, co-senior investigator on one of the studies.

Putting CellNet to the test

The researchers—including co-first authors Patrick Cahan, PhD and Samantha Morris, PhD, of Boston Children's, and Hu Li, PhD, of the Mayo Clinic, first used CellNet to assess the quality of eight kinds of cells created in 56 published studies.

In a second study, they applied CellNet's teachings to a recurring question in stem cell biology: Is it feasible to directly convert one specialized cell type to another, bypassing the laborious process of first creating an iPS cell? This study looked at two kinds of directly converted cells: liver cells made from skin cells, and macrophages made
'/>"/>

SOURCE Boston Children's Hospital
Copyright©2014 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6

Related biology technology :

1. New method for producing precursor of neurons, bone and other important tissues from stem cells
2. BioStorage Technologies Partners with Susan G. Komen for the Cure Tissue Bank at IU Simon Cancer Center to Raise Money and Awareness for Breast Cancer Research
3. U.S. Tissue Engineering Markets
4. Dyadic International Launches FibreZyme® G5000 High Performance Powder Pulp and Paper Enzyme in Booth #1065 at Tissue World Americas Conference
5. IntelliCell BioSciences Announces Collaborative Agreement with the University of Florida on Stem Cell and Tissue Repair Research
6. Beike Earns AABB Accreditation for Cord Blood and Cord Tissue Banking
7. AllCells Introduces Autoimmune Diseased Cells and Tissue Products
8. Will new methods that increase blood flow to bone implants improve viability of engineered bone tissue?
9. Precisely engineering 3-D brain tissues
10. The Alliance for Regenerative Medicine forms Tissue Engineering and Biomaterials Committee
11. Krishagni Enables University of New South Wales (Australia) to Adopt caTissue Plus
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/1/2014)... Slone Partners , a national recruitment ... Laboratory Testing industries, reported a 120% increase in placements ... and above from July 2013 to July 2014. ... rapid breakthroughs in diagnostics, reimbursement has failed to keep ... forced to fold, consolidate, or carry on without payment ...
(Date:9/30/2014)... German . , The ... a semiconductor layer. Quantum dots are small structures that spontaneously ... short laser pulse is fired at the photonic crystal, its ... change in the electromagnetic field around it. This change can ... the dot. As soon as the refractive index recovers its ...
(Date:9/30/2014)... NEW YORK , Sept. 30, 2014 /PRNewswire/ ... trends and segments with highest potential revenues Do ... Visiongain,s updated report gives you revenue predictions for ... ahead. For those therapies you find financial data, ... new analysis you get sales forecasts to 2024 ...
(Date:9/30/2014)... (PRWEB) September 30, 2014 Follow ... level of each type of cholesterol carrier or lipoprotein ... presence of excessive cholesterol levels in the body, especially ... condition to heart attack and other cardiovascular disorders. Cardiovascular ... therefore testing for cholesterol levels on a regular basis, ...
Breaking Biology Technology:Slone Partners Meets Growing Demand as Industry Focuses on Reimbursement & Regulation 2Ultrafast remote switching of light emission 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 2Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 3Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 4Biosimilars and Follow-On Biologics: World Industry and Market Prospects 2014-2024 5Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 2Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 3Surging Diabetic, Obese and Hypertensive Population Drives the Global Cholesterol Testing Market, According to New Report by Global Industry Analysts, Inc. 4
... has reaffirmed its support for stem cell research - ... ,Illinois Gov. Rod Blagojevich last week announced that Illinois ... stem cell research. The announcement makes Illinois the fourth ... after New Jersey, California and Connecticut. , ,The ...
... Sonic Foundry announced on Monday that Darrin ... be promoted to senior vice president of worldwide field ... the company's Mediasite applications. , ,Prior to joining Sonic ... Americas Enterprise Business division and executive vice president of ...
... Wis. - When Milwaukee-based coffee chain Stone ... the company chose an emerging tool to enhance customer ... company's technology and marketing director, the blog can bring ... that goes beyond mere press releases or other traditional ...
Cached Biology Technology:Illinois stem cell funding could aid issue's visibility 2Business blogs increase customer interactions 2Business blogs increase customer interactions 3Business blogs increase customer interactions 4Business blogs increase customer interactions 5
(Date:9/30/2014)... burning is published today in the first authoritative scientific ... tensions on both sides of the grouse moor management ... on the Ecohydrology of River basins) project has shown ... to support red grouse populations for gun sports, has ... physical properties, river water chemistry and river ecology. , ...
(Date:9/30/2014)... salmon, and strawberries all have in common? Unlike ... chromosomes and are diploid, these organisms are all polyploid, ... watermelon and salmon have 3 and 4 sets of ... might seem surprising, in fact most plant species are ... a century ago, but only recently, with the development ...
(Date:9/30/2014)... team of environmental scientists and engineers, led by ... a three-year, $5.25 million grant from the U.S. ... Research to make a direct positive impact on ... and disposal of radioactive contaminants. , "Understanding the ... dealing with environmental aspects of nuclear technologies is ...
Breaking Biology News(10 mins):Grouse moor burning causes widespread environmental changes 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 2Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 3Gene doubling shapes the world: Instant speciation, biodiversity, and the root of our existence 4Researchers get $5.25 million to advance nuclear technologies in South Carolina 2
... 26, 2012   Goldfarb LLP is investigating whether ... (OTC: AOBI) violated shareholder protection laws as evidenced through ... investors who purchased stock before June 15, 2012 are ... hlindley@goldfarbllp.com about their rights and remedies. ...
... have invented a new toilet system that will turn human ... of water needed for flushing by up to 90 per ... the No-Mix Vacuum Toilet, it has two chambers that separate ... as those used in aircraft lavatories, flushing liquids would now ...
... study from more than 60 years ago suggesting that males ... may, in fact, be wrong, say life scientists who are ... methods as the original. In 1948, English ... fruit flies gain an evolutionary advantage from having multiple mates, ...
Cached Biology News:NTU's new loo turns poo into power 2NTU's new loo turns poo into power 3UCLA biologists reveal potential 'fatal flaw' in iconic sexual selection study 2UCLA biologists reveal potential 'fatal flaw' in iconic sexual selection study 3UCLA biologists reveal potential 'fatal flaw' in iconic sexual selection study 4UCLA biologists reveal potential 'fatal flaw' in iconic sexual selection study 5
... fume hood ventilates and purifies ... release of exhaust. Bonded charcoal ... Configurations are available with vertical ... final HEPA filter, work bench ...
Sigmas E-TOXATE (Limulus Amebocyte Lysate) test kits are intended for the detection and semiquantitation,of endotoxins for research purposes....
...
... enclosures are designed for ... other process gas to ... HEPA filtration, heating/cooling, humidification, ... also available, along with ...
Biology Products: