Navigation Links
Tips from the journals of the American Society for Microbiology
Date:12/23/2008

veloped enteric viruses and their surrogates by a novel alcohol-based hand sanitizer. Applied and Environmental Microbiology, 74. 16: 5047-5052.)


New Oral Vaccine May Protect Against Bubonic Plague

Researchers from the Institut Pasteur in Paris, France used a less virulent ancestor to the highly infectious bubonic plague to develop a potentially safe, efficient and inexpensive live oral vaccine. They report their findings in the August 2008 issue of the journal Infection and Immunity.

Transmitted by infected fleas, Yersinia pestis is the causative agent responsible for bubonic and pneumonic plague. Both highly contagious, the bubonic form of the disease is the most common in the world and can be treated; however, pneumonic plague is almost always fatal within 3 days of infection. Pneumonic plague can also be generated into aerosols and transmitted from human to human placing it at serious risk for use as weapon of bioterrorism.

Yersinia pseudotuberculosis shares a genetic identity rate of 95% with Y. pestis, but is much less virulent and rarely attributed to disease-related fatalities. In the study 41 strains of Y. pseudotuberculosis were screened for low pathogenicity. Researchers identified one strain (IP32680) which was then tested and found to persist in the mouse intestine for 2 months following intragastric and subcutaneous inoculation without any clinical signs of disease. The previously inoculated mice were then challenged intravenously with Y. pestis following which low levels of the bacteria were found in the organs and blood. Finally, IP32680 was administered orally and results showed that one dose protected 75% of mice, while two doses protected 88%.

"We report that oral inoculation with a Y. pseudotuberculosis strain, selected for its very low virulence, induces an efficient immunity against bubonic plague without causing adverse reaction
'/>"/>

Contact: Carrie Slijepcevic
cslijepcevic@asmusa.org
American Society for Microbiology
Source:Eurekalert

Page: 1 2 3 4

Related biology technology :

1. Tips from the journals of the American Society for Microbiology
2. Tips from the journals of the American Society for Microbiology
3. Three Expert Opinion Journals now Publishing Original Research
4. ScienceDirect to Host French-Language Journals from Elsevier Masson
5. Tips from the Journals of the American Society for Microbiology
6. Elsevier Introduces The American Journal of Medicine Blog
7. The American Ceramic Society releases new ACerS-NIST phase equilibria diagrams CD-ROM database
8. Transgenomic Receives Accreditation From College of American Pathologists
9. Proteolix Announces Positive Data From Two Ongoing Phase 2 Clinical Trials of Carfilzomib in Multiple Myeloma at the 50th Annual Meeting of the American Society of Hematology
10. Multiple Vimpat(R) (lacosamide) Studies Presented at American Epilepsy Society Annual Meeting
11. Proteolix Presents Preclinical Data for Oral Proteasome Inhibitor PR-047 at the 50th Annual Meeting of the American Society of Hematology
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/15/2014)... Two champions of science, technology, engineering, and ... annual competition for middle and high school students designed ... study. The competition presents students with real-world problems experienced ... Mathematics, and Sciences is a program administered by ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of Notched Sound ... Patients listen to sound therapy that is tailor-made for ... to months, their tinnitus volume decreases. , AudioNotch has previously ... Notched White Noise. Now, AudioNotch is pleased to announce to ...
(Date:1/14/2014)... 2014  3D Communications, a leading provider of strategic communications services to ... events in the United States and ... Cox , JD, is returning to the firm,s Washington, ... 3D after more than two years of service as Associate Commissioner ...
(Date:1/14/2014)... MA (PRWEB) January 14, 2014 iLab Solutions, ... Detwiler as the new Director of Product Strategy. In this ... well as iLab sub-teams to guide in the development of ... iLab provides the maximum possible benefit to the scientific community ...
Breaking Biology Technology:Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 2Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 3Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 4Technology Student Association Partners with Leaders in STEM Education Advocacy for Annual Competition 5Former FDA Associate Commissioner Returns To 3D Communications 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2
... Net 2004 in Lille, France. This four-year-old conference ... the transformative power of technology. As the lead speaker ... Economic and Social Conditions, I was eager, frankly, to ... order to hear from and debate my fellow panelists. ...
... Inc., through its non-profit arm the SBC Foundation, has ... Business Journal of Milwaukee has reported. , ... and underserved populations received money to help them use ... Excelerator program , which typically gives from $2,500 to ...
... While the Madison chapter of the World Future Society ... and technological developments, Scott Converse showed them how looking to ... see where the next big thing is coming from. , ... Business and founder of the Web integration firm Cant Dance ...
Cached Biology Technology:Achieving digital solidarity 2Achieving digital solidarity 3Achieving digital solidarity 4Business-school IT director points to reasons for wireless trend 2
(Date:4/23/2014)... of Toronto Scarborough research shows that male black widow ... a rare example of mate preference by male ... post-doc Emily MacLeod and Maydianne Andrade, a professor in ... field studies and the wild that males overwhelmingly chose ... male black widows can tell whether a potential mate ...
(Date:4/23/2014)... TX (4/23/14) -- Researchers have found evidence of ... factors that increase aggressive behavior in children, especially ... not all children exposed to prenatal smoking will ... will not," said Brian Boutwell, Assistant Professor at ... and senior author on the study. "One ...
(Date:4/23/2014)... today announced Sophie Martin of the University of Lausanne, ... Medal. The award acknowledges her work to understand the ... the cell. , Martin has been working for the ... the way in which the spatial organization of cells ... last 11 years, she has been using fission yeast, ...
Breaking Biology News(10 mins):Picky male black widow spiders prefer well-fed virgins 2Genetics risk, prenatal smoking may predict behavioral problems 2EMBO Gold Medal 2014 awarded to Sophie Martin 2
... October 29, 2007 The average price for all ... gallon nationwide, but the pain at the pump might ... may eliminate one of the biggest hurdles to the ... assistant professor of chemical and biomolecular engineering, led the ...
... University have developed a cancer fighting technology which uses ... tumours. Therapeutic antibodies have long been recognised ... target tumour cells has proved to be very difficult. ... Thompson from Newcastle University have developed a procedure to ...
... Institution of Oceanography at UC San Diego, that allows ... world oceans simultaneously is approaching its coverage goal after ... profiling floats measures ocean water temperature, salinity and velocity ... Committee, the international panel of scientists that manage the ...
Cached Biology News:Fuel cells gearing up to power auto industry 2Fuel cells gearing up to power auto industry 3UV light improving chances of fighting cancer 2Unprecedented global measurement network achieves full coverage of oceans 2Unprecedented global measurement network achieves full coverage of oceans 3
Conjugation services for Antibodies, Proteins, Oligos, Peptides, Beads, bioconjugation, antibody-oligonucleotide, LNA peptide, LNA protein, LNA antibody, HRP, Alkaline phosphatase, phycoerythrin, FIT...
SCP-1 (P-17)...
Immunogen: Purified native p24 from strain IIIB. Storage: -20 C, Avoid Freeze/Thaw Cycles...
Biotin d anti-mouse Tim-1...
Biology Products: