Navigation Links
Time of day crucial to accurately test for diseases, new research finds
Date:7/10/2014

A new study published today in the journal PNAS (Proceedings of the National Academy of Sciences), has found that time of day and sleep deprivation have a significant effect on our metabolism. The finding could be crucial when looking at the best time of day to test for diseases such as cancer and heart disease, and for administering medicines effectively.

Researchers from the University of Surrey and The Institute of Cancer Research, London, investigated the links between sleep deprivation, body clock disruption and metabolism, and discovered a clear variation in metabolism according to the time of day.

Healthy male volunteers were put in an environment where light, sleep, meals and posture were controlled. Researchers collected blood samples every two hours to show how metabolic biomarkers change during the day. For the first 24 hours, the participants experienced a normal wake/sleep cycle. This was followed by 24 hours of wakefulness, to investigate the effect of sleep deprivation on metabolic rhythms. The results showed that metabolic processes are significantly increased during sleep deprivation. 27 metabolites, including serotonin, were found at higher levels in periods of sleep deprivation compared to levels during sleep.

Lead author Professor Debra Skene from the University of Surrey, said: "Our results show that if we want to develop a diagnostic test for a disease, it is imperative to take the time of day when taking blood samples into account, since this has a significant effect on metabolism. This is also key for administering medicines and determining when they will be at their most effective. Of course, this will have to be considered on a case-by-case basis, since many people such as shift workers will have a different sleep/wake cycle and timings will need to be adapted to their body clocks."

Co-Senior author, Dr Florence Raynaud, a group leader at The Institute of Cancer Research, London, said: "The study made accurate measurements of a large number of metabolites as they varied by time of day and under different sleep patterns. Our findings are likely to be important in interpreting the results of blood tests, and in understanding why some individuals respond differently to medication. They also set reference points for future studies looking at the connection between metabolic processes and diseases such as cancer."

The research was funded by a grant from the BBSRC awarded to a large team of researchers, and was conducted at the University of Surrey's Faculty of Health and Medical Sciences and at The Institute of Cancer Research, London.

Media enquiries: Peter La, Media Relations Office at the University of Surrey, Tel: 01483 689191 or E-mail: p.la@surrey.ac.uk

Notes to Editors:

About the University of Surrey

The University of Surrey is one of the UK's leading professional, scientific and technological universities with a world class research profile and a reputation for excellence in teaching and research. Ground-breaking research at the University is bringing direct benefit to all spheres of life helping industry to maintain its competitive edge and creating improvements in the areas of health, medicine, space science, the environment, communications, defence and social policy. Programmes in science and technology have gained widespread recognition and it also boasts flourishing programmes in dance and music, social sciences, management and languages and law. In addition to the campus on 150 hectares just outside Guildford, Surrey, the University also owns and runs the Surrey Research Park, which provides facilities for 110 companies employing 2,750 staff.


'/>"/>

Contact: Peter La
p.la@surrey.ac.uk
0044-148-368-9191
University of Surrey
Source:Eurekalert

Related biology technology :

1. Farm weeds have crucial role in sustainable agriculture
2. Botanical compound could prove crucial to healing influenza
3. Lucintel's Analysis of Global Catalysts Industry: Chemical and Automobile Industries Play Crucial Role in Growth
4. Study In Prenatal Diagnosis Finds Sequenom CMMs MaterniT21™ PLUS Lab-developed Test Accurately Detects Fetal Trisomies In Pregnant Women Carrying Twins Or Triplets
5. Blue Brain Project accurately predicts connections between neurons
6. Peer Reviewed Clinical Study Shows New Blood Test More Accurately Predicts Risk Of A Heart Attack
7. Wolters Kluwer Research Now Available via Bloomberg Tradebook
8. ACORN Research, LLC Announces Partnership with AdeptBio, LLC
9. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
10. Researching graphene nanoelectronics for a post-silicon world
11. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/12/2017)... ... 12, 2017 , ... The Blavatnik Family Foundation and the ... of the 2017 Blavatnik Regional Awards for Young Scientists. Established in 2007, ... the New York Academy of Sciences to honor the excellence of outstanding postdoctoral ...
(Date:10/12/2017)... ... 12, 2017 , ... AMRI, a global contract research, development ... patient outcomes and quality of life, will now be offering its impurity solutions ... new regulatory requirements for all new drug products, including the finalization of ICH ...
(Date:10/11/2017)... ... , ... Personal eye wash is a basic first aid supply for any work environment, but ... do you rinse first if a dangerous substance enters both eyes? It’s one less decision, ... its unique dual eye piece. , “Whether its dirt and debris, or an acid or ...
(Date:10/11/2017)... LAGUNA HILLS, Calif. , Oct. 11, 2017 /PRNewswire/ ... London (ICR) and University of ... tool to risk-stratify patients with multiple myeloma (MM), in a ... . The University of Leeds is ... Myeloma UK, and ICR will perform the testing services to ...
Breaking Biology Technology:
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market by Solution ... Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast to 2022", ... 14.30 Billion in 2017 to USD 31.75 Billion by 2022, at a ... ... MarketsandMarkets Logo ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ... appointment of independent Directors Mr. Robin D. Richards ... Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive ... their guidance and benefiting from their considerable expertise as we ...
Breaking Biology News(10 mins):