Navigation Links
Therapeutic Cells Derived From Reprogrammed (iPS) Stem Cells Display Early Aging
Date:2/10/2010

WORCESTER, Mass., Feb. 11 /PRNewswire-FirstCall/ -- Advanced Cell Technology, Inc. (OTCBB: ACTC) reported that a range of therapeutic cell types obtained from induced pluripotent stem (iPS) cells exhibit abnormal expansion and early cellular aging.  The research, which appears online (published-ahead-of- print) in the journal STEM CELLS by ACT and its collaborators at Stem International (SCRMI), Harvard Medical School, and the University of Illinois, compares a variety of replacement cell types derived from human iPS cells to their embryonic stem (ES) cell counterparts. 

The research shows that human iPS cells can generate blood, vascular and retinal cells with characteristics similar to those derived from ES cells, but with a dramatic decreased efficiency.  However, in distinct contrast to the ES cell derivatives, major differences were observed in cells derived from iPS cells, including significantly increased cell death (apoptosis), severely limited growth and expansion capability, as well as a substantially decreased capacity to generate blood progenitors.  After further differentiation into red blood cells, over a thousand-fold difference in expansion capability was observed in iPS cells versus ES cell progenitors.  Although vascular cells derived from iPS cells were capable of forming capillary-like structures, the cells also demonstrated early cell aging (senescence). Similarly, retinal cells derived from iPS cells also displayed early signs of aging.  

"Before clinical application, it will be necessary to determine the cause and extent of such abnormalities, and whether they also occur in stem cells generated using different reprogramming methods" said Robert Lanza, M.D., Chief Scientific Officer at ACT, and senior author of t
'/>"/>

SOURCE Advanced Cell Technology, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4

Related biology technology :

1. United Therapeutics Corporation to Announce Fourth Quarter and Annual 2009 Financial Results Before Market Open on Tuesday, February 16, 2010
2. Corgenix and Tulane Announce Award of Additional NIH Contract to Expand Lassa Fever Research Towards Development of Vaccines and Improved Therapeutic Agents
3. Amicus Therapeutics Board of Directors Names Chief Executive Officer John F. Crowley Chairman of the Board
4. Silence Therapeutics to Present at 12th Annual BIO CEO & Investor Conference
5. Aegera Therapeutics Initiates a Randomized Phase 2 Study with AEG35156 for the Treatment of Hepatocellular Carcinoma
6. Oxygen Biotherapeutics, Inc. Outlines Plans for New Products During Investor Conference Presentation
7. The Honorable Tommy G. Thompson Joins the United Therapeutics Corporation Board of Directors
8. Cell Therapeutics Commits to PhRMAs Code on Interactions With Healthcare Professionals
9. WellGen, Inc. and RFI Ingredients to Collaborate on Therapeutic Nutrition Opportunities
10. Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market Forecasts to 2015, Pipeline Analysis and Reimbursement
11. Dennis Winger Joins Nektar Therapeutics Board of Directors
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... -- Smith & Nephew (LSE:SN, NYSE: SNN ... its entry into the forefoot market with the ... Comprised of three separate repair options, the HAT-TRICK ... and reconstruction, a metatarsal osteotomy guide, and a ... also known as hammer toe correction. ...
(Date:7/31/2014)... Held at the Stanford Cancer Center, the ... the disease and its treatment. Survivors will find information ... as updates on the state-of-the-art with respect to newer ... organizing this educational opportunity,” says KCA CEO Bill Bro, ... colleagues have put together a program that balances the ...
(Date:7/31/2014)... The global market for molecular diagnostics ... according to a new study by Grand View Research, ... the subsequent introduction of advanced cancer diagnostic technologies are ... the next six years. Moreover, the growing global base ... coupled with disease triggering lifestyle habits such as smoking ...
(Date:7/31/2014)... July 31, 2014 “Rapid technological ... across the U.S., increasing unemployment, depressing American consumer ... It is a Catch 22—we need automated manufacturing ... means fewer jobs,” says economist and corporate relocation ... Corporate Top 10 Pro-Business States for 2014, co-published ...
Breaking Biology Technology:Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 2Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 3Smith & Nephew scores a HAT-TRICK with its entry into the high-growth hammer toe repair market 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 2Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 3Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 4Molecular Diagnostics Market - Global Industry Size, Share, Trends, Analysis, Players, Opportunity, Outlook and Forecast From 2014 to 2020 5ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 2ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 3ITRA Global Affiliate’s Pollina Corporate Top 10 Pro-Business States Minimize the Impact of Automation on Middle Class and Unemployment 4
... of Eli Lilly,and Company employees in nearly 50 nations ... community needs in celebration of Lilly,s,first-ever Global Day of ... place on one day., Beginning at sunrise in ... donating time and energy to improve the health and,well-being ...
... 14 Sagent Pharmaceuticals, Inc.,a privately-held specialty pharmaceutical ... the American Red Cross to assist the victims,of ... part of the global community, we were saddened ... Sichuan province," said Jeffrey M. Yordon,chief executive officer, ...
... /PRNewswire-FirstCall/ - Vasogen Inc.,(NASDAQ: VSGND ; TSX:VAS) today ... present a Company overview at the Rodman & ... at 12:30 p.m. local time (6:30,a.m. ET) on ... of the presentation can be accessed through Vasogen,s,website ...
Cached Biology Technology:Lilly Employees from Nearly 50 Nations Participate in Company's First-Ever Global Day of Service 2Vasogen to Webcast Presentation at the Rodman & Renshaw 5th Annual Global Healthcare Conference 2Vasogen to Webcast Presentation at the Rodman & Renshaw 5th Annual Global Healthcare Conference 3
(Date:7/30/2014)... pledge of $1 million from the Cornelia Cogswell Rossi ... Biometry Center. , The newly established Connie ... to develop a greater breadth and depth of knowledge ... the pace of research to improve human health. , ... for the Laboratory and its external partners, supporting research ...
(Date:7/30/2014)... POTSDAM, N.Y. , July 30, 2014 /PRNewswire/ ... of spoof mitigation and liveness detection solutions for ... FIDO Alliance, an industry consortium revolutionizing online authentication ... COO Mark Cornett , "The decision to ... help make biometric authentication pervasive in use. We ...
(Date:7/30/2014)... Americans make better decisions about what they eat, the ... significant changes to the Nutrition Facts label found on ... in Chemical & Engineering News (C&EN), the ... the suggested updates and the fight that has ... points out that while the Nutrition Facts label has ...
Breaking Biology News(10 mins):Rossi Foundation pledges $1M for JAX neurobehavioral research center 2NexID Biometrics Joins the FIDO Alliance 2
... Thailands Western Forest Complex a 6,900 square ... reserves can potentially support some 2,000 tigers, making ... big cats, according to a new study by Thailands ... the New York-based Wildlife Conservation Society. The study, ...
... -- world leader and,patent-holder in camera-enabled gesture interfaces ... AirPoint System, and announced the,first installation for Fortune ... unit that allows users to control interactive,multi-media content ... simple hand,motions above the unit. No interface device ...
... 2007 - The National Fish and Wildlife Foundation ... Manomet Center for Conservation Sciences to sustain the ... the decline of shorebird populations throughout the Western ... by the Western Hemisphere Shorebird Reserve Network (WHSRN), ...
Cached Biology News:Study says 2000 tigers possible in Thailand 2GestureTek/Imagination Launch AirPoint, World's First Hand-Tracking Unit, for Shell Group. 2GestureTek/Imagination Launch AirPoint, World's First Hand-Tracking Unit, for Shell Group. 3Manomet Center awarded major NFWF grant to foster shorebird conservation 2Manomet Center awarded major NFWF grant to foster shorebird conservation 3