Navigation Links
The X factor in liver metabolism
Date:12/21/2012

After you eat, your liver switches from producing glucose to storing it. At the same time, a cellular signaling pathway known as the unfolded protein response (UPR) is transiently activated, but it is not clear how this pathway contributes to the liver's metabolic switch. In this issue of the Journal of Clinical Investigation, researchers led by Phillip Scherer at the University of Texas Southwestern Medical Center report that activation of the UPR triggers the expression of Xbp1s, a protein that regulates genes needed for the metabolic switch. Scherer and colleagues found that they could induce changes in liver metabolism just by increasing expression of Xbps1. These results suggest that Xbps1 could play a role in metabolic disease.

TITLE:
The Xbp1s/GalE axis links ER stress to postprandial hepatic metabolism

AUTHOR CONTACT:
Philipp E. Scherer
The University of Texas Southwestern Medical Center, Dallas, TX, USA
Phone: (214) 648-8715; Fax: (214) 648-8720; E-mail: philipp.scherer@utsouthwestern.edu

View this article at: http://www.jci.org/articles/view/62819?key=17adb760d62c3d29b6fb


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. Pro Bono Bio Announces the Successful Development of Subcutaneous and Long-Acting Blood Factors VIIa,VIII and IX for the Treatment of Haemophilia
2. PROLOR Biotech Announces Presentation of Data on Its Long-Acting Clotting Factors at World Federation of Hemophilia World Congress
3. 2012 Global Factor Assays Market Outlook: Test Volume Forecasts by Country and Market Segment
4. Ariosa Diagnostics Announces Publication of Study on Influential Factors Affecting Fetal DNA Concentration in Blood of Pregnant Women
5. CSL Behring Data Shows 4-Factor Prothrombin Complex Concentrate Is As Effective and a More Rapid Treatment for Vitamin K Antagonist Reversal Than Current Standard of Care
6. Inspiration Biopharmaceuticals Announces Filing of Biologics License Application (BLA) for IB1001, a Recombinant Factor IX Product for People with Hemophilia B
7. MUSA's Validated Cloud: Fully Qualified Citrix® Application Delivery - IQ & OQ Library Now Includes: NetScaler® & XenApp®
8. 2012 mHealth Summit Delivered Leaders from 56 Countries
9. Amarantus BioSciences Announces Positive Data for MANF in Delivery Diffusion Animal Model of Parkinsons Disease
10. Elektas Monaco System Used for First Time to Create VMAT Plan for Delivery on Varian Treatment System
11. Aviir, Inc.s CEO Dr. Douglas Harrington Delivered The Facts Surrounding Heart Disease At The Los Angeles Ultimate Womens Expo
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/26/2017)... ... July 26, 2017 , ... NLP Logix today ... of diagnostic excellence by Mayo Clinic and the experience in developing and deploying ... distributed through the Microsoft Azure platform and will focus on assisting physicians to ...
(Date:7/25/2017)... ... July 25, 2017 , ... Fiberstar, Inc ., a global ... offers Citri-Fi® 125. This natural citrus fiber is used to improve tomato-based food products ... in sauces, condiments and spreads. Today, more than ever, consumers connect ingredients to the ...
(Date:7/24/2017)... BALTIMORE , July 24, 2017 Intralytix, ... equity funding from Lesaffre, a French family group. This ... both companies to develop and commercialize bacteriophage-based products, for ... of mutual interest. ... fermentation, Lesaffre designs manufactures and markets innovative solutions for ...
(Date:7/20/2017)... (PRWEB) , ... July 20, 2017 , ... ... online directory of leading radiology and imaging centers around the U.S. that offer ... and highly accurate alternative to needle biopsy for staging liver fibrosis assessment. ...
Breaking Biology Technology:
(Date:3/30/2017)... LOS ANGELES , March 30, 2017  On ... Hack the Genome hackathon at ... This exciting two-day competition will focus on developing health ... experience. Hack the Genome is ... has been tremendous. The world,s largest companies in the ...
(Date:3/29/2017)... -- higi, the health IT company that operates the largest ... , today announced a Series B investment from BlueCross ... new investment and acquisition accelerates higi,s strategy to create ... health activities through the collection and workflow integration of ... and secures data today on behalf of over 36 ...
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed Anwar ... the prestigious international IAIR Award for the most innovative high security ePassport ... ... Maldives Immigration Controller General, Mr. ... on the right) have received the IAIR award for the "Most innovative ...
Breaking Biology News(10 mins):