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The Adult Stem Cell Technology Center, LLC Continues to Develop Technologies for Homologous Adult Stem Cell Therapies and Drug Development
Date:7/23/2014

really an illusion created by two limitations. First, the stem cells that are most readily obtained and multiplied are mesenchymal stem cells (MSCs), which are found in tissues like fat, bone marrow, skin, and joints, but are not the primary stem cells that form many of the organs and tissues in need of regenerative medicine treatments (e.g., pancreas, heart, nerves, liver). Second, although much research has been conducted with MSCs, what they might accomplish in human patients after heterologous transplantation can only be learned by conducting high-quality clinical trials.

Whether or not heterologous stem cell transplantation therapy, with all of its noted reservations, proves beneficial, extending homologous regenerative therapies – like bone marrow stem cell transplantation – to more organs and tissues is an important regenerative medicine goal. Contributing to achieving this goal is the core business of Boston’s ASCTC.

The ASCTC recently announced the approval of a new patent for producing induced pluripotent stem cells more efficiently. The new patent has a foundation in the ACSTC’s portfolio of patents for methods to multiply adult stem cells from diverse organs and tissues that are important targets for regenerative medicine therapies.

The lead adult stem cell expansion technology currently pursued by the company is for human liver adult stem cells. Produced in sufficient quantity, human liver stem cells could be used to produce functionally mature human liver cells called hepatocytes. Hepatocytes are essential for drug testing before advancing to clinical drug trials with patients. Current sources of these cruci
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