Navigation Links
Technology brings new life to the study of diseases in old bones
Date:10/25/2012

A study led by The University of Manchester has demonstrated that new technology that can analyse millions of gene sequences in a matter of seconds is an effective way to quickly and accurately identify diseases in skeletons.

Professor Terry Brown, working in partnership with Professor Charlotte Roberts from Durham University, used a next generation sequencing approach, including hybridization capture technology, to identify tuberculosis genes in a 19th century female skeleton found in a crypt in Leeds.

Their study is part of wider research into the identification of strains of TB in skeletons dating from 100 AD to the late 19th century. It's hoped that understanding how the disease has evolved over time will help improve treatments and vaccines. TB rates have been increasing around the world, and it's estimated that one third of the world's population has latent TB. After HIV it kills more people than any other infectious disease.

Certain strains of TB affect the sufferer's bones, especially in the spine. The marks made by the disease remain evident on the bones long after the person's death. It's this evidence that Professor Roberts used to find suitable skeletons to screen for tuberculosis genes.

She sourced 500 skeletons from across Europe that showed evidence of TB dating from the Roman period to the 19th century. Bone samples from these skeletons were screened for TB DNA, and of those 100 were chosen for this particular study.

Professor Roberts explains: "So many skeletons were needed as it's very hard to tell if any DNA will have survived in the bones. You don't really know if there will be any present until you start screening and in the past that has been a lengthy process."

Professor Terry Brown then took on the search for TB DNA in the skeletons. Each small section of bone was ground up and placed in a solution. That was then put in a special machine which captured every gene sequence in the DNA
'/>"/>

Contact: Morwenna Grills
Morwenna.Grills@manchester.ac.uk
44-161-275-2111
University of Manchester
Source:Eurekalert

Page: 1 2 3

Related biology technology :

1. New HIV prevention technology shows promise
2. Tel Aviv University to spearhead groundbreaking nanotechnology consortium
3. Germany Prioritizes Medical Biotechnology with New Initiatives
4. New Report: "Innovations in Drug Delivery - Broad-based Proprietary Technology Platforms to Address Delivery Efficiency and Improve Patient Compliance" Now Available at Twease.org
5. Islet Sciences Announces Exclusive License Agreement with Winthrop University Hospital to Commercialize a Beta Cell Loss Measurement Technology in Diabetes
6. Algae.Tec Biofuels Technology to Feature at 2012 ILA Berlin Airshow
7. Indian Pharma MNC Piramal Investing in German Molecular Imaging Technology
8. Biomass characterization technology research highlighted in Industrial Biotechnology journal
9. Breakthrough in nanotechnology
10. Bolder BioTechnology Announces Publication of Data Demonstrating Utility of the Companys Long-Acting IL-11 Analog to Prevent Renal Ischemia Reperfusion Injury
11. Bode Technology Offers First Rapid DNA Service Delivering a DNA Profile from Evidentiary Samples in Under 90 Minutes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/2/2014)... Australia (PRWEB) September 02, 2014 The ... a cure for chronic tinnitus are seeking support for ... on the Indiegogo platform ( http://igg.me/at/tinaway ), was launched ... be a therapeutic ‘mHealth’ app and is based on ... of a team of biomedical and software engineers, Dr. ...
(Date:8/31/2014)... September 01, 2014 Available spectra ... needs for research and cultivation of a wide ... Valoya’s proprietary LEDs with proven patented and pending ... uncompromised light uniformity in critical applications in contrast ... LEDs. , “Our customers have a large variety ...
(Date:8/29/2014)... Electronic circuits are based on electrons, but one of ... photonic circuits, i.e. circuits based on light (photons) instead ... to create a stream of single photons and control ... sorts of attempts to achieve this control, but now ... creating a steady stream of photons emitted one at ...
(Date:8/29/2014)... Local veterinarian, Dr. Keith Clement, and his ... to participate in an investigational study of donor stem ... of this study is to determine if a single ... arthritically affected joints can help reduce pain and inflammation ... current investigational study must be older than nine months, ...
Breaking Biology Technology:tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 2tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 3tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 4tinAway Pty. Ltd. launch a crowdfunding campaign to fund a clinical trial of tinAway, a new potential cure for chronic tinnitus 5Breakthrough in light sources for new quantum technology 2Burnt Hills Veterinary Hospital Seeks Candidates for an Investigational Study of Stem Cells for Dogs with Arthritis 2
... Information technology professionals in Wisconsin announced on ... of Wisconsin, a forum for information exchange and ... $14B in revenue and hires more than 55,000 employees, ... founding members, of which approximately a third are IT ...
... In our last two columns, we looked at both the ... the growth of Specialty Pharma particularly in the U.S. market. ... drugs (drugs that sell $1 billion or more) but the ... year) and the mega-blockbuster drugs (the one drug, Pfizers Lipitor ...
... software developers will have the chance to combine their ... first annual Games+Learning+Society conference at the Monona ... by Games And Professional Practice Simulations, a joint project ... a group of instructors at the UW-Madison School of ...
Cached Biology Technology:Statewide IT association will address IT issues and priorities 2Statewide IT association will address IT issues and priorities 3Line between big pharma, big biotech continues to blur 2Line between big pharma, big biotech continues to blur 3Education conference to draw together games researchers 2
(Date:8/29/2014)... available in German . ... the natural nitrogen cycle on Earth and in biological ... thought to depend on nitrite as their source of ... Daims, a microbiologist at the University of Vienna, has ... an alternative source of energy. The oxidation of hydrogen ...
(Date:8/29/2014)... - In a cell,s nucleus, chromosomal DNA is ... an amalgam biologists call chromatin. Until about two ... "sidekick," the mere packing material around which the ... have developed a greater appreciation for how DNA/histone ... from multiple research institutions studying the sequence of ...
(Date:8/28/2014)... Invasives is now available from the Lady Bird Johnson ... for identifying harmful non-native plant, insect and other invasive ... States cause about $137 billion in economic and other ... kill native plants and more. , "By having streamlined ... invasive species occur, we,re more likely to catch these ...
Breaking Biology News(10 mins):Hydrogen powers important nitrogen-transforming bacteria 2Hydrogen powers important nitrogen-transforming bacteria 3'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 2'K-to-M' histone mutations: How repressing the repressors may drive tissue-specific cancers 3Mobile app makes ID of harmful plants, insects in Texas a snap 2
... pan out. Neither did two other potential anti-aging agents. ... is now a front- runner in ongoing animal experiments ... inflammation, cancer and other destructive processes, can boost the ... meeting of the American Aging Association, University of Michigan ...
... discovery of how some abnormal cells can avoid a ... and repairing the damage, is giving investigators at St. ... cancer cells use to survive and thrive. , The ... have cheated death once by disabling the main suicide ...
... (DPI) fisheries scientists are investigating ways to boost the ... by anglers. , Some guidelines designed to improve fish ... trevally, mulloway, sand whiting, yellowfin bream and dusky flathead. ... and funded by NSW DPI and the Recreational Fishing ...
Cached Biology News:Agent slows aging in mice 2Cells re-energize to come back from the brink of death 2Releasing fish for the future 2
NORMAL DONOR DONKEY SERUM...
... EPS 301 Power Supply, 1. ... maximum.Constant voltage or constant current modes.Single-unit ... precision and reproducibility.Suitable for submarine, mini ... as well as semidry and mini ...
B3-1...
Human CCL26/Eotaxin-3 MAb (Clone 115002)...
Biology Products: