Navigation Links
Takeda and Zinfandel Pharmaceuticals Sign Licensing Agreement for Alzheimer's Disease Biomarker in Combination with Pioglitazone
Date:1/10/2011

OSAKA, Japan and DURHAM, N.C., Jan. 10, 2011 /PRNewswire/ -- Takeda Pharmaceutical Company Limited and Zinfandel Pharmaceuticals, Inc. today announced that they have entered into an exclusive, worldwide licensing agreement regarding Zinfandel's TOMM40 assay as a biomarker for the risk of Alzheimer's disease in high-risk older adults with normal cognition. The companies will study pioglitazone in connection with the TOMM40 biomarker and Alzheimer's disease. Pioglitazone is the active ingredient currently marketed in Takeda's ACTOS® (pioglitazone HCl).

The TOMM40 biomarker, recently discovered by a team led by Allen Roses, M.D., Chief Executive Officer of Zinfandel, is being developed to identify individuals at high risk of developing Alzheimer's disease within the subsequent five years. Under this license agreement, Takeda and Zinfandel will attempt to prospectively validate the TOMM40 biomarker as a test of individual risk.

"There is intense interest within the medical community in identifying treatments to help delay progression or potentially prevent the onset of Alzheimer's disease, in an effort to reduce the burden of this disease," said Shigenori Ohkawa, Ph.D., Chief Scientific Officer, Takeda Pharmaceutical Company Limited. "We are energized by this partnership and the opportunity to develop an effective treatment for healthy at-risk older adults."

Under the terms of agreement, Zinfandel will receive an upfront payment of $9 million and subsequent payments of up to $78 million for development milestones from Takeda. Additional commercial milestones and royalties were also outlined in the agreement. Takeda will obtain an exclusive license, with the right to sublicense, develop, make, use and commercialize the TOMM40 biomarker assay, and to use the assay to identify high-risk older adults who would be candidates for clinical trials with pioglitazone to evaluate its utility.

"At Zinfandel, we have been exploring pharmacogene
'/>"/>

SOURCE Takeda Pharmaceutical Company Limited; Zinfandel Pharmaceutcals, Inc.
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2

Related biology technology :

1. Takeda San Francisco, Inc. Appoints Gregory Landes, Ph.D. Vice President of Antibody Research
2. FDA Continues Review of Takedas New Drug Application for Alogliptin (SYR-322), a DPP-4 Agent for Type 2 Diabetes
3. Keryx Biopharmaceuticals, Inc. to Hold Conference Call on Second Quarter 2008 Financial Results on Monday, August 11, at 8:30 A.M. EDT
4. ISTA Pharmaceuticals Reports Second Quarter 2008 Financial Results
5. SGX Pharmaceuticals Announces Financial Results for the Three and Six Months Ended June 30, 2008
6. ADVENTRX Pharmaceuticals to Report Second Quarter 2008 Results
7. Merrimack Pharmaceuticals Initiates Enrollment in a Phase 1 Study of MM-121, an ErbB3 Antagonist
8. VIA Pharmaceuticals to Present at Fourth Annual Noble Financial Equity Conference
9. Anthera Pharmaceuticals Completes $19 Million Financing; Appoints Christopher S. Henney as Chairman
10. Access Pharmaceuticals to Present at the Noble Financial Equity Conference
11. Indevus Pharmaceuticals Announces Issuance of U.S. Patent for SANCTURA XR(TM)
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/7/2015)... (PRWEB) , ... July 07, 2015 , ... ... held in Munich, Germany, 21-25 June, featured highlights including two Nobel Laureates who ... pioneering work to enhance the resolution of microscopes. , SPIE Optical Metrology ...
(Date:7/7/2015)... July 7, 2015 Summary ... Therapy Market Analysis" report is an essential source ... field. Using detailed company data, deal analysis, corporate ... in-depth analysis of the current and future growth ... discusses the key factors shaping and driving the ...
(Date:7/7/2015)... July 7, 2015 Genes in Space, ... 7-12, is landing at New England Biolabs® (NEB®) ... day of scientific exploration and celebration, on Thursday, ... partnership between Boeing®, The Center for Advancement of ... asked students to design an experiment to solve ...
(Date:7/7/2015)... ... July 07, 2015 , ... An aging population, ... of the factors driving the pharmaceutical contract manufacturing market. BCC Research reveals in ... manufacturing organizations (CMOs), are driving market growth. Drug manufacturers are increasing their outsourcing ...
Breaking Biology Technology:Light-Based Technologies at Work: ‘Seeing’ Through Walls, Monitoring Cancer Treatments and Air Pollution, Preserving Artworks -- and Much More 2Light-Based Technologies at Work: ‘Seeing’ Through Walls, Monitoring Cancer Treatments and Air Pollution, Preserving Artworks -- and Much More 3Light-Based Technologies at Work: ‘Seeing’ Through Walls, Monitoring Cancer Treatments and Air Pollution, Preserving Artworks -- and Much More 4Light-Based Technologies at Work: ‘Seeing’ Through Walls, Monitoring Cancer Treatments and Air Pollution, Preserving Artworks -- and Much More 5PharmaSphere: Emerging Biotechnologies - Gene Therapy Market Analysis 2Genes in Space finalists attend laboratory workshop and celebration at New England Biolabs' headquarters 2More Drug Companies Increasing Outsourcing Budgets; CMO Partners Spring Up as Market Thrives, According to BCC Research 2More Drug Companies Increasing Outsourcing Budgets; CMO Partners Spring Up as Market Thrives, According to BCC Research 3
... Calif., April 28 Telik, Inc. (Nasdaq: TELK ) ... that were presented at the 100th annual meeting of the American ... can be found on the Telik website, www.telik.com ... Action of Orally Active Aurora Kinase/ VEGFR Inhibitors; Abstract # 1764 ...
... Pa., April 28 Particle Sciences, Inc. today announced ... Director, Quality Assurance. Mr. Garcia will report to ... Sciences following more than 30 years experience in pharmaceutical ... Wyeth as Senior Director of Quality Operations. Prior ...
... More listings for life science postgraduates than any other ... Career Center has become the nation,s number one jobs ... board, www.biocareercenter.com , is only for ... with 19 of the most prestigious universities in the ...
Cached Biology Technology:Telik Reports Preclinical Results at AACR Annual Meeting 2Telik Reports Preclinical Results at AACR Annual Meeting 3Hector Garcia Joins Particle Sciences as Director of Quality Assurance 2Bio Career Center Becomes Top in Nation for Life Sciences Careers 2
(Date:7/7/2015)... DUBLIN , June 30, 2015 ... ) has announced the addition of the ... their offering. To this date, fingerprint ... biometric technology and fingerprint sensors are well developed. ... capacitive sensing technology. The domain of ...
(Date:7/7/2015)... MOUNTAIN VIEW, Calif. , July 7, 2015 ... mobile biometrics market, Frost & Sullivan recognizes Credence ... & Sullivan Entrepreneurial Company of the Year ... product suite to aid in its mission of ... and under-recognized populations globally. As Credence ID was ...
(Date:7/7/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") a ... a revised version of one of its first 30 second commercials ... in New York , Chicago ... Francisco metro areas.    , , , ... all the cards in your wallet and keep your identity secure. ...
Breaking Biology News(10 mins):Worldwide Capacitive Fingerprint Sensors Patent Landscape Market Report 2015-2020 - Main IP Holders include Seiko Epson, AuthenTec, Sony and STMicroelectronics 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 2Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 3Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 4Frost & Sullivan Acknowledges the Distinctive Customer-focused Attributes of Credence ID's Mobile Biometric Product Suite 5Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 2Wocket Smart Wallet Commercials Airing on CNBC to Showcase This Summer's Must- Have Tech Product 3
... research has found that if you want some of the ... vegetables, you need to eat the real thing a ... far less value if taken as a supplement. The ... Oregon State University, is one of the first of its ...
... down shortly after an asteroid plowed into the Gulf of ... to widespread global extinctions including the demise of big dinosaurs, ... to show themselves following the global catastrophe. While ... on the survival and proliferation of mammals, paleo-botanical studies show ...
... Mich.---It,s "Waterworld" snail style: Ocean-dwelling snails that spend most ... of mucus bubbles. Scientists have known about ... wondered how the rafting habit evolved. What, exactly, were ... Michigan graduate student Celia Churchill and coauthors believe they,ve ...
Cached Biology News:Health benefits of broccoli require the whole food, not supplements 2Health benefits of broccoli require the whole food, not supplements 3Worms among first animals to surface after K-T extinction event, CU-led study finds 2Worms among first animals to surface after K-T extinction event, CU-led study finds 3In bubble-rafting snails, the eggs came first 2In bubble-rafting snails, the eggs came first 3In bubble-rafting snails, the eggs came first 4
Schneider's Drosophila - Insect medium...
... proteomic service includes protein separation by ... the PDQuest software package from Bio-Rad ... spectrometry. In order to meet customers ... data analysis and format of the ...
... Dual-Binary Analytical System more than doubles the ... LC/MS. The fast analysis cycles of the ... to 100% in tandem mode. Difficult separations ... Using backflush or heartcut configurations, on-line sample ...
... molecular weight of 16 kDa. Leptin is a ... adipocytes [1,2]. Leptin is thought to play a ... In the human, leptin levels are elevated with ... A relationship between serum leptin levels and several measures ...
Biology Products: