Navigation Links
Study improves understanding of surface molecules in controlling size of gold nanoparticles
Date:6/18/2012

North Carolina State University researchers have shown that the "bulkiness" of molecules commonly used in the creation of gold nanoparticles actually dictates the size of the nanoparticles with larger so-called ligands resulting in smaller nanoparticles. The research team also found that each type of ligand produces nanoparticles in a particular array of discrete sizes.

"This work advances our understanding of nanoparticle formation, and gives us a new tool for controlling the size and characteristics of gold nanoparticles," says Dr. Joseph Tracy, an assistant professor of materials science and engineering at NC State and co-author of a paper describing the research. Gold nanoparticles are used in industrial chemical processes, as well as medical and electronics applications.

When creating gold nanoparticles, scientists often use organic molecules called ligands to facilitate the process. The ligands effectively bring gold atoms together in a solution to create the nanoparticles. In the process, ligands essentially line up side by side and surround the nanoparticles in all three dimensions.

The researchers wanted to see whether the bulkiness of the ligands affected nanoparticle size, and opted to assess three types of thiol ligands a family of ligands commonly used to synthesize gold nanoparticles. Specifically, the molecules bound to the gold nanoparticles are linear hexanethiolate (-SC6), cyclohexanethiolate (-SCy) and 1-adamantanethiolate (-SAd). Each of these ligands has a bulkier configuration than the last.

For example, picture each ligand as a slice of pie, with a gold atom attached to the pointed end. -SC6 looks like a very narrow slice of pie. -SCy is slightly larger, and -SAd is the largest of the three with the "crust" end of the pie wedge far wider than the pointed end.

The researchers found that the bulkiness of the ligands determined the size of the nanoparticles. Because fewer -SAd and -SCy ligands can line up next to each other in three dimensions, fewer gold atoms are brought together in the core. Therefore, the nanoparticles are smaller. -SC6, the least bulky of the thiolates, can create the largest nanoparticles.

"While we've shown that this is an effective means of controlling size in gold nanoparticles, we think it may have implications for other materials as well," says Peter Krommenhoek, a Ph.D. student at NC State and lead author of the paper. "That's something we're exploring."

But the researchers made another interesting finding as well.

When particularly small nanoparticles form, they tend to form at very specific sizes, called discrete sizes. For instance, some types of nanoparticles may consist of 25 or 28 atoms but never 26 or 27 atoms.

In this study, the researchers found that the bulkiness of the ligands also changed the discrete sizes of the nanoparticles. "This is interesting, in part, because each discrete size represents a different number of gold atoms and ligands," Tracy says, "which could influence the nanoparticle's chemical behavior. That question has yet to be addressed."


'/>"/>
Contact: Matt Shipman
matt_shipman@ncsu.edu
919-515-6386
North Carolina State University
Source:Eurekalert  

Related biology technology :

1. Positive Clinical Study Results for BSPs HyperQ Technology
2. 15-Minute Data From Phase 3 Study of Avanafil Featured as a Late Breaking Abstract at SMSNA Annual Meeting
3. DermTechs Non-invasive Melanoma Detection Assay Poised to Enter Clinical Validation Study
4. Marshall study shows nanoparticles used as additives in diesel fuels can travel from lungs to liver
5. Clionsky Neuro Systems (CNS-Neuro) Announces Publication of Study Finding Elderly Patients Unable to Recognize Their Memory Loss
6. Convergence Pharmaceuticals Initiates Phase I Multiple Ascending Dose Study for CNV2197944
7. AtheroNova Inc. Preclinical Study Demonstrates 95% Reduction in Arterial Plaque Formation
8. Singapore scientists lead human embryonic stem cell study
9. GeneTex Antibody Company to Launch New Line of Primary Antibodies for the Study of Spindle Assembly
10. Nutra Pharma Announces Publication of a New Mechanism Study of Alpha-Cobratoxin in the Treatment of Pain
11. Metabolex Announces Positive Results From its Clinical Study of Arhalofenate in Combination With Febuxostat
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Study improves understanding of surface molecules in controlling size of gold nanoparticles
(Date:6/23/2016)... , June 23, 2016 Apellis Pharmaceuticals, ... 1 clinical trials of its complement C3 inhibitor, ... and multiple ascending dose studies designed to assess ... of subcutaneous injection in healthy adult volunteers. ... either as a single dose (ranging from 45 ...
(Date:6/23/2016)... , June 23, 2016 ... Review, 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published ... the peer-reviewed journal from touchONCOLOGY, Andrew D ... cost of cancer care is placing an increasing ... of expensive biologic therapies. With the patents on ...
(Date:6/23/2016)... ... June 23, 2016 , ... ClinCapture, the only ... Center and will showcase its product’s latest features from June 26 to June ... scientific poster on Disrupting Clinical Trials in The Cloud during the conference. ...
(Date:6/23/2016)... ... June 23, 2016 , ... Velocity Products, ... tools designed, tuned and optimized exclusively for Okuma CNC machining centers at The ... of a collaboration among several companies with expertise in toolholding, cutting tools, machining ...
Breaking Biology Technology:
(Date:6/15/2016)... New York , June 15, 2016 /PRNewswire/ ... a new market report titled "Gesture Recognition Market by ... and Forecast, 2016 - 2024". According to the report, ... USD 11.60 billion in 2015 and is estimated ... reach USD 48.56 billion by 2024.  ...
(Date:6/2/2016)... June 2, 2016 The Department of ... awarded the 44 million US Dollar project, for the ... Plates including Personalization, Enrolment, and IT Infrastructure , ... the production and implementation of Identity Management Solutions. Numerous renowned ... Decatur was selected for the most ...
(Date:5/20/2016)... MINNEAPOLIS , May 20, 2016  VoiceIt ... technology partnership with VoicePass. By working ... user experience.  Because VoiceIt and VoicePass take slightly ... two engines increases both security and usability. ... expressed excitement about this new partnership. ...
Breaking Biology News(10 mins):