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Studies Assess Hydroxyurea Therapy and Pre-Operative Transfusions for Patients with Sickle Cell Disease
Date:12/11/2011

of Medicine in Houston. "Results from this study contribute to a growing body of evidence suggesting that in vivo genotoxicity of hydroxyurea in sickle cell anemia appears to be low. Taken together with the clinical benefits demonstrated in the BABY HUG study, hydroxyurea may be considered as a potential therapeutic option for even very young, asymptomatic children with sickle cell anemia."

Dr. McGann will present this study in an oral presentation on Sunday, December 11, at 4:45 p.m. PST at the Manchester Grand Hyatt in the Elizabeth Ballroom AB.

Pre-Operative Transfusion Reduces Serious Adverse Events in Patients with Sickle Cell Disease (SCD): Results From the Transfusion Alternatives Preoperatively in Sickle Cell Disease (TAPS) Randomised Controlled Multicentre Clinical Trial [Abstract 9]

New research suggests that patients with sickle cell disease (SCD) who are undergoing surgeries, such as abdominal surgery or tonsillectomy, should receive pre-operative transfusions to reduce their risk of post-operative complications.

Pre-operative blood transfusions have been used to reduce complications after surgery for SCD patients, who are at higher risk for these complications than the general population. However, some experts have claimed that the procedure is not necessary and can be safely omitted prior to surgery.

To assess the clinical benefit of pre-operative transfusion to alleviate perioperative complications in patients with SCD undergoing low- or medium-risk surgery, researchers embarked on the multicenter, randomized controlled Transfusion Alternatives Pre-Operatively in Sickle Cell Disease (TAPS) Trial. The trial was carried out between November 2007 and March 2011 at 22 clinical sites in the United Kingdom, the Netherlands, and Canada.

Patients with HbSS and HbSbo thalassemia, the most severe forms of SCD, we
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SOURCE American Society of Hematology
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