Navigation Links
Studies Assess Hydroxyurea Therapy and Pre-Operative Transfusions for Patients with Sickle Cell Disease
Date:12/11/2011

and Efficacy of Continued Treatment -- the BABY HUG Follow-up Study [Abstract 7]

Hydroxyurea is the only federally approved therapy to prevent sickle cell complications in adults with sickle cell anemia (SCA). However, based on positive results from previous trials assessing clinical benefits for use in children, specialists are increasingly considering the use of hydroxyurea in their pediatric patients. Results from the BABY HUG Follow-up Study I suggest that continued use of hydroxyurea is both safe and effective in infants with SCA.

The Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) was a multicenter, randomized clinical trial that assessed the clinical benefits of hydroxyurea in very young patients with SCA. Results from the study demonstrated that hydroxyurea administered to infants with SCA provided substantial clinical benefit over placebo.

Researchers launched the BABY HUG Follow-Up Study I in 2008 to assess the safety and efficacy of continued treatment with hydroxyurea in infants with SCA. The Follow-Up Study I included 163 children between the ages of 28 and 44 months who had participated in the BABY HUG trial and who had completed at least 18 months of randomized treatment of either hydroxyurea or placebo. Investigators collected clinical and laboratory data every six months from patient medical records, including use and dosage of hydroxyurea, blood counts, clinical imaging, and frequency of sickle cell-related complications.

At Follow-Up Study entry, families enrolling their children did not know their child's randomized study treatment assignment in BABY HUG; 82 percent initially chose clinical prescription of open-label hydroxyurea, demonstrating a high acceptance rate for the drug. Through the 36 months of follow-up, acceptance remained high, with 68 to 75 percent of the participating families reporting that their children continued
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. ICON Medical Imaging Launches New Service to Boost Reliability of Cardiology Studies
2. OpenClinica EDC Solution Deployed for Retina Implant Studies
3. Pressure BioSciences, Inc. Releases Novel, PCT-dependent Sample Preparation Kit for Systems Biology Studies
4. Leading Biopharmas Will Deliver Case Studies on Achieving Productivity Excellence through Engagement, Technology, Other Tools
5. NIST studies how new helium ion microscope measures up
6. Five New Clinical Studies Show Value of Masimo PVI & PI
7. ACTEMRA(R) (tocilizumab) Studies to be Featured at American College of Rheumatology Annual Scientific Meeting
8. Isolagen to Host Investor Conference Call to Present an Analysis of the Data from Phase III Wrinkle Studies
9. New Clinical Studies Presented at the American Society of Anesthesiology (ASA) Annual Meeting Show Masimo Technologies Provide Advanced Clinical Intelligence
10. Vaxart Demonstrates Efficacy of Oral Avian Flu Vaccine in Preclinical Studies
11. Trubion Reports Re-treatment Results Following Phase 1/2a and Phase 2b Studies Evaluating TRU-015 for Rheumatoid Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/15/2014)... State University have developed a technique for controlling the ... voltages, opening the door to a new generation of ... hinges on the fact that the oxide "skin" of ... acts as a surfactant, lowering the surface tension ... researchers used a liquid metal alloy of gallium and ...
(Date:9/15/2014)... 2014 Zymo Research Corp., has announced the ... safe ambient temperature storage and transport of infectious ... of agents in such samples is completely inactivated ... the viral nucleic acids for subsequent analyses.  With ... in West Africa and ...
(Date:9/15/2014)... September 2014 Die zweite jährliche ... 12. bis 18. Oktober stattfinden. Die IPAW ist ... Association (PPTA) und ihrer Mitgliedsunternehmen ... globale Bewusstsein für die Gewinnung von Quellplasma zu ... Retten und Verbessern von Leben zu würdigen ...
(Date:9/14/2014)... Baltimore, MD (PRWEB) September 15, 2014 ... will be held on Tuesday, October 21, 2014, from ... an overview of the program’s innovative curriculum and practice-oriented ... how a graduate degree can help advance their career ... please RSVP online . , About UMBC’s ...
Breaking Biology Technology:Researchers control surface tension to manipulate liquid metals 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 2Safe storage and transport of Ebola, Mers-CoV, and other viruses: Groundbreaking viral inactivation solution capable of preserving nucleic acids 3International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 2International Plasma Awareness Week feiert Spender und rückt seltene Krankheiten in den Mittelpunkt 3UMBC Biotechnology Graduate Programs’ Virtual Info Session, October 21, 2014 2
... Encorium Group, Inc. (Nasdaq:  ENCO), (the "Company"), ... conducting studies in over 30 countries for many ... today announced that, on October 20, 2010, it ... (the "Panel") has determined to delist the Company,s ...
... available in German . Jena (21 ... in improving a fabrication process for Atomic Force Microscopy (AFM) ... scan surfaces so that even tiniest nano structures become visible. ... development of new materials and carrier systems for active substances. ...
... Transgenomic, Inc. (OTC Bulletin Board: TBIO ) ... company as Medical Director for Laboratory Services.  In this ... leading the strategic vision and managing the day-to-day operations ... Dr. Johnson brings to Transgenomic nearly 20 years of ...
Cached Biology Technology:Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 2Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 3Encorium Announces NASDAQ Panel Decision to Delist Common Stock; Announces Changes to its Board of Directors 4AFM tips from the microwave 2Dr. Eric Johnson Joins Transgenomic as Medical Director for Laboratory Services 2Dr. Eric Johnson Joins Transgenomic as Medical Director for Laboratory Services 3Dr. Eric Johnson Joins Transgenomic as Medical Director for Laboratory Services 4
(Date:9/16/2014)... vessel returned to Spain culminating the around the world ... picture of how the global ocean works and what ... from the atmosphere is not limited to coastal areas, ... the planet, and it is already affecting the ocean ... in CSIC Residence for Researchers in Barcelona, in a ...
(Date:9/16/2014)... salmon-rich waters of Southeast Alaska to the white sand ... lumber and tourist towns, coastal residents around the U.S. ... divide along political lines. That,s a primary finding of ... published this month in the journal Society & ... environment-related differences from place to place to place. Each ...
(Date:9/16/2014)... functions in an organism. For example, they catalyze ... control immune system responses. Researchers established some years ... each other, but instead form complex networks. , ... many similarities with online social networks," says Dr. ... Biology. "Some proteins are good networkers that maintain ...
Breaking Biology News(10 mins):The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 2The Malaspina Expedition confirms that pollution reaches even the most remote areas of the ocean 3Politics divide coastal residents' views of environment, UNH research finds 2Politics divide coastal residents' views of environment, UNH research finds 3Good networkers make prime targets 2
... 10, 2009If you are spending the holidays with big Uncle ... be better off with another family, spare a thought for ... McMaster University and the University of New South Wales has ... members make strategic decisions about their living situation. ...
... tool use as a defining feature of humans. That,s until ... with birds and an array of other mammals. Now, a ... , a Cell Press publication, adds an octopus to the ... study manages a behavioral trick that the researchers call stilt ...
... Dec. 14 MODA Technology Partners, a global software ... testing for the Pharmaceutical industry, today announced the general ... data acquisition platform. The latest release enables quality control ... , MODA 3.0 includes the following new capabilities: ...
Cached Biology News:Tool use in an invertebrate: The coconut-carrying octopus 2MODA Announces Availability of Third Generation Mobile Data Acquisition Platform 2
... This CLS number is a new ... Cornings product number. If showing no ... old Sigma-Aldrich number (C6671) or contact ... treated yes Surface area 148 cm ...
... System is intended for use in the ... an in-house validated in vitro nucleic acid ... • The CHEMICON ... capture assay designed to detect amplified nucleic ...
... PhageMaker System is optimized for maximum packaging efficiencies ... any bacteriophage l vector. Using a test insert ... pfu/g arms (> 4 x 10^8 pfu/g ligated ... system is extremely easy to use; simply add ...
BD BioCoat Laminin 150 mm Culture Dishes...
Biology Products: