Navigation Links
Studies Assess Hydroxyurea Therapy and Pre-Operative Transfusions for Patients with Sickle Cell Disease
Date:12/11/2011

and Efficacy of Continued Treatment -- the BABY HUG Follow-up Study [Abstract 7]

Hydroxyurea is the only federally approved therapy to prevent sickle cell complications in adults with sickle cell anemia (SCA). However, based on positive results from previous trials assessing clinical benefits for use in children, specialists are increasingly considering the use of hydroxyurea in their pediatric patients. Results from the BABY HUG Follow-up Study I suggest that continued use of hydroxyurea is both safe and effective in infants with SCA.

The Pediatric Hydroxyurea Phase III Clinical Trial (BABY HUG) was a multicenter, randomized clinical trial that assessed the clinical benefits of hydroxyurea in very young patients with SCA. Results from the study demonstrated that hydroxyurea administered to infants with SCA provided substantial clinical benefit over placebo.

Researchers launched the BABY HUG Follow-Up Study I in 2008 to assess the safety and efficacy of continued treatment with hydroxyurea in infants with SCA. The Follow-Up Study I included 163 children between the ages of 28 and 44 months who had participated in the BABY HUG trial and who had completed at least 18 months of randomized treatment of either hydroxyurea or placebo. Investigators collected clinical and laboratory data every six months from patient medical records, including use and dosage of hydroxyurea, blood counts, clinical imaging, and frequency of sickle cell-related complications.

At Follow-Up Study entry, families enrolling their children did not know their child's randomized study treatment assignment in BABY HUG; 82 percent initially chose clinical prescription of open-label hydroxyurea, demonstrating a high acceptance rate for the drug. Through the 36 months of follow-up, acceptance remained high, with 68 to 75 percent of the participating families reporting that their children continued
'/>"/>

SOURCE American Society of Hematology
Copyright©2010 PR Newswire.
All rights reserved

Page: 1 2 3 4 5 6 7

Related biology technology :

1. ICON Medical Imaging Launches New Service to Boost Reliability of Cardiology Studies
2. OpenClinica EDC Solution Deployed for Retina Implant Studies
3. Pressure BioSciences, Inc. Releases Novel, PCT-dependent Sample Preparation Kit for Systems Biology Studies
4. Leading Biopharmas Will Deliver Case Studies on Achieving Productivity Excellence through Engagement, Technology, Other Tools
5. NIST studies how new helium ion microscope measures up
6. Five New Clinical Studies Show Value of Masimo PVI & PI
7. ACTEMRA(R) (tocilizumab) Studies to be Featured at American College of Rheumatology Annual Scientific Meeting
8. Isolagen to Host Investor Conference Call to Present an Analysis of the Data from Phase III Wrinkle Studies
9. New Clinical Studies Presented at the American Society of Anesthesiology (ASA) Annual Meeting Show Masimo Technologies Provide Advanced Clinical Intelligence
10. Vaxart Demonstrates Efficacy of Oral Avian Flu Vaccine in Preclinical Studies
11. Trubion Reports Re-treatment Results Following Phase 1/2a and Phase 2b Studies Evaluating TRU-015 for Rheumatoid Arthritis
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2015)... 2015  Navitas Life Sciences is delighted to announce the ... and Regulatory Services. Shalabh is a proven leader in Life ... of Kinapse, as well as a Strategy consultant at Accenture. ... http://photos.prnewswire.com/prnh/20150423/201261LOGO ... am delighted to welcome Shalabh into this critical role and ...
(Date:4/23/2015)... April 24, 2015 Ralco announced today ... Birthright Nutrition® (ABN) for the exclusive worldwide rights to ... new technology is a new in-line milk system that ... allowing them to move supplementation milk cups within a ... , “This technology lets producers get Birthright™ milk to ...
(Date:4/23/2015)... 2015 /CNW/ - A new and innovative service has ... North America,s largest packaging trade ... in the "Sustainability, service" category of the PAC ... Comparison" is a service that scores clients, packaging ... peers. This benchmarking process shows clients how their ...
(Date:4/23/2015)... April 23, 2015  Neurocrine Biosciences, Inc. (Nasdaq: ... its first quarter 2015 results before the Nasdaq market ... host a live conference call and webcast to discuss its ... April 30, 2015 at 8:00 a.m. Eastern Time (5:00 ... live conference call by dialing 866-952-1906 (US) or 785-424-1825 ...
Breaking Biology Technology:Shalabh Kumar Joins Navitas Life Sciences to Lead their Clinical and Regulatory Services Teams 2Ralco Acquires License to Birthright™ Moveable Milk Cup 2Neurocrine Biosciences Announces Conference Call and Webcast to Report First Quarter 2015 Results 2
... Richard Duffey, M.D., to its LASIK Directory. ... also serves patients from Pensacola, Florida and from ... Mississippi.,Trusted LASIK Surgeons launched its revolutionary Trusted LASIK ... consumers at www.TrustedLASIKSurgeons.com . What sets the ...
... Varian, Inc.,(NasdaqGS: VARI) introduced its new dual wavelength ... proteins. The SuperNova(TM) is the,first dual wavelength diffraction ... It includes innovations in both X-ray,technology and data ... crystals., Single crystal X-ray diffraction is used ...
... Quality and process,improvement efforts gained new momentum ... higher efficiencies fueled by a stagnating economy.,Biopharmaceutical companies ... pipelines are affecting the bottom line, competition for ... brought more scrutiny to R&D,and New Product Development ...
Cached Biology Technology:Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 2Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 3Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 4Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 5Trusted LASIK Surgeons Welcomes Mobile Alabama Expert Refractive Eye Surgeon Richard Duffey, M.D. to Its LASIK Directory For Consumers 6New Dual Wavelength X-ray Diffractometer From Oxford Diffraction, Now a Part of Varian, Inc., Allows Increased Throughput for Challenging Single Crystal Analyses 2Leading Biopharmas Will Deliver Case Studies on Achieving Productivity Excellence through Engagement, Technology, Other Tools 2
(Date:4/2/2015)... 2, 2015 Fingerprint Cards (FPC) ... FPC1025 from the distributor World Peace Industrial Group (WPI), ... 2015 although the major part of the shipments will ... used by smartphone manufacturers in China ... in the communicated revenue guidance of + 1 000 MSEK ...
(Date:3/31/2015)... March 31, 2015   Guidepoint , a leading ... the Post-Surgical Pain Management TRACKER, part of the ... trends in the medical device and therapeutics markets. The ... including treatment volumes, market share, and adoption rates across ... with joint surgery. The Post-Surgical Pain Management ...
(Date:3/24/2015)... 24, 2015 Research and Markets ( http://www.researchandmarkets.com/research/kvdtcw/face_and_voice ) ... - Global Strategic Business Report" report to their offering. ... Biometrics in US$ Thousands by the following Segments: Face Biometrics, and ... Canada , Japan , ... Middle East & Africa , and ...
Breaking Biology News(10 mins):Fingerprint Cards Receives Touch Fingerprint Sensor Order of SEK 110 Million 2Guidepoint Launches Post-Surgical Pain Management TRACKER 2Guidepoint Launches Post-Surgical Pain Management TRACKER 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 2Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 3Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 4Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 5Face and Voice Biometrics - Global Strategic Business Report 2015: Face Recognition Gains Prominence in Immigration Control 6
... environs to take up residence in a large and ... University Bloomington scientists report in this week's Science that ... , "Plants that reproduce clonally or are capable of ... the nucleus," said graduate student Yaniv Brandvain, lead author ...
... and give a short-term boost to cognitive skills, a University ... Professor Ian Macdonald found that consumption of a cocoa drink ... blood flow to key areas of the brain for two ... areas of the brain may help to increase performance in ...
... Dentistry (NYUCD) research team has found the first oral bacterial ... Africa to Asia. , The team, led by ... NYUCD, discovered that Streptoccocus mutans, a bacterium associated with dental ... clear line that can be traced back to a single ...
Cached Biology News:Mitochondrial genes move to the nucleus -- but it's not for the sex 2Boosting brain power -- with chocolate 2'Ancestral eve' was mother of all tooth decay 2
... This product has been developed to significantly ... labeled proteins. Stability is increased at ... 2-8 centigrade. This product is subjected ... mercury or azide. This formulation insures ...
...
These 25x25 square No.1 Corning cover glasses are made from No. 0211 zinc titania glass and are 0.16 to 0.19mm thick. • Approx. Pcs Oz : 102...
... Bead Separation is a powerful tool for ... Typical applications are DNA/RNA or protein purification ... has been fully automated on the Genesis ... Te-MagS. ,In combination with the RoMa ...
Biology Products: