Navigation Links
Stem cells produce compact, regenerated bone in mandible transplants
Date:3/15/2013

Durham, NC (PRWEB) March 15, 2013

Bone transplantation is a major strategy for the repair of bone defects. However, reconstruction of the mandible (jawbone) has long been a difficult challenge for oral surgeons — at least up to now. A new study in the latest issue of STEM CELLS Translational Medicine shows how stem cells can be used to successfully repair the mandible after a molar extraction and, years later, the new bone is still functioning properly.

Interestingly, the regenerated bone is also hard, rather than the spongy kind normally found in the jaw.

The new study is a follow-up to previous investigations by an international team of researchers in which they discovered that mesenchymal stem cells taken from dental pulp and seeded on a collagen scaffold successfully repaired the mandible bone. In this latest work, they checked on patients who had received the mandible bone grafts three years earlier to assess the stability and quality of the regenerated bone and vessel network.

They found the new bone had normal function and was richly vascularized, although was much more compact than the spongy type normally found in the mandible. The team theorized that, most probably, regeneration of compact bone occurs because grafted dental-pulp stem cells do not follow the local signals of the surrounding spongy bone.

“The mandible is constructed from spongey bone on account of its role linked to the presence of teeth and their movements, so regeneration of a compact, rather than a spongy bone type, is difficult to justify physiologically. We concluded, therefore, that grafted dental pulp stem cells do not pursue the local environmental signals emanating from the alveolar bone surrounding the graft site,” said Gianpaolo Papaccio, M.D., Ph.D., of the Department of Experimental Medicine at Second University of Naples, Naples, Italy. He led the study team that included colleagues from Second University as well as researchers from Università Politecnica delle Marche, Ancona, Italy; Université CB, Lyon; European Synchrotron Radiation Facility, Grenoble, France; and the University of Michigan in the United States.

“This must be taken into consideration when grafting stem cells,” Dr. Papaccio continued. “Their behavior may be quite variable and, consequently, their differentiation fate in some cases may be affected more by their specific origin than by the local signals of the treated area.

“Although the bone regenerated at the graft sites is not of the proper type found in the mandible,” he added, “it does seem to have a positive clinical impact. In fact, it creates steadier mandibles, may well increase implant stability and, additionally, may improve resistance to mechanical, physical, chemical and pharmacological agents.”

“Dental pulp is an interesting source of ready-to-use stem cells to treat bone defects,” said Anthony Atala, M.D., Editor of STEM CELLS Translational Medicine and Director of the Wake Forest Institute for Regenerative Medicine. “The finding that these cells regenerate compact bone in the mandible indicates a potential role in the treatment of oral cancer.”

###

The full article, “Three years after transplants in human mandibles, histological and in-line HT revealed that stem cells regenerated a compact rather than a spongy bone: biological and clinical implications,” can be accessed at http://www.stemcellstm.com.

About STEM CELLS Translational Medicine: STEM CELLS TRANSLATIONAL MEDICINE (SCTM), published by AlphaMed Press, is a monthly peer-reviewed publication dedicated to significantly advancing the clinical utilization of stem cell molecular and cellular biology. By bridging stem cell research and clinical trials, SCTM will help move applications of these critical investigations closer to accepted best practices.

About AlphaMed Press: Established in 1983, AlphaMed Press with offices in Durham, NC, San Francisco, CA, and Belfast, Northern Ireland, publishes two other internationally renowned peer-reviewed journals: STEM CELLS® (http://www.StemCells.com), in its 31st year, is the world's first journal devoted to this fast paced field of research. The Oncologist® (http://www.TheOncologist.com), also a monthly peer-reviewed publication, entering its 18th year, is devoted to community and hospital-based oncologists and physicians entrusted with cancer patient care. All three journals are premier periodicals with globally recognized editorial boards dedicated to advancing knowledge and education in their focused disciplines.

Read the full story at http://www.prweb.com/releases/2013/3/prweb10531683.htm.


'/>"/>
Source: PRWeb
Copyright©2012 Vocus, Inc.
All rights reserved

Related biology technology :

1. New method for producing precursor of neurons, bone and other important tissues from stem cells
2. Biocept and Academic Collaborators to Present Posters at San Antonio Breast Cancer Symposium on Circulating Tumor Cells (CTCs)
3. Notre Dame researchers develop paint-on solar cells
4. Cord Blood America Announces Exclusive Agreement With National Childrens Leukemia Foundation to Store Stem Cells
5. Stem Cells: Worldwide Markets for Transplantation, Cord Blood Banking and Drug Development
6. In solar cells, tweaking the tiniest of parts yields big jump in efficiency
7. Mesenchymal Stem Cells Have New Cell Culture Environment
8. Discovery in Nature elucidates immune cells in skin and supports novel vaccine approach
9. Scientists Discover How a Bacterial Pathogen Breaks Down Barriers to Enter and Infect Cells
10. IntelliCell BioSciences Signs Technology Licensing Agreement with Stem Cells 21 Thailand
11. Study dusts sugar coating off little-known regulation in cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... 25, 2017 , ... Throughout this webinar, participants will learn ... development and economic goals were achieved in both industry and academic settings. Attendees ... along with techniques for scaling production of mesenchymal stem cells (MSCs) and new ...
(Date:5/24/2017)... WEST BOUNTIFUL, Utah (PRWEB) , ... May 24, ... ... announces the selection and implementation of CLEARAS Water Recovery’s Advanced Biological Nutrient ... is a key component of a $24 million plant upgrade to sustainably meet ...
(Date:5/24/2017)... -- As Ebola resurfaces in the Democratic Republic ... cases now reported, a new analysis of the Ebola gene ... between the 2014 and 2017 outbreaks of the disease.  ... which preceded the 2014 outbreak. An analysis of the latest ... in 2014-15, which again precedes the current outbreak in the ...
(Date:5/23/2017)... ... May 23, 2017 , ... ... its 20th anniversary, marking the occasion with a strong presence at Bio-IT World ... Reception and further extends an invitation to all attendees to view posters ...
Breaking Biology Technology:
(Date:4/13/2017)... April 13, 2017 UBM,s Advanced Design and ... will feature emerging and evolving technology through its 3D ... will run alongside the expo portion of the event ... and demonstrations focused on trending topics within 3D printing ... and manufacturing event will take place June 13-15, 2017 at ...
(Date:4/11/2017)... NXT-ID, Inc. (NASDAQ:   NXTD ) ... appointment of independent Directors Mr. Robin D. Richards ... Directors, furthering the company,s corporate governance and expertise. ... Gino Pereira , Chief Executive ... their guidance and benefiting from their considerable expertise as we ...
(Date:4/4/2017)... 2017   EyeLock LLC , a leader of ... States Patent and Trademark Office (USPTO) has issued U.S. ... of an iris image with a face image acquired ... company,s 45 th issued patent. ... given the multi-modal biometric capabilities that have recently come ...
Breaking Biology News(10 mins):