Navigation Links
Spanish researchers sequence non-infiltrating bladder cancer exome
Date:10/19/2013

Bladder cancer represents a serious public health problem in many countries, especially in Spain, where 11,200 new cases are recorded every year, one of the highest rates in the world. The majority of these tumours have a good prognosis -- 70-80% five-year survival after diagnosis -- and they do not infiltrate the bladder muscle at the time of diagnosis -- in around 80% of cases.

Despite this, many of the tumours recur, requiring periodic cytoscopic tumour surveillance. This type of follow-up affects patients' quality of life, at the same time as incurring significant healthcare costs.

Researchers at the Spanish National Cancer Research Centre (CNIO), coordinated by Francisco X. Real, head of the Epithelial Carcinogenesis Group and Nuria Malats, head of the Genetic & Molecular Epidemiology Group, have carried out the first exome sequencing for non-infiltrating bladder cancer, the most frequent type of bladder cancer and the one with the highest risk of recurrence (the exome is the part of the genome that contains protein synthesis information).

The results reveal new genetic pathways involved in the disease, such as cellular division and DNA repair, as well as new genes -- not previously described -- that might be crucial for understanding its origin and evolution.

"We know very little about the biology of bladder cancer, which would be useful for classifying patients, predicting relapses and even preventing the illness", says Cristina Balbs, a predoctoral researcher in Real's laboratory who is the lead author of the study.

The work consisted of analysing the exome from 17 patients diagnosed with bladder cancer and subsequently validating the data via the study of a specific group of genes in 60 additional patients.

"We found up to 9 altered genes that hadn't been described before in this type of tumour, and of these we found that STAG2 was inactive in almost 40% of the least aggressive tumours", says Rea
'/>"/>

Contact: Nuria Noriega
comunicacion@cnio.es
Centro Nacional de Investigaciones Oncologicas (CNIO)
Source:Eurekalert  

Page: 1 2

Related biology technology :

1. Spanish scientists design a revolutionary data storage device
2. Spanish researchers writing in cell describe the 9 hallmarks of aging
3. Oven Releases Their 5C7-195 Temperature Controller in Spanish Speaking Locations
4. New England Biolabs Introduces Polbase, an Information Repository of Scientific Data for Polymerase Researchers
5. In new quantum-dot LED design, researchers turn troublesome molecules to their advantage
6. Multidisciplinary team of researchers develop world’s lightest material
7. Researchers shrink tumors and minimize side effects using tumor-homing peptide to deliver treatment
8. Innovative MetaMorph® NX Software Shatters Barriers Between Researchers and Image Analysis Goals with Exclusive Visual Workflow
9. UCLA researchers demonstrate fully printed carbon nanotube transistor circuits for displays
10. Penn and Brown researchers demonstrate earthquake friction effect at the nanoscale
11. Two Top Biological Imaging Centers Offer Powerful Free Online Tool to Researchers, Educators, and Public
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Spanish researchers sequence non-infiltrating bladder cancer exome
(Date:9/3/2015)... 2015  Vermillion, Inc. (NASDAQ: VRML ), a ... that Herbert Fritsche , Ph.D., the Lab Director ... recipient of the 2015 Abbott Award, given by the ... contributions to the field of basic or clinical oncology. ... th in Zakopane, Poland . ...
(Date:9/3/2015)... DIEGO , Sept. 3, 2015  StemProtein ... and a recent spinout of Stemedica Cell Technologies ... H. Silberg as CEO of StemProtein. Silberg ... for producing and preserving Stem Cell Factors (SCFs), ... seasoned professional in the pharmaceutical and biopharmaceutical industries ...
(Date:9/3/2015)... , ... September 03, 2015 , ... Park Systems ... manufacturing on Sept. 17, 2015 at 9am PST. The webinar will focus on the ... popularly known as 3D printing, additive manufacturing is a broad term that encompasses “addition ...
(Date:9/3/2015)... ... ... If you plan to attend the 27th annual Tradeline College and University ... up for the tour of Framingham State University's newest addition to Hemenway Hall taking ... (8) chemistry teaching labs that are exclusively utilizing (49) filtered fume hoods that ...
Breaking Biology Technology:Vermillion Announces Dr. Herbert Fritsche as Recipient of the 2015 Abbott Award from the International Society of Oncology and Biomarkers 2StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 2StemProtein Names Thomas H. Silberg As CEO, To Focus On Stem Cell Secreted Proteins Addresing A Variety Of Health And Beauty Related Needs 3Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 2Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 3Park Systems Announces Webinar on 3D Printing and Additive Manufacturing for Nano-Scientists, Researchers in Nanotechnology and Engineers 4Erlab Invites You to Tour the Largest Installation of Filtered Fume Hoods in the World 2
... S*BIO Pte Ltd and Tragara Pharmaceuticals Inc. today ... to Tragara to develop and commercialize its novel multi-kinase ... is eligible to receive up to US$112.5 million in ... milestone payments and up to double-digit royalties. Additionally, ...
... Education Virtual Lecture and Podcast for Healthcare ProfessionalsVOORHEES, N.J., ... infection (CDI) is critical for several reasons. The ... by increasing rates and more severe disease. In ... an expanding list of states across the United States ...
... SHANGHAI, China, Jan. 20 /PRNewswire-Asia-FirstCall/ -- ... ("China-Biotics," "the Company"), a leading Chinese ... marketing and,distribution of probiotics products, today ... has approved manufacturing certificates for the ...
Cached Biology Technology:S*BIO and Tragara Announce an Exclusive Worldwide License Agreement for Novel Multi-kinase Inhibitor SB1317 2S*BIO and Tragara Announce an Exclusive Worldwide License Agreement for Novel Multi-kinase Inhibitor SB1317 3Clostridium difficile Infection: Current Challenges and Controversies 2China-Biotics, Inc. Receives Manufacturing Certificate for New Products 2China-Biotics, Inc. Receives Manufacturing Certificate for New Products 3
(Date:8/12/2015)... August 12, 2015 As the ... payment innovation and advanced biometrics technology is accelerating beyond ... consumers rely on using their credit cards, the digital ... future for payment services led by companies in the ... :  Google, Inc. (NASDAQ: GOOG ), Apple Inc. ...
(Date:8/12/2015)... SAN JOSE, Calif. , Aug. 12, 2015 ... leading developer of human interface solutions, today announced ... the recently announced Match-in-Sensor solution, have officially been ... (FIDO) Alliance. As part of the certification, Synaptics, ... the FIDO 1.0 Universal Authentication Framework (UAF) standard ...
(Date:8/10/2015)... Germany , August 10, 2015 /PRNewswire/ ... world leader in Eye Tracking Technology for more than ... Eye Tracking Platform for integration into all consumer display ... designs for seamless integration of eye tracking into consumer ... and augmented reality smart glasses. Omnivision,s leading sensor technology ...
Breaking Biology News(10 mins):Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 2Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 3Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 4Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 5Digital Wallet Devices & Mobile Payment Management Services Gain a Distinct Advantage in the Digital Payment Evolution as Demand Continues to Grow 6Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 2Synaptics Announces FIDO Certification of Natural ID Fingerprint Solutions 3SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 2SMI Completes OEM Eye Tracking Platform to Cover All Consumer Displays 3
... of Technology (TU/e) in The Netherlands will award an ... the Institute for BioNanotechnology in Medicine, at Northwestern University, ... of TU/e, on Friday, 24 April 2009. Stupp (57) ... matter and applications for complex molecular systems in biomedical ...
... State University faculty members are among the 486 newly ... of Science (AAAS), a prestigious international scientific society. AAAS ... Allenby, Richard Creath, James Elser, Patricia Gober, Nancy Grimm, ... recognized Feb. 14 at the Fellows forum, during the ...
... researchers have been named AAAS Fellows by the American ... is bestowed on association members by their scientific peers. ... scientifically or socially distinguished efforts to advance science or ... George Kraus, director of the Institute ...
Cached Biology News:Samuel Stupp to receive honorary doctorate from TU/e 2Eight ASU faculty elected as AAAS Fellows 2Eight ASU faculty elected as AAAS Fellows 3Eight ASU faculty elected as AAAS Fellows 4American Association for the Advancement of Science honors four Iowa Staters 2
... DNA Engine Tetrad thermal cycler expands ... pioneering PTC-200 DNA Engine cycler. ... capacity with a footprint only twice ... for laboratories that run massive quantities ...
The PROTEAN II xi multi-cell 2-D conversion kit converts the PROTEAN II xi multi-cell to the PROTEAN II XL multi-cell for a wider format cell that accepts 17 to 18 cm IPG strips....
4',6-Diamidino-2-phenylindole, dihydrochloride (DAPI)...
... cocktail is tailored to highly ... of rat spleen cells. Cells ... (or compatible 0.5 Tesla) immunomagnetic ... cell content of the enriched ...
Biology Products: