Navigation Links
Small peptide ameliorates autoimmune skin blistering disease in mice
Date:1/9/2013

Pemphigus vulgaris is a life-threatening autoimmune skin disease that is occurs when the body's immune system generates antibodies that target proteins in the skin known as desomogleins. Desmogleins help to form the adhesive bonds that hold skin cells together and keep the skin intact. Currently, pemphigus vulgaris is treated by long-term immune suppression; however, this can leave the patient susceptible to infection. In this issue of the Journal of Clinical Investigation, researchers led by Jens Waschke at the Institute of Anatomy and Cell Biology in Munich, Germany, report on a small peptide that blocked antibody recognition of desmogleins. Importantly, the peptide could prevent antibody-mediated skin blistering when applied topically to mice. At the cellular level, the peptide improved cell-cell adhesion and attenuated signaling pathways that are activated by antibody binding. These results suggest that this peptide could serve as a treatment option for pemphigus vulgaris.

TITLE:
Peptide-mediated desmoglein 3 crosslinking prevents pemphigus vulgaris autoantibody-induced skin blistering

AUTHOR CONTACT:
Jens Waschke
Ludwig-Maximilians-University Munich, Munich, , DEU
Phone: 0049-89-5160-4811; Fax: 0049-89-5160-4802; E-mail: jens.waschke@med.uni-muenchen.de

View this article at: http://www.jci.org/articles/view/60139?key=b333192372ea9937c9be


'/>"/>

Contact: Jillian Hurst
press_releases@the-jci.org
Journal of Clinical Investigation
Source:Eurekalert

Page: 1

Related biology technology :

1. Researchers develop one of the worlds smallest electronic circuits
2. The smallest conceivable switch
3. The worlds smallest steam engine
4. Navy researchers investigate small-scale autonomous planetary explorers
5. Smaller and more powerful electronics requires the understanding of quantum jamming physics
6. Graphene quantum dots: The next big small thing
7. The worlds smallest magnetic data storage unit
8. LoneStar Heart Acquires Worldwide Exclusive Rights to New Class of Small Molecules That May Lead to New Treatments for Diabetes
9. How well does protective headgear work for small children engaged in Winter activities?
10. Survey: Small Medical Practice Confidence Index Rises in 2012
11. Plasma startup creates high-energy light to make smaller microchips
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... 21, 2015 Cambridge Semantics, the leading provider ... announced that 2014 was a record-breaking year across the board ... the Anzo Smart Data Platform and our Smart Data solutions, ... from diverse data which led to record growth for the ...
(Date:1/22/2015)... Protocol Networks brings independent technology consulting to the ... consultants, Protocol Networks has recently announced its expansion into ... his company has attracted several clients in The Constitution ... as others. With the success of these engagements, Rogers ...
(Date:1/22/2015)... California (PRWEB) January 22, 2015 Pipette.com ... Offer to their comprehensive portfolio of Eppendorf products. ... customers to purchase a Centrifuge 5424/5424 R and receive ... of either Eppendorf Research plus or Eppendorf Reference 2 ...
(Date:1/22/2015)... 2015 Dr. Greg Leyer of UAS Labs ... Natural Supplements Pre-Conference seminar on probiotics in San Diego, CA. ... continuing education conference for health care professionals. This year’s pre-conference ... of probiotics in health. Dr. Leyer spoke about the emerging ...
Breaking Biology Technology:Cambridge Semantics Announces Record Results for 2014 2Protocol Networks Brings Independent Technology Consulting to the Constitution State 2Eppendorf Announces Promotional Bundle Which Includes: Eppendorf Centrifuge 5424, 3-Pack of Pipettes, and Tips - Available Now at Pipette.com 2
... relying on existing telecommunications satellites, has put a second satellite ... weather information clients. , ,Last September, Loral Skynet ... and rerouted its customers to Telstar 5 and 6. The ... Birch, data services product manager for Weather Central, said his ...
... startups, biotech , ,Entrepreneurship, nanotechnology and biomedical engineering ... in Madison and Milwaukee, giving substance to what Wisconsin ... , , Tips for Entrepreneurs , ,Established entrepreneurs ... Entrepreneurs Conference , which runs June 1-2 at the ...
... MILWAUKEE Advocates of Windows and open-source software vied ... presentation of Wednesdays session of the ITEC conference in ... Labs , said that open-source software provides a technically ... companies that want a single, obvious place to turn ...
Cached Biology Technology:Doyles Entrepreneurs and Research week nears 2Doyles Entrepreneurs and Research week nears 3Linux and Windows duke it out at ITEC 2Linux and Windows duke it out at ITEC 3
(Date:1/22/2015)... , Europe,s most ... Patent Office to present a video retrospective of the most exciting ... Christofer Toumazou and Sophie Wilson   ... the Award   Starting on 22 January 2015 on   ...
(Date:1/22/2015)... Jan. 22, 2015 Infinisource has launched its new NXG ... model. The G2 sets a higher standard for collecting attendance ... management solution. With plug-and-play installation, touch screen interface and seamless ... a robust time collection solution for the small to mid-size ...
(Date:12/22/2014)... 22, 2014 Research and Markets ( ... "The Global Watermarking and Fingerprinting Markets" ... http://photos.prnewswire.com/prnh/20130307/600769 This insight provides ... and fingerprinting markets. Watermarking aims to control and ...
Breaking Biology News(10 mins):Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 2Ten Years of the European Inventor Award: A Retrospective Look at the Inventors and Ideas That Have Changed Our Lives 3Infinisource's NXG series sets new time clock standard 2The Global Watermarking and Fingerprinting Markets 2
... 2013 -- American Associates, Ben-Gurion University of the Negev (AABGU) ... late Dr. Jordan Baruch, to fund stem cell research at ... The Jordan Baruch Stem Cell Research Fund was dedicated at ... Baruch and 20 members of her extended family. "Jordan ...
... new study has found that tamoxifen, a well-known breast ... mouse model of Duchenne muscular dystrophy (DMD). At present, ... the symptoms in boys with DMD, a debilitating muscular ... and cardiac impairments, paralysis, and premature death. This study ...
... TORONTO, Jan 14, 2013Taking a vitamin D supplement and drinking ... how much vitamin D is in a child,s body, new ... than even skin colour and exposure to the sun, according ... Michael,s Hospital. "Early childhood is a critical stage in ...
Cached Biology News:Ben-Gurion U. establishes stem cell research fund in honor of inventor Jordan Baruch 2Tamoxifen ameliorates symptoms of Duchenne muscular dystrophy 2Supplements and cow's milk play biggest roles in determining vitamin D levels in children 2
...
MultiWash III w/ 12-portStandard Manifold...
... 5 ml. The same high performance ... columns for fast, reliable purification of ... 5/50 GL, XK 16/20, or other ... required.Extremely useful for exploiting either the ...
...
Biology Products: